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2024-03-29 03:33:31, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000075               2020 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens cyclin-dependent kinase 4 (CDK4), mRNA.
ACCESSION   NM_000075 NM_032913
VERSION     NM_000075.3  GI:345525417
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Kabuta,T., Mitsui,T., Takahashi,M., Fujiwara,Y., Kabuta,C.,
            Konya,C., Tsuchiya,Y., Hatanaka,Y., Uchida,K., Hohjoh,H. and
            Wada,K.
  TITLE     Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel
            potentiator of cyclin-dependent kinases to enhance cell
            proliferation independently of its hydrolase activity
  JOURNAL   J. Biol. Chem. 288 (18), 12615-12626 (2013)
   PUBMED   23543736
  REMARK    GeneRIF: UCH-L1 physically interacts with CDK1, CDK4, and CDK5,
            enhancing their kinase activity.
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Schachter,M.M., Merrick,K.A., Larochelle,S., Hirschi,A., Zhang,C.,
            Shokat,K.M., Rubin,S.M. and Fisher,R.P.
  TITLE     A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
  JOURNAL   Mol. Cell 50 (2), 250-260 (2013)
   PUBMED   23622515
  REMARK    GeneRIF: Activating phosphorylation of Cdk7 rises concurrently with
            that of Cdk4 as cells exit quiescence and accelerates Cdk4
            activation in vitro.
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Talagas,M., Marcorelles,P., Uguen,A., Redon,S., Quintin-Roue,I.,
            Costa,S., Ferec,C., Morel,F., Hieu,P.D. and De Braekeleer,M.
  TITLE     Identification of a novel population in high-grade oligodendroglial
            tumors not deleted on 1p/19q using array CGH
  JOURNAL   J. Neurooncol. 109 (2), 405-413 (2012)
   PUBMED   22825724
  REMARK    GeneRIF: The results of this study showed that strong association
            between CDK4 gene alternation and high-grade oligodendroglial
            tumors.
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Dean,J.L., McClendon,A.K. and Knudsen,E.S.
  TITLE     Modification of the DNA damage response by therapeutic CDK4/6
            inhibition
  JOURNAL   J. Biol. Chem. 287 (34), 29075-29087 (2012)
   PUBMED   22733811
  REMARK    GeneRIF: CDK4/6 inhibition can antagonize cytotoxic therapeutic
            strategies and increases utilization of error-prone DNA repair
            mechanisms that could contribute to disease progression.
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Shafiq,M.I., Steinbrecher,T. and Schmid,R.
  TITLE     Fascaplysin as a specific inhibitor for CDK4: insights from
            molecular modelling
  JOURNAL   PLoS ONE 7 (8), E42612 (2012)
   PUBMED   22905154
  REMARK    GeneRIF: Fascaplysin is a specific inhibitor for CDK4, as shown
            from molecular modelling
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Hall,M., Bates,S. and Peters,G.
  TITLE     Evidence for different modes of action of cyclin-dependent kinase
            inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to
            cyclins
  JOURNAL   Oncogene 11 (8), 1581-1588 (1995)
   PUBMED   7478582
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Tassan,J.P., Jaquenoud,M., Leopold,P., Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of human cyclin-dependent kinase 8, a putative
            protein kinase partner for cyclin C
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (19), 8871-8875 (1995)
   PUBMED   7568034
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Mitchell,E.L., White,G.R., Santibanez-Koref,M.F., Varley,J.M. and
            Heighway,J.
  TITLE     Mapping of gene loci in the Q13-Q15 region of chromosome 12
  JOURNAL   Chromosome Res. 3 (4), 261-262 (1995)
   PUBMED   7606365
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Hanks,S.K.
  TITLE     Homology probing: identification of cDNA clones encoding members of
            the protein-serine kinase family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (2), 388-392 (1987)
   PUBMED   2948189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI832658.1, BC003644.2,
            AC025165.27 and BQ773564.1.
            On Sep 6, 2011 this sequence version replaced gi:16936531.
            
            Summary: The protein encoded by this gene is a member of the
            Ser/Thr protein kinase family. This protein is highly similar to
            the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a
            catalytic subunit of the protein kinase complex that is important
            for cell cycle G1 phase progression. The activity of this kinase is
            restricted to the G1-S phase, which is controlled by the regulatory
            subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase
            was shown to be responsible for the phosphorylation of
            retinoblastoma gene product (Rb). Mutations in this gene as well as
            in its related proteins including D-type cyclins, p16(INK4a) and Rb
            were all found to be associated with tumorigenesis of a variety of
            cancers. Multiple polyadenylation sites of this gene have been
            reported. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M14505.1, BC005864.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BI832658.1         1-153
            154-1509            BC003644.2         1-1356
            1510-1803           AC025165.27        141845-142138       c
            1804-2020           BQ773564.1         1-217               c
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14"
     gene            1..2020
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="cyclin-dependent kinase 4"
                     /db_xref="GeneID:1019"
                     /db_xref="HGNC:1773"
                     /db_xref="HPRD:00447"
                     /db_xref="MIM:123829"
     exon            1..273
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     variation       34
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2069500"
     variation       168
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:238531"
     misc_feature    236..238
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="upstream in-frame stop codon"
     exon            274..510
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     CDS             293..1204
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 4"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4"
                     /protein_id="NP_000066.1"
                     /db_xref="GI:4502735"
                     /db_xref="CCDS:CCDS8953.1"
                     /db_xref="GeneID:1019"
                     /db_xref="HGNC:1773"
                     /db_xref="HPRD:00447"
                     /db_xref="MIM:123829"
                     /translation="
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
"
     misc_feature    305..1177
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Cyclin-Dependent protein Kinase 4; Region: STKc_CDK4;
                     cd07863"
                     /db_xref="CDD:143368"
     misc_feature    308..1177
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(311..328,356..358,362..364,377..379,383..385,
                     581..586,596..598,608..610,740..742)
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="CDK/INK4 inhibitor interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143368"
     misc_feature    order(326..343,350..352,389..391,395..397,455..457,
                     506..508,569..580,587..589,593..598,710..712,716..718,
                     722..727,731..733,764..766,773..775,806..808,812..823,
                     827..829,938..943)
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="active site"
                     /db_xref="CDD:143368"
     misc_feature    order(326..337,350..352,389..391,395..397,506..508,
                     569..580,587..589,596..598,722..727,731..733,764..766)
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:143368"
     misc_feature    order(419..427,437..439,443..445,449..457,461..466,
                     473..478,485..493,518..529,536..538)
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="CDK/cyclin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:143368"
     misc_feature    440..460
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11802.2);
                     Region: Required for binding D-type cyclins"
     misc_feature    order(455..457,593..595,710..712,716..718,773..775,
                     806..808,812..823,827..829,938..940)
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:143368"
     misc_feature    761..829
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:143368"
     misc_feature    806..808
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P11802.2); phosphorylation site"
     misc_feature    806..808
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            511..646
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     variation       537
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3211612"
     STS             575..663
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /standard_name="PMC25103P2"
                     /db_xref="UniSTS:272282"
     exon            647..814
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     variation       739
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2069501"
     exon            815..924
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     variation       826
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11547327"
     exon            925..975
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     exon            976..1111
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     variation       988
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2227953"
     variation       1069
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3211622"
     exon            1112..2002
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /inference="alignment:Splign:1.39.8"
     variation       1178
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2227954"
     STS             1234..1456
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /standard_name="STS-M14505"
                     /db_xref="UniSTS:1480"
     variation       1248
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2069510"
     STS             1249..1358
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /standard_name="D12S1972"
                     /db_xref="UniSTS:40227"
     variation       1414
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2069511"
     variation       1478
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3180722"
     variation       1482
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3179899"
     variation       1507
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3180723"
     polyA_site      1509
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
     STS             1515..1836
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /standard_name="GDB:384863"
                     /db_xref="UniSTS:157112"
     variation       1574
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3473"
     STS             1629..1891
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /standard_name="GDB:593068"
                     /db_xref="UniSTS:157933"
     variation       1641
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3472"
     variation       1644
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3211635"
     STS             1763..1889
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /standard_name="D15S1477"
                     /db_xref="UniSTS:474482"
     variation       1991
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2859601"
     polyA_site      2002
                     /gene="CDK4"
                     /gene_synonym="CMM3; PSK-J3"
ORIGIN      
cacctcctgtccgcccctcagcgcatgggtggcggtcacgtgcccagaacgtccggcgttcgccccgccctcccagtttccgcgcgcctctttggcagctggtcacatggtgagggtgggggtgagggggcctctctagcttgcggcctgtgtctatggtcgggccctctgcgtccagctgctccggaccgagctcgggtgtatggggccgtaggaaccggctccggggccccgataacgggccgcccccacagcaccccgggctggcgtgagggtctcccttgatctgagaatggctacctctcgatatgagccagtggctgaaattggtgtcggtgcctatgggacagtgtacaaggcccgtgatccccacagtggccactttgtggccctcaagagtgtgagagtccccaatggaggaggaggtggaggaggccttcccatcagcacagttcgtgaggtggctttactgaggcgactggaggcttttgagcatcccaatgttgtccggctgatggacgtctgtgccacatcccgaactgaccgggagatcaaggtaaccctggtgtttgagcatgtagaccaggacctaaggacatatctggacaaggcacccccaccaggcttgccagccgaaacgatcaaggatctgatgcgccagtttctaagaggcctagatttccttcatgccaattgcatcgttcaccgagatctgaagccagagaacattctggtgacaagtggtggaacagtcaagctggctgactttggcctggccagaatctacagctaccagatggcacttacacccgtggttgttacactctggtaccgagctcccgaagttcttctgcagtccacatatgcaacacctgtggacatgtggagtgttggctgtatctttgcagagatgtttcgtcgaaagcctctcttctgtggaaactctgaagccgaccagttgggcaaaatctttgacctgattgggctgcctccagaggatgactggcctcgagatgtatccctgccccgtggagcctttccccccagagggccccgcccagtgcagtcggtggtacctgagatggaggagtcgggagcacagctgctgctggaaatgctgacttttaacccacacaagcgaatctctgcctttcgagctctgcagcactcttatctacataaggatgaaggtaatccggagtgagcaatggagtggctgccatggaaggaagaaaagctgccatttcccttctggacactgagagggcaatctttgcctttatctctgaggctatggagggtcctcctccatctttctacagagattactttgctgccttaatgacattcccctcccacctctccttttgaggcttctccttctccttcccatttctctacactaaggggtatgttccctcttgtccctttccctacctttatatttggggtccttttttatacaggaaaaacaaaacaaagaaataatggtcttttttttttttttaatgtttcttcctctgtttggctttgccattgtgcgatttggaaaaaccacttggaagaagggactttcctgcaaaaccttaaagactggttaaattacagggcctaggaagtcagtggagccccttgactgacaaagcttagaaaggaactgaaattgcttctttgaatatggattttaggcggggcgtggtggctcacgcctataatcccagcacgttgggaggccaacgcgggtggatcacctgaggtcaggagttcgagaccagcctgactaacatggtgaaaccctgtctctactaaaaatacaaaattagtcaggcgtggtggtgcacacctgtaatcccagctacttgggagactgaggcaggaggatcgcttgaacccgggaggcagaggttgcggtgagccgagatcatgccattgcactccagcctgggcaacagagcaagactctgtgtcaaaaaaaaaaaaagaatatagatttttaaatggcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1019 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IDA
            GeneID:1019 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1019 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:1019 -> Molecular function: GO:0030332 [cyclin binding] evidence: IEA
            GeneID:1019 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
            GeneID:1019 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: IMP
            GeneID:1019 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:1019 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:1019 -> Biological process: GO:0007165 [signal transduction] evidence: IEA
            GeneID:1019 -> Biological process: GO:0007623 [circadian rhythm] evidence: IEA
            GeneID:1019 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP
            GeneID:1019 -> Biological process: GO:0009636 [response to toxic substance] evidence: IEA
            GeneID:1019 -> Biological process: GO:0010288 [response to lead ion] evidence: IEA
            GeneID:1019 -> Biological process: GO:0010468 [regulation of gene expression] evidence: IMP
            GeneID:1019 -> Biological process: GO:0031100 [organ regeneration] evidence: IEA
            GeneID:1019 -> Biological process: GO:0033574 [response to testosterone stimulus] evidence: IEA
            GeneID:1019 -> Biological process: GO:0042493 [response to drug] evidence: IGI
            GeneID:1019 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:1019 -> Biological process: GO:0045727 [positive regulation of translation] evidence: IEA
            GeneID:1019 -> Biological process: GO:0045793 [positive regulation of cell size] evidence: IEA
            GeneID:1019 -> Biological process: GO:0048146 [positive regulation of fibroblast proliferation] evidence: IMP
            GeneID:1019 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:1019 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IEA
            GeneID:1019 -> Biological process: GO:0055093 [response to hyperoxia] evidence: IEA
            GeneID:1019 -> Cellular component: GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] evidence: IDA
            GeneID:1019 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
            GeneID:1019 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:1019 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:1019 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:1019 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:1019 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
            GeneID:1019 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:1019 -> Cellular component: GO:0005923 [tight junction] evidence: IEA
            GeneID:1019 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA
            GeneID:1019 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_000066 -> EC 2.7.11.22

by @meso_cacase at DBCLS
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