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2024-04-27 04:22:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000043 2755 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens Fas cell surface death receptor (FAS), transcript
variant 1, mRNA.
ACCESSION NM_000043
VERSION NM_000043.4 GI:325652050
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2755)
AUTHORS Li,Y. and Shively,J.E.
TITLE CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its
interaction with beta-catenin
JOURNAL Exp. Cell Res. 319 (8), 1061-1072 (2013)
PUBMED 23499736
REMARK GeneRIF: CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells
via its interaction with beta-catenin.
REFERENCE 2 (bases 1 to 2755)
AUTHORS Roziek,M.S., Hammam,O.A., Abd El-Sattar,H., El-Tiby,D.M. and
El-Dessouky,Y.M.
TITLE Expression of Fas protein (CD95) and Fas ligand in liver tissue of
patients with HCV-induced chronic liver disease and its correlation
with the disease progression
JOURNAL J Egypt Soc Parasitol 43 (1), 235-244 (2013)
PUBMED 23697029
REMARK GeneRIF: Semiquantitative analysis of the pattern and distribution
of the Fas antigen and Fas Ligand as indicators for hepatic
apoptosis was studied and assessed.
REFERENCE 3 (bases 1 to 2755)
AUTHORS Hauck,F., Magerus-Chatinet,A., Vicca,S., Rensing-Ehl,A.,
Roesen-Wolff,A., Roesler,J. and Rieux-Laucat,F.
TITLE Somatic loss of heterozygosity, but not haploinsufficiency alone,
leads to full-blown autoimmune lymphoproliferative syndrome in 1 of
12 family members with FAS start codon mutation
JOURNAL Clin. Immunol. 147 (1), 61-68 (2013)
PUBMED 23524443
REMARK GeneRIF: Results suggest that FAS haploinsufficiency does not cause
autoimmune lymphoproliferative syndrome (ALPS)-FAS, but that
modifying genetic events are crucial for its pathogenesis.
REFERENCE 4 (bases 1 to 2755)
AUTHORS Spes,A., Sobotic,B., Turk,V. and Turk,B.
TITLE Cysteine cathepsins are not critical for TRAIL- and CD95-induced
apoptosis in several human cancer cell lines
JOURNAL Biol. Chem. 393 (12), 1417-1431 (2012)
PUBMED 23667901
REMARK GeneRIF: Data indicate that cysteine cathepsins are not required
for the TRAIL- and CD95-mediated apoptosis in various human cancer
cell lines.
REFERENCE 5 (bases 1 to 2755)
AUTHORS Jenkins,M., Keir,M. and McCune,J.M.
TITLE A membrane-bound Fas decoy receptor expressed by human thymocytes
JOURNAL J. Biol. Chem. 275 (11), 7988-7993 (2000)
PUBMED 10713117
REFERENCE 6 (bases 1 to 2755)
AUTHORS Cascino,I., Papoff,G., Eramo,A. and Ruberti,G.
TITLE Soluble Fas/Apo-1 splicing variants and apoptosis
JOURNAL Front. Biosci. 1, D12-D18 (1996)
PUBMED 9159204
REMARK GeneRIF: A review of alternative spliced APO-1 variants and their
possible biological roles.
Review article
Publication Status: Online-Only
REFERENCE 7 (bases 1 to 2755)
AUTHORS Brunner,T., Mogil,R.J., LaFace,D., Yoo,N.J., Mahboubi,A.,
Echeverri,F., Martin,S.J., Force,W.R., Lynch,D.H., Ware,C.F. et al.
TITLE Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates
activation-induced apoptosis in T-cell hybridomas
JOURNAL Nature 373 (6513), 441-444 (1995)
PUBMED 7530336
REFERENCE 8 (bases 1 to 2755)
AUTHORS Cheng,J., Zhou,T., Liu,C., Shapiro,J.P., Brauer,M.J., Kiefer,M.C.,
Barr,P.J. and Mountz,J.D.
TITLE Protection from Fas-mediated apoptosis by a soluble form of the Fas
molecule
JOURNAL Science 263 (5154), 1759-1762 (1994)
PUBMED 7510905
REFERENCE 9 (bases 1 to 2755)
AUTHORS Inazawa,J., Itoh,N., Abe,T. and Nagata,S.
TITLE Assignment of the human Fas antigen gene (Fas) to 10q24.1
JOURNAL Genomics 14 (3), 821-822 (1992)
PUBMED 1385309
REFERENCE 10 (bases 1 to 2755)
AUTHORS Oehm,A., Behrmann,I., Falk,W., Pawlita,M., Maier,G., Klas,C.,
Li-Weber,M., Richards,S., Dhein,J., Trauth,B.C. et al.
TITLE Purification and molecular cloning of the APO-1 cell surface
antigen, a member of the tumor necrosis factor/nerve growth factor
receptor superfamily. Sequence identity with the Fas antigen
JOURNAL J. Biol. Chem. 267 (15), 10709-10715 (1992)
PUBMED 1375228
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB284727.1, BC012479.1 and
AK290978.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 10, 2011 this sequence version replaced gi:23510419.
Summary: The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor contains a death domain. It
has been shown to play a central role in the physiological
regulation of programmed cell death, and has been implicated in the
pathogenesis of various malignancies and diseases of the immune
system. The interaction of this receptor with its ligand allows the
formation of a death-inducing signaling complex that includes
Fas-associated death domain protein (FADD), caspase 8, and caspase
10. The autoproteolytic processing of the caspases in the complex
triggers a downstream caspase cascade, and leads to apoptosis. This
receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and
MAPK8/JNK, and is found to be involved in transducing the
proliferating signals in normal diploid fibroblast and T cells.
Several alternatively spliced transcript variants have been
described, some of which are candidates for nonsense-mediated mRNA
decay (NMD). The isoforms lacking the transmembrane domain may
negatively regulate the apoptosis mediated by the full length
isoform. [provided by RefSeq, Mar 2011].
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC012479.1, X63717.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025086 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-36 DB284727.1 321-356
37-987 BC012479.1 1-951
988-1723 AK290978.1 888-1623
1724-2755 BC012479.1 1688-2719
FEATURES Location/Qualifiers
source 1..2755
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24.1"
gene 1..2755
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="Fas cell surface death receptor"
/db_xref="GeneID:355"
/db_xref="HGNC:11920"
/db_xref="HPRD:00609"
/db_xref="MIM:134637"
exon 1..376
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 45
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:368829675"
variation 52
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:9658677"
misc_feature 188..190
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="upstream in-frame stop codon"
variation 248
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:12251390"
variation 252
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:2274355"
variation 290..291
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace=""
/replace="g"
/db_xref="dbSNP:199985519"
variation 291
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace=""
/replace="c"
/db_xref="dbSNP:9658678"
variation 313
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:5030766"
STS 317..1170
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="GDB:682147"
/db_xref="UniSTS:158638"
variation 337
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:200181814"
variation 342
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:193250321"
CDS 347..1354
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="isoform 1 precursor is encoded by transcript
variant 1; tumor necrosis factor receptor superfamily,
member 6; APO-1 cell surface antigen; apoptosis antigen 1;
FAS 827dupA; Fas AMA; CD95 antigen; FASLG receptor;
apoptosis-mediating surface antigen FAS; Delta
Fas/APO-1/CD95; Fas (TNF receptor superfamily, member 6);
TNF receptor superfamily member 6"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member 6 isoform 1 precursor"
/protein_id="NP_000034.1"
/db_xref="GI:4507583"
/db_xref="CCDS:CCDS7393.1"
/db_xref="GeneID:355"
/db_xref="HGNC:11920"
/db_xref="HPRD:00609"
/db_xref="MIM:134637"
/translation="
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
"
sig_peptide 347..421
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 422..1351
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/product="Tumor necrosis factor receptor superfamily
member 6"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P25445.1)"
misc_feature 485..595
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P25445.1);
Region: TNFR-Cys 1"
misc_feature 503..787
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cd00185"
/db_xref="CDD:29147"
misc_feature order(527..556,584..598,704..712)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature order(527..529,539..541,545..547,587..589,596..598,
629..631)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature 596..727
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P25445.1);
Region: TNFR-Cys 2"
misc_feature order(617..619,650..652,683..685,749..751,773..775)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(626..631,647..655)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 728..844
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P25445.1);
Region: TNFR-Cys 3"
misc_feature order(749..751,773..787)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="90's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 866..916
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P25445.1);
transmembrane region"
misc_feature 941..943
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/experiment="experimental evidence, no additional details
recorded"
/note="palmitoylation site; modified site"
misc_feature 971..973
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P25445.1); phosphorylation site"
misc_feature 980..1297
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P25445.1);
Region: Interaction with HIPK3 (By similarity)"
misc_feature 1013..1303
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="Death domain of FAS or TNF receptor superfamily
member 6; Region: Death_FAS_TNFRSF6; cd08316"
/db_xref="CDD:176731"
misc_feature order(1028..1033,1037..1042,1049..1054,1058..1063,
1097..1099,1196..1204,1208..1213,1217..1219,1226..1234,
1238..1246,1250..1252,1259..1273,1277..1279,1286..1291)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="FAS-FADD heterodimer interface [polypeptide
binding]; other site"
/db_xref="CDD:176731"
misc_feature order(1097..1099,1265..1270,1277..1279,1289..1291,
1298..1303)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="octamer interface [polypeptide binding]; other
site"
/db_xref="CDD:176731"
misc_feature order(1232..1234,1241..1243,1253..1255,1262..1267,
1286..1288,1295..1300)
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/note="tetramer interface [polypeptide binding]; other
site"
/db_xref="CDD:176731"
STS 347..682
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="GDB:362780"
/db_xref="UniSTS:156762"
exon 377..542
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 379
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="t"
/db_xref="dbSNP:113022949"
variation 384
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:372880667"
variation 385
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:377196867"
variation 392
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:3218619"
variation 425
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:201624874"
variation 443
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:55766344"
variation 449
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:9333296"
variation 487
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:3218621"
variation 509
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="g"
/db_xref="dbSNP:148677058"
variation 529
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:3218613"
exon 543..680
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 568
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229521"
variation 593
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:199790261"
STS 599..1425
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="GDB:682143"
/db_xref="UniSTS:158637"
STS 677..1015
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="GDB:362783"
/db_xref="UniSTS:156763"
exon 681..789
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 699
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:121913083"
variation 707
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:121913078"
variation 711
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:3218614"
variation 715
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:28362318"
variation 737
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:147866832"
variation 744
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="t"
/db_xref="dbSNP:373422165"
exon 790..851
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 823
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="g"
/db_xref="dbSNP:371144668"
variation 845
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:374502752"
exon 852..914
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 878
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:121913084"
variation 879
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:372866793"
variation 896
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:28362322"
exon 915..997
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 921
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:371290262"
variation 924
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:150489856"
variation 926
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:56006128"
STS 944..2085
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="GDB:681362"
/db_xref="UniSTS:158618"
variation 959
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:376146907"
variation 987..988
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:3218617"
variation 988
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:2234978"
exon 998..1022
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
STS 1012..1355
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="GDB:362785"
/db_xref="UniSTS:156764"
variation 1013
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:143318339"
exon 1023..2689
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/inference="alignment:Splign:1.39.8"
variation 1041
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:121913079"
STS 1048..1313
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="PMC96480P1"
/db_xref="UniSTS:273628"
variation 1067
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:121913076"
variation 1068
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:201072885"
variation 1069
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:376882067"
variation 1080
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="g"
/replace="t"
/db_xref="dbSNP:200778245"
variation 1085
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="g"
/db_xref="dbSNP:138606548"
STS 1086..1205
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="RH91808"
/db_xref="UniSTS:89274"
variation 1086
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="g"
/db_xref="dbSNP:121913085"
variation 1095
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="g"
/db_xref="dbSNP:121913080"
variation 1099
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:114658485"
variation 1109
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:121913082"
variation 1124
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="g"
/replace="t"
/db_xref="dbSNP:121913086"
variation 1125
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="t"
/db_xref="dbSNP:28929498"
variation 1155
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:121913081"
variation 1163
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:121913077"
variation 1168
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:112369298"
variation 1213
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:377337130"
variation 1216
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:370426812"
variation 1260
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:3218611"
variation 1294
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:114502430"
variation 1296
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:200864612"
variation 1302
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:372459755"
variation 1304
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:146209060"
variation 1307
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:137898188"
STS 1350..2041
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="TNFRSF6_1709"
/db_xref="UniSTS:277831"
variation 1373
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:185945540"
variation 1382
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="g"
/replace="t"
/db_xref="dbSNP:367859151"
variation 1397
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:190852915"
variation 1422
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="g"
/db_xref="dbSNP:75338675"
variation 1424
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="g"
/db_xref="dbSNP:80330323"
variation 1426
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:79014610"
variation 1428
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:79516148"
variation 1493
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:180894914"
variation 1496
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:9658774"
variation 1564
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:150332608"
variation 1729
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:55845561"
variation 1737
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:138025457"
variation 1743
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:9658775"
STS 1785..1940
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="RH11007"
/db_xref="UniSTS:72023"
variation 1790
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:143388574"
variation 1871
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="t"
/db_xref="dbSNP:187244054"
variation 1919
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="t"
/db_xref="dbSNP:1051070"
polyA_signal 1983..1988
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
variation 1992
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:192032778"
polyA_site 2007
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
variation 2029
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:182807520"
variation 2085
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:367885235"
variation 2119
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:9658776"
variation 2274
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:113329139"
STS 2311..2647
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/standard_name="D10S2281"
/db_xref="UniSTS:79142"
variation 2332
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:181225729"
variation 2353..2354
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace=""
/replace="c"
/db_xref="dbSNP:35457596"
variation 2407
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:374529697"
variation 2438
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:1468063"
variation 2471
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/db_xref="dbSNP:56386801"
variation 2479
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:17847994"
variation 2480
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:9658777"
variation 2557
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:190060976"
variation 2648
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="t"
/db_xref="dbSNP:9658778"
variation 2654
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:182693978"
variation 2666
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="c"
/replace="t"
/db_xref="dbSNP:187980745"
variation 2667
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="g"
/db_xref="dbSNP:192544176"
polyA_signal 2670..2675
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
variation 2687
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:9658779"
polyA_site 2689
/gene="FAS"
/gene_synonym="ALPS1A; APO-1; APT1; CD95; FAS1; FASTM;
TNFRSF6"
ORIGIN
cctacccgcgcgcaggccaagttgctgaatcaatggagccctccccaacccgggcgttccccagcgaggcttccttcccatcctcctgaccaccggggcttttcgtgagctcgtctctgatctcgcgcaagagtgacacacaggtgttcaaagacgcttctggggagtgagggaagcggtttacgagtgacttggctggagcctcaggggcgggcactggcacggaacacaccctgaggccagccctggctgcccaggcggagctgcctcttctcccgcgggttggtggacccgctcagtacggagttggggaagctctttcacttcggaggattgctcaacaaccatgctgggcatctggaccctcctacctctggttcttacgtctgttgctagattatcgtccaaaagtgttaatgcccaagtgactgacatcaactccaagggattggaattgaggaagactgttactacagttgagactcagaacttggaaggcctgcatcatgatggccaattctgccataagccctgtcctccaggtgaaaggaaagctagggactgcacagtcaatggggatgaaccagactgcgtgccctgccaagaagggaaggagtacacagacaaagcccatttttcttccaaatgcagaagatgtagattgtgtgatgaaggacatggcttagaagtggaaataaactgcacccggacccagaataccaagtgcagatgtaaaccaaactttttttgtaactctactgtatgtgaacactgtgacccttgcaccaaatgtgaacatggaatcatcaaggaatgcacactcaccagcaacaccaagtgcaaagaggaaggatccagatctaacttggggtggctttgtcttcttcttttgccaattccactaattgtttgggtgaagagaaaggaagtacagaaaacatgcagaaagcacagaaaggaaaaccaaggttctcatgaatctccaactttaaatcctgaaacagtggcaataaatttatctgatgttgacttgagtaaatatatcaccactattgctggagtcatgacactaagtcaagttaaaggctttgttcgaaagaatggtgtcaatgaagccaaaatagatgagatcaagaatgacaatgtccaagacacagcagaacagaaagttcaactgcttcgtaattggcatcaacttcatggaaagaaagaagcgtatgacacattgattaaagatctcaaaaaagccaatctttgtactcttgcagagaaaattcagactatcatcctcaaggacattactagtgactcagaaaattcaaacttcagaaatgaaatccaaagcttggtctagagtgaaaaacaacaaattcagttctgagtatatgcaattagtgtttgaaaagattcttaatagctggctgtaaatactgcttggttttttactgggtacattttatcatttattagcgctgaagagccaacatatttgtagatttttaatatctcatgattctgcctccaaggatgtttaaaatctagttgggaaaacaaacttcatcaagagtaaatgcagtggcatgctaagtacccaaataggagtgtatgcagaggatgaaagattaagattatgctctggcatctaacatatgattctgtagtatgaatgtaatcagtgtatgttagtacaaatgtctatccacaggctaaccccactctatgaatcaatagaagaagctatgaccttttgctgaaatatcagttactgaacaggcaggccactttgcctctaaattacctctgataattctagagattttaccatatttctaaactttgtttataactctgagaagatcatatttatgtaaagtatatgtatttgagtgcagaatttaaataaggctctacctcaaagacctttgcacagtttattggtgtcatattatacaatatttcaattgtgaattcacatagaaaacattaaattataatgtttgactattatatatgtgtatgcattttactggctcaaaactacctacttctttctcaggcatcaaaagcattttgagcaggagagtattactagagctttgccacctctccatttttgccttggtgctcatcttaatggcctaatgcacccccaaacatggaaatatcaccaaaaaatacttaatagtccaccaaaaggcaagactgcccttagaaattctagcctggtttggagatactaactgctctcagagaaagtagctttgtgacatgtcatgaacccatgtttgcaatcaaagatgataaaatagattcttatttttcccccacccccgaaaatgttcaataatgtcccatgtaaaacctgctacaaatggcagcttatacatagcaatggtaaaatcatcatctggatttaggaattgctcttgtcatacccccaagtttctaagatttaagattctccttactactatcctacgtttaaatatctttgaaagtttgtattaaatgtgaattttaagaaataatatttatatttctgtaaatgtaaactgtgaagatagttataaactgaagcagatacctggaaccacctaaagaacttccatttatggaggatttttttgccccttgtgtttggaattataaaatataggtaaaagtacgtaattaaataatgtttttggtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:355 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS
GeneID:355 -> Molecular function: GO:0004872 [receptor activity] evidence: NAS
GeneID:355 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: IEA
GeneID:355 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:355 -> Molecular function: GO:0019900 [kinase binding] evidence: IPI
GeneID:355 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:355 -> Biological process: GO:0002377 [immunoglobulin production] evidence: IEA
GeneID:355 -> Biological process: GO:0003014 [renal system process] evidence: IEA
GeneID:355 -> Biological process: GO:0006461 [protein complex assembly] evidence: TAS
GeneID:355 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:355 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:355 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:355 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
GeneID:355 -> Biological process: GO:0006924 [activation-induced cell death of T cells] evidence: IEA
GeneID:355 -> Biological process: GO:0006925 [inflammatory cell apoptotic process] evidence: IEA
GeneID:355 -> Biological process: GO:0006927 [transformed cell apoptotic process] evidence: IEA
GeneID:355 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:355 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: IEA
GeneID:355 -> Biological process: GO:0009636 [response to toxic substance] evidence: IEA
GeneID:355 -> Biological process: GO:0010467 [gene expression] evidence: IEA
GeneID:355 -> Biological process: GO:0010940 [positive regulation of necrotic cell death] evidence: IMP
GeneID:355 -> Biological process: GO:0019724 [B cell mediated immunity] evidence: IEA
GeneID:355 -> Biological process: GO:0032464 [positive regulation of protein homooligomerization] evidence: IEA
GeneID:355 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: NAS
GeneID:355 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP
GeneID:355 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:355 -> Biological process: GO:0045060 [negative thymic T cell selection] evidence: IEA
GeneID:355 -> Biological process: GO:0045619 [regulation of lymphocyte differentiation] evidence: IEA
GeneID:355 -> Biological process: GO:0045637 [regulation of myeloid cell differentiation] evidence: IEA
GeneID:355 -> Biological process: GO:0048536 [spleen development] evidence: IEA
GeneID:355 -> Biological process: GO:0050869 [negative regulation of B cell activation] evidence: IEA
GeneID:355 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IEA
GeneID:355 -> Biological process: GO:0051384 [response to glucocorticoid stimulus] evidence: IEA
GeneID:355 -> Biological process: GO:0051402 [neuron apoptotic process] evidence: IEA
GeneID:355 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:355 -> Biological process: GO:0071285 [cellular response to lithium ion] evidence: IEA
GeneID:355 -> Biological process: GO:0071455 [cellular response to hyperoxia] evidence: IMP
GeneID:355 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:355 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
GeneID:355 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:355 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:355 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:355 -> Cellular component: GO:0005829 [cytosol] evidence: NAS
GeneID:355 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:355 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:355 -> Cellular component: GO:0009897 [external side of plasma membrane] evidence: IEA
GeneID:355 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:355 -> Cellular component: GO:0031264 [death-inducing signaling complex] evidence: IDA
GeneID:355 -> Cellular component: GO:0031265 [CD95 death-inducing signaling complex] evidence: IDA
GeneID:355 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA
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