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2019-03-23 03:03:24, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_000017               1934 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens acyl-CoA dehydrogenase, C-2 to C-3 short chain
            (ACADS), mRNA.
ACCESSION   NM_000017
VERSION     NM_000017.2  GI:161377444
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1934)
  AUTHORS   Vatanavicharn,N., Liammongkolkul,S., Sakamoto,O.,
            Sathienkijkanchai,A. and Wasant,P.
  TITLE     Phenotypic and mutation spectrums of Thai patients with isovaleric
            acidemia
  JOURNAL   Pediatr Int 53 (6), 990-994 (2011)
   PUBMED   22004070
  REMARK    GeneRIF: IVD mutations in Asian populations are distinct from these
            in Western populations.
REFERENCE   2  (bases 1 to 1934)
  AUTHORS   Lucas,T.G., Henriques,B.J., Rodrigues,J.V., Bross,P., Gregersen,N.
            and Gomes,C.M.
  TITLE     Cofactors and metabolites as potential stabilizers of mitochondrial
            acyl-CoA dehydrogenases
  JOURNAL   Biochim. Biophys. Acta 1812 (12), 1658-1663 (2011)
   PUBMED   21968293
  REMARK    GeneRIF: physiological concentrations of flavin adenine
            dinucleotide resulted in a spectacular enhancement of the thermal
            stabilities of SCAD and prevented enzymatic activity loss
REFERENCE   3  (bases 1 to 1934)
  AUTHORS   Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wagele B,
            Altmaier E, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de
            Angelis MH, Kastenmuller G, Kottgen A, Kronenberg F, Mangino M,
            Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J,
            Ried JS, Romisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G,
            Illig T, Spector TD, Adamski J, Soranzo N and Gieger C.
  CONSRTM   CARDIoGRAM
  TITLE     Human metabolic individuality in biomedical and pharmaceutical
            research
  JOURNAL   Nature 477 (7362), 54-60 (2011)
   PUBMED   21886157
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1934)
  AUTHORS   Hornbak,M., Banasik,K., Justesen,J.M., Krarup,N.T., Sandholt,C.H.,
            Andersson,A., Sandbaek,A., Lauritzen,T., Pisinger,C., Witte,D.R.,
            Sorensen,T.A., Pedersen,O. and Hansen,T.
  TITLE     The minor C-allele of rs2014355 in ACADS is associated with reduced
            insulin release following an oral glucose load
  JOURNAL   BMC Med. Genet. 12, 4 (2011)
   PUBMED   21211036
  REMARK    GeneRIF: In glucose-tolerant individuals the minor C-allele of
            rs2014355 of ACADS was associated with reduced measures of
            glucose-stimulated insulin release during an oral glucose tolerance
            test.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1934)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS ONE 5 (9), E12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1934)
  AUTHORS   Kelly,C.L., Hinsdale,M.E. and Wood,P.A.
  TITLE     Cloning and characterization of the mouse short-chain acyl-CoA
            dehydrogenase cDNA
  JOURNAL   Genomics 18 (1), 137-140 (1993)
   PUBMED   8276399
REFERENCE   7  (bases 1 to 1934)
  AUTHORS   Vanhove,G., Van Veldhoven,P.P., Eyssen,H.J. and Mannaerts,G.P.
  TITLE     Mitochondrial short-chain acyl-CoA dehydrogenase of human liver and
            kidney can function as an oxidase
  JOURNAL   Biochem. J. 292 (PT 1), 23-30 (1993)
   PUBMED   8503850
REFERENCE   8  (bases 1 to 1934)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
REFERENCE   9  (bases 1 to 1934)
  AUTHORS   Naito,E., Indo,Y. and Tanaka,K.
  TITLE     Identification of two variant short chain acyl-coenzyme A
            dehydrogenase alleles, each containing a different point mutation
            in a patient with short chain acyl-coenzyme A dehydrogenase
            deficiency
  JOURNAL   J. Clin. Invest. 85 (5), 1575-1582 (1990)
   PUBMED   1692038
REFERENCE   10 (bases 1 to 1934)
  AUTHORS   Naito,E., Ozasa,H., Ikeda,Y. and Tanaka,K.
  TITLE     Molecular cloning and nucleotide sequence of complementary DNAs
            encoding human short chain acyl-coenzyme A dehydrogenase and the
            study of the molecular basis of human short chain acyl-coenzyme A
            dehydrogenase deficiency
  JOURNAL   J. Clin. Invest. 83 (5), 1605-1613 (1989)
   PUBMED   2565344
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB487184.1, M26393.1 and
            BU682624.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Nov 30, 2007 this sequence version replaced gi:4557232.
            
            Summary: This gene encodes a a tetrameric mitochondrial
            flavoprotein, which is a member of the acyl-CoA dehydrogenase
            family. This enzyme catalyzes the initial step of the mitochondrial
            fatty acid beta-oxidation pathway. Mutations in this gene have been
            associated with Short Chain Acyl-CoA Dehydrogenase Deficiency.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025963.1, M26393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                DB487184.1         34-129
            97-1598             M26393.1           11-1512
            1599-1934           BU682624.1         1-336               c
FEATURES             Location/Qualifiers
     source          1..1934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1934
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /note="acyl-CoA dehydrogenase, C-2 to C-3 short chain"
                     /db_xref="GeneID:35"
                     /db_xref="HGNC:90"
                     /db_xref="HPRD:06053"
                     /db_xref="MIM:606885"
     exon            1..164
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       1
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186841031"
     CDS             119..1357
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /EC_number="1.3.8.1"
                     /note="acyl-Coenzyme A dehydrogenase, C-2 to C-3 short
                     chain; short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial; butyryl-CoA dehydrogenase; unsaturated
                     acyl-CoA reductase; mitochondrial short-chain specific
                     acyl-CoA dehydrogenase; short-chain acyl-CoA
                     dehydrogenase"
                     /codon_start=1
                     /product="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_000008.1"
                     /db_xref="GI:4557233"
                     /db_xref="CCDS:CCDS9207.1"
                     /db_xref="GeneID:35"
                     /db_xref="HGNC:90"
                     /db_xref="HPRD:06053"
                     /db_xref="MIM:606885"
                     /translation="
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
"
     transit_peptide 119..190
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
     mat_peptide     191..1354
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /product="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial"
     misc_feature    215..1354
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /note="Acyl-CoA dehydrogenases [Lipid metabolism]; Region:
                     CaiA; COG1960"
                     /db_xref="CDD:32143"
     misc_feature    224..1342
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /note="Short chain acyl-CoA dehydrogenases and eukaryotic
                     short/branched chain acyl-CoA dehydrogenases; Region:
                     SCAD_SBCAD; cd01158"
                     /db_xref="CDD:173847"
     misc_feature    order(572..574,581..583,599..601,671..673,677..679,
                     1211..1213,1223..1225,1292..1294)
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173847"
     misc_feature    order(587..589,602..604,671..673,800..814,1007..1009,
                     1016..1018,1043..1045,1055..1060,1064..1066,1073..1075,
                     1097..1099,1166..1168,1199..1201,1211..1213,1226..1228,
                     1232..1234,1238..1243,1253..1255,1262..1267,1274..1279,
                     1283..1285,1304..1306,1313..1315,1322..1324)
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:173847"
     misc_feature    order(599..604,911..913,920..925,932..934,1016..1018,
                     1292..1294)
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:173847"
     misc_feature    923..934
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P16219.1);
                     Region: Substrate binding"
     misc_feature    1292..1294
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173847"
     exon            165..328
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       165
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147494970"
     variation       177
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139981498"
     variation       242
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143948985"
     variation       254
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:121908003"
     variation       265
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202193021"
     variation       277
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147303048"
     variation       282
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147442301"
     variation       307
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371096896"
     variation       311
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377388400"
     variation       321
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148789330"
     variation       322
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374124706"
     exon            329..478
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       333
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142476255"
     variation       343
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370478896"
     variation       346
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375620690"
     variation       367
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150507331"
     variation       373
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113118479"
     variation       374
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374930037"
     variation       386
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:121908005"
     variation       392
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:121908004"
     variation       402
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369400082"
     variation       412
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143169456"
     variation       428..430
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace=""
                     /replace="gag"
                     /db_xref="dbSNP:387906308"
     variation       437
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61732144"
     variation       439
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3914"
     variation       440
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117356004"
     variation       441
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:387906951"
     variation       445
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144083614"
     variation       478
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76543640"
     exon            479..590
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       480
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372873554"
     variation       531
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17848085"
     variation       532
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201825471"
     variation       535
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149107232"
     variation       541
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2239686"
     variation       542
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375450502"
     variation       543
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148297461"
     variation       578
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368500899"
     variation       583
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141492002"
     exon            591..742
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       616
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187551593"
     variation       625
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147038701"
     variation       629
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1800556"
     variation       640
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143925225"
     variation       647
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:57443665"
     variation       693
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28940874"
     variation       696
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369167716"
     variation       720
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151059234"
     exon            743..913
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       743
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1799958"
     variation       772
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149430391"
     variation       773
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144815059"
     variation       774
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148588313"
     variation       786
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143131689"
     variation       787
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17848089"
     variation       790
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373660425"
     exon            914..1051
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       926
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370283455"
     variation       933
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374726386"
     variation       937
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368859841"
     variation       943
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200652158"
     variation       944
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199717731"
     variation       968
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201430078"
     variation       973
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372164287"
     variation       979
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375272147"
     variation       1006
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111686208"
     variation       1018
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150980955"
     variation       1032
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:550921"
     exon            1052..1147
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       1091
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:121908006"
     variation       1106
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140853839"
     variation       1107
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199633532"
     variation       1108
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3915"
     variation       1129
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200346345"
     exon            1148..1204
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       1149
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:387906950"
     variation       1171
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145594828"
     variation       1172
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202078273"
     variation       1176
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28941773"
     variation       1183
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:697853"
     variation       1186
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377559470"
     exon            1205..1917
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /inference="alignment:Splign:1.39.8"
     variation       1213
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368469075"
     variation       1222
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200165866"
     variation       1223
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145466253"
     variation       1235
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371934737"
     variation       1248
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183161718"
     variation       1249
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374867417"
     variation       1256
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28940875"
     variation       1257
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368064268"
     variation       1265
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28940872"
     variation       1266
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35233375"
     variation       1267
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371323002"
     variation       1271
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202124189"
     variation       1313
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375931905"
     variation       1316
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369840561"
     variation       1324
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374043146"
     variation       1327
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377069922"
     variation       1349
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369416846"
     variation       1362
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2229533"
     variation       1378
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3916"
     variation       1384
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188190117"
     variation       1393
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372567027"
     variation       1394
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377080695"
     variation       1438
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371172924"
     variation       1443
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374762327"
     variation       1472
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2229534"
     variation       1557
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137990231"
     variation       1606
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:628909"
     variation       1630
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369720260"
     variation       1667
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116733542"
     variation       1674
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373553465"
     variation       1738
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192425836"
     variation       1744
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11065238"
     STS             1750..1895
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /standard_name="RH75794"
                     /db_xref="UniSTS:87176"
     variation       1857
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:639667"
     variation       1884
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9204"
     polyA_signal    1897..1902
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
     polyA_site      1917
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
     variation       1917
                     /gene="ACADS"
                     /gene_synonym="ACAD3; SCAD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113752987"
ORIGIN      
cggccccgctcccgaggccctacgggcgtggcctctgtcccgggtcccgccccccagcactccggaacagcgcgctcgcagcgggaggtcgcgaagcctgggactgtgtctgtcgcccatggccgccgcgctgctcgcccgggcctcgggccctgcccgcagagctctctgtcctagggcctggcggcagttacacaccatctaccagtctgtggaactgcccgagacacaccagatgttgctccagacatgccgggactttgccgagaaggagttgtttcccattgcagcccaggtggataaggaacatctcttcccagcggctcaggtgaagaagatgggcgggcttgggcttctggccatggacgtgcccgaggagcttggcggtgctggcctcgattacctggcctacgccatcgccatggaggagatcagccgtggctgcgcctccaccggagtcatcatgagtgtcaacaactctctctacctggggcccatcttgaagtttggctccaaggagcagaagcaggcgtgggtcacgcctttcaccagtggtgacaaaattggctgctttgccctcagcgaaccagggaacggcagtgatgcaggagctgcgtccaccaccgcccgggccgagggcgactcatgggttctgaatggaaccaaagcctggatcaccaatgcctgggaggcttcggctgccgtggtctttgccagcacggacagagccctgcaaaacaagggcatcagtgccttcctggtccccatgccaacgcctgggctcacgttggggaagaaagaagacaagctgggcatccggggctcatccacggccaacctcatctttgaggactgtcgcatccccaaggacagcatcctgggggagccagggatgggcttcaagatagccatgcaaaccctggacatgggccgcatcggcatcgcctcccaggccctgggcattgcccagaccgccctcgattgtgctgtgaactacgctgagaatcgcatggccttcggggcgcccctcaccaagctccaggtcatccagttcaagttggcagacatggccctggccctggagagtgcccggctgctgacctggcgcgctgccatgctgaaggataacaagaagcctttcatcaaggaggcagccatggccaagctggccgcctcggaggccgcgaccgccatcagccaccaggccatccagatcctgggcggcatgggctacgtgacagagatgccggcagagcggcactaccgcgacgcccgcatcactgagatctacgagggcaccagcgaaatccagcggctggtgatcgccgggcatctgctcaggagctaccggagctgagcccgcggcggactgccccaggactgcgggaaggcgcgggagccaggggcctccaccccaaccccggctcagagactgggcggcccggcgggggctccctggggaccccagatgggctcagtgctgccacccagatcagatcacatgggaatgaggccctccgaccattggcagctccgcctctgggcctttccgcctcctcaccactgtgcctcaagttcctcatctaagtggccctggcctcctgggggcggggttgtgggggggctgagcgacactcagggacacctcagttgtcctcccgcgggccctggtgccctggcatgaaggcccagtgcgacaggcccttggtggggtctgtcttttccttgaggtcagaggtcaggagcagggctggggtcaggatgacgaggcctggggtcctggtgttgggcaggtggtggggctgggccatggagctggcccagaggcccctcagccctttgtaaagtctgatgaaggcaggggtggtgattcatgctgtgtgactgactgtgggtaataaacacacctgtcccccaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:35 -> Molecular function: GO:0000062 [fatty-acyl-CoA binding] evidence: IEA
            GeneID:35 -> Molecular function: GO:0003995 [acyl-CoA dehydrogenase activity] evidence: TAS
            GeneID:35 -> Molecular function: GO:0004085 [butyryl-CoA dehydrogenase activity] evidence: IEA
            GeneID:35 -> Molecular function: GO:0050660 [flavin adenine dinucleotide binding] evidence: IEA
            GeneID:35 -> Biological process: GO:0006635 [fatty acid beta-oxidation] evidence: TAS
            GeneID:35 -> Biological process: GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] evidence: IEA
            GeneID:35 -> Biological process: GO:0042594 [response to starvation] evidence: IEA
            GeneID:35 -> Biological process: GO:0044255 [cellular lipid metabolic process] evidence: TAS
            GeneID:35 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:35 -> Biological process: GO:0046359 [butyrate catabolic process] evidence: IEA
            GeneID:35 -> Biological process: GO:0051289 [protein homotetramerization] evidence: IEA
            GeneID:35 -> Biological process: GO:0051384 [response to glucocorticoid stimulus] evidence: IEA
            GeneID:35 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:35 -> Cellular component: GO:0005759 [mitochondrial matrix] evidence: TAS
            GeneID:35 -> Cellular component: GO:0031966 [mitochondrial membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_000008 -> EC 1.3.8.1

by @meso_cacase at DBCLS
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