GGRNA | NM_001042475.2

LOCUS       NM_001042475            7653 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens centrosomal protein 85kDa-like (CEP85L), transcript
            variant 1, mRNA.
ACCESSION   NM_001042475
VERSION     NM_001042475.2  GI:295842356
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7653)
  AUTHORS   Ritchie,M.D., Denny,J.C., Zuvich,R.L., Crawford,D.C.,
            Schildcrout,J.S., Bastarache,L., Ramirez,A.H., Mosley,J.D.,
            Pulley,J.M., Basford,M.A., Bradford,Y., Rasmussen,L.V., Pathak,J.,
            Chute,C.G., Kullo,I.J., McCarty,C.A., Chisholm,R.L., Kho,A.N.,
            Carlson,C.S., Larson,E.B., Jarvik,G.P., Sotoodehnia,N.,
            Manolio,T.A., Li,R., Masys,D.R., Haines,J.L. and Roden,D.M.
  CONSRTM   Cohorts for Heart and Aging Research in Genomic Epidemiology
            (CHARGE) QRS Group
  TITLE     Genome- and phenome-wide analyses of cardiac conduction identifies
            markers of arrhythmia risk
  JOURNAL   Circulation 127 (13), 1377-1385 (2013)
   PUBMED   23463857
REFERENCE   2  (bases 1 to 7653)
  AUTHORS   Smith,J.G., Avery,C.L., Evans,D.S., Nalls,M.A., Meng,Y.A.,
            Smith,E.N., Palmer,C., Tanaka,T., Mehra,R., Butler,A.M., Young,T.,
            Buxbaum,S.G., Kerr,K.F., Berenson,G.S., Schnabel,R.B., Li,G.,
            Ellinor,P.T., Magnani,J.W., Chen,W., Bis,J.C., Curb,J.D.,
            Hsueh,W.C., Rotter,J.I., Liu,Y., Newman,A.B., Limacher,M.C.,
            North,K.E., Reiner,A.P., Quibrera,P.M., Schork,N.J.,
            Singleton,A.B., Psaty,B.M., Soliman,E.Z., Solomon,A.J.,
            Srinivasan,S.R., Alonso,A., Wallace,R., Redline,S., Zhang,Z.M.,
            Post,W.S., Zonderman,A.B., Taylor,H.A., Murray,S.S., Ferrucci,L.,
            Arking,D.E., Evans,M.K., Fox,E.R., Sotoodehnia,N., Heckbert,S.R.,
            Whitsel,E.A. and Newton-Cheh,C.
  CONSRTM   CARe and COGENT consortia
  TITLE     Impact of ancestry and common genetic variants on QT interval in
            African Americans
  JOURNAL   Circ Cardiovasc Genet 5 (6), 647-655 (2012)
   PUBMED   23166209
REFERENCE   3  (bases 1 to 7653)
  AUTHORS   Wu,X., Scelo,G., Purdue,M.P., Rothman,N., Johansson,M., Ye,Y.,
            Wang,Z., Zelenika,D., Moore,L.E., Wood,C.G., Prokhortchouk,E.,
            Gaborieau,V., Jacobs,K.B., Chow,W.H., Toro,J.R., Zaridze,D.,
            Lin,J., Lubinski,J., Trubicka,J., Szeszenia-Dabrowska,N.,
            Lissowska,J., Rudnai,P., Fabianova,E., Mates,D., Jinga,V.,
            Bencko,V., Slamova,A., Holcatova,I., Navratilova,M., Janout,V.,
            Boffetta,P., Colt,J.S., Davis,F.G., Schwartz,K.L., Banks,R.E.,
            Selby,P.J., Harnden,P., Berg,C.D., Hsing,A.W., Grubb,R.L. III,
            Boeing,H., Vineis,P., Clavel-Chapelon,F., Palli,D., Tumino,R.,
            Krogh,V., Panico,S., Duell,E.J., Quiros,J.R., Sanchez,M.J.,
            Navarro,C., Ardanaz,E., Dorronsoro,M., Khaw,K.T., Allen,N.E.,
            Bueno-de-Mesquita,H.B., Peeters,P.H., Trichopoulos,D.,
            Linseisen,J., Ljungberg,B., Overvad,K., Tjonneland,A., Romieu,I.,
            Riboli,E., Stevens,V.L., Thun,M.J., Diver,W.R., Gapstur,S.M.,
            Pharoah,P.D., Easton,D.F., Albanes,D., Virtamo,J., Vatten,L.,
            Hveem,K., Fletcher,T., Koppova,K., Cussenot,O., Cancel-Tassin,G.,
            Benhamou,S., Hildebrandt,M.A., Pu,X., Foglio,M., Lechner,D.,
            Hutchinson,A., Yeager,M., Fraumeni,J.F. Jr., Lathrop,M.,
            Skryabin,K.G., McKay,J.D., Gu,J., Brennan,P. and Chanock,S.J.
  TITLE     A genome-wide association study identifies a novel susceptibility
            locus for renal cell carcinoma on 12p11.23
  JOURNAL   Hum. Mol. Genet. 21 (2), 456-462 (2012)
   PUBMED   22010048
REFERENCE   4  (bases 1 to 7653)
  AUTHORS   Chmielecki,J., Peifer,M., Viale,A., Hutchinson,K., Giltnane,J.,
            Socci,N.D., Hollis,C.J., Dean,R.S., Yenamandra,A., Jagasia,M.,
            Kim,A.S., Dave,U.P., Thomas,R.K. and Pao,W.
  TITLE     Systematic screen for tyrosine kinase rearrangements identifies a
            novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and
            an associated myeloproliferative neoplasm
  JOURNAL   Genes Chromosomes Cancer 51 (1), 54-65 (2012)
   PUBMED   21938754
  REMARK    GeneRIF: Detection of a novel imatinib-sensitive C6orf204-PDGFRB
            fusion in a patient with precursor T lymphoblastic lymphoma (T-ALL)
            and an associated myeloproliferative neoplasm with eosinophilia.
REFERENCE   5  (bases 1 to 7653)
  AUTHORS   Eijgelsheim,M., Newton-Cheh,C., Sotoodehnia,N., de Bakker,P.I.,
            Muller,M., Morrison,A.C., Smith,A.V., Isaacs,A., Sanna,S., Dorr,M.,
            Navarro,P., Fuchsberger,C., Nolte,I.M., de Geus,E.J., Estrada,K.,
            Hwang,S.J., Bis,J.C., Ruckert,I.M., Alonso,A., Launer,L.J.,
            Hottenga,J.J., Rivadeneira,F., Noseworthy,P.A., Rice,K.M., Perz,S.,
            Arking,D.E., Spector,T.D., Kors,J.A., Aulchenko,Y.S., Tarasov,K.V.,
            Homuth,G., Wild,S.H., Marroni,F., Gieger,C., Licht,C.M.,
            Prineas,R.J., Hofman,A., Rotter,J.I., Hicks,A.A., Ernst,F.,
            Najjar,S.S., Wright,A.F., Peters,A., Fox,E.R., Oostra,B.A.,
            Kroemer,H.K., Couper,D., Volzke,H., Campbell,H., Meitinger,T.,
            Uda,M., Witteman,J.C., Psaty,B.M., Wichmann,H.E., Harris,T.B.,
            Kaab,S., Siscovick,D.S., Jamshidi,Y., Uitterlinden,A.G.,
            Folsom,A.R., Larson,M.G., Wilson,J.F., Penninx,B.W., Snieder,H.,
            Pramstaller,P.P., van Duijn,C.M., Lakatta,E.G., Felix,S.B.,
            Gudnason,V., Pfeufer,A., Heckbert,S.R., Stricker,B.H.,
            Boerwinkle,E. and O'Donnell,C.J.
  TITLE     Genome-wide association analysis identifies multiple loci related
            to resting heart rate
  JOURNAL   Hum. Mol. Genet. 19 (19), 3885-3894 (2010)
   PUBMED   20639392
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 7653)
  AUTHORS   Vasan,R.S., Glazer,N.L., Felix,J.F., Lieb,W., Wild,P.S.,
            Felix,S.B., Watzinger,N., Larson,M.G., Smith,N.L., Dehghan,A.,
            Grosshennig,A., Schillert,A., Teumer,A., Schmidt,R., Kathiresan,S.,
            Lumley,T., Aulchenko,Y.S., Konig,I.R., Zeller,T., Homuth,G.,
            Struchalin,M., Aragam,J., Bis,J.C., Rivadeneira,F., Erdmann,J.,
            Schnabel,R.B., Dorr,M., Zweiker,R., Lind,L., Rodeheffer,R.J.,
            Greiser,K.H., Levy,D., Haritunians,T., Deckers,J.W., Stritzke,J.,
            Lackner,K.J., Volker,U., Ingelsson,E., Kullo,I., Haerting,J.,
            O'Donnell,C.J., Heckbert,S.R., Stricker,B.H., Ziegler,A.,
            Reffelmann,T., Redfield,M.M., Werdan,K., Mitchell,G.F., Rice,K.,
            Arnett,D.K., Hofman,A., Gottdiener,J.S., Uitterlinden,A.G.,
            Meitinger,T., Blettner,M., Friedrich,N., Wang,T.J., Psaty,B.M., van
            Duijn,C.M., Wichmann,H.E., Munzel,T.F., Kroemer,H.K.,
            Benjamin,E.J., Rotter,J.I., Witteman,J.C., Schunkert,H.,
            Schmidt,H., Volzke,H. and Blankenberg,S.
  TITLE     Genetic variants associated with cardiac structure and function: a
            meta-analysis and replication of genome-wide association data
  JOURNAL   JAMA 302 (2), 168-178 (2009)
   PUBMED   19584346
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 7653)
  AUTHORS   Newton-Cheh,C., Eijgelsheim,M., Rice,K.M., de Bakker,P.I., Yin,X.,
            Estrada,K., Bis,J.C., Marciante,K., Rivadeneira,F.,
            Noseworthy,P.A., Sotoodehnia,N., Smith,N.L., Rotter,J.I.,
            Kors,J.A., Witteman,J.C., Hofman,A., Heckbert,S.R., O'Donnell,C.J.,
            Uitterlinden,A.G., Psaty,B.M., Lumley,T., Larson,M.G. and
            Stricker,B.H.
  TITLE     Common variants at ten loci influence QT interval duration in the
            QTGEN Study
  JOURNAL   Nat. Genet. 41 (4), 399-406 (2009)
   PUBMED   19305408
REFERENCE   8  (bases 1 to 7653)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun. 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048977.1, BC064835.1, AF308284.1, AL589993.5 and BC045657.1.
            On May 7, 2010 this sequence version replaced gi:109715851.
            
            Summary: The protein encoded by this gene was identified as a
            breast cancer antigen. Nothing more is known of its function at
            this time. Three transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036553.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-996               BC048977.1         1-996
            997-2294            BC064835.1         489-1786
            2295-3149           AF308284.1         931-1785
            3150-6346           AL589993.5         84632-87828         c
            6347-7653           BC045657.1         2933-4239
FEATURES             Location/Qualifiers
     source          1..7653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22"
     gene            1..7653
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /note="centrosomal protein 85kDa-like"
                     /db_xref="GeneID:387119"
                     /db_xref="HGNC:21638"
     exon            1..661
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    454..456
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /note="upstream in-frame stop codon"
     CDS             589..3006
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /note="isoform a is encoded by transcript variant 1;
                     serologically defined breast cancer antigen NY-BR-15;
                     centrosomal protein of 85 kDa-like"
                     /codon_start=1
                     /product="centrosomal protein of 85 kDa-like isoform a"
                     /protein_id="NP_001035940.1"
                     /db_xref="GI:109715852"
                     /db_xref="CCDS:CCDS43498.1"
                     /db_xref="GeneID:387119"
                     /db_xref="HGNC:21638"
                     /translation="

MWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNHIRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHVMPSNSSASISKLRESLTPDGSKWSTSLMQTLGNHSRGEQDSSLDMKDFRPLRKWSSLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEINKKRSSTLDCKYKFESCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPWQQQQIEDFRQGSETPMQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIRDNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKEKQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNENDNLRQQNETASKIIDSQQDEIDRMILEIQSMQGKLSKEKLTTQKMMEELEKKERNVQRLTKALLENQRQTDETCSLLDQGQEPDQSRQQTVLSKRPLFDLTVIDQLFKEMSCCLFDLKALCSILNQRAQGKEPNLSLLLGIRSMNCSAEETENDHSTETLTKKLSDVCQLRRDIDELRTTISDRYAQDMGDNCITQ

"
     misc_feature    <2041..2745
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /note="Chromosome segregation ATPases [Cell division and
                     chromosome partitioning]; Region: Smc; COG1196"
                     /db_xref="CDD:31389"
     misc_feature    2608..2613
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Breakpoint for translocation to form the
                     CEP85L-PDGFRB fusion protein; propagated from
                     UniProtKB/Swiss-Prot (Q5SZL2.1); other site"
     exon            662..820
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            821..1608
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     variation       997
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3734381"
     STS             1063..1189
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /standard_name="RH93170"
                     /db_xref="UniSTS:89002"
     variation       1339
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3734382"
     exon            1609..1727
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            1728..1845
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            1846..2025
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            2026..2178
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            2179..2333
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            2334..2451
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            2452..2502
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            2503..2610
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            2611..2842
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
     exon            2843..7639
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; NY-BR-15;
                     RP11-57K17.2"
                     /inference="alignment:Splign:1.39.8"
ORIGIN

agtatcgcaaaataggccaagtcgctgccctctactcaactcgcagggcgggaggatggagacagagggatgcggcgggagggcgggacagcccagtcgccgccaaggaggcgaagcggggtcggggtagctcacccgccccccgcagtccccgccccccgcagtccccgccccgcgcggcgccgcgcacgcctgaagtcattgcccgaggccccgccccctcgcggccccagccccggctctggctctgccggcggagggggcggagagaacccgcagctgcaacttcgcctggagcctttgagcctgggctcagccggggatctagcagccgtcaccgccgagtcgccgcttccccggcgcgggcctcagcccagccggcttggccatggcaggcgccggcagtgcggcgaatctggcccctgcgctccccgcccgtagctgagcagccgttaaccagccatcccgcctttcctcctgcccgtgtcgccgaggcccacgctccgcgcaagtttccgccgccgaagaagcaggaggacggacgtgaggagtcgggcgtccctggcccacccggccctctcgcccgcgatgtgggggcgcttcctggctccggaggccagcggccgggatagccccggcggagcccgcagcttccctgccggcccagattattcatcagcatggctacctgctaatgaatcattgtggcaggccacaactgttccatctaaccatcgaaataaccatatcaggagacacagtatagcttctgacagtggagacactggcattggaacttcctgttctgatagcgtggaagatcattcaacttcaagtggcacattatcttttaagcctagtcaatcattgattactcttcctactgcccatgtgatgccgtctaattccagcgcttcaatttccaaacttagggaatcattgacaccagatggctcaaaatggagtacaagcctcatgcaaacattgggaaaccacagtaggggggagcaggactcttccctagacatgaaggacttccggccacttcggaaatggtcatctttatccaaactcactgccccggataactgtggccagggtggcactgtatgcagagaagagtcaaggaatggtttggagaagatagggaaggctaaggctttaacatcacaactgaggacaattgggcctagctgtttacatgatagtatggagatgcttaggttagaggacaaggaaataaataaaaaacggtcatcaactctggactgcaagtataaatttgagagctgtagcaaggaggactttagagcctcttcctctactcttaggagacagcctgtagacatgacatatagtgccttacctgaaagcaagcccattatgacaagctcagaggcttttgaacctccaaaatatttaatgcttggtcaacaggcagtaggtggagttcccattcagccttccgtaaggactcagatgtggcttacagagcagctgcggacaaatcctttggaaggtagaaatacagaggattcttacagtttagctccttggcaacagcagcaaattgaagactttcgacaaggaagtgaaacaccaatgcaggttttgactggatcatctcgtcaaagttattcacctggctatcaggatttcagtaagtgggaatcaatgttgaaaataaaagaaggacttctaaggcagaaagaaattgtaatcgatcggcagaagcaacaaattacccacctgcatgagaggataagggataatgaattacgggctcaacatgccatgttaggacattatgtaaattgtgaggattcttatgtggctagtttgcagccacaatatgagaacacttcactccagacaccattttcagaggaatcagtttcccattcccaacaaggggaatttgagcaaaagcttgcatctactgagaaagaagttttacagcttaatgagtttctcaaacaaagactaagcctatttagtgaagagaagaagaaactagaggaaaaacttaaaactagagatcgatacatcagtagtctgaaaaagaaatgccagaaggaatctgaacaaaacaaagaaaagcagagaagaattgagaccttggaaaagtatctggctgatcttccaactctagatgatgtacagagtcagagtctacagctgcagattctggaagaaaaaaataagaatttacaagaggctttgatagatacagaaaaaaaacttgaagagatcaaaaagcagtgtcaagataaagagacacagttaatatgccagaaaaagaaagaaaaggagttagtaactaccgttcagagtttgcaacaaaaagtagaaagatgccttgaagatggaatccgccttcccatgttagatgcaaaacagcttcagaatgaaaatgataatctcagacaacaaaatgagactgctagtaagataatagacagccaacaagatgagattgacagaatgattttagaaattcagtctatgcaaggaaagctttctaaagagaaactgaccactcaaaagatgatggaagagctggaaaagaaagaaagaaatgtacagagattaacaaaagcattgcttgaaaaccaaagacaaacagatgagacatgctctttattggatcagggccaggaacctgaccaatctaggcagcagacagttctttccaaacggccactatttgatttgactgtgattgatcagctgttcaaggaaatgtcctgttgtttgtttgacttgaaagcattgtgtagtattcttaatcagcgtgctcagggcaaggagcctaatctttcattattactgggaataagatcaatgaactgttcagctgaagagactgagaatgaccacagcacagaaacactcactaaaaagctgtcagatgtgtgccagttacgaagagacattgatgaattaaggactacaatatcagaccgctatgctcaggacatgggagacaactgcattactcagtgatcaagtgttagtcccacagcaataatgacctgttgtttaaatgctgctgtgttatggagccataatggaaggttgcaagtgacatgacttgcacttagggattttttttctgtggatttgttttgttgaaggggagaagggaagtgaagagattttgaaggggcttatctaatcaggcaaaaagaaaaaaaatcaaattacctttggaaaatatgataaaatctacaaggaaaaaaatgtctatattctcaaactactgattgtaggaccaagctgtgaagagtacccttcacatgaaggagtaggattccttttaatcctatagctttgtgtgtttgtgtgtgcatgtatgtgtgttgttgtgtgtgtgtgcacgtgctttattcacaaatttataagggtttctagggtcagagcagagcttctgagaaaggcacacgctgtttattcttatatttctttcatatagaagcttgtgttgtactttgggattttcagtggctggctgaacaagagttcaaacagcaggcaagtgttgtcatggtagtacaggaggcaaaaccatttatattttgaacacttactgcactgataggatgtttgtggttgagctgattttagtactgtagataggtcagctgtttttccagagtgattgtggatttcccaagaggtgtgaaattttgacgtgatgctctttttccttagcattgtaatgtatgtgttacaagaaaggttaacataacttgaactaattttaacatgttccttactatttacaattttttatttatatgttttatatatatacatatataaatgtaaacaaagccatatataattaataaaggcattggatcattattataaaaggaagattaacaaagttaccctggaacaatagcttacttatccaaatctcaacatttacattttaacagttttgtatgtttcaaagttgaaactactgtaagagaaagccaatactatttatatctgaatcaacagtagcataaacattttttaattgagattgtattttaatcccttttgttaaagtacattaacaacagtttttcacaggatatgaacttggcgaaattagttcttaatctgaattacagggtattactatgaaatgcagttgattttgcagtagacgtacagtcatttaaacttccaaatgagtgttgtccatgtttctgttggtattttggaaggattatacattttattgccttcagcattgattatgttcttttgaatatacttagttttggcgaaagccttgtcctttgtaagttggtttgatcttgtgatgcaaccaagtctcatttaggtcaagactaaataagagatggaggggtagagggtgtgactcaagcaggataatattgatttgataaagagcatatcacatgcctgttttcttgccagataaagggcatagcacatgcctgttttcttatatactagaataaaggctctcctaggaaagatttttcttaaatatttaaaagtgaaaatgtgagacaaggccttcaaggagactacccaggaagatacacagtttaaaatgttggctatacagctctcaatagattattttatagttatagttgaataatcagttataatacactgtaaagaaatcagattttccttctgtttggtgtctgagtccttcctgctcttcttacttctgagaatctgggcactaagaaatcagtaagtacattgtagtgctcctgcatcccagagtccttaacctaaggagggtcttagtcactggtaagaacttggctttctaattatattcacttggtttttaacattagtagcttgacgataatcagggtatagtaaatttccaccaaaaatgtgatgcgaagaattctgccttggtcctttatggtaaaacagataataacgtctaaaatagatcagccacaagtgcagcaaatatttttacactctctttgaatagaatcccaaccaccctcccccatgattttagaaataaaggcttcctaaaataatagaacaaattggcaaacaatcactaattggaccagtaggttcttacttaaatatctctcctagatttttagtgtatgttttgggattttatgggtttatttatttttttttttttaagcagacgttacagtttgttttaatctactatagatacgtttttgttttttggcttagttggggataaaataatttatttgtaagttagctttctaaaacttagagaaagtaatttaattcacgtatcttaaaaataaaattccaaagttaaaaaatttctgacttagtaggaagttaacaaaactactgctgatgcatttcagtttccaaaatctgtaccctccccccataaaaaagggagttaagatgtgctagtttaagtagttagctgaattatagattgatcctcttaaaatctggagtttgtaaaggggcctacataaacagtagatagacttggagggattttgtgggggaattgaaactaatagtattctatctagtttgtcagtatttactttttgatttttatttttcagaaaattttcctttcccaggacaccctcttgtattagaatatcctcttctgtatcacattaaaaacagattttactgttagaccaaataagatgggcaaatagcaacactagagcatctcacccagtttgaactaggatgttcgtggaagttatgacaccaatatattcctgaaatgaaaattaacctaaattttaaagtgaatctatttgaaaatttacttagataatgaaacctcgttttaattgtgctttttgtgaatccaacacttgtttgcttagaaagtatcttatccagtattaatattttgttcttttgggttttaaagttgagcttattcagcctcaatcacattacagcaagcataaagtaacagttgactcaatgaaagacccaaattgcctgtacagataaaattcactgaatcaaaggcacaatagctatcttttcacttgagctcagaaaagtaaaatggcttaatttgaactattaattttcagtggcctctaattaaacaaaaacaaaaaaccacaaatactggctaggtaagatattcctgaggtcattttaaaagaagtgtggcacctaggattcaatatttaatgctaacagtattatattttagtgaaatttattttggtggtgacagtttattaaacctaattagacttctttcaatagcttgttgtagagacaatctcaagggctggaaagtgttgctaaaatgaatgtcatacatttctgatatactaaggagcttataaagtaattctttcatagtgcaagaattattaatttcttagaggatgtttttaaaggagctacttaattgggaaaatgttctttaaatatcagtaatagttcattaagtaacatagtagctaagaacatggactatattttcacagcatagttcagcttaggcacacctttagtttggattattggcattctcttacgtaggaattatatcattgtagatatgtaattatggtaataagcaattttcataaccatgctcactcagactatatcatttgaaactgccatgtttccatttttgacaattcatgttcacaaaacaacaggaacaatttcctatttggtataaagagcaaaatttccaactttgccccaaaatgccatgggtggcatattgccatatgattatatcatatatttaatcatgtatgggaaagattttggattttttttcttatttaaaaaagtgctaaatataagaatatagttttaaatcagcaagtctaataacactattgcagctgtacacagagagaaccttttgtgcctttttgcctgcagtaagcatttatttctattttacatgagttctaagaatgttgatgattattgcaccttgttcttctgtatataaacttgattaaggaatttttttttttaaagcaaggagccgttttttgttactaggtggataccttagtaaacatgaggggaattatcagatagatgtctttggagcccagccttccctgtgtagtgagctggaaactcctttagattgtattcattggtgtgtatgtatatgtacatatatgtataaatagttaaatacataaacataaaacttaacatcgcattgttgtgatgacaagaagtagtaaggtgctaggtggttacattaaaaagcacagcacagtgtataatcagtcactatgactggtggttttgtaagctgggttcagtttttgaaccacccagaatacctcatgtgtaaatacagtgttcatgacttaattgaaatacagttattgtttaaaaaaaaaaaaaaagaatgtgaagccactggttggcttatgccttctgatctatcattcttgcctctttttttgtaaaggggttttcttcttgttgttctgttttttaatagggtttacagctagaattttgaatgccaaagttctatttattaaattaagaaaaaagttttcaatgttaatggctagtatttttccactggactattgtttgttgatgttggaatttgtatttacagagaaataaattttttataaaaagaaaaaaaaaaaaaaa

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