Home |
Help |
Advanced search
2025-05-09 16:51:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_198679 6204 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens Rap guanine nucleotide exchange factor (GEF) 1
(RAPGEF1), transcript variant 2, mRNA.
ACCESSION NM_198679
VERSION NM_198679.1 GI:38373676
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6204)
AUTHORS Gutierrez-Herrero,S., Maia,V., Gutierrez-Berzal,J., Calzada,N.,
Sanz,M., Gonzalez-Manchon,C., Pericacho,M., Ortiz-Rivero,S.,
Gonzalez-Porras,J.R., Arechederra,M., Porras,A. and Guerrero,C.
TITLE C3G transgenic mouse models with specific expression in platelets
reveal a new role for C3G in platelet clotting through its GEF
activity
JOURNAL Biochim. Biophys. Acta 1823 (8), 1366-1377 (2012)
PUBMED 22659131
REMARK GeneRIF: C3G plays an important role in platelet clotting through a
mechanism involving its GEF activity and suggest that it might be
also involved in neutrophil development.
REFERENCE 2 (bases 1 to 6204)
AUTHORS He,Y., Kapoor,A., Cook,S., Liu,S., Xiang,Y., Rao,C.V., Kenis,P.J.
and Wang,F.
TITLE The non-receptor tyrosine kinase Lyn controls neutrophil adhesion
by recruiting the CrkL-C3G complex and activating Rap1 at the
leading edge
JOURNAL J. Cell. Sci. 124 (PT 13), 2153-2164 (2011)
PUBMED 21628423
REMARK GeneRIF: Lyn controls spatial activation of Rap1 by recruiting the
CrkL-C3G protein complex to the leading edge
REFERENCE 3 (bases 1 to 6204)
AUTHORS Samuelsson,J., Alonso,S., Ruiz-Larroya,T., Cheung,T.H., Wong,Y.F.
and Perucho,M.
TITLE Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in
gastrointestinal and gynecological cancer
JOURNAL Int. J. Oncol. 38 (6), 1575-1577 (2011)
PUBMED 21399874
REMARK GeneRIF: found somatic demethylation of a relaxed-criterion CpG
island (CGI-B) located in the first intron of RAPGEF1 in 40% of
colon cancers and 8% of gastric cancers relative to their matching
normal tissues that were always methylated
REFERENCE 4 (bases 1 to 6204)
AUTHORS Dayma,K. and Radha,V.
TITLE Cytoskeletal remodeling by C3G to induce neurite-like extensions
and inhibit motility in highly invasive breast carcinoma cells
JOURNAL Biochim. Biophys. Acta 1813 (3), 456-465 (2011)
PUBMED 21223981
REMARK GeneRIF: C3G overexpression induces neurite-like extensions in
MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of
other cancer cell lines examined.
REFERENCE 5 (bases 1 to 6204)
AUTHORS Mitra,A., Kalayarasan,S., Gupta,V. and Radha,V.
TITLE TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G
(RapGEF1) and negatively regulates differentiation of human
neuroblastoma cells
JOURNAL PLoS ONE 6 (8), E23681 (2011)
PUBMED 21876762
REMARK GeneRIF: The possibility of cellular phospho-C3G (pC3G) being a
substrate of the intracellular T-cell protein tyrosine phosphatase
TC-PTP (PTPN2) using the human neuroblastoma cell line, was
studied.
REFERENCE 6 (bases 1 to 6204)
AUTHORS Smit,L., van der Horst,G. and Borst,J.
TITLE Sos, Vav, and C3G participate in B cell receptor-induced signaling
pathways and differentially associate with Shc-Grb2, Crk, and Crk-L
adaptors
JOURNAL J. Biol. Chem. 271 (15), 8564-8569 (1996)
PUBMED 8621483
REFERENCE 7 (bases 1 to 6204)
AUTHORS Gotoh,T., Hattori,S., Nakamura,S., Kitayama,H., Noda,M., Takai,Y.,
Kaibuchi,K., Matsui,H., Hatase,O., Takahashi,H. et al.
TITLE Identification of Rap1 as a target for the Crk SH3 domain-binding
guanine nucleotide-releasing factor C3G
JOURNAL Mol. Cell. Biol. 15 (12), 6746-6753 (1995)
PUBMED 8524240
REFERENCE 8 (bases 1 to 6204)
AUTHORS Knudsen,B.S., Feller,S.M. and Hanafusa,H.
TITLE Four proline-rich sequences of the guanine-nucleotide exchange
factor C3G bind with unique specificity to the first Src homology 3
domain of Crk
JOURNAL J. Biol. Chem. 269 (52), 32781-32787 (1994)
PUBMED 7806500
REFERENCE 9 (bases 1 to 6204)
AUTHORS Takai,S., Tanaka,M., Sugimura,H., Yamada,K., Naito,Y., Kino,I. and
Matsuda,M.
TITLE Mapping of the human C3G gene coding a guanine nucleotide releasing
protein for Ras family to 9q34.3 by fluorescence in situ
hybridization
JOURNAL Hum. Genet. 94 (5), 549-550 (1994)
PUBMED 7959692
REFERENCE 10 (bases 1 to 6204)
AUTHORS Tanaka,S., Morishita,T., Hashimoto,Y., Hattori,S., Nakamura,S.,
Shibuya,M., Matuoka,K., Takenawa,T., Kurata,T., Nagashima,K. et al.
TITLE C3G, a guanine nucleotide-releasing protein expressed ubiquitously,
binds to the Src homology 3 domains of CRK and GRB2/ASH proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (8), 3443-3447 (1994)
PUBMED 7512734
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG546427.1, BG429001.1,
BC041710.1, BQ054243.1, BQ772947.1 and AJ420417.1.
Summary: This gene encodes a human guanine nucleotide exchange
factor. It transduces signals from CRK by binding the SH3 domain of
CRK, and activating several members of the Ras family of GTPases.
This signaling cascade that may be involved in apoptosis,
integrin-mediated signal transduction, and cell transformation.
Several alternatively spliced transcript variants of this gene have
been described, but the full-length nature of some variants has not
been determined. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) encodes the longer isoform
(b).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC041710.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-23 BG546427.1 41-63
24-121 BG429001.1 25-122
122-4354 BC041710.1 1-4233
4355-4778 BQ054243.1 218-641
4779-5649 BC041710.1 4658-5528
5650-5998 BQ772947.1 194-542 c
5999-6204 AJ420417.1 1546-1751
FEATURES Location/Qualifiers
source 1..6204
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34.3"
gene 1..6204
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/note="Rap guanine nucleotide exchange factor (GEF) 1"
/db_xref="GeneID:2889"
/db_xref="HGNC:4568"
/db_xref="HPRD:02627"
/db_xref="MIM:600303"
misc_feature 88..90
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/note="upstream in-frame stop codon"
CDS 160..3447
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/note="isoform b is encoded by transcript variant 2;
guanine nucleotide-releasing factor 2 (specific for crk
proto-oncogene); rap guanine nucleotide exchange factor 1;
CRK SH3-binding GNRP"
/codon_start=1
/product="rap guanine nucleotide exchange factor 1 isoform
b"
/protein_id="NP_941372.1"
/db_xref="GI:38373677"
/db_xref="CCDS:CCDS48048.1"
/db_xref="GeneID:2889"
/db_xref="HGNC:4568"
/db_xref="HPRD:02627"
/db_xref="MIM:600303"
/translation="
MGNAIEKQKPLKRSHLYPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
"
misc_feature 1105..1107
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1141..1143
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1144..1146
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1153..1155
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1291..1293
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1723..1725
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00796"
misc_feature 2299..2643
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/note="Guanine nucleotide exchange factor for Ras-like
GTPases; N-terminal domain (RasGef_N), also called REM
domain (Ras exchanger motif). This domain is common in
nucleotide exchange factors for Ras-like small GTPases and
is typically found immediately...; Region: REM; cd06224"
/db_xref="CDD:100121"
misc_feature order(2332..2334,2467..2469,2479..2484,2491..2493,
2500..2505,2611..2616,2623..2625)
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/note="GTPase interaction site [polypeptide binding];
other site"
/db_xref="CDD:100121"
misc_feature 2719..3393
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/note="Guanine nucleotide exchange factor for Ras-like
small GTPases. Small GTP-binding proteins of the Ras
superfamily function as molecular switches in fundamental
events such as signal transduction, cytoskeleton dynamics
and intracellular trafficking; Region: RasGEF; cd00155"
/db_xref="CDD:29070"
misc_feature order(2809..2817,2848..2853,2857..2865,2869..2874,
2881..2886,2893..2895,2992..2994,3001..3006,3010..3018,
3022..3033,3037..3042,3085..3087,3094..3096,3109..3117,
3124..3126,3163..3171,3178..3186,3190..3198,3202..3213,
3253..3255,3265..3267,3367..3369,3376..3381)
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/note="Ras interaction site [polypeptide binding]; other
site"
/db_xref="CDD:29070"
variation 1072
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1128780"
variation 1277
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1062978"
STS 3677..3865
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/standard_name="STS-D21239"
/db_xref="UniSTS:75875"
variation 4355
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3739497"
variation 5650
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:943851"
STS 5879..6075
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/standard_name="A002Q14"
/db_xref="UniSTS:54080"
STS 5921..6125
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/standard_name="RH11721"
/db_xref="UniSTS:8448"
variation 5961
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:6879"
STS 5987..6125
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/standard_name="D9S2054"
/db_xref="UniSTS:8447"
polyA_signal 6144..6149
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
polyA_site 6174
/gene="RAPGEF1"
/gene_synonym="C3G; GRF2"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
gagattcctcaggcttcccttgtgaggctgcctgggttctgccgctgggtggtttgggatgtccaagagatatcccctttcagccagtgactcggtcctcagttgctgctccggaaagacgctggggctgggaagggccctgtgtcctctggctttaaaatgggcaatgctattgaaaaacagaagcccttgaaacgaagtcatctgtacccctggaaacaagactctcagcgttctcatctctcttccttcaccatgaagctgatggacaaattccactcacccaaaatcaagagaacgccatcaaagaagggaaaaccagctgaggtgtccgtaaagattccagagaagcctgtgaacaaagaggcaacagacagatttctaccagagggctaccctctccccttggatctggagcagcaggcagtagaatttatgtccaccagtgctgtggcttccaggtctcaaaggcagaagaacctgagctggctggaggagaaagagaaggaagttgtcagtgccctgcgctactttaagaccattgtggacaaaatggcaattgataagaaggtactggagatgcttccagggtcagccagcaaggtgctggaggccatcttacccctggtgcagaacgatcctcgaattcagcacagctcagccctctcttcctgctatagccgagtgtaccaaagcctcgccaacctcattcgctggtctgaccaagtgatgctggaaggcgtgaactcagaagacaaggagatggtgacgactgtgaagggggtcatcaaggctgtgctggatggagtgaaggagctggtcaggctcaccatcgagaagcagggacgtccgtctccgacgagccccgtgaagcccagttcccctgccagcaagcctgatggcccagcagagctccccctgacagaccgcgaggtagagatcctaaacaagacgactgggatgtcacagtcaactgagctcctcccagatgccacggatgaagaggtcgcgccccccaagcctcctctgcctggcattcgggtggttgataatagtcctccaccagcattgccacccaagaaaagacagtcggcgccgtcccctacccgagtggctgtggtggcccccatgagccgagccaccagtggctccagtttgcctgttggaatcaataggcaggattttgatgttgactgttacgcacagaggcgactgtcaggaggcagccactcatatggtggagagtcgccccgcctctccccctgcagcagcataggcaagctcagcaagtcagacgagcagctgtcctctctggacagggacagtgggcagtgctcccggaacacaagctgtgaaacactagaccactatgatcccgactatgaattcctccagcaagacctctctaacgcagaccagatacctcagcagacggcctggaaccttagcccgttgccagagtctttgggggagtctgggtctccatttcttggccctcctttccagctgcctcttggcggccatccccagccagacggacctctggccccagggcagcagacagatacgccacctgctctccccgagaagaagcgcaggagcgcagcctcccagacggcggacggctctggctgcagggtgtcctacgagcggcatccctcgcagtatgacaacatctctggggaggacctgcagagcacagccccgatcccatccgtcccctacgcgccctttgctgctattctgccctttcagcatggaggttcctcagcccctgtcgaatttgtgggtgattttactgctcctgagtcaaccggtgacccagaaaaaccacctcctctaccagagaagaaaaacaaacacatgctggcctacatgcagttgctggaggactactcggagccgcagccctctatgttctaccagacgccacagaacgagcacatctaccagcagaagaacaagctcctcatggaggtatacggcttcagcgactccttcagtggggtggactccgtgcaggagctggccccgccgcccgccctaccccccaagcagcggcagctggagccaccggctgggaaagacggacatcccagagatccctcagcggtcagcggcgtccctgggaaggacagcagagacggcagtgagagggccccaaagtcaccagatgctctggagtcggctcagtcggaggaggaagtggacgagctgtccctcattgaccacaacgaaattatgtccaggctgacgctcaagcaggagggtgatgacgggccggacgtccgcggaggatctggggacatcttactggtccatgctactgagactgacaggaaagatttggtgttgtactgcgaggcattcctgaccacctacaggaccttcatctccccagaggagctcatcaagaagctgcagtacagatatgagaaattctctccctttgccgacacattcaagaagcgcgtcagcaagaacacgttcttcgtgctggtacgggtggtggatgagctctgcctggtggagttgacagaagagatcctgaagctgctgatggaactggtcttccgcctggtgtgcaatggggagctgagcctggcccgtgtgctccggaagaacatcctggacaaggtggaccagaagaagctactcaggtgtgccacctccagccagcccctggcagcccggggggtagcagccaggccggggaccttgcacgactttcacagccatgagatagcggagcagctaacgctgctggatgctgagctcttctataaaatagagattcctgaggttttgctttgggcaaaagagcagaatgaggagaagagccccaacttgacccagttcacggagcacttcaacaacatgtcctactgggtccggtccataatcatgttacaggaaaaggcccaggacagggaacggctgctcttgaagttcatcaagatcatgaagcacttgcggaagctgaataacttcaactcctacttggccatcctctctgccctggactcggcgcccatccgcaggctggagtggcagaagcagacttcagagggcctggccgagtactgcacactgatcgacagctcgtcctccttccgagcctaccgggccgccctctcggaggtggaaccgccgtgcatcccgtacctggggctgatcctgcaggacctgaccttcgttcacctgggaaacccagactacatcgacgggaaagtgaacttctccaagcggtggcagcagttcaacatcctcgacagcatgcgctgcttccagcaggcgcactatgacatgcggaggaacgacgacattataaacttcttcaatgacttcagtgaccacctggctgaggaggccctatgggaactgtctctgaaaattaaacccaggaacataacaaggagaaaaacagaccgggaagagaagacctaggagcagacgccgggatccaggagaatgctcgaggggcgcagagggcagctcccagaccggagaggaccttggacctgttaggcgcatggcaggagtcccggcctcggagccatgaggctggccagccctcagcggggccgggcgggagctggagcctgccagccgcttcctgcctccttcctctgtgggagcagacccgtgggcctcagggcagccagcaggcaggtcttgttgccaatttacaaaccggtggttttctggtttggttttgttttctgcttttacttccatctctcccctcttgaccttccacccactcccctccagggagagagcagcagagacctcatcagcagaccaaggaagtggtgggtgctccccctccctaagctccagggtccctgaatcttctgaaatctcaaatgagtggaggcctcctggggtggcctgtcctgcaggggccctggaatgggggcaagcagctgggtgggcagaatgcagagtagactcgggggaggatcctttcactttccgcttccccttctgatgcatggaggatggtgtgagcttttcagcaggcccggaaaggtacgcaggtgacgccttagcagccccgcagctggtgctctgccccgcggtactggcgccatcagggcctcccttgcccgcctgagagcagcagcagtctctgtcatcccgtcgccccttaccccccaccccaggccactgggcccctcccacaccacctggggagctgagaagaggaggctggagtaagggaggacttgatcatccaagaaatactttttattgctgggagtcttctgaacctcaccaaactgaggccagagctgagctcctgggggagttaattcagaggggagaggccagcacctccctcctccatcgctcgctgtgtgccttaaactccatctcatgtccctccccatcccctggctttccctccctccttgccccatcctgggccagccagcagggctcctcctctggctcttcagacctttcagccagtgctgtcagtgcccctgggagggaagggcatccctgaggcacccgaatggtccctcagggtgcagggaggcagaagcctggccacagaggagcctcctaaggcagcagctgcagcaagcgcaccctctccccactctccccacgccagagcggcttccagagcagatgctgtttccatcctcctcgtcaaaaccattctcgctgctgagcttgacaatctgggcaaggcttgtggggcgcttgacaaacagaatctgccctgtgccgcctggttccgtggcctccagcatgagcctgcaggcagggcgctgcgggaacccagttgtgctgccccagcccatgcctccgggtctgctgtgcatgaatgagtgctcacttgtcccgggtttaggacgtggtcaagtgaacagcagggtctaactgtgcttacttagcccagttcaaacagaacaaaggaaaaatatagaaagcaacatctgttgatcatttaggtttttttttaaaccaccatgtcactttgagtccttcatgggtttttgaacagcatttatcaagaagaaaatgtgggctttttcccctctcccgtgttttgtttgtcctgtagatagagggaggaaagccgtgcagtggcaggcgggaccccctctggtggcgggaccccctcttgcggtggtcttgcggggccagccgggacctgtcactttattatttaaggagtgtgtgtgtagagtcgctggcttattaacagtattgtgtgtgggttgggtttttagtttgttccttctttttgaagtcccttcatttcaatccttgactctctctccccttcccttgcccagctctgttgaatgctgctgtgcgcgtgtgagggccgctctgcacacagggcccttgggttgtgtgaactgaaattctccctgtatttgtgagactcgcaggagtccccatctgtagcacaggcaatgccagtgccatgctgcagcctcagaaaccaggcctctcactccagcagcaggcagaaccgtgtctgtggtcgggtgctgtccacagctctgtctgccttgttcttgggcttgagctggatagaggtggggtctcttcaccttccctgaattcagaacagaccctgtgcctggccccagtgtgcccaggcaattccccaggccctcactgggagcccttggtgttctgagcagcagggcccaggcagcacatgagcagtgcccaggggctccctgcgtgaggacggcaaggtgcgatgtatgtctaacttattgatggcaggcagccccctgtgccccctaagcctggccctggttattgctgagctctgtgctcagtgctgcggcctggccgtggctcgtctgttcctttggggggcccgggcgggttgtgggaatcagtcttcacagacagacgtgagccaggcggaggactcgttccttgcagaggtcagtcctcacctgcaggtgtcggggtgggggggggcaaggaggggcaggcacacaccatgtctgacctgaacccgattctggggagcatcttcccgctccggccccacgacctccacagggttacattgtaatatatatgccccagctaacctgtctgatggtggcatcttcctgcagacatttcaaacatgtaacttttatatgaaaaaaaataaacacagatgaaagctgcccaatgccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2889 -> Molecular function: GO:0005085 [guanyl-nucleotide exchange factor activity] evidence: IEA
GeneID:2889 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2889 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
GeneID:2889 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: TAS
GeneID:2889 -> Biological process: GO:0001568 [blood vessel development] evidence: IEA
GeneID:2889 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:2889 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: TAS
GeneID:2889 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: IEA
GeneID:2889 -> Biological process: GO:0016337 [cell-cell adhesion] evidence: IEA
GeneID:2889 -> Biological process: GO:0048008 [platelet-derived growth factor receptor signaling pathway] evidence: IEA
GeneID:2889 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:2889 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: IEA
GeneID:2889 -> Cellular component: GO:0005768 [endosome] evidence: TAS
GeneID:2889 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.