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2025-05-09 17:14:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_194071 7471 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens cAMP responsive element binding protein 3-like 2
(CREB3L2), transcript variant 1, mRNA.
ACCESSION NM_194071 XM_291242
VERSION NM_194071.3 GI:359339003
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7471)
AUTHORS Ishikura-Kinoshita,S., Saeki,H. and Tsuji-Naito,K.
TITLE BBF2H7-mediated Sec23A pathway is required for endoplasmic
reticulum-to-Golgi trafficking in dermal fibroblasts to promote
collagen synthesis
JOURNAL J. Invest. Dermatol. 132 (8), 2010-2018 (2012)
PUBMED 22495181
REMARK GeneRIF: the BBF2H7-mediated Sec23A pathway is required for
ER-to-Golgi procollagen trafficking to promote collagen synthesis
REFERENCE 2 (bases 1 to 7471)
AUTHORS Moller,E., Hornick,J.L., Magnusson,L., Veerla,S., Domanski,H.A. and
Mertens,F.
TITLE FUS-CREB3L2/L1-positive sarcomas show a specific gene expression
profile with upregulation of CD24 and FOXL1
JOURNAL Clin. Cancer Res. 17 (9), 2646-2656 (2011)
PUBMED 21536545
REMARK GeneRIF: FUS-CREB3L2/L1-positive sarcomas show a specific gene
expression profile with upregulation of CD24 and FOXL1.
REFERENCE 3 (bases 1 to 7471)
AUTHORS Fox,R.M., Hanlon,C.D. and Andrew,D.J.
TITLE The CrebA/Creb3-like transcription factors are major and direct
regulators of secretory capacity
JOURNAL J. Cell Biol. 191 (3), 479-492 (2010)
PUBMED 21041443
REMARK GeneRIF: The human Creb3L2 can activate SPCG transcription in a
heterologous system(Drosophila embryos), which suggests a general
and direct role for this family of bZip transcription factors in
mediating high-level secretory capacity.
REFERENCE 4 (bases 1 to 7471)
AUTHORS Panagopoulos,I., Monsef,N., Collin,A. and Mertens,F.
TITLE Characterization of an alternative transcript of the human CREB3L2
gene
JOURNAL Oncol. Rep. 24 (5), 1133-1139 (2010)
PUBMED 20878102
REMARK GeneRIF: We characterized a widely expressed transcript of CREB3L2
generated by an intronic polyadenylation site in intron 4 of the
gene.
REFERENCE 5 (bases 1 to 7471)
AUTHORS Bartuma,H., Moller,E., Collin,A., Domanski,H.A., Von Steyern,F.V.,
Mandahl,N. and Mertens,F.
TITLE Fusion of the FUS and CREB3L2 genes in a supernumerary ring
chromosome in low-grade fibromyxoid sarcoma
JOURNAL Cancer Genet. Cytogenet. 199 (2), 143-146 (2010)
PUBMED 20471519
REMARK GeneRIF: Fusion of the FUS and CREB3L2 genes in a supernumerary
ring chromosome is associated with low-grade fibromyxoid sarcoma.
REFERENCE 6 (bases 1 to 7471)
AUTHORS Lui,W.O., Zeng,L., Rehrmann,V., Deshpande,S., Tretiakova,M.,
Kaplan,E.L., Leibiger,I., Leibiger,B., Enberg,U., Hoog,A.,
Larsson,C. and Kroll,T.G.
TITLE CREB3L2-PPARgamma fusion mutation identifies a thyroid signaling
pathway regulated by intramembrane proteolysis
JOURNAL Cancer Res. 68 (17), 7156-7164 (2008)
PUBMED 18757431
REMARK GeneRIF: findings identify a novel CREB3L2-PPARgamma gene fusion
mutation in thyroid carcinoma and reveal a thyroid signaling
pathway that is regulated by intramembrane proteolysis and
disrupted in cancer
REFERENCE 7 (bases 1 to 7471)
AUTHORS Guillou,L., Benhattar,J., Gengler,C., Gallagher,G.,
Ranchere-Vince,D., Collin,F., Terrier,P., Terrier-Lacombe,M.J.,
Leroux,A., Marques,B., Aubain Somerhausen Nde,S., Keslair,F.,
Pedeutour,F. and Coindre,J.M.
TITLE Translocation-positive low-grade fibromyxoid sarcoma:
clinicopathologic and molecular analysis of a series expanding the
morphologic spectrum and suggesting potential relationship to
sclerosing epithelioid fibrosarcoma: a study from the French
Sarcoma Group
JOURNAL Am. J. Surg. Pathol. 31 (9), 1387-1402 (2007)
PUBMED 17721195
REMARK GeneRIF: Presence of FUS/CREB3L2 and FUS/CREB3L1 in low-grade
fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma
suggests these neoplasms may be related.
REFERENCE 8 (bases 1 to 7471)
AUTHORS Kondo,S., Saito,A., Hino,S., Murakami,T., Ogata,M., Kanemoto,S.,
Nara,S., Yamashita,A., Yoshinaga,K., Hara,H. and Imaizumi,K.
TITLE BBF2H7, a novel transmembrane bZIP transcription factor, is a new
type of endoplasmic reticulum stress transducer
JOURNAL Mol. Cell. Biol. 27 (5), 1716-1729 (2007)
PUBMED 17178827
REMARK GeneRIF: BBF2H7, a novel transmembrane bZIP transcription factor,
is a new type of endoplasmic reticulumm stress transducer.
REFERENCE 9 (bases 1 to 7471)
AUTHORS Panagopoulos,I., Moller,E., Dahlen,A., Isaksson,M., Mandahl,N.,
Vlamis-Gardikas,A. and Mertens,F.
TITLE Characterization of the native CREB3L2 transcription factor and the
FUS/CREB3L2 chimera
JOURNAL Genes Chromosomes Cancer 46 (2), 181-191 (2007)
PUBMED 17117415
REMARK GeneRIF: CREB3L2 is not only structurally, but also functionally
very similar to CREB3L1.
REFERENCE 10 (bases 1 to 7471)
AUTHORS Storlazzi,C.T., Mertens,F., Nascimento,A., Isaksson,M., Wejde,J.,
Brosjo,O., Mandahl,N. and Panagopoulos,I.
TITLE Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma
JOURNAL Hum. Mol. Genet. 12 (18), 2349-2358 (2003)
PUBMED 12915480
REMARK GeneRIF: BBF2H7 was fused with FUS in a low grade myxoid
liposarcoma.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CN394705.1, BQ711676.1, AK131517.1, BX649143.1, AC022173.7 and
CR749563.1.
On Dec 3, 2011 this sequence version replaced gi:56550066.
Summary: This gene encodes a member of the oasis bZIP transcription
factor family. Members of this family can dimerize but form
homodimers only. The encoded protein is a transcriptional
activator. Translocations between this gene on chromosome 7 and the
gene fused in sarcoma on chromosome 16 can be found in some tumors.
Multiple transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq, Dec 2011].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer protein (isoform 1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC110813.1, AJ549092.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1 CN394705.1 2-2
2-307 BQ711676.1 1-306
308-1508 AK131517.1 274-1474
1509-2679 BX649143.1 1101-2271
2680-4928 AC022173.7 90542-92790
4929-7471 CR749563.1 4609-7151
FEATURES Location/Qualifiers
source 1..7471
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q34"
gene 1..7471
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/note="cAMP responsive element binding protein 3-like 2"
/db_xref="GeneID:64764"
/db_xref="HGNC:23720"
/db_xref="HPRD:16391"
/db_xref="MIM:608834"
exon 1..498
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
misc_feature 364..366
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/note="upstream in-frame stop codon"
CDS 397..1959
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/note="isoform 1 is encoded by transcript variant 1;
TCAG_1951439; basic transcription factor 2; cyclic
AMP-responsive element-binding protein 3-like protein 2;
B-ZIB transcription factor; FUS/BBF2H7 protein; BBF2 human
homolog on chromosome 7; cAMP-responsive element-binding
protein 3-like protein 2"
/codon_start=1
/product="cyclic AMP-responsive element-binding protein
3-like protein 2 isoform 1"
/protein_id="NP_919047.2"
/db_xref="GI:56550067"
/db_xref="CCDS:CCDS34760.1"
/db_xref="GeneID:64764"
/db_xref="HGNC:23720"
/db_xref="HPRD:16391"
/db_xref="MIM:608834"
/translation="
MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF
"
misc_feature 967..969
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q70SY1.3); phosphorylation site"
misc_feature 967..969
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1282..1371
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q70SY1.3);
Region: Basic motif (By similarity)"
misc_feature <1315..1440
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/note="basic region leucin zipper; Region: BRLZ;
smart00338"
/db_xref="CDD:197664"
misc_feature 1402..1467
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q70SY1.3);
Region: Leucine-zipper (By similarity)"
misc_feature 1534..1596
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q70SY1.3);
transmembrane region"
exon 499..715
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 716..891
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 892..979
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 980..1164
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 1165..1311
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 1312..1370
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 1371..1439
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 1440..1539
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 1540..1666
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 1667..1883
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
exon 1884..7456
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/inference="alignment:Splign:1.39.8"
variation 3042
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/replace="c"
/replace="t"
/db_xref="dbSNP:373410712"
STS 3157..3257
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/standard_name="SHGC-37420"
/db_xref="UniSTS:6850"
variation 6484
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/replace="c"
/replace="g"
/db_xref="dbSNP:9757"
variation 6726
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/replace="a"
/replace="g"
/db_xref="dbSNP:201014952"
variation 6802
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/replace="a"
/replace="g"
/db_xref="dbSNP:9584"
STS 7142..7286
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/standard_name="D7S2910"
/db_xref="UniSTS:62393"
STS 7256..7375
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/standard_name="A006D34"
/db_xref="UniSTS:9880"
STS 7256..7375
/gene="CREB3L2"
/gene_synonym="BBF2H7"
/standard_name="G20729"
/db_xref="UniSTS:9879"
ORIGIN
gctgggtcctggagcagagccgaggagccctggggtccctcaaagtttgtgtctggagccgtagcggcaagtgggcttgcggctaagggattttcctgggatgagagcgggtcttctgccttcattttggatgcacatcccgctttagccccggcagcctttggtccggctcgtgtccctggggattctcggatctccgaggacaccggacgggagcgcttggccatcctctctccggcagaggagcagacgtttgctttccaagtgcaaaactacagacacgcgcgcgcacacacgcaagcacacgcggagagagaggaaccttgccggtccgaggcagctctgcgcgtcccctcctgcgcttagcatcctcggcccagcgcggcccgcaccgccatggaggtgctggagagcggggagcagggcgtgctgcagtgggaccgcaagctgagcgagctgtcagagcccggggacggcgaggccctcatgtaccacacgcacttctcagaacttctggatgagttttcccagaacgtcttgggtcagctcctgaatgatcctttcctctcagagaagagtgtgtcaatggaggtggaaccttccccgacgtccccggcgcctctcatccaggctgagcacagctactccctgtgcgaggagcctcgggcccagtcgcccttcacccacattaccaccagtgacagcttcaatgacgatgaggtggaaagtgagaaatggtacctgtctacagacttcccttcaacatccatcaagacagagccagttacagacgaaccacccccaggactcgttccgtctgtcactctgaccatcacagccatctccaccccgttggaaaaggaggaacctcctctggaaatgaacactggggttgattcctcgtgccagaccattattcctaaaattaagctggagcctcatgaagtggatcagtttctaaacttctctcctaaagaagccccagtggaccacctgcatttgccgcccacccctccgagcagtcacggcagtgactcagagggcagcctgagtcccaacccacgcctgcaccccttcagcctgcctcagacccacagcccctccagagctgcaccccgggccccctccgccctctccagctcccctctcctcacggctcctcataaactgcagggatcaggccctctggtcctgacagaggaggagaagaggaccctgatcgctgagggctatcccatccccaccaaattgcccctgtcaaaatcagaggagaaggccctgaagaaaattcggaggaagatcaagaataagatttctgctcaggaaagtaggagaaagaagaaagaatacatggacagcctggagaaaaaagtggagtcttgttcaactgagaacttggagcttcggaagaaggtagaggttctagagaacactaataggactctccttcagcaactccagaagcttcagactttggtgatgggcaaggtttctcgaacctgcaagttagctggcacgcagactggcacctgcctcatggttgtggtgctgtgctttgccgttgcattcggcagcttctttcaaggctacgggccctatccttctgccaccaagatggctctgcccagccagcattccctgcaggagccctacacagcctccgtggtgagatccagaaacctgctgatctacgaggaacattctcccccagaggagtcatccagcccgggctcggctggggagctggggggctgggatagaggttcctccctgctcagggtgtcagggctggagtccaggccggatgtggatcttccccatttcattatctcgaatgagaccagcctggagaagtcagtgcttttggagctgcagcagcacctggtcagcgccaaactggaggggaatgaaacactaaaagttgtagaactcgacagaagagtgaacaccactttctaaagaggctgcctgcaccccctccctttcccttaactctacttttacatccccaaaccacctttgtcatcagcttttcctctttgccactggatcttcatggagacatgggcaagcattagtggcttcagattggagaccagcctgggacttccctgcagtgagagagcatctccccctggtccatgcccctcctgtgcagaagggagcctgcatccctcccttcctttctcttactgccataggaaattattttaggggttggaggtgggacaagcaggcttgtttccaccaatagtgccaaaaagatattgcctaatgtgcacctgtgaggtgtaaccccccgctttggagacgagatggctcttgttcagtcaagaccccagactctggccacaaaaatgccataatgcctgttggtatttggcaaagcactgacccgtgtcctccgttgctcgcactggggtctctggtgtgaacacccccgacagcagccctccgcccactctgccccctgggagccctcgctggatcgtctcgtctcctgcagcagcactggcaggcgagggctctcgttcatattctcaggccgcaagtgcaatgcctgaggggatcaggcttttctactccaggcaaacctgccccatcttgtcgcttttaggacctcccacaacctggttccccacacatccatagttctgcctccccagcttctcctccccagttgtaaatagtatttattagcttgccgaggcttcctgctagcaaccacactgaagagatcgatgcctcctttcaagctagccaagttttctgcgagccttcagagctaggagggcaccctaggctctgggatcccgtgtctttccagacaatgttttgtttcctttcctttgttttttcttttaactggaataattaccattgaaaaagaagttcctttgagcatgtatgtgtctgcctctaggatgagctcagagcgagagatgacacaatgcctcactcaggccccgggctccctggccacaagctttttctatcctgttttcatgacagagaaggggaagccctgttctgacaacagacatttcagacaaccttgctggctttccacacctgcctggccccctcctccctccacacttccactttgtcctcctcgtcccctacctcaacaaagcagggtggggtaggtgacatttgtgtatccacattcttacctttggtagtcaggtttggctactttgcagctcgcccaaagagatacaacctaatccccaacctacttttagtttttttgttttttttttatggttaaaagtaacttttgtagtttaaaaaaatctttcctctttcatataaataagaagtggaaattgcctttttattgtgtaatgtagaaaaccctcaagtgttttttccgagcttgggaaagattttgtgtaggaaatgtgcatagagtttgtattttatttttattagcagctgaaatgcctttggttttggcttctctctctccctctctctctctgtctctccttctctctctccccccaccacccacccccacacacgtcatctgcattgttattggagcctgtacttagagggattaagcccacaccctggcttccattccatatcaggtacaggatttgatgttattaacatttgtcgtcatacctcataagtcggtccctgccttgtctgtctaggcccatttggggctccctgtgagtgattcccctctctctgctatgctggagacggttccagcctggaaagcggccaagttcatcttctcactgtgagtggaagctggatcgggcccccgtagtcctggcagccctgttgtctggagggttcttgttgtccctcccattagccagggcggagactgtctgagctgtgcaggaggagggttgctagtaggttctgcttctgcttctctctgctccactgtctgcagcccagatcctgttgggcctggctggtgtctggtaaccatgggcctccactgacccatccctctcttttaaactgtcaggtcattatcaggcataggcagcctatagggcccaaagaaggcaaaaagataagatttactcaagtagcatttgggcaatgaggaaggaaaggtttcaaatttaggggcagaagtgagagaatgagccaacccatgtacctgctgcaactgaaccagactgggttttcaaggctcccagacgtagagtaggaaacgtgctcttctaaatgaggagggagaagataaaggaaacttctagcccctgtccttagtgctttgaggattttattttctcccttactacgcttgcttgacgtcactctctctcgacctccaaacagcaggactctttctctgggaaaccatccttccaaaacggaatctatgtagacaatgggacgttaggcagagagctcagatggcccttttaagggggctccaagaaccaacatcactgctcttttagataaacctctgccctccactccttgcttgagtgggttaaaggaactaacagttgtccctttaggaggacaaaatggggtcaagaggacacagaagagttgtatagcaccagattggttccaaatagttaatggatgtgtgcacattttctgttcagggattaagaccagaatatcagtggatttgttttccccaccaagtggcctcttagactagtcattaacttatgattagctctaaagatttcaaatagtggcagacagtgtcttctgaatgtaagttttgagaaatacgagtctgtcagagcggccataagccataaagagtcaatctcttaattatatttttcatcatgtaaacaagtttcccatttccctttcttagattgcaccagtgaaggagatgttttgcaaagattcagagaactaatttttcactggataagacctgagtaacccagaccccccaccgtggttcttttcacagccctcgactttgcacttaaaaagggatattgtaaatgaaaggctgcagtgccagttttaagaaagaatttctgtgaagtgtgaggactctggagtctagctcacataaagagagtgttatataaaaatccgacagctgaactaggttgctcttttttggcagggagtggggatgagatttgacaccaatatgggcaaaattagataaccttttggttaatataaatgattttgatttggaggcctaatttgtagattgtgaaagcagcttttagtttaacttattcacagaccccttataattaccatgtttttttttttcttcctaaatctcttggttcagcttgtgaatcttacgtgcccgtaaagttgggatgttgaattggctcttctttgttctggcagtgagtcaagtgtccagcattttttcataagtgttttttaaaattgttctccagcattttatggctcctccctcccatgtcctcagacccagcaaaagcgtagaggcagaattagaggcctctccaggccagctcctctgcccacatgtcatacaaggtgtgaatttgagcacagtccagaaatggagacatcccacccccagttgaataatggcccattcatgccaaccttgccaacacggagagggcagagatgcactagaagaccttcatcctccccttcctctgccccaagtcactacagttggttctattgaagccagtctttaagaaacctgggttaaagacaccagcacttctgcttgctgggctggctggacctgtgaagccatgggcaggtagtgccctcttgagagtcattttatttggccaccttcaggtgagactatccatagacacatgctaggataggccccgctgggagggcagttacaggagagagtaggtggtggtgacgtgagggctgtgaaggatccagagacaagacttagatgtttcgttcattcactcactcattcagttactcctaagacttttcagtttcataaggaagagtgttgcctgaggccctagggaatattggggaatagaagggattgaggaaacattaataatagttattcaaaagacccaaatgcttatacttctctctcccttcttctctctctgacacacacacacacacacacacacacacacacacacacgtgcacattcctcccttacatgctcatttgtgccttaaatgtgccttataggtaaatccaggatgactgaggaatccctcgtcactgggagattttgtatatattcttttattattagattgagttgggtgtggggaaaaatttttttctgaaggctcaaaagtggtttcctaaaagtgagccactatcagatttgcacatcaggagaaaagaaatagggttacgtccattaggaaaatcccagtttgcaggagtgcaatcacatcaaaaaaacaaccagccaggattaaaggtattataaatcctcatagcggaacatttctcagggcaaaggaacctggctcatttgaagattaatgttccatgcctttgtggtcaaagggtcagcacttaacacaggaaaaaactaggtgttgttttgttttgttattttggacaacataaaattcaggaatgttttatttagccttggtttctagaaggaagggaaataatatttcttgagcatttactagggtgttgcgtgctgtgctaagtaaattttaagtctttcagttttatagatacggaaaacaagggtgactctttaccacaggatgaataaagaactaagtaatatgggaaatgcagcaatttctggactagctgagccgattccttcctgtgagcacactgtaagctttcaagttctctgggcaggaattacagcacctgtcccctgcaatggccctgctgtgtgatgctcatcgcttcccttcgtgctggagcagtcccccaggtgtccatctcctatctttttgttccaatcttctgtgagttccagctagcaggctttacatctggggaaaggaaaaccaggggttttagctctgttctctgctcccatccttcgctcaccagctgagtgagaacatgaactttttgcaccatgtacccatggcttacactacttagaaaatcaccttttcagataaaacagtttatgagttcatagagaacaccagcactctttgacaaaactgtgagtgaccctttttaaacaatgctgagcaggccctgagctataatcaacggtgagctttaatgtctatgctgacagttaggttttgctctcttttgtaacaggttacgtagaccagcagtgtttaaatctaaatacgttgtgagtctgttatctgtcctatcgcgttttttaaatgactttttattctttatcatagctaagtaaataccaaaaaaaaaaaaaagctttgtaggacacttgtacttagtttgggaaaaaaaaataaattgaaattgttatgcttttgtatttccatttcttgcaaataaatattttttcttaaatagtaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:64764 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:64764 -> Molecular function: GO:0035497 [cAMP response element binding] evidence: IMP
GeneID:64764 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:64764 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IMP
GeneID:64764 -> Biological process: GO:0002062 [chondrocyte differentiation] evidence: ISS
GeneID:64764 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:64764 -> Biological process: GO:0006888 [ER to Golgi vesicle-mediated transport] evidence: IEA
GeneID:64764 -> Biological process: GO:0006986 [response to unfolded protein] evidence: IEA
GeneID:64764 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IEP
GeneID:64764 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:64764 -> Biological process: GO:0051216 [cartilage development] evidence: ISS
GeneID:64764 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:64764 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
GeneID:64764 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
GeneID:64764 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
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