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2025-05-09 16:58:05, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_138715 3761 bp mRNA linear PRI 05-MAY-2013
DEFINITION Homo sapiens macrophage scavenger receptor 1 (MSR1), transcript
variant SR-AI, mRNA.
ACCESSION NM_138715
VERSION NM_138715.2 GI:109148504
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3761)
AUTHORS Hendrickx,D.A., Koning,N., Schuurman,K.G., van Strien,M.E., van
Eden,C.G., Hamann,J. and Huitinga,I.
TITLE Selective upregulation of scavenger receptors in and around
demyelinating areas in multiple sclerosis
JOURNAL J. Neuropathol. Exp. Neurol. 72 (2), 106-118 (2013)
PUBMED 23334594
REMARK GeneRIF: The results of this study found that SR-AI/II was highly
expressed on the surface of foamy macrophages in MS lesions.
REFERENCE 2 (bases 1 to 3761)
AUTHORS Ben,J., Jin,G., Zhang,Y., Ma,B., Bai,H., Chen,J., Zhang,H.,
Gong,Q., Zhou,X., Zhang,H., Qian,L., Zhu,X., Li,X., Yang,Q., Hu,Z.,
Xu,Y., Shen,H. and Chen,Q.
TITLE Class A scavenger receptor deficiency exacerbates lung
tumorigenesis by cultivating a procarcinogenic microenvironment in
humans and mice
JOURNAL Am. J. Respir. Crit. Care Med. 186 (8), 763-772 (2012)
PUBMED 22878280
REMARK GeneRIF: We identified in a Chinese population a functional
polymorphism in SR-A linked to lung cancer risk. In vivo and in
vitro studies demonstrated that SR-A may negatively modulate lung
cancer growth and angiogenesis by regulating MMP9 production.
REFERENCE 3 (bases 1 to 3761)
AUTHORS Lin,C.S., Lin,F.Y., Ho,L.J., Tsai,C.S., Cheng,S.M., Wu,W.L.,
Huang,C.Y., Lian,C.H., Yang,S.P. and Lai,J.H.
TITLE PKCdelta signalling regulates SR-A and CD36 expression and foam
cell formation
JOURNAL Cardiovasc. Res. 95 (3), 346-355 (2012)
PUBMED 22687273
REMARK GeneRIF: Through regulating PI3K/Akt and ERK activity, PKCdelta
affects SR-A and CD36 expression and foam cell formation.
REFERENCE 4 (bases 1 to 3761)
AUTHORS Piechota,M., Banaszewska,A., Dudziak,J., Slomczynski,M. and
Plewa,R.
TITLE Highly upregulated expression of CD36 and MSR1 in circulating
monocytes of patients with acute coronary syndromes
JOURNAL Protein J. 31 (6), 511-518 (2012)
PUBMED 22763563
REMARK GeneRIF: In patients with symptoms of acute coronary syndrome the
amount of CD36 and MSR1 mRNA in circulating monocytes, as well as
the density of both receptors on the cells surface was
significantly higher.
REFERENCE 5 (bases 1 to 3761)
AUTHORS Jozefowski,S.
TITLE [The role of the class A scavenger receptors, SR-A and MARCO, in
the immune system. Part 2. Contribution to recognition and
phagocytosis of pathogens as well as induction of immune response]
JOURNAL Postepy Hig Med Dosw (Online) 66, 120-131 (2012)
PUBMED 22470186
REMARK GeneRIF: This review demonstrated that class A SR and MARCO are
major pattern recognition receptors mediating opsonin-independent
phagocytosis.
Review article
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3761)
AUTHORS Ashkenas,J., Penman,M., Vasile,E., Acton,S., Freeman,M. and
Krieger,M.
TITLE Structures and high and low affinity ligand binding properties of
murine type I and type II macrophage scavenger receptors
JOURNAL J. Lipid Res. 34 (6), 983-1000 (1993)
PUBMED 8394868
REFERENCE 7 (bases 1 to 3761)
AUTHORS Asaoka,H., Matsumoto,A., Itakura,H. and Kodama,T.
TITLE [Structural and function of the human macrophage scavenger
receptor]
JOURNAL Nippon Rinsho 51 (6), 1677-1683 (1993)
PUBMED 8391600
REMARK Review article
REFERENCE 8 (bases 1 to 3761)
AUTHORS Emi,M., Asaoka,H., Matsumoto,A., Itakura,H., Kurihara,Y., Wada,Y.,
Kanamori,H., Yazaki,Y., Takahashi,E., Lepert,M. et al.
TITLE Structure, organization, and chromosomal mapping of the human
macrophage scavenger receptor gene
JOURNAL J. Biol. Chem. 268 (3), 2120-2125 (1993)
PUBMED 8093617
REFERENCE 9 (bases 1 to 3761)
AUTHORS Naito,M., Suzuki,H., Mori,T., Matsumoto,A., Kodama,T. and
Takahashi,K.
TITLE Coexpression of type I and type II human macrophage scavenger
receptors in macrophages of various organs and foam cells in
atherosclerotic lesions
JOURNAL Am. J. Pathol. 141 (3), 591-599 (1992)
PUBMED 1519666
REFERENCE 10 (bases 1 to 3761)
AUTHORS Matsumoto,A., Naito,M., Itakura,H., Ikemoto,S., Asaoka,H.,
Hayakawa,I., Kanamori,H., Aburatani,H., Takaku,F., Suzuki,H. et al.
TITLE Human macrophage scavenger receptors: primary structure,
expression, and localization in atherosclerotic lesions
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (23), 9133-9137 (1990)
PUBMED 2251254
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA995755.1, D90187.1 and
AC023396.4.
This sequence is a reference standard in the RefSeqGene project.
On Jun 15, 2006 this sequence version replaced gi:20357511.
Summary: This gene encodes the class A macrophage scavenger
receptors, which include three different types (1, 2, 3) generated
by alternative splicing of this gene. These receptors or isoforms
are macrophage-specific trimeric integral membrane glycoproteins
and have been implicated in many macrophage-associated
physiological and pathological processes including atherosclerosis,
Alzheimer's disease, and host defense. The isoforms type 1 and type
2 are functional receptors and are able to mediate the endocytosis
of modified low density lipoproteins (LDLs). The isoform type 3
does not internalize modified LDL (acetyl-LDL) despite having the
domain shown to mediate this function in the types 1 and 2
isoforms. It has an altered intracellular processing and is trapped
within the endoplasmic reticulum, making it unable to perform
endocytosis. The isoform type 3 can inhibit the function of
isoforms type 1 and type 2 when co-expressed, indicating a dominant
negative effect and suggesting a mechanism for regulation of
scavenger receptor activity in macrophages. [provided by RefSeq,
Jul 2008].
Transcript Variant: This variant (SR-AI), also known as phSR1,
encodes the longest isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D90187.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-152 DA995755.1 2-153
153-1283 D90187.1 1-1131
1284-1420 AC023396.4 83124-83260
1421-3761 AC023396.4 93460-95800
FEATURES Location/Qualifiers
source 1..3761
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p22"
gene 1..3761
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/note="macrophage scavenger receptor 1"
/db_xref="GeneID:4481"
/db_xref="HGNC:7376"
/db_xref="HPRD:01092"
/db_xref="MIM:153622"
exon 1..194
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
variation 28
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace=""
/replace="t"
/db_xref="dbSNP:72563174"
variation 45
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:381178"
variation 61
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:433235"
variation 121
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="c"
/db_xref="dbSNP:41423547"
variation 166
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:13306541"
STS 172..1601
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/db_xref="UniSTS:481933"
misc_feature 184..186
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/note="upstream in-frame stop codon"
exon 195..301
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
CDS 199..1554
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/note="isoform type 1 is encoded by transcript variant
SR-AI; scavenger receptor class A, member 1; macrophage
scavenger receptor type III; macrophage acetylated LDL
receptor I and II; macrophage scavenger receptor types I
and II; scavenger receptor class A member 1"
/codon_start=1
/product="macrophage scavenger receptor types I and II
isoform type 1"
/protein_id="NP_619729.1"
/db_xref="GI:20357512"
/db_xref="CCDS:CCDS5995.1"
/db_xref="GeneID:4481"
/db_xref="HGNC:7376"
/db_xref="HPRD:01092"
/db_xref="MIM:153622"
/translation="
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL
"
misc_feature 349..426
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21757.1);
transmembrane region"
misc_feature 427..525
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21757.1);
Region: Spacer (Probable)"
misc_feature 559..705
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/note="Macrophage scavenger receptor; Region: Macscav_rec;
pfam03523"
/db_xref="CDD:112346"
misc_feature 643..>945
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/note="Tho complex subunit 7; Region: THOC7; pfam05615"
/db_xref="CDD:191317"
misc_feature 1012..1200
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/note="Collagen triple helix repeat (20 copies); Region:
Collagen; pfam01391"
/db_xref="CDD:189968"
misc_feature 1246..1548
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/note="Scavenger receptor Cys-rich; Region: SR;
smart00202"
/db_xref="CDD:197572"
variation 239
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:372589091"
variation 266
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="g"
/replace="t"
/db_xref="dbSNP:35175081"
exon 302..415
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
variation 333
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35778274"
variation 369
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:35874867"
exon 416..828
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
variation 511
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:13306549"
STS 622..723
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/standard_name="GDB:580807"
/db_xref="UniSTS:157850"
variation 643
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="g"
/replace="t"
/db_xref="dbSNP:72552388"
exon 829..1015
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
STS 841..983
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/standard_name="PMC310830P19"
/db_xref="UniSTS:272764"
variation 867
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35425627"
variation 1004
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306543"
exon 1016..1096
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
variation 1021
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="g"
/db_xref="dbSNP:2229388"
variation 1032
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="g"
/replace="t"
/db_xref="dbSNP:34797070"
variation 1079
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:41440349"
exon 1097..1177
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
exon 1178..1231
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
variation 1212
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:13306540"
exon 1232..1420
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
variation 1236
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:34175190"
STS 1259..1397
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/standard_name="PMC310830P18"
/db_xref="UniSTS:272763"
variation 1326
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:35962364"
exon 1421..3761
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/inference="alignment:Splign:1.39.8"
variation 1751
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:398221"
variation 1794
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306544"
STS 1816..2143
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/standard_name="SHGC-12479"
/db_xref="UniSTS:17702"
variation 1841
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="g"
/db_xref="dbSNP:13306546"
variation 1882
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:34783252"
variation 1979
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:917"
variation 2066
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35882049"
variation 2070
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:918"
variation 2158
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35281051"
variation 2237
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34918250"
variation 2281
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="t"
/db_xref="dbSNP:36124634"
variation 2379
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="g"
/replace="t"
/db_xref="dbSNP:35122258"
variation 2438
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="t"
/db_xref="dbSNP:34247147"
variation 2439
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="g"
/replace="t"
/db_xref="dbSNP:35796001"
variation 2458
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="g"
/replace="t"
/db_xref="dbSNP:34973311"
variation 2459
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:36031660"
variation 2525
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306547"
variation 2625
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306537"
variation 2641
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306538"
variation 2795
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="c"
/replace="t"
/db_xref="dbSNP:36032449"
variation 3025
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace="a"
/replace="t"
/db_xref="dbSNP:13306539"
variation 3434..3435
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace=""
/replace="gtacta"
/db_xref="dbSNP:36030723"
polyA_signal 3738..3743
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
variation 3749..3750
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
/replace=""
/replace="a"
/replace="c"
/db_xref="dbSNP:34581646"
polyA_site 3761
/gene="MSR1"
/gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SRA"
ORIGIN
aaatttagattttgcaaacctgtgcattgatgagagtgctattgaaacacattaagaaagattttcaacgcaggaatgtgtcatttcctttcttcatgtaccagatgctgaaatactatgagataaagattttaggtttcaattgtaaagagagagaagtggataaatcagtgctgctttctttaggacgaaagaagtatggagcagtgggatcactttcacaatcaacaggaggacactgatagctgctccgaatctgtgaaatttgatgctcgctcaatgacagctttgcttcctccgaatcctaaaaacagcccttcccttcaagagaaactgaagtccttcaaagctgcactgattgccctttacctcctcgtgtttgcagttctcatccctctcattggaatagtggcagctcaactcctgaagtgggaaacgaagaattgctcagttagttcaactaatgcaaatgatataactcaaagtctcacgggaaaaggaaatgacagcgaagaggaaatgagatttcaagaagtctttatggaacacatgagcaacatggagaagagaatccagcatattttagacatggaagccaacctcatggacacagagcatttccaaaatttcagcatgacaactgatcaaagatttaatgacattcttctgcagctaagtaccttgttttcctcagtccagggacatgggaatgcaatagatgaaatctccaagtccttaataagtttgaataccacattgcttgatttgcagctcaacatagaaaatctgaatggcaaaatccaagagaataccttcaaacaacaagaggaaatcagtaaattagaggagcgtgtttacaatgtatcagcagaaattatggctatgaaagaagaacaagtgcatttggaacaggaaataaaaggagaagtgaaagtactgaataacatcactaatgatctcagactgaaagattgggaacattctcagaccttgagaaatatcactttaattcaaggtcctcctggacccccgggtgaaaaaggagatcgaggtcccactggagaaagtggtccacgaggatttccaggtccaataggtcctccgggtcttaaaggtgatcggggagcaattggctttcctggaagtcgaggactcccaggatatgccggaaggccaggaaattctggaccaaaaggccagaaaggggaaaaggggagtggaaacacattaactccatttacgaaagttcgactggtcggtgggagcggccctcacgaggggagggtggagatactccacagcggccagtggggtacaatttgtgacgatcgctgggaagtgcgcgttggacaggtcgtctgtaggagcttgggatacccaggtgttcaagccgtgcacaaggcagctcactttggacaaggtactggtccaatatggctgaatgaagtgttttgttttgggagagaatcatctattgaagaatgtaaaattcggcaatgggggacaagagcctgttcacattctgaagatgctggagtcacttgcactttataatgcatcatattttcattcacaactatgaaatcgctgctcaaaaatgattttattaccttgttcctgtaaaatccatttaatcaatatttaagagattaagaatattgcccaaataatattttagattacaggattaatatattgaacaccttcatgcttactattttatgtctatatttaaatcattttaacttctataggtttttaaatggaattttctaatataatgacttatatgctgaattgaacattttgaagtttatagcttccagattacaaaggccaagggtaatagaaatgcataccagtaattggctccaattcataatatgttcaccaggagattacaattttttgctcttcttgtctttgtaatctatttagttgattttaattactttctgaataacggaagggatcagaagatatcttttgtgcctagattgcaaaatctccaatccacacatattgttttaaaataagaatgttatccaactattaagatatctcaatgtgcaataacttgtgtattagatatcaatgttaatgatatgtcttggccactatggaccagggagcttatttttcttgtcatgtactgacaactgtttaattgaatcatgaagtaaattgaaagcaggacatatgagaaaactgaccatcagtatatttgtccagataattggtggatcaaaaatgccacttaacaggaagtttagtttgttatgcactttaaatggaataattagcttgttacaattctaggacatggtgtttaaaatttaaatctgattaatccattttaacaaacaatgcaaacatcttcagtgcagaaggaagagtggtttcaactgtttggagtcttttatgaagtcagtcaacatttacaaccaaagggcgggggggggggtggggggtgcgtctttagtcctaaagggacaataactctgagcatgccccaaaaaagtagtttagcaaccttttgttggtagtcaacccatccccagggccatagtgtagagtgtgaaaagctaccctgaaacccagtaattctaccctgaaagtgactgcctgcagaaagaccagcagttgatattaaagcgcaaatgaattcaacctcagccctgaaaataacagaattctgaagtttcctatgactaattcacaaaaaaagtaattgtaaactagtactattatggaattactctactgttctttctttaatagtggcaaatgaaagcataagcttaagcattttttcatattctgaagtctcaccacacataataaccaagtggtagactcacagccgtccaacttaaaaaggcaaaaccttaccttggaattggaattactgtaaacagcctactgaaaatgcatttttatcatgtaacattcttctacttgtttaacattgctgattttctctggcagcataattttgtggttaagagaatgaattctgaatgtacactttctgtctcaaaccctggctgtaatttcagctagttaataattctttgtgttcagttccactatctaggtattttcttcaaaaggtaaatacaatggtttctgaaagaatcatttgcattatcagcctgtttgggatgtctgagatcagtgcctctgggttgttaatactgtattgctgtatggtatatgtatgctgatttactacttatgcgtaagtggtatgcatgggatgtctgaaatcagtgcctatgggttgtcaatagtattaactattagtgttaactgttagtattaactattagtattattaacactaataatagtactattactattactatttttattttaaaataaaatttacctttaaaataataatagtactattgctagtactagtactattgctattactagtactattactagtactagtactatgacactgttaatagtactattaacaacccataggcacttgggatgtctgagatcagtgcctatgggttgttaatactatattgctgtatggtatatgcatgctgatttaccacttatgcatagatatatctttaataagtaatctaaaaatcctttttgtatttgagagaatctactaagttcagtccagtcaagaaaagaacctaatagcaccaatacaaattgaggacttaatttactttggaatgttgaattgcatttgttccattaaaaaaaacagaaatttgcga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4481 -> Molecular function: GO:0005044 [scavenger receptor activity] evidence: IEA
GeneID:4481 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4481 -> Molecular function: GO:0030169 [low-density lipoprotein particle binding] evidence: ISS
GeneID:4481 -> Biological process: GO:0006898 [receptor-mediated endocytosis] evidence: TAS
GeneID:4481 -> Biological process: GO:0010744 [positive regulation of macrophage derived foam cell differentiation] evidence: ISS
GeneID:4481 -> Biological process: GO:0010886 [positive regulation of cholesterol storage] evidence: ISS
GeneID:4481 -> Biological process: GO:0030301 [cholesterol transport] evidence: ISS
GeneID:4481 -> Biological process: GO:0034381 [plasma lipoprotein particle clearance] evidence: ISS
GeneID:4481 -> Biological process: GO:0042221 [response to chemical stimulus] evidence: IEA
GeneID:4481 -> Biological process: GO:0042953 [lipoprotein transport] evidence: IEA
GeneID:4481 -> Cellular component: GO:0005581 [collagen] evidence: IEA
GeneID:4481 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:4481 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:4481 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:4481 -> Cellular component: GO:0030666 [endocytic vesicle membrane] evidence: TAS
GeneID:4481 -> Cellular component: GO:0034362 [low-density lipoprotein particle] evidence: IEA
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