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2025-05-09 16:40:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032510 3847 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens par-6 partitioning defective 6 homolog gamma (C.
elegans) (PARD6G), mRNA.
ACCESSION NM_032510 XM_938856
VERSION NM_032510.3 GI:115495001
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3847)
AUTHORS Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
TITLE Comprehensive proteomic analysis of human Par protein complexes
reveals an interconnected protein network
JOURNAL J. Biol. Chem. 279 (13), 12804-12811 (2004)
PUBMED 14676191
REFERENCE 2 (bases 1 to 3847)
AUTHORS Kohjima,M., Noda,Y., Takeya,R., Saito,N., Takeuchi,K. and
Sumimoto,H.
TITLE PAR3beta, a novel homologue of the cell polarity protein PAR3,
localizes to tight junctions
JOURNAL Biochem. Biophys. Res. Commun. 299 (4), 641-646 (2002)
PUBMED 12459187
REFERENCE 3 (bases 1 to 3847)
AUTHORS Suzuki,A., Yamanaka,T., Hirose,T., Manabe,N., Mizuno,K.,
Shimizu,M., Akimoto,K., Izumi,Y., Ohnishi,T. and Ohno,S.
TITLE Atypical protein kinase C is involved in the evolutionarily
conserved par protein complex and plays a critical role in
establishing epithelia-specific junctional structures
JOURNAL J. Cell Biol. 152 (6), 1183-1196 (2001)
PUBMED 11257119
REFERENCE 4 (bases 1 to 3847)
AUTHORS Noda,Y., Takeya,R., Ohno,S., Naito,S., Ito,T. and Sumimoto,H.
TITLE Human homologues of the Caenorhabditis elegans cell polarity
protein PAR6 as an adaptor that links the small GTPases Rac and
Cdc42 to atypical protein kinase C
JOURNAL Genes Cells 6 (2), 107-119 (2001)
PUBMED 11260256
REFERENCE 5 (bases 1 to 3847)
AUTHORS Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
TITLE The cell-polarity protein Par6 links Par3 and atypical protein
kinase C to Cdc42
JOURNAL Nat. Cell Biol. 2 (8), 531-539 (2000)
PUBMED 10934474
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC060797.1, AC139100.4 and AA502508.1.
On Oct 3, 2006 this sequence version replaced gi:40254990.
##Evidence-Data-START##
Transcript exon combination :: BC060797.1, AB044556.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1681 BC060797.1 1-1681
1682-3831 AC139100.4 175504-177653 c
3832-3847 AA502508.1 310-325
FEATURES Location/Qualifiers
source 1..3847
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q23"
gene 1..3847
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/note="par-6 partitioning defective 6 homolog gamma (C.
elegans)"
/db_xref="GeneID:84552"
/db_xref="HGNC:16076"
/db_xref="HPRD:10138"
/db_xref="MIM:608976"
exon 1..238
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/inference="alignment:Splign:1.39.8"
misc_feature 125..127
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/note="upstream in-frame stop codon"
CDS 167..1297
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/note="PAR-6 gamma protein; PAR6D"
/codon_start=1
/product="partitioning defective 6 homolog gamma"
/protein_id="NP_115899.1"
/db_xref="GI:14210518"
/db_xref="CCDS:CCDS12022.1"
/db_xref="GeneID:84552"
/db_xref="HGNC:16076"
/db_xref="HPRD:10138"
/db_xref="MIM:608976"
/translation="
MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL
"
misc_feature 221..460
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/note="The PB1 domain is an essential part of Par6 protein
which in complex with Par3 and aPKC proteins is crucial
for establishment of apical-basal polarity of animal
cells. The PB1 domain is a modular domain mediating
specific protein-protein interactions...; Region:
PB1_Par6; cd06403"
/db_xref="CDD:99724"
misc_feature order(224..226,230..232,251..259,263..265,308..310,
320..322,440..442)
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/note="PB1 interaction surface [polypeptide binding];
other site"
/db_xref="CDD:99724"
misc_feature 545..928
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BYG4.1);
Region: Interaction with PARD3 and CDC42 (By similarity)"
misc_feature 635..910
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/note="PDZ domain found in a variety of Eumetazoan
signaling molecules, often in tandem arrangements. May be
responsible for specific protein-protein interactions, as
most PDZ domains bind C-terminal polypeptides, and binding
to internal (non-C-terminal)...; Region: PDZ_signaling;
cd00992"
/db_xref="CDD:29049"
misc_feature order(671..682,686..688,860..865,872..877)
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29049"
exon 239..461
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/inference="alignment:Splign:1.39.8"
exon 462..3836
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/inference="alignment:Splign:1.39.8"
STS 2309..2394
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2936
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:12201"
variation 3045
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:3087701"
STS 3483..3733
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/standard_name="RH11667"
/db_xref="UniSTS:58304"
STS 3565..3672
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/standard_name="A004B28"
/db_xref="UniSTS:32587"
variation 3568
/gene="PARD6G"
/gene_synonym="PAR-6G; PAR6gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132560"
ORIGIN
gaggcgcgcggccagcccagctcgggcccgcagcaccgggagcagcccgccggccaagcgagcgcgggccggggccggggccggggcctgggggcgccgcccccgggagtctttctgcggcccctgaggagcgagggcgacggcgaggctgaccggggccgaaaccatgaaccgaagttttcacaagtctcagaccttgcgattctacgattgcagcgcagtggaagtcaagagcaagtttggggcggaattccgaaggttctctctggaccgtcataagcctgggaagtttgaagatttctacaagctggttgtgcacacccaccatatctccaacagtgatgtaactattggctatgcagatgtgcacggagacctgctgcccatcaacaatgatgacaacttctgcaaggcggtttctagtgcaaatcccctgctcagggtcttcatccagaaacgagaggaggccgagcgtggcagcctcggcgcgggctcgctgtgcaggcggaggcgggcgctgggcgcgctgcgtgatgaaggaccccggcggcgtgcacacctggacatcggcctcccgcgcgacttccgccccgtatcatccatcatcgatgtggacctggtccccgagacgcaccggcgagtgcggctgcaccggcacggctgcgagaagccgctgggcttctacatccgcgatggcgccagcgtgcgcgtgaccccgcacgggctggagaaggtgcccggcatcttcatctcgcgcatggtacccgggggcctggcggagagcaccgggctgctggctgtgaatgacgaggtcctggaggtgaacggcattgaggtggccgggaagacgctggaccaggtcacggacatgatgatcgccaacagccacaacctcatcgtcaccgtcaagcccgccaaccagcgcaacaacgtggtgcgcggcggccgcgcgttgggcagctcgggaccgccctcggacggcaccgcgggcttcgtgggtccccccgccccgcgcgtcctgcagaacttccaccccgacgaggcggagagcgatgaggacaacgacgtcgtcatcgagggcacactggagcctgcacgtcccccccagaccccgggcgcgcccgcaggcagcctctcccgggtcaatggcgcgggcctggcgcagcggctgcagcgggacctggccctggacggcggcctccagcggctgctcagctccctgcgggccgacccccgtcacagcctggcgctgccgccaggcggcgtggaggagcacgggcccgcggtcacgctctagactcccgagaggcccccaaatcctagctccagttccccggtaaggacagggacaggacctgcagactgcatccgctcattttttgttgtttttgtgaccacaaaaacaacgctgctctttgtttcaacttccggatataaaaacacaagtattgcctatttttatagaatttcgccacagaacttaaaatgaacgcctgtagagacactctataccaggcctgagtgcaggtcttggcgcctttgcaaagtgatagaaaagatctgaccaagtgcaaaaaaatgctttttaaaatttttacaaatactttgtttttaaagtgaagctttaaaattacttttttaaaatagtcaaattcatgtttttaagtaagttggcccatgcaacatatctcagcattcttgctgtgctctctgctgacttgcaggcgaggccgactgtgctgatgtacgtgacaagaggctggtttttaataacgaatgcagccaggtgcagtggctcacgtctgtaatcccagcactttgggaggcctacgtgggctgatcacgaggtcaggaggtcgagaccagcatggccaacatggtgaaaccctgtctctactaaaaatataaaaattagccaggtgtggtggcaggcgcctgtaatcccagctaccttgggaggctgaggcaggagaatcgcttgaacccgggaggcagaggttgcagtgagctgagatcgcaccactgcactccagcctgggtgacagagcaagactctgtctcgggaaaaaaaaaaaatacacccaaacctgtccatgtacaaccatggagatgaattccagattttcacactgttcatagtcataattcggttgggacaggagagctcccaccagcacacttatggcacccgcagctgtggaattgttccggggcttttttttgtttgttttgagacatagtgtcttgttctgtcatccaagctggagggatctcagctcactgcaacctccgcctcctgggttcaagcaattctcctgcctcagcctcccaaggagctgggacaggcacatgccaccatacccagctaatttttgtatttttagtagagatgggatttcaccacgttggtcaggctggtcttgaactcctgacctcaggtgatacggtcccccctcagcctccaaaaatgctaggattatagacgtgagccacagcaccagaccaggggctatttttgtgacccacataggtggcccattcagcctcaaggggaaatccagggtaggaagcagcagctctgctggactgggctcagcagtcccatttgggatgtaagcctctattgcctctaagatgacccttttcctgtgggttgactgactctgagggcgatttcggaaatgttttcagcagaaatgaaggataagcatcgcacatgtccagcaatgtctttgagaatgcagtcatttgcacgtgagttctcatctttgttttctgaaacagacgtttcttttagtaagtcacaatacatgctaattttcatttctagaatggtcactggcagttctcacttttaactataagaagtcacgtggaacttagtgatttttaacaaatactaaattcatcctcactttatgttgatcttccagcaacgtttatatatttagtaattttaaaaattcctatttgatacaattaaattttatataatgtgttttgcttgaataaaatgttacatttatactttgagaactctgaccaaatctttcatacagatacaggtaaagaaatatttttctaggttgtcggagctgcgtacctcccgctgcttctccttgtggtccagcaccacctgctggtcagtggcagaactgtcctgacttcgtgaacatggaactgctaagagggaaaactgcatctcagcattttcattttttctgaatattaagtgaaaagcaagttctatttttaagaaatagcttttgctgaggagttgtgaattcctgcacctgtgtttgatgttatttgtatgcaatggattgctggccctttgttcctaagcaagagaagaccaaagatgcttccccatgacctctccggtgaggatccgcaccccccggacttgctctctgatgaagggcatgtcgttcagtgccccagcagtcagaagcagtttttgtggaactaaaactaataatgttaccctcacaaaggaaatgttcttttactaagttattgctgattcttgaatgtctgttatataactgggtcggctatcaagaaggaaggttatatttcttatcacattttaagttgttaagcaaatgtgagtttttttttaagaaatgaggctttcactgagatttgtgtgctattcataattttaggaattactgcttagaacagctgcttgggtgtatttttctacacaggtctgtacttctgccactttctccttttaaaaaaacaaaactatgcatattatgtattaaagttttcttggttttatatatcagagaataaaaacttttttgacttttgagtaaacaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84552 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:84552 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:84552 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
GeneID:84552 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
GeneID:84552 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:84552 -> Biological process: GO:0070830 [tight junction assembly] evidence: TAS
GeneID:84552 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:84552 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:84552 -> Cellular component: GO:0005923 [tight junction] evidence: IEA
GeneID:84552 -> Cellular component: GO:0043234 [protein complex] evidence: IEA
by
@meso_cacase at
DBCLS
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