2025-05-09 16:35:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_021058 481 bp mRNA linear PRI 16-MAR-2013 DEFINITION Homo sapiens histone cluster 1, H2bj (HIST1H2BJ), mRNA. ACCESSION NM_021058 VERSION NM_021058.3 GI:20336753 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 481) AUTHORS Kitazawa,M., Ohnuma,T., Takebayashi,Y., Shibata,N., Baba,H., Ohi,K., Yasuda,Y., Nakamura,Y., Aleksic,B., Yoshimi,A., Okochi,T., Ikeda,M., Naitoh,H., Hashimoto,R., Iwata,N., Ozaki,N., Takeda,M. and Arai,H. TITLE No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (4), 456-464 (2012) PUBMED 22488895 REMARK GeneRIF: The genes HIST1H2BJ, PRSS16, and PGBD1 were not associated with Japanese patients with schizophrenia. REFERENCE 2 (bases 1 to 481) AUTHORS Shi,J., Levinson,D.F., Duan,J., Sanders,A.R., Zheng,Y., Pe'er,I., Dudbridge,F., Holmans,P.A., Whittemore,A.S., Mowry,B.J., Olincy,A., Amin,F., Cloninger,C.R., Silverman,J.M., Buccola,N.G., Byerley,W.F., Black,D.W., Crowe,R.R., Oksenberg,J.R., Mirel,D.B., Kendler,K.S., Freedman,R. and Gejman,P.V. TITLE Common variants on chromosome 6p22.1 are associated with schizophrenia JOURNAL Nature 460 (7256), 753-757 (2009) PUBMED 19571809 REMARK GeneRIF: Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) REFERENCE 3 (bases 1 to 481) AUTHORS Benyamin,B., McRae,A.F., Zhu,G., Gordon,S., Henders,A.K., Palotie,A., Peltonen,L., Martin,N.G., Montgomery,G.W., Whitfield,J.B. and Visscher,P.M. TITLE Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels JOURNAL Am. J. Hum. Genet. 84 (1), 60-65 (2009) PUBMED 19084217 REFERENCE 4 (bases 1 to 481) AUTHORS Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T., Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and Zhao,Y. TITLE Substrate and functional diversity of lysine acetylation revealed by a proteomics survey JOURNAL Mol. Cell 23 (4), 607-618 (2006) PUBMED 16916647 REFERENCE 5 (bases 1 to 481) AUTHORS Pavri,R., Zhu,B., Li,G., Trojer,P., Mandal,S., Shilatifard,A. and Reinberg,D. TITLE Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II JOURNAL Cell 125 (4), 703-717 (2006) PUBMED 16713563 REFERENCE 6 (bases 1 to 481) AUTHORS El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A. TITLE Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter JOURNAL Mol. Cell. Biol. 18 (5), 2535-2544 (1998) PUBMED 9566873 REFERENCE 7 (bases 1 to 481) AUTHORS Albig,W. and Doenecke,D. TITLE The human histone gene cluster at the D6S105 locus JOURNAL Hum. Genet. 101 (3), 284-294 (1997) PUBMED 9439656 REFERENCE 8 (bases 1 to 481) AUTHORS Frohm,M., Gunne,H., Bergman,A.C., Agerberth,B., Bergman,T., Boman,A., Liden,S., Jornvall,H. and Boman,H.G. TITLE Biochemical and antibacterial analysis of human wound and blister fluid JOURNAL Eur. J. Biochem. 237 (1), 86-92 (1996) PUBMED 8620898 REFERENCE 9 (bases 1 to 481) AUTHORS Alnemri,E.S. and Litwack,G. TITLE Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease JOURNAL J. Biol. Chem. 264 (7), 4104-4111 (1989) PUBMED 2917990 REFERENCE 10 (bases 1 to 481) AUTHORS Zhong,R., Roeder,R.G. and Heintz,N. TITLE The primary structure and expression of four cloned human histone genes JOURNAL Nucleic Acids Res. 11 (21), 7409-7425 (1983) PUBMED 6647026 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X00088.1. On Apr 29, 2002 this sequence version replaced gi:18105046. Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..481 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6p22.1" gene 1..481 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /note="histone cluster 1, H2bj" /db_xref="GeneID:8970" /db_xref="HGNC:4761" /db_xref="HPRD:13657" /db_xref="MIM:615044" exon 1..481 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /inference="alignment:Splign:1.39.8" variation complement(3) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:368914832" variation complement(8) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="t" /db_xref="dbSNP:140038883" variation complement(26) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:369123719" variation complement(27) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:375361357" variation complement(31) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:200132353" misc_feature 32..34 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /note="upstream in-frame stop codon" variation complement(35) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:367898735" variation complement(36) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="t" /db_xref="dbSNP:375706565" variation complement(37) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:372245814" variation complement(38) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:368661004" variation complement(40) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:115858242" variation complement(45) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:200742374" CDS 47..427 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /note="H2B histone family, member R; histone 1, H2bj; histone H2B.1; histone H2B.r" /codon_start=1 /product="histone H2B type 1-J" /protein_id="NP_066402.2" /db_xref="GI:20336754" /db_xref="CCDS:CCDS4618.1" /db_xref="GeneID:8970" /db_xref="HGNC:4761" /db_xref="HPRD:13657" /db_xref="MIM:615044" /translation="
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
" misc_feature 62..64 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); acetylation site" misc_feature 62..64 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 80..82 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); acetylation site" misc_feature 80..82 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 83..85 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); acetylation site" misc_feature 83..85 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 89..91 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by STK4/MST1; propagated from UniProtKB/Swiss-Prot (P06899.3); phosphorylation site" misc_feature 92..94 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); acetylation site" misc_feature 92..94 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 95..97 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); acetylation site" misc_feature 95..97 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 107..109 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); acetylation site" misc_feature 107..109 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 116..118 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 149..151 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-crotonyl-L-lysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); modified site" misc_feature 152..418 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /note="Histone H2B; Region: H2B; smart00427" /db_xref="CDD:197718" misc_feature 185..187 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-methyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); methylation site" misc_feature 218..220 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6,N6-dimethyllysine; propagated from UniProtKB/Swiss-Prot (P06899.3); methylation site" misc_feature 371..373 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /experiment="experimental evidence, no additional details recorded" /note="N6-methyllysine, alternate; propagated from UniProtKB/Swiss-Prot (P06899.3); methylation site" variation complement(60) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:189027890" variation complement(68) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="g" /replace="t" /db_xref="dbSNP:376935770" variation complement(73) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:114929382" variation complement(78) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:373616171" variation complement(82) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:61745028" variation complement(85) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:201335271" variation complement(86) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:199664020" variation complement(88) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:149297601" variation complement(89) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:184989736" variation complement(91) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:115912638" variation complement(96) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="t" /db_xref="dbSNP:369110288" variation complement(98) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:114239522" variation complement(105) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:116386548" variation complement(112) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:376532164" variation complement(122) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:371880685" variation complement(124) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:138662108" variation complement(125) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:199559364" variation complement(127) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:375851364" variation complement(136) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:150162235" variation complement(138) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:115796933" variation complement(144) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:137867381" variation complement(148) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:200758184" variation complement(208) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:145348548" variation complement(209) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:368313493" variation complement(221) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:140265793" variation complement(229) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:151166771" variation complement(230) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:116071754" variation complement(248) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:369866529" variation complement(250) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:142947459" variation complement(283) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:369739205" variation complement(324) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:116395770" variation complement(354) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:114646640" variation complement(358) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:145874703" variation complement(385) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:2272811" variation complement(393) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:115254614" variation complement(400) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:144900182" variation complement(401) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="g" /db_xref="dbSNP:372796717" variation complement(406) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:368534636" variation complement(430) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="a" /replace="c" /db_xref="dbSNP:201706170" variation complement(438) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="g" /db_xref="dbSNP:367881404" stem_loop 461..476 /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /note="palindromic termination element" /function="transcription termination" variation complement(480) /gene="HIST1H2BJ" /gene_synonym="H2B/r; H2BFR; H2BJ" /replace="c" /replace="t" /db_xref="dbSNP:41269245" ORIGIN
cacgctgtttttccttttcgttggcgctttatagctacacagtgctatgccagagccagcgaagtctgctcccgccccgaaaaagggctccaagaaggcggtgactaaggcgcagaagaaagacggcaagaagcgcaagcgcagccgcaaggagagctattccatctatgtgtacaaggttctgaagcaggtccaccctgacaccggcatttcgtccaaggccatgggcatcatgaattcgtttgtgaacgacattttcgagcgcatcgcaggtgaggcttcccgcctggcgcattacaacaagcgctcgaccatcacctccagggagatccagacggccgtgcgcctgctgctgcctggggagttggccaagcacgccgtgtccgagggtactaaggccgtcaccaagtacaccagcgctaagtaaacagtgagttggttgcaaactctcaaccctaacggctcttttaagagccaccca
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:8970 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS GeneID:8970 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA GeneID:8970 -> Biological process: GO:0006334 [nucleosome assembly] evidence: NAS GeneID:8970 -> Biological process: GO:0042742 [defense response to bacterium] evidence: IEA GeneID:8970 -> Cellular component: GO:0000786 [nucleosome] evidence: NAS GeneID:8970 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
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@meso_cacase at
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