Home |
Help |
Advanced search
2025-05-09 16:30:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_021025 1513 bp mRNA linear PRI 08-JUN-2013
DEFINITION Homo sapiens T-cell leukemia homeobox 3 (TLX3), mRNA.
ACCESSION NM_021025
VERSION NM_021025.2 GI:50355977
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1513)
AUTHORS Dadi,S., Le Noir,S., Payet-Bornet,D., Lhermitte,L.,
Zacarias-Cabeza,J., Bergeron,J., Villarese,P., Vachez,E., Dik,W.A.,
Millien,C., Radford,I., Verhoeyen,E., Cosset,F.L., Petit,A.,
Ifrah,N., Dombret,H., Hermine,O., Spicuglia,S., Langerak,A.W.,
Macintyre,E.A., Nadel,B., Ferrier,P. and Asnafi,V.
TITLE TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL
via interaction with ETS1 and suppression of TCRalpha gene
expression
JOURNAL Cancer Cell 21 (4), 563-576 (2012)
PUBMED 22516263
REMARK GeneRIF: The cortical thymic maturation arrest in T-lineage Acute
lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due
to binding of TLX1/TLX3 to ETS1.
REFERENCE 2 (bases 1 to 1513)
AUTHORS Della Gatta,G., Palomero,T., Perez-Garcia,A., Ambesi-Impiombato,A.,
Bansal,M., Carpenter,Z.W., De Keersmaecker,K., Sole,X., Xu,L.,
Paietta,E., Racevskis,J., Wiernik,P.H., Rowe,J.M., Meijerink,J.P.,
Califano,A. and Ferrando,A.A.
TITLE Reverse engineering of TLX oncogenic transcriptional networks
identifies RUNX1 as tumor suppressor in T-ALL
JOURNAL Nat. Med. 18 (3), 436-440 (2012)
PUBMED 22366949
REMARK GeneRIF: these results place TLX1 and TLX3 at the top of an
oncogenic transcriptional network controlling leukemia development,
and identify RUNX1 as a tumor-suppressor gene in T-ALL
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 1513)
AUTHORS Tada,Y., Yokomizo,A., Shiota,M., Tsunoda,T., Plass,C. and Naito,S.
TITLE Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates
cisplatin sensitivity in bladder cancer
JOURNAL Int. J. Oncol. 39 (3), 727-733 (2011)
PUBMED 21617853
REMARK GeneRIF: We found that 22 (21%) out of 110 clinical samples of
bladder cancer showed the methylated pattern using the COBRA assay
in TLX3. We found a correlation between TLX3 methylation and the
sensitivity to cisplatin in the clinical samples by SDI test.
REFERENCE 4 (bases 1 to 1513)
AUTHORS Kondo,T., Matsuoka,A.J., Shimomura,A., Koehler,K.R., Chan,R.J.,
Miller,J.M., Srour,E.F. and Hashino,E.
TITLE Wnt signaling promotes neuronal differentiation from mesenchymal
stem cells through activation of Tlx3
JOURNAL Stem Cells 29 (5), 836-846 (2011)
PUBMED 21374761
REMARK GeneRIF: Results identify Tlx3 as a novel target for canonical Wnt
signaling that confers somatic stem cells with a sensory neuron
phenotype upon neural induction.
REFERENCE 5 (bases 1 to 1513)
AUTHORS Oliveira,J.L., Kumar,R., Khan,S.P., Law,M.E., Erickson-Johnson,M.,
Oliveira,A.M., Ketterling,R.P. and Dogan,A.
TITLE Successful treatment of a child with T/myeloid acute bilineal
leukemia associated with TLX3/BCL11B fusion and 9q deletion
JOURNAL Pediatr Blood Cancer 56 (3), 467-469 (2011)
PUBMED 21225930
REMARK GeneRIF: High TLX3/BCL11B fusion protein expression is associated
with T/myeloid acute bilineal leukemia.
REFERENCE 6 (bases 1 to 1513)
AUTHORS Ballerini,P., Blaise,A., Busson-Le Coniat,M., Su,X.Y.,
Zucman-Rossi,J., Adam,M., van den Akker,J., Perot,C.,
Pellegrino,B., Landman-Parker,J., Douay,L., Berger,R. and
Bernard,O.A.
TITLE HOX11L2 expression defines a clinical subtype of pediatric T-ALL
associated with poor prognosis
JOURNAL Blood 100 (3), 991-997 (2002)
PUBMED 12130513
REMARK GeneRIF: HOX11L2 expression defines a clinical subtype of pediatric
T-ALL associated with poor prognosis.
REFERENCE 7 (bases 1 to 1513)
AUTHORS Bernard,O.A., Busson-LeConiat,M., Ballerini,P., Mauchauffe,M.,
Della Valle,V., Monni,R., Nguyen Khac,F., Mercher,T.,
Penard-Lacronique,V., Pasturaud,P., Gressin,L., Heilig,R.,
Daniel,M.T., Lessard,M. and Berger,R.
TITLE A new recurrent and specific cryptic translocation,
t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene
in T acute lymphoblastic leukemia
JOURNAL Leukemia 15 (10), 1495-1504 (2001)
PUBMED 11587205
REFERENCE 8 (bases 1 to 1513)
AUTHORS Lee-Kirsch,M.A., Engel,K., Paditz,E., Rosen-Wolff,A., Lee,Y.A. and
Gahr,M.
TITLE Assignment of the human homeobox 11-like 2 gene (HOX11L2) to
chromosome 5q34-->q35 by radiation hybrid mapping
JOURNAL Cytogenet. Cell Genet. 92 (3-4), 358 (2001)
PUBMED 11435718
REFERENCE 9 (bases 1 to 1513)
AUTHORS Cinti,R., Fava,M., Sancandi,M., Matera,I., Ravazzolo,R. and
Ceccherini,I.
TITLE Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and
of its murine homolog to mouse chromosome bands 11A4-A5 by in situ
hybridization
JOURNAL Cytogenet. Cell Genet. 92 (3-4), 354-355 (2001)
PUBMED 11435716
REFERENCE 10 (bases 1 to 1513)
AUTHORS Dear,T.N., Sanchez-Garcia,I. and Rabbitts,T.H.
TITLE The HOX11 gene encodes a DNA-binding nuclear transcription factor
belonging to a distinct family of homeobox genes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (10), 4431-4435 (1993)
PUBMED 8099440
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC017291.2.
On Jul 18, 2004 this sequence version replaced gi:10440563.
Summary: RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox
genes that encode DNA-binding nuclear transcription factors.
Members of the HOX11 gene family are characterized by a
threonine-47 replacing cytosine in the highly conserved homeodomain
(Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC017291.2, BG828093.1 [ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1513
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q35.1"
gene 1..1513
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/note="T-cell leukemia homeobox 3"
/db_xref="GeneID:30012"
/db_xref="HGNC:13532"
/db_xref="MIM:604640"
exon 1..503
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/inference="alignment:Splign:1.39.8"
variation 41
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:376460561"
variation 82
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:201757280"
CDS 83..958
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/note="homeo box 11-like 2; T-cell leukemia, homeobox 3;
homeobox protein Hox-11L2"
/codon_start=1
/product="T-cell leukemia homeobox protein 3"
/protein_id="NP_066305.2"
/db_xref="GI:50355978"
/db_xref="CCDS:CCDS34288.1"
/db_xref="GeneID:30012"
/db_xref="HGNC:13532"
/db_xref="MIM:604640"
/translation="
MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV
"
misc_feature 581..745
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:238039"
misc_feature order(581..595,599..601,650..652,668..670,707..709,
713..718,725..730,734..742)
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:238039"
misc_feature order(587..589,596..598,716..718,725..730,737..739)
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:238039"
variation 102
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:376677458"
variation 108
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:370753140"
variation 118
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:373303131"
variation 179
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:199762968"
variation 187
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:2303742"
variation 234
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:200774344"
variation 239
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:200001019"
variation 278
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:146976707"
variation 283
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="g"
/replace="t"
/db_xref="dbSNP:36095128"
variation 331
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="g"
/replace="t"
/db_xref="dbSNP:370425875"
variation 335
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="c"
/db_xref="dbSNP:34255055"
variation 338
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:368190023"
variation 373
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:372536922"
variation 417
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="g"
/db_xref="dbSNP:201883284"
variation 442
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="g"
/replace="t"
/db_xref="dbSNP:150863748"
exon 504..747
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/inference="alignment:Splign:1.39.8"
variation 571
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="g"
/replace="t"
/db_xref="dbSNP:200530381"
variation 639
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:199546814"
variation 673
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:201413999"
variation 724
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:182364316"
exon 748..1493
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/inference="alignment:Splign:1.39.8"
variation 777
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:200588592"
variation 809
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="c"
/db_xref="dbSNP:142802207"
variation 861
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="g"
/db_xref="dbSNP:377207191"
variation 905
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:369063976"
variation 924
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="g"
/db_xref="dbSNP:146143286"
variation 927
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="g"
/db_xref="dbSNP:140182232"
variation 935
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="t"
/db_xref="dbSNP:149813712"
variation 941
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="g"
/db_xref="dbSNP:201600677"
variation 952
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="c"
/replace="g"
/db_xref="dbSNP:145807029"
variation 1191
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="a"
/replace="g"
/db_xref="dbSNP:918472"
variation 1445
/gene="TLX3"
/gene_synonym="HOX11L2; RNX"
/replace="g"
/replace="t"
/db_xref="dbSNP:60850132"
ORIGIN
gccgggcgctccatggccgcgccgtaacggggacccagccgcctccccgcccagcccagcccagcccttccgcccgcccaggatggaggcgcccgccagcgcgcagaccccgcacccgcacgagcccatcagcttcggcatcgaccagatccttaacagcccggaccaggacagcgcacccgccccgcggggccccgacggcgccagctacctgggagggccccccgggggccgtccgggcgccacatacccgtctctgcccgcctcctttgcgggcctcggcgcgcccttcgaggacgcgggatcttacagtgtgaacctgagcctagcgcccgcaggcgtgatccgggtgccggcgcacaggccgctgcccggggccgtgccaccgcctctgccaagcgcgctacccgccatgccctccgtgcccacggtctccagccttggcggtctcaatttcccctggatggagagcagccgccgcttcgtgaaagaccgcttcacagcggcggccgcactcacgcccttcaccgtgacccggcgcatcggccacccctaccagaaccggacgccgcccaagcgtaagaagccgcgcacgtccttttcccgggtgcagatctgcgagctggaaaagcgcttccatcgccagaagtacctggcctctgccgagagggcggcgctcgccaagtccctcaaaatgacggacgcgcaggtcaagacctggttccaaaaccggaggaccaagtggcggcggcagacggcggaggagcgggaggcggagcggcagcaggcgagccggctcatgctgcagctgcaacacgacgccttccaaaagagcctcaacgactccatccagcctgacccgctctgtctgcacaactcgtcactctttgctctgcagaatctgcagccctgggaggaggatagttccaaggttcccgctgtcacctccctggtgtgagcccaccagcgcgcaccgtcgccacggatcgccgcccccacccagccgggcgccccggaccccccaggagggctgcgggggaaccggcgccgagaggggaaggggccgcctagcccgagtaggccccagggcgcggccacagactggcgggccgcggaagggggtagggcccgagctccgcgcggccgcacaatccgagcccccgccccgcgccccgtcccgccccaggcccgggcctgacaagaaagcgccttacgtttctccgccccccgcccgcaccccccgggccgggcgcctgtattatactttgtacttttgcccaaacgtgtaaataataaaaaagttttggcttttttctttagaaaccggccacctgcttcccccgcgggggccgctggaggaagggcagccgacccggccgctgggggaagtgccaggggcccggggcaccctgcgtttaggctgggtccactcttcttctttttcgttccttttatttaagtctttttatttaataaaaaagttagctatttcaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:30012 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:30012 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:30012 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:30012 -> Biological process: GO:0001764 [neuron migration] evidence: IEA
GeneID:30012 -> Biological process: GO:0002087 [regulation of respiratory gaseous exchange by neurological system process] evidence: IEA
GeneID:30012 -> Biological process: GO:0007417 [central nervous system development] evidence: IEA
GeneID:30012 -> Biological process: GO:0007585 [respiratory gaseous exchange] evidence: IEA
GeneID:30012 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
GeneID:30012 -> Biological process: GO:0048665 [neuron fate specification] evidence: IEA
GeneID:30012 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.