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2025-05-09 16:33:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018647 1625 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens tumor necrosis factor receptor superfamily, member 19
(TNFRSF19), transcript variant 1, mRNA.
ACCESSION NM_018647
VERSION NM_018647.3 GI:325120956
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1625)
AUTHORS Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
and Borecki,I.B.
CONSRTM GIANT Consortium; MAGIC Consortium; GLGC Consortium
TITLE Genome-wide association for abdominal subcutaneous and visceral
adipose reveals a novel locus for visceral fat in women
JOURNAL PLoS Genet. 8 (5), E1002695 (2012)
PUBMED 22589738
REFERENCE 2 (bases 1 to 1625)
AUTHORS Eriksson,N., Tung,J.Y., Kiefer,A.K., Hinds,D.A., Francke,U.,
Mountain,J.L. and Do,C.B.
TITLE Novel associations for hypothyroidism include known autoimmune risk
loci
JOURNAL PLoS ONE 7 (4), E34442 (2012)
PUBMED 22493691
REFERENCE 3 (bases 1 to 1625)
AUTHORS Zidi,I.T., M'farrej,S.M., Bergaoui,S.D., Ghariani,N.Z.,
Bartegi,A.B., Ben Amor,N.N. and Nouira,R.B.
TITLE Tumor necrosis factor-receptor 2 and TROY gene expression patterns
in cutaneous squamous cell carcinoma in a Tunisian population
JOURNAL Saudi Med J 32 (11), 1202-1203 (2011)
PUBMED 22057614
REMARK GeneRIF: study demonstrated that TNFR2 and TROY mRNA levels are
enhanced in cutaneous squamous cell carcinoma cells compared to
healthy ones in a Tunisian population
REFERENCE 4 (bases 1 to 1625)
AUTHORS Kong,M., Kim,Y. and Lee,C.
TITLE A strong synergistic epistasis between FAM134B and TNFRSF19 on the
susceptibility to vascular dementia
JOURNAL Psychiatr. Genet. 21 (1), 37-41 (2011)
PUBMED 21127458
REMARK GeneRIF: The FAM134B and TNFRSF19 showed a dramatically strong
synergistic epistasis in explaining the genetic dissection of the
susceptibility to complex vascular dementia.
REFERENCE 5 (bases 1 to 1625)
AUTHORS Paulino,V.M., Yang,Z., Kloss,J., Ennis,M.J., Armstrong,B.A.,
Loftus,J.C. and Tran,N.L.
TITLE TROY (TNFRSF19) is overexpressed in advanced glial tumors and
promotes glioblastoma cell invasion via Pyk2-Rac1 signaling
JOURNAL Mol. Cancer Res. 8 (11), 1558-1567 (2010)
PUBMED 20881009
REMARK GeneRIF: TNFRSF19 overexpression in glioma cells activates Rac1
signaling in a Pyk2-dependent manner to drive glioma cell invasion
and migration
REFERENCE 6 (bases 1 to 1625)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE 7 (bases 1 to 1625)
AUTHORS Naito,A., Yoshida,H., Nishioka,E., Satoh,M., Azuma,S., Yamamoto,T.,
Nishikawa,S. and Inoue,J.
TITLE TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (13), 8766-8771 (2002)
PUBMED 12060722
REFERENCE 8 (bases 1 to 1625)
AUTHORS Kojima,T., Morikawa,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
Senba,E. and Kitamura,T.
TITLE TROY, a newly identified member of the tumor necrosis factor
receptor superfamily, exhibits a homology with Edar and is
expressed in embryonic skin and hair follicles
JOURNAL J. Biol. Chem. 275 (27), 20742-20747 (2000)
PUBMED 10764796
REFERENCE 9 (bases 1 to 1625)
AUTHORS Eby,M.T., Jasmin,A., Kumar,A., Sharma,K. and Chaudhary,P.M.
TITLE TAJ, a novel member of the tumor necrosis factor receptor family,
activates the c-Jun N-terminal kinase pathway and mediates
caspase-independent cell death
JOURNAL J. Biol. Chem. 275 (20), 15336-15342 (2000)
PUBMED 10809768
REFERENCE 10 (bases 1 to 1625)
AUTHORS Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
and Morton,C.C.
TITLE Isolation of novel and known genes from a human fetal cochlear cDNA
library using subtractive hybridization and differential screening
JOURNAL Genomics 23 (1), 42-50 (1994)
PUBMED 7829101
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB223760.1, AF167555.1,
BC047321.1 and AL161422.14.
On Mar 3, 2011 this sequence version replaced gi:23238201.
Summary: The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor is highly expressed during
embryonic development. It has been shown to interact with TRAF
family members, and to activate JNK signaling pathway when
overexpressed in cells. This receptor is capable of inducing
apoptosis by a caspase-independent mechanism, and it is thought to
play an essential role in embryonic development. Alternatively
spliced transcript variants encoding distinct isoforms have been
described. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) is also called TRADEbeta. It
encodes the longest isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF167555.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025086 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-494 DB223760.1 1-494
495-800 AF167555.1 355-660
801-1449 BC047321.1 896-1544
1450-1625 AL161422.14 85150-85325
FEATURES Location/Qualifiers
source 1..1625
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q12.11-q12.3"
gene 1..1625
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="tumor necrosis factor receptor superfamily, member
19"
/db_xref="GeneID:55504"
/db_xref="HGNC:11915"
/db_xref="HPRD:05838"
/db_xref="MIM:606122"
exon 1..170
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 67..69
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace=""
/replace="c"
/db_xref="dbSNP:11451799"
variation 86
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:370317324"
exon 171..273
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
misc_feature 184..186
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="upstream in-frame stop codon"
CDS 205..1476
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="isoform 1 precursor is encoded by transcript
variant 1; toxicity and JNK inducer"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member 19 isoform 1 precursor"
/protein_id="NP_061117.2"
/db_xref="GI:23238202"
/db_xref="CCDS:CCDS9302.1"
/db_xref="GeneID:55504"
/db_xref="HGNC:11915"
/db_xref="HPRD:05838"
/db_xref="MIM:606122"
/translation="
MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRSGNCVPCNQCGPGMELSKECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSATSDAICGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALATVLLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMVPTFFGSLTQSICGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAVPVQSHSENFTAATDLSRYNNTLVESASTQDALTMRSQLDQESGAVIHPATQTSLQVRQRLGSL
"
sig_peptide 205..291
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 292..1473
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/product="Tumor necrosis factor receptor superfamily
member 19"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NS68.1)"
misc_feature 301..420
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NS68.1);
Region: TNFR-Cys 1"
misc_feature 304..618
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cd00185"
/db_xref="CDD:29147"
misc_feature order(304..309,442..444,472..474,502..504,571..573,
607..609)
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(316..318,352..354,364..366,370..372,415..417,
424..426,454..456)
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature order(352..381,412..426,523..531)
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature 424..546
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NS68.1);
Region: TNFR-Cys 2"
misc_feature order(451..456,469..477)
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 550..651
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NS68.1);
Region: TNFR-Cys 3"
misc_feature order(571..573,607..618)
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/note="90's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 715..777
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NS68.1);
transmembrane region"
variation 239
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:370996963"
variation 248
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:369820179"
variation 265
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:149183306"
exon 274..384
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 289
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="g"
/replace="t"
/db_xref="dbSNP:149976451"
variation 290
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="g"
/replace="t"
/db_xref="dbSNP:145209736"
variation 291
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="g"
/replace="t"
/db_xref="dbSNP:149214359"
variation 292
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:143949723"
variation 295
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="t"
/db_xref="dbSNP:9550987"
variation 328
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:141570513"
variation 329
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:200993556"
variation 346
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:181343678"
variation 366
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:376690464"
exon 385..563
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 396
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:145815290"
variation 406
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:138634567"
variation 411
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="t"
/db_xref="dbSNP:373247986"
variation 433
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:142769629"
variation 438
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:147369656"
variation 464
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:372392866"
variation 494
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="g"
/replace="t"
/db_xref="dbSNP:374008761"
variation 502
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:149498209"
variation 546
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:375719826"
exon 564..649
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 578
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:373411330"
variation 579
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:145592847"
variation 589
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:144154174"
variation 606
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:199955294"
variation 623
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="t"
/db_xref="dbSNP:371112090"
variation 626
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:373486475"
variation 630
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:148702020"
variation 644
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:368876279"
variation 645
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:143483716"
variation 647
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:200629776"
exon 650..814
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 670
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:116629724"
variation 680
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:61756242"
variation 686
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:139502219"
variation 701
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:373490793"
variation 705
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:61741509"
variation 729
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:114811052"
variation 762
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:185953608"
variation 763
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:202190525"
exon 815..940
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 823
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:115048916"
variation 824
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:372905269"
variation 825
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:114789019"
variation 827
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:141048197"
variation 828
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:3751364"
variation 847
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:377622468"
variation 860
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:145810971"
variation 861
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:369538551"
variation 863
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="g"
/replace="t"
/db_xref="dbSNP:149014293"
variation 892
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="g"
/replace="t"
/db_xref="dbSNP:374264420"
variation 902
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:200301452"
variation 911
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:115547743"
variation 917
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:377726164"
variation 935
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="c"
/db_xref="dbSNP:376817601"
variation 936
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:147110068"
variation 939
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:138676880"
exon 941..1043
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 941
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:373980471"
variation 946
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:202087628"
variation 949
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:370337019"
variation 964
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:34983774"
variation 987
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:61745191"
variation 988
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:35041805"
variation 995
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:368392120"
exon 1044..1625
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/inference="alignment:Splign:1.39.8"
variation 1055
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:201152842"
variation 1059
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:141678624"
variation 1061
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:115141233"
variation 1073
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:200602341"
variation 1074
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:368402583"
variation 1083
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:201218290"
variation 1094
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:112056395"
variation 1097
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:200218483"
variation 1210
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:367870672"
variation 1217
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:58111610"
variation 1219
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:145301348"
variation 1238
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:115520634"
variation 1239
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:141890871"
variation 1264
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:146263697"
variation 1294
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:115260428"
variation 1298
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="t"
/db_xref="dbSNP:377014124"
variation 1303
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:146078649"
variation 1326
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:144179899"
variation 1346
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:369698575"
variation 1373
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:144227429"
variation 1376
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:373236855"
variation 1378
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:199672653"
variation 1411
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:148756021"
variation 1413
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:3751363"
variation 1417
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:3751362"
variation 1424
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="c"
/db_xref="dbSNP:199606342"
variation 1427
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:141714394"
variation 1459
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:201826458"
variation 1460
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:145685720"
variation 1493
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="g"
/db_xref="dbSNP:370032629"
variation 1510
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="g"
/db_xref="dbSNP:372358582"
variation 1515
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="c"
/db_xref="dbSNP:370467190"
variation 1543..1544
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace=""
/replace="t"
/db_xref="dbSNP:11383459"
variation 1544
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="g"
/replace="t"
/db_xref="dbSNP:185330768"
variation 1573
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="c"
/replace="t"
/db_xref="dbSNP:3751361"
variation 1610..1611
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace=""
/replace="t"
/db_xref="dbSNP:200628302"
variation 1618
/gene="TNFRSF19"
/gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
/replace="a"
/replace="t"
/db_xref="dbSNP:3751360"
ORIGIN
gttgccgggctacgggagagcgcggagccctgcgctgggaggtgcacggtgtgcacgctggactggacccccatgcaaccccgcgccctgcgccttaaccaggactgctccgcgcgcccctgagcctcgggctccggcccggacctgcagcctcccaggtggctgggaagaactctccaacaataaatacatttgataagaaagatggctttaaaagtgctactagaacaagagaaaacgtttttcactcttttagtattactaggctatttgtcatgtaaagtgacttgtgaatcaggagactgtagacagcaagaattcagggatcggtctggaaactgtgttccctgcaaccagtgtgggccaggcatggagttgtctaaggaatgtggcttcggctatggggaggatgcacagtgtgtgacgtgccggctgcacaggttcaaggaggactggggcttccagaaatgcaagccctgtctggactgcgcagtggtgaaccgctttcagaaggcaaattgttcagccaccagtgatgccatctgcggggactgcttgccaggattttataggaagacgaaacttgtcggctttcaagacatggagtgtgtgccttgtggagaccctcctcctccttacgaaccgcactgtgccagcaaggtcaacctcgtgaagatcgcgtccacggcctccagcccacgggacacggcgctggctgccgttatctgcagcgctctggccaccgtcctgctggccctgctcatcctctgtgtcatctattgtaagagacagtttatggagaagaaacccagctggtctctgcggtcacaggacattcagtacaacggctctgagctgtcgtgttttgacagacctcagctccacgaatatgcccacagagcctgctgccagtgccgccgtgactcagtgcagacctgcgggccggtgcgcttgctcccatccatgtgctgtgaggaggcctgcagccccaacccggcgactcttggttgtggggtgcattctgcagccagtcttcaggcaagaaacgcaggcccagccggggagatggtgccgactttcttcggatccctcacgcagtccatctgtggcgagttttcagatgcctggcctctgatgcagaatcccatgggtggtgacaacatctctttttgtgactcttatcctgaactcactggagaagacattcattctctcaatccagaacttgaaagctcaacgtctttggattcaaatagcagtcaagatttggttggtggggctgttccagtccagtctcattctgaaaactttacagcagctactgatttatctagatataacaacacactggtagaatcagcatcaactcaggatgcactaactatgagaagccagctagatcaggagagtggtgctgtcatccacccagccactcagacgtccctccaggtaaggcagcgactgggttccctgtgaacacagcactgacttacagtagatcagaactctgttcccagcataagatttgggggaacctgatgagttttttttttgcatctttaataatttcttgtatgttgtagagtatgttttaaaataaatttcaagtatttttttaaaaaact
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55504 -> Molecular function: GO:0005031 [tumor necrosis factor-activated receptor activity] evidence: NAS
GeneID:55504 -> Biological process: GO:0001942 [hair follicle development] evidence: IEA
GeneID:55504 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:55504 -> Biological process: GO:0006917 [induction of apoptosis] evidence: NAS
GeneID:55504 -> Biological process: GO:0007254 [JNK cascade] evidence: NAS
GeneID:55504 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: NAS
GeneID:55504 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: RCA
GeneID:55504 -> Cellular component: GO:0016021 [integral to membrane] evidence: NAS
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@meso_cacase at
DBCLS
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