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2025-05-09 16:36:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005865 2881 bp mRNA linear PRI 14-APR-2013
DEFINITION Homo sapiens protease, serine, 16 (thymus) (PRSS16), mRNA.
ACCESSION NM_005865
VERSION NM_005865.3 GI:257467637
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2881)
AUTHORS Kitazawa,M., Ohnuma,T., Takebayashi,Y., Shibata,N., Baba,H.,
Ohi,K., Yasuda,Y., Nakamura,Y., Aleksic,B., Yoshimi,A., Okochi,T.,
Ikeda,M., Naitoh,H., Hashimoto,R., Iwata,N., Ozaki,N., Takeda,M.
and Arai,H.
TITLE No associations found between the genes situated at 6p22.1,
HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with
schizophrenia
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (4), 456-464
(2012)
PUBMED 22488895
REMARK GeneRIF: The genes HIST1H2BJ, PRSS16, and PGBD1 were not associated
with Japanese patients with schizophrenia.
REFERENCE 2 (bases 1 to 2881)
AUTHORS Girgenti,M.J., LoTurco,J.J. and Maher,B.J.
TITLE ZNF804a regulates expression of the schizophrenia-associated genes
PRSS16, COMT, PDE4B, and DRD2
JOURNAL PLoS ONE 7 (2), E32404 (2012)
PUBMED 22384243
REMARK GeneRIF: ZNF804a regulates expression of the
schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
REFERENCE 3 (bases 1 to 2881)
AUTHORS Shi,J., Levinson,D.F., Duan,J., Sanders,A.R., Zheng,Y., Pe'er,I.,
Dudbridge,F., Holmans,P.A., Whittemore,A.S., Mowry,B.J., Olincy,A.,
Amin,F., Cloninger,C.R., Silverman,J.M., Buccola,N.G.,
Byerley,W.F., Black,D.W., Crowe,R.R., Oksenberg,J.R., Mirel,D.B.,
Kendler,K.S., Freedman,R. and Gejman,P.V.
TITLE Common variants on chromosome 6p22.1 are associated with
schizophrenia
JOURNAL Nature 460 (7256), 753-757 (2009)
PUBMED 19571809
REMARK GeneRIF: Observational study, meta-analysis, and genome-wide
association study of gene-disease association. (HuGE Navigator)
REFERENCE 4 (bases 1 to 2881)
AUTHORS Stefansson,H., Ophoff,R.A., Steinberg,S., Andreassen,O.A.,
Cichon,S., Rujescu,D., Werge,T., Pietilainen,O.P., Mors,O.,
Mortensen,P.B., Sigurdsson,E., Gustafsson,O., Nyegaard,M.,
Tuulio-Henriksson,A., Ingason,A., Hansen,T., Suvisaari,J.,
Lonnqvist,J., Paunio,T., Borglum,A.D., Hartmann,A., Fink-Jensen,A.,
Nordentoft,M., Hougaard,D., Norgaard-Pedersen,B., Bottcher,Y.,
Olesen,J., Breuer,R., Moller,H.J., Giegling,I., Rasmussen,H.B.,
Timm,S., Mattheisen,M., Bitter,I., Rethelyi,J.M.,
Magnusdottir,B.B., Sigmundsson,T., Olason,P., Masson,G.,
Gulcher,J.R., Haraldsson,M., Fossdal,R., Thorgeirsson,T.E.,
Thorsteinsdottir,U., Ruggeri,M., Tosato,S., Franke,B.,
Strengman,E., Kiemeney,L.A., Melle,I., Djurovic,S., Abramova,L.,
Kaleda,V., Sanjuan,J., de Frutos,R., Bramon,E., Vassos,E.,
Fraser,G., Ettinger,U., Picchioni,M., Walker,N., Toulopoulou,T.,
Need,A.C., Ge,D., Yoon,J.L., Shianna,K.V., Freimer,N.B.,
Cantor,R.M., Murray,R., Kong,A., Golimbet,V., Carracedo,A.,
Arango,C., Costas,J., Jonsson,E.G., Terenius,L., Agartz,I.,
Petursson,H., Nothen,M.M., Rietschel,M., Matthews,P.M., Muglia,P.,
Peltonen,L., St Clair,D., Goldstein,D.B., Stefansson,K. and
Collier,D.A.
CONSRTM Genetic Risk and Outcome in Psychosis (GROUP)
TITLE Common variants conferring risk of schizophrenia
JOURNAL Nature 460 (7256), 744-747 (2009)
PUBMED 19571808
REFERENCE 5 (bases 1 to 2881)
AUTHORS Viken,M.K., Blomhoff,A., Olsson,M., Akselsen,H.E., Pociot,F.,
Nerup,J., Kockum,I., Cambon-Thomsen,A., Thorsby,E., Undlien,D.E.
and Lie,B.A.
TITLE Reproducible association with type 1 diabetes in the extended class
I region of the major histocompatibility complex
JOURNAL Genes Immun. 10 (4), 323-333 (2009)
PUBMED 19295542
REMARK GeneRIF: our results identify PRSS16 and BTN3A2, two genes thought
to play important roles in regulating the immune response, as
potentially novel susceptibility genes for Type I diabetes.
GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
REFERENCE 6 (bases 1 to 2881)
AUTHORS Luther,C., Wienhold,W., Oehlmann,R., Heinemann,M.K., Melms,A. and
Tolosa,E.
TITLE Alternatively spliced transcripts of the thymus-specific protease
PRSS16 are differentially expressed in human thymus
JOURNAL Genes Immun. 6 (1), 1-7 (2005)
PUBMED 15592422
REFERENCE 7 (bases 1 to 2881)
AUTHORS Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
Dunham,I., Rogers,J. and Beck,S.
TITLE The DNA sequence and analysis of human chromosome 6
JOURNAL Nature 425 (6960), 805-811 (2003)
PUBMED 14574404
REFERENCE 8 (bases 1 to 2881)
AUTHORS Lie,B.A., Akselsen,H.E., Bowlus,C.L., Gruen,J.R., Thorsby,E. and
Undlien,D.E.
TITLE Polymorphisms in the gene encoding thymus-specific serine protease
in the extended HLA complex: a potential candidate gene for
autoimmune and HLA-associated diseases
JOURNAL Genes Immun. 3 (5), 306-312 (2002)
PUBMED 12140752
REMARK GeneRIF: The gene encoding thymus-specific serine protease (PRSS16)
maps to the extended HLA complex, which harbours several genes
predisposing for autoimmune diseases.
REFERENCE 9 (bases 1 to 2881)
AUTHORS Bowlus,C.L., Ahn,J., Chu,T. and Gruen,J.R.
TITLE Cloning of a novel MHC-encoded serine peptidase highly expressed by
cortical epithelial cells of the thymus
JOURNAL Cell. Immunol. 196 (2), 80-86 (1999)
PUBMED 10527559
REFERENCE 10 (bases 1 to 2881)
AUTHORS Gruen,J.R., Nalabolu,S.R., Chu,T.W., Bowlus,C., Fan,W.F.,
Goei,V.L., Wei,H., Sivakamasundari,R., Liu,Y., Xu,H.X., Parimoo,S.,
Nallur,G., Ajioka,R., Shukla,H., Bray-Ward,P., Pan,J. and
Weissman,S.M.
TITLE A transcription map of the major histocompatibility complex (MHC)
class I region
JOURNAL Genomics 36 (1), 70-85 (1996)
PUBMED 8812418
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK314037.1, AF052514.1,
AK093590.1 and BG119060.1.
On Sep 9, 2009 this sequence version replaced gi:21396490.
Summary: This gene encodes a serine protease expressed exclusively
in the thymus. It is thought to play a role in the alternative
antigen presenting pathway used by cortical thymic epithelial cells
during the positive selection of T cells. The gene is found in the
large histone gene cluster on chromosome 6, near the major
histocompatibility complex (MHC) class I region. A second
transcript variant has been described, but its full length nature
has not been determined. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK314037.1, AF052514.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-550 AK314037.1 1-550
551-1232 AF052514.1 548-1229
1233-1747 AK093590.1 1122-1636
1748-2505 AF052514.1 1745-2502
2506-2726 AK093590.1 2395-2615
2727-2881 BG119060.1 290-444
FEATURES Location/Qualifiers
source 1..2881
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21"
gene 1..2881
/gene="PRSS16"
/gene_synonym="TSSP"
/note="protease, serine, 16 (thymus)"
/db_xref="GeneID:10279"
/db_xref="HGNC:9480"
/db_xref="HPRD:06205"
/db_xref="MIM:607169"
exon 1..85
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
CDS 16..1560
/gene="PRSS16"
/gene_synonym="TSSP"
/note="thymus specific serine peptidase; serine protease
16"
/codon_start=1
/product="thymus-specific serine protease"
/protein_id="NP_005856.1"
/db_xref="GI:5031993"
/db_xref="CCDS:CCDS4623.1"
/db_xref="GeneID:10279"
/db_xref="HGNC:9480"
/db_xref="HPRD:06205"
/db_xref="MIM:607169"
/translation="
MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVGWLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDGQTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV
"
misc_feature 205..1497
/gene="PRSS16"
/gene_synonym="TSSP"
/note="Serine carboxypeptidase S28; Region: Peptidase_S28;
pfam05577"
/db_xref="CDD:114307"
variation 21
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:146400295"
variation 22
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:138254301"
variation 77
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:149623864"
exon 86..252
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 100
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:144485144"
variation 134
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:114674760"
variation 141
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:185312781"
variation 144
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:145018357"
variation 156
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:374589944"
variation 180
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:368859680"
variation 195
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:372265510"
variation 202
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:147127802"
variation 225
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:140318437"
variation 239
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:150849072"
exon 253..352
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 267
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:139981185"
variation 307
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:375923335"
variation 326
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:5030965"
variation 350
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:375736451"
exon 353..482
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 360
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:200804935"
variation 384
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:376298678"
variation 385
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:149942995"
variation 423
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:199723551"
variation 425
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:367792034"
variation 461
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:145240806"
exon 483..606
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 488..489
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="t"
/db_xref="dbSNP:35193701"
variation 503
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="g"
/db_xref="dbSNP:367779428"
variation 506
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:372674948"
variation 509..510
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="g"
/db_xref="dbSNP:35505122"
variation 534..536
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="ctc"
/db_xref="dbSNP:145433670"
exon 607..684
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 626
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="g"
/db_xref="dbSNP:35466700"
variation 644
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:368386726"
variation 665
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:199924462"
exon 685..732
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 703
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:369039018"
variation 705
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:200343894"
exon 733..1023
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 735
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:145057645"
variation 785
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:373693994"
variation 802
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:201036521"
variation 825
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:376394921"
variation 834
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:370382383"
variation 840
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:374127733"
variation 875
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:367668932"
variation 877
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:199812226"
variation 878
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:201412510"
variation 921
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:376340080"
variation 930
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:370172983"
variation 936
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:34132190"
variation 976
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:374424134"
variation 977..978
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="c"
/db_xref="dbSNP:374906013"
variation 980
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="g"
/db_xref="dbSNP:201343810"
variation 998
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:368893993"
exon 1024..1165
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 1071
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:199666358"
variation 1127
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:140528789"
variation 1153
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:376962461"
variation 1158
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:191407230"
exon 1166..1345
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 1166
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="t"
/db_xref="dbSNP:145885657"
variation 1200
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:368818262"
variation 1216
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:372392587"
variation 1233
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062834"
variation 1255
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:199614851"
variation 1272
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:148977056"
variation 1282
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:143725538"
variation 1290
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:141944192"
variation 1298
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:201267315"
exon 1346..1491
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
variation 1384
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:371863087"
variation 1398
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:375471259"
variation 1417
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:369828855"
variation 1418
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:150255818"
variation 1486
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:138897744"
exon 1492..2865
/gene="PRSS16"
/gene_synonym="TSSP"
/inference="alignment:Splign:1.39.8"
STS 1506..1705
/gene="PRSS16"
/gene_synonym="TSSP"
/standard_name="RH103917"
/db_xref="UniSTS:98242"
variation 1531..1545
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="aaggagagccagatt"
/db_xref="dbSNP:141138864"
variation 1531
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="aaggagagccagatt"
/db_xref="dbSNP:5030663"
variation 1535..1549
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="agagccagattaagg"
/db_xref="dbSNP:371606222"
variation 1535
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:143492910"
variation 1535
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="agagccagattaagg"
/db_xref="dbSNP:75688361"
variation 1536
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:147170589"
variation 1537
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="t"
/db_xref="dbSNP:140280737"
variation 1538
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:201493618"
variation 1539
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:199705677"
variation 1540
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:142712601"
variation 1541
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="t"
/db_xref="dbSNP:200987021"
variation 1543
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:144604424"
variation 1553
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="t"
/db_xref="dbSNP:368262432"
variation 1628
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:142829853"
variation 1660
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:146063903"
variation 1690
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:3734578"
variation 1700
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:190153998"
variation 1708
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:3734577"
variation 1830
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="g"
/db_xref="dbSNP:5030953"
variation 1933
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="t"
/db_xref="dbSNP:3734576"
variation 1973
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="a"
/replace="c"
/db_xref="dbSNP:141891269"
variation 2017
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:192968631"
variation 2120
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:184847039"
variation 2126
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:188561309"
variation 2127
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:180706651"
variation 2180
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:5030954"
variation 2344..2347
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="tctc"
/db_xref="dbSNP:373601841"
variation 2433..2435
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="tcta"
/db_xref="dbSNP:35237909"
variation 2436
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:199522641"
variation 2440..2441
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="atct"
/db_xref="dbSNP:70981152"
STS 2454..2649
/gene="PRSS16"
/gene_synonym="TSSP"
/standard_name="RH36539"
/db_xref="UniSTS:8123"
variation 2525..2526
/gene="PRSS16"
/gene_synonym="TSSP"
/replace=""
/replace="ct"
/db_xref="dbSNP:200311156"
variation 2588
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:146267002"
variation 2594
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="g"
/replace="t"
/db_xref="dbSNP:185140362"
polyA_signal 2678..2683
/gene="PRSS16"
/gene_synonym="TSSP"
polyA_site 2716
/gene="PRSS16"
/gene_synonym="TSSP"
variation 2780
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:58265076"
variation 2862
/gene="PRSS16"
/gene_synonym="TSSP"
/replace="c"
/replace="t"
/db_xref="dbSNP:189220208"
polyA_site 2865
/gene="PRSS16"
/gene_synonym="TSSP"
ORIGIN
agagtcccgaacaccatggccgtctggcttgcccagtggctgggccctctgctcttggtttccctctggggactcttggctccagcctcccttcttaggcgcctgggtgagcacattcagcagtttcaggagagctctgcccagggcctgggcctgagcctggggccaggtgctgcagccctcccaaaagtggggtggctggagcaactgctggaccccttcaacgtgtccgacagacgatccttcctacagcgttactgggtgaatgaccaacattgggttggccaggatggacccatattcctgcatctagggggtgagggcagccttgggcctggctcagtgatgagaggccatcccgcagccttggccccagcctggggcgccctggtgataagcctggaacacagattttatggcctgagtatacctgctggaggcctggaaatggcccagctccgcttcttgtccagccgccttgcgctggctgatgtggtctctgcccgcctggcactttcccgcctctttaacatctcctcctccagcccctggatctgcttcggaggctcctatgccggctccttggccgcctgggcccggctgaagttcccccatctcattttcgcgtcggtcgcctcctccgccccggtgcgggccgtgctggatttctccgagtataatgacgtggtatcccgaagcctaatgagcaccgcgatcggcgggtccctggagtgccgggcggcggtgtccgtcgccttcgctgaagtggagcggcggctgcgctcgggtggggcggctcaagcagcattgcggacggagctgagcgcttgcgggcccctgggccgcgctgaaaaccaggcggagctgttgggggcgctgcaggcactggtgggaggtgtagtgcagtatgatgggcagacgggagcgccgctaagcgtgcgacagctctgcggacttctcctcgggggcgggggcaaccgcagccactccacgccctactgcgggcttcgtcgggcggtgcagattgtcttgcacagcctgggccagaagtgtttaagcttttcccgagcagagacagtggcacagctgaggagcacagaacctcaactgtctggtgtgggtgaccggcagtggttgtatcagacatgtaccgagttcggcttctatgtcacctgtgagaatcccagatgtcctttctcccagctcccagcactgccctcccagctagacctatgtgagcaggtgtttgggctctcagccttgtcagtagcccaggctgtggctcagacgaactcctactacggtggccagacccctggggctaacaaagtgctgtttgttaatggggacacagacccctggcatgtgctaagtgtaacacaggctttaggatcctcagaatcaactcttcttatccgcactggctcccactgcttggacatggcacctgagaggccctcagactcccccagcctccgcctagggcgccagaacatcttccagcagctacagacctggctcaagctggcaaaggagagccagattaagggtgaagtctgaatctcataccctttccactccctgcatggtcacctcagtcctggacatacttgttcactgaacaaaagaaagcagcttgttttgaaagaagaaactcccaggaattggaattcagcacctgttccgcacgtaattggcatgtgtctgcaaacatccttattcccaacttaaagtgctttattgcagagagttatggaaatataagtggatgattattctcattgtaaatattggtattttgaatgttaaatgtcaaacaaatgtgacttatgctggtgccctcgccctgctgatcagattctggttcaaattctgccactccagctcctgggttaggggctttgctgtaagtttctttttctggactttagatcctgaacctgtccttgcttctcagtttctctcactgtacccctttccctcagtctcttcctctctctttcccctgtcactatttgtctttctaatctccttctgtttctctgaatatcttcatttctatctctgtgtttctgtctatttctctgtttatctttctgtccttcaatctgtgtttttgtttctggctctccgtcagtgtctttttctctcctctctctcttgctctgccatggctatttccactgctctatttctgactctcatttttggtctctgtgtgtctcctagtcactttctttctcactctgtctctgtctctatttctgtctctcctctgctgtgtcctcaatctctctgtctccctgaggctctatttctgtctctcctctgctgtgtcctcaatctctctgtctccctgaggctctatttctgtctctgatgctcttcttctgtgtctctatttctcttcctgtcacttaatcttttccttctctatctctcttatttagtcttccttccacacccttcactcaccatcttttcccacaatcaaatatcactccctggtacttccagcttccaactctagggattcatgattctggtggagattccttcttccagggcctgggaggatagggctaatcccaagggtgcctgcttaggctatgttagctgtgacaggaacctgccatagatttgcactgttctttcctaaagatcaattattttcagcaataaatacttctcagctttttgtatgtctttgtatgcacagagatggtagttttagagttttatccagtttcatatttccttgtgggtaagaggcaacctcctcatgctgtcataccaaagtcaatctccactacactttagttctgcctgttcttgatctttatataaatggaaacttgcagtataaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10279 -> Molecular function: GO:0008236 [serine-type peptidase activity] evidence: NAS
GeneID:10279 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:10279 -> Biological process: GO:0030163 [protein catabolic process] evidence: NAS
GeneID:10279 -> Cellular component: GO:0005764 [lysosome] evidence: IDA
GeneID:10279 -> Cellular component: GO:0005768 [endosome] evidence: IDA
GeneID:10279 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IEA
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@meso_cacase at
DBCLS
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