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2025-05-09 16:31:21, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005255 4549 bp mRNA linear PRI 08-JUL-2013
DEFINITION Homo sapiens cyclin G associated kinase (GAK), mRNA.
ACCESSION NM_005255 XM_938227 XM_943587 XM_943590 XM_943594 XM_943598
XM_943600 XM_943603
VERSION NM_005255.2 GI:157384970
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4549)
AUTHORS Li,N.N., Chang,X.L., Mao,X.Y., Zhang,J.H., Zhao,D.M., Tan,E.K. and
Peng,R.
TITLE GWAS-linked GAK locus in Parkinson's disease in Han Chinese and
meta-analysis
JOURNAL Hum. Genet. 131 (7), 1089-1093 (2012)
PUBMED 22198721
REMARK GeneRIF: study demonstrated that the rs1564282 variant in GAK
(PARK17) increases the risk of Parkinson's disease in Han Chinese
patients from mainland China
REFERENCE 2 (bases 1 to 4549)
AUTHORS Naito,Y., Shimizu,H., Kasama,T., Sato,J., Tabara,H., Okamoto,A.,
Yabuta,N. and Nojima,H.
TITLE Cyclin G-associated kinase regulates protein phosphatase 2A by
phosphorylation of its B'gamma subunit
JOURNAL Cell Cycle 11 (3), 604-616 (2012)
PUBMED 22262175
REMARK GeneRIF: GAK as a regulator of dephosphorylation events under the
control of the PP2A B'gamma subunit.
REFERENCE 3 (bases 1 to 4549)
AUTHORS Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM,
Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M,
Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano
AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T,
Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle
JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA,
Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB,
Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP, Young
P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP and Bertram
L.
CONSRTM 23andMe Genetic Epidemiology of Parkinson's Disease Consortium;
International Parkinson's Disease Genomics Consortium; Parkinson's
Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2)
TITLE Comprehensive research synopsis and systematic meta-analyses in
Parkinson's disease genetics: The PDGene database
JOURNAL PLoS Genet. 8 (3), E1002548 (2012)
PUBMED 22438815
REFERENCE 4 (bases 1 to 4549)
AUTHORS Do,C.B., Tung,J.Y., Dorfman,E., Kiefer,A.K., Drabant,E.M.,
Francke,U., Mountain,J.L., Goldman,S.M., Tanner,C.M.,
Langston,J.W., Wojcicki,A. and Eriksson,N.
TITLE Web-based genome-wide association study identifies two novel loci
and a substantial genetic component for Parkinson's disease
JOURNAL PLoS Genet. 7 (6), E1002141 (2011)
PUBMED 21738487
REFERENCE 5 (bases 1 to 4549)
AUTHORS Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M,
Simon-Sanchez J, Schulte C, Lesage S, Sveinbjornsdottir S,
Stefansson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T,
Singleton AB and Wood NW.
CONSRTM International Parkinson Disease Genomics Consortium
TITLE Imputation of sequence variants for identification of genetic risks
for Parkinson's disease: a meta-analysis of genome-wide association
studies
JOURNAL Lancet 377 (9766), 641-649 (2011)
PUBMED 21292315
REFERENCE 6 (bases 1 to 4549)
AUTHORS Zhao,X., Greener,T., Al-Hasani,H., Cushman,S.W., Eisenberg,E. and
Greene,L.E.
TITLE Expression of auxilin or AP180 inhibits endocytosis by
mislocalizing clathrin: evidence for formation of nascent pits
containing AP1 or AP2 but not clathrin
JOURNAL J. Cell. Sci. 114 (PT 2), 353-365 (2001)
PUBMED 11148137
REFERENCE 7 (bases 1 to 4549)
AUTHORS Umeda,A., Meyerholz,A. and Ungewickell,E.
TITLE Identification of the universal cofactor (auxilin 2) in clathrin
coat dissociation
JOURNAL Eur. J. Cell Biol. 79 (5), 336-342 (2000)
PUBMED 10887964
REFERENCE 8 (bases 1 to 4549)
AUTHORS Greener,T., Zhao,X., Nojima,H., Eisenberg,E. and Greene,L.E.
TITLE Role of cyclin G-associated kinase in uncoating clathrin-coated
vesicles from non-neuronal cells
JOURNAL J. Biol. Chem. 275 (2), 1365-1370 (2000)
PUBMED 10625686
REFERENCE 9 (bases 1 to 4549)
AUTHORS Kimura,S.H., Tsuruga,H., Yabuta,N., Endo,Y. and Nojima,H.
TITLE Structure, expression, and chromosomal localization of human GAK
JOURNAL Genomics 44 (2), 179-187 (1997)
PUBMED 9299234
REFERENCE 10 (bases 1 to 4549)
AUTHORS Kanaoka,Y., Kimura,S.H., Okazaki,I., Ikeda,M. and Nojima,H.
TITLE GAK: a cyclin G associated kinase contains a tensin/auxilin-like
domain
JOURNAL FEBS Lett. 402 (1), 73-80 (1997)
PUBMED 9013862
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA680073.1, D88435.1, AC139887.3 and BC000816.1.
On Sep 20, 2007 this sequence version replaced gi:4885250.
Summary: In all eukaryotes, the cell cycle is governed by
cyclin-dependent protein kinases (CDKs), whose activities are
regulated by cyclins and CDK inhibitors in a diverse array of
mechanisms that involve the control of phosphorylation and
dephosphorylation of Ser, Thr or Tyr residues. Cyclins are
molecules that possess a consensus domain called the 'cyclin box.'
In mammalian cells, 9 cyclin species have been identified, and they
are referred to as cyclins A through I. Cyclin G is a direct
transcriptional target of the p53 tumor suppressor gene product and
thus functions downstream of p53. GAK is an association partner of
cyclin G and CDK5. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D88435.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-153 DA680073.1 6-158
154-217 DA680073.1 160-223
218-3201 D88435.1 19-3002
3202-3242 AC139887.3 128141-128181 c
3243-3365 AC139887.3 126899-127021 c
3366-3482 AC139887.3 121383-121499 c
3483-3707 AC139887.3 113527-113751 c
3708-3856 AC139887.3 112713-112861 c
3857-4033 AC139887.3 111669-111845 c
4034-4512 AC139887.3 111073-111551 c
4513-4549 BC000816.1 1375-1411
FEATURES Location/Qualifiers
source 1..4549
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16"
gene 1..4549
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="cyclin G associated kinase"
/db_xref="GeneID:2580"
/db_xref="HGNC:4113"
/db_xref="MIM:602052"
exon 1..344
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
misc_feature 125..127
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="upstream in-frame stop codon"
CDS 200..4135
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/EC_number="2.7.11.1"
/note="auxilin-2"
/codon_start=1
/product="cyclin-G-associated kinase"
/protein_id="NP_005246.2"
/db_xref="GI:157384971"
/db_xref="CCDS:CCDS3340.1"
/db_xref="GeneID:2580"
/db_xref="HGNC:4113"
/db_xref="MIM:602052"
/translation="
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDSPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF
"
misc_feature 203..205
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (O14976.2); acetylation site"
misc_feature 245..247
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 350..1126
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 359..1126
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(359..361,398..400,404..406,494..496,566..577,
584..586,590..592,716..718,722..724,728..733,737..739,
770..772,779..781,866..874)
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(359..361,398..400,404..406,494..496,566..577,
584..586,716..718,722..724,728..733,737..739,770..772)
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(584..586,590..592,716..718,722..724,728..730,
779..781,866..874)
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(767..787,866..874)
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1565..1567
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 1907..2323
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="C2 domain of PTEN tumour-suppressor protein;
Region: PTEN_C2; pfam10409"
/db_xref="CDD:204476"
misc_feature 2507..2509
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 2675..2677
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 2684..2686
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 2699..2701
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 3014..3016
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 3485..3487
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 3725..3727
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature 3752..3754
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14976.2); phosphorylation site"
misc_feature <3977..4111
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
protein 40) proteins are highly conserved and play crucial
roles in protein translation, folding, unfolding,
translocation, and degradation. They act primarily by
stimulating the ATPase activity of Hsp70s; Region: DnaJ;
cd06257"
/db_xref="CDD:99751"
misc_feature order(4022..4030,4064..4066,4073..4078,4085..4090)
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/note="HSP70 interaction site [polypeptide binding]; other
site"
/db_xref="CDD:99751"
exon 345..406
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 407..466
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 467..581
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 557
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="c"
/replace="t"
/db_xref="dbSNP:1141284"
exon 582..724
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 725..850
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 851..940
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 941..1076
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 1077..1189
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 1190..1280
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 1281..1404
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 1396
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="c"
/replace="t"
/db_xref="dbSNP:2279181"
exon 1405..1454
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 1455..1603
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 1604..1726
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 1656
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="a"
/replace="g"
/db_xref="dbSNP:1802538"
exon 1727..1860
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 1861..2055
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 1957
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="a"
/replace="g"
/db_xref="dbSNP:35964990"
exon 2056..2173
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 2137
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="c"
/replace="t"
/db_xref="dbSNP:41333249"
exon 2174..2253
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 2254..2447
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 2448..2594
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 2535
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="a"
/replace="g"
/db_xref="dbSNP:1056673"
exon 2595..3071
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 2817
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="a"
/replace="c"
/db_xref="dbSNP:1141285"
exon 3072..3242
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 3202
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="c"
/replace="t"
/db_xref="dbSNP:1064207"
exon 3243..3365
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 3308
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="g"
/replace="t"
/db_xref="dbSNP:77455473"
variation 3334
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="a"
/replace="g"
/db_xref="dbSNP:1026738"
exon 3366..3482
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 3483..3707
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 3708..3856
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
exon 3857..4033
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
variation 3993
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="a"
/replace="g"
/db_xref="dbSNP:2306242"
variation 4017..4018
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="c"
/replace="t"
/db_xref="dbSNP:76111882"
variation 4018
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="c"
/replace="t"
/db_xref="dbSNP:8093"
exon 4034..4531
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/inference="alignment:Splign:1.39.8"
STS 4069..4530
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/standard_name="GAK__6772"
/db_xref="UniSTS:466196"
variation 4088
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="a"
/replace="g"
/db_xref="dbSNP:1134921"
STS 4277..4532
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/standard_name="WI-20233"
/db_xref="UniSTS:57018"
STS 4281..4494
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/standard_name="SHGC-68043"
/db_xref="UniSTS:53741"
variation 4412
/gene="GAK"
/gene_synonym="DNAJ26; DNAJC26"
/replace="c"
/replace="t"
/db_xref="dbSNP:6964"
ORIGIN
gaggccgcggcggaggggacggggctaggccgggtcgccgcctgacgcgacgcgtcctcacgggcgcctacgtcacggcgtcgaggcggaagatggtgcacctccgggccggcggttgctgagctgacccggacggcgagggagcgggagcccgagcccgaccactccggctgccgcggggtgcggcgcagccaccgccatgtcgctgctgcagtcggcgctcgacttcttggcgggtccaggctccctgggcggtgcttccggccgcgaccagagtgacttcgtggggcagacggtggaactgggcgagctgcggctgcgggtgcggcgggtcctggccgaaggagggtttgcatttgtgtatgaagctcaagatgtggggagtggcagagagtatgcattaaagaggctattatccaatgaagaggaaaagaacagagccatcattcaagaagtttgcttcatgaaaaagctttccggccacccgaacattgtccagttttgttctgcagcgtctataggaaaagaggagtcagacacggggcaggctgagttcctcttgctcacagagctctgtaaagggcagctggtggaatttttgaagaaaatggaatctcgaggccccctttcgtgcgacacggttctgaagatcttctaccagacgtgccgcgccgtgcagcacatgcaccggcagaagccgcccatcatccacagggacctcaaggttgagaacttgttgcttagtaaccaagggaccattaagctgtgtgactttggcagtgccacgaccatctcgcactaccctgactacagctggagcgcccagaggcgagccctggtggaggaagagatcacgaggaatacaacaccaatgtatagaacaccagaaatcatagacttgtattccaacttcccgatcggcgagaagcaggatatctgggccctgggctgcatcttgtacctgctgtgcttccggcagcacccttttgaggatggagcgaaacttcgaatagtcaatgggaagtactcgatccccccgcacgacacgcagtacacggtcttccacagcctcatccgcgccatgctgcaggtgaacccggaggagcggctgtccatcgccgaggtggtgcaccagctgcaggagatcgcggccgcccgcaacgtgaaccccaagtctcccatcacagagctcctggagcagaatggaggctacgggagcgccacactgtcccgagggccaccccctcccgtgggccccgctggcagtggctacagtggaggcctggcgctggcggagtacgaccagccgtatggcggcttcctggacattctgcggggtgggacagagcggctcttcaccaacctcaaggacacctcctccaaggtcatccagtccgtcgctaattatgcaaagggtgacctggacatatcttacatcacatccagaattgcagtgatgtcattcccagcagaaggtgtggagtcagcgctcaaaaacaacatcgaagatgtgcggttgttcctggactccaagcacccagggcactatgccgtctacaacctgtccccgaggacctaccggccctccaggttccacaaccgggtctccgagtgtggctgggcagcacggcgggccccacacctgcacaccctgtacaacatctgcaggaacatgcacgcctggctgcggcaggaccacaagaacgtctgcgtcgtgcactgcatggacgggagagccgcgtctgctgtggccgtctgctccttcctgtgcttctgccgtctcttcagcaccgcggaggccgccgtgtacatgttcagcatgaagcgctgcccaccaggcatctggccatcccacaaaaggtacatcgagtacatgtgtgacatggtggcggaggagcccatcacaccccacagcaagcccatcctggtgagggccgtggtcatgacacccgtgccgctgttcagcaagcagaggagcggctgcaggcccttctgcgaggtctacgtgggggacgagcgtgtggccagcacctcccaggagtacgacaagatgcgggactttaagattgaagatggcaaagcggtgattcccctgggcgtcacggtgcaaggagacgtgctcatcgtcatctatcacgcccggtccactctgggcggccggctgcaggccaagatggcatccatgaagatgttccagattcagttccacacggggtttgtgcctcggaacgccaccactgtgaaatttgccaagtatgacctggacgcgtgtgacattcaagaaaaatacccggatttatttcaagtgaacctggaagtggaggtggagcccagggacaggccgagccgggaagccccaccatgggagaactcgagcatgagggggctgaaccccaaaatcctgttttccagccgggaggagcagcaagacattctgtctaagtttgggaagccggagcttccccggcagcctggctccacggctcagtatgatgctggggcagggtccccggaagccgaacccacagactctgactcaccgccaagcagcagcgcggacgccagtcgcttcctgcacacgctggactggcaggaagagaaggaggcagagactggtgcagaaaatgcctcttccaaggagagcgagtctgccctgatggaggacagagacgagagtgaggtgtcagatgaagggggatccccgatctccagcgagggccaggaacccagggccgacccagagccccccggcctggcagcagggctggtgcagcaggacttggtttttgaggtggagacaccggctgtgctgccagagcctgtgccacaggaagacggggtcgacctcctgggcctgcactccgaggtgggcgcagggccagctgtacccccgcaggcctgcaaggccccctccagcaacaccgacctgctcagctgcctccttgggccccctgaggccgcctcccaggggcccccggaggatctgctcagcgaggacccgctgctcctggcaagcccggcccctcccctgagcgtgcagagcaccccaagaggagggccccctgccgctgctgacccctttggcccgcttctgccgtcttcaggcaacaactcccagccctgctccaatcctgatctcttcggcgaatttctcaattcggactctgtgaccgtcccaccatccttcccgtctgcccacagtgctccgcccccatcctgcagcgccgacttcctgcacctgggggatctgccaggagagcccagcaagatgacagcctcgtccagcaacccagacctgctgggaggatgggctgcctggaccgagactgcagcatcggcagtggcccccacgccagccacagaaggccccctcttctctcctggaggtcagccggccccttgtggctctcaggccagctggaccaagtctcagaacccggacccatttgctgaccttggcgacctcagctccggcctccaaggctcaccagctggattccctcctgggggcttcattcccaaaacggccaccacgcccaaaggcagcagctcctggcagacaagtcggccgccagcccagggcgcctcatggccccctcaggccaagccgccccccaaagcctgcacacagccaaggcctaactatgcctcgaacttcagtgtgatcggggcgcgggaggagcggggggtccgcgcacccagctttgctcaaaagccaaaagtctctgagaacgactttgaagatctgttgtccaatcaaggcttctcctccaggtctgacaagaaagggccaaagaccattgcagagatgaggaagcaggacctggctaaagacacggacccactcaagctgaagctcctggactggattgagggcaaggagcggaacatccgggccctgctgtccacgctgcacacagtgctgtgggacggggagagccgctggacgcccgtgggcatggccgacctggtggctccggagcaagtgaagaagcactatcgccgcgcggtgctggctgtgcaccccgacaaggctgcggggcagccgtacgagcagcacgccaagatgatcttcatggagctgaatgacgcctggtcggagtttgagaaccagggctcccggcccctcttctgaggccgcagtggtggtggctgcgcacacagctccacaggttgggagccgtcgtgggacctgggtccccaccgtgaggaccccgtgggcgacagcaggtgtggccagggtggggctccgagccccgggtcaccgcccgcccagcgttccaggcacatgaagagaaagcattccaaagcctctgattgttgtttcctttttctcctcccgaaggaacagctgattcatgctcctcccgcaattgtcacgtctgtgatttatttggtgtttcgggcgtggcctctggagccccggcacgtggtgggccacgctgctggcgctcatgggccctggtgtttgcaccgcactttgtaatcagtcccgtggttgtctgtacagaattaaactattttccgatgaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2580 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:2580 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2580 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:2580 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:2580 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2580 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:2580 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
GeneID:2580 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005246 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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