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2025-05-09 16:26:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004555 6453 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens nuclear factor of activated T-cells, cytoplasmic,
calcineurin-dependent 3 (NFATC3), transcript variant 2, mRNA.
ACCESSION NM_004555
VERSION NM_004555.3 GI:312283724
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6453)
AUTHORS Yissachar,N., Sharar Fischler,T., Cohen,A.A., Reich-Zeliger,S.,
Russ,D., Shifrut,E., Porat,Z. and Friedman,N.
TITLE Dynamic response diversity of NFAT isoforms in individual living
cells
JOURNAL Mol. Cell 49 (2), 322-330 (2013)
PUBMED 23219532
REMARK GeneRIF: The closely related transcription factors NFAT1 and NFAT4
possess distinct nuclear localization dynamics in response to cell
stimulation.
REFERENCE 2 (bases 1 to 6453)
AUTHORS Ulrich,J.D., Kim,M.S., Houlihan,P.R., Shutov,L.P., Mohapatra,D.P.,
Strack,S. and Usachev,Y.M.
TITLE Distinct activation properties of the nuclear factor of activated
T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons
JOURNAL J. Biol. Chem. 287 (45), 37594-37609 (2012)
PUBMED 22977251
REMARK GeneRIF: Data indicate that NFATc3 undergoes rapid
dephosphorylation and nuclear translocation that are essentially
complete within 20 min, although NFATc4 remains phosphorylated and
localized to the cytosol.
REFERENCE 3 (bases 1 to 6453)
AUTHORS Wollebo,H.S., Melis,S., Khalili,K., Safak,M. and White,M.K.
TITLE Cooperative roles of NF-kappaB and NFAT4 in polyomavirus JC
regulation at the KB control element
JOURNAL Virology 432 (1), 146-154 (2012)
PUBMED 22749879
REMARK GeneRIF: The authors report that NFAT4 and NF-kappaB interact at
the KB element to co-operatively activate both human polyomavirus
JC early and late transcription and viral DNA replication.
REFERENCE 4 (bases 1 to 6453)
AUTHORS Jin,S.M., Cho,H.J., Kim,Y.W., Hwang,J.Y. and Mook-Jung,I.
TITLE Abeta-induced Ca(2+) influx regulates astrocytic BACE1 expression
via calcineurin/NFAT4 signals
JOURNAL Biochem. Biophys. Res. Commun. 425 (3), 649-655 (2012)
PUBMED 22846573
REMARK GeneRIF: Abeta-activated NFAT4 proteins were associated with
astrocytic BACE1 gene expression via direct interaction with the
BACE1 promoter region.
REFERENCE 5 (bases 1 to 6453)
AUTHORS Urso,K., Alfranca,A., Martinez-Martinez,S., Escolano,A., Ortega,I.,
Rodriguez,A. and Redondo,J.M.
TITLE NFATc3 regulates the transcription of genes involved in T-cell
activation and angiogenesis
JOURNAL Blood 118 (3), 795-803 (2011)
PUBMED 21642596
REMARK GeneRIF: NFATc3 is specifically required for IL2 and
cyclooxygenase-2 (COX2) gene expression in T cells and for T-cell
proliferation and NFATc3 regulates COX2 in endothelial cells
REFERENCE 6 (bases 1 to 6453)
AUTHORS Masuda,E.S., Liu,J., Imamura,R., Imai,S.I., Arai,K.I. and Arai,N.
TITLE Control of NFATx1 nuclear translocation by a calcineurin-regulated
inhibitory domain
JOURNAL Mol. Cell. Biol. 17 (4), 2066-2075 (1997)
PUBMED 9121455
REFERENCE 7 (bases 1 to 6453)
AUTHORS Rao,A., Luo,C. and Hogan,P.G.
TITLE Transcription factors of the NFAT family: regulation and function
JOURNAL Annu. Rev. Immunol. 15, 707-747 (1997)
PUBMED 9143705
REMARK Review article
REFERENCE 8 (bases 1 to 6453)
AUTHORS Hoey,T., Sun,Y.L., Williamson,K. and Xu,X.
TITLE Isolation of two new members of the NF-AT gene family and
functional characterization of the NF-AT proteins
JOURNAL Immunity 2 (5), 461-472 (1995)
PUBMED 7749981
REFERENCE 9 (bases 1 to 6453)
AUTHORS Masuda,E.S., Naito,Y., Tokumitsu,H., Campbell,D., Saito,F.,
Hannum,C., Arai,K. and Arai,N.
TITLE NFATx, a novel member of the nuclear factor of activated T cells
family that is expressed predominantly in the thymus
JOURNAL Mol. Cell. Biol. 15 (5), 2697-2706 (1995)
PUBMED 7739550
REFERENCE 10 (bases 1 to 6453)
AUTHORS Vacca,A., Farina,M., Maroder,M., Alesse,E., Screpanti,I., Frati,L.
and Gulino,A.
TITLE Human immunodeficiency virus type-1 tat enhances interleukin-2
promoter activity through synergism with phorbol ester and
calcium-mediated activation of the NF-AT cis-regulatory motif
JOURNAL Biochem. Biophys. Res. Commun. 205 (1), 467-474 (1994)
PUBMED 7999066
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BU849493.1, L41067.1,
AC020978.10 and CA418693.1.
On Nov 20, 2010 this sequence version replaced gi:27886542.
Summary: The product of this gene is a member of the nuclear
factors of activated T cells DNA-binding transcription complex.
This complex consists of at least two components: a preexisting
cytosolic component that translocates to the nucleus upon T cell
receptor (TCR) stimulation and an inducible nuclear component.
Other members of this family participate to form this complex also.
The product of this gene plays a role in the regulation of gene
expression in T cells and immature thymocytes. Several transcript
variants encoding distinct isoforms have been identified for this
gene. [provided by RefSeq, Nov 2010].
Transcript Variant: This variant (2) contains an additional segment
in the coding region, which causes a frameshift, compared to
variant 1. The resulting isoform (2) contains a shorter and
distinct C-terminus compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: L41067.1, EU887605.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-106 BU849493.1 1-106
107-4074 L41067.1 1-3968
4075-6418 AC020978.10 111815-114158 c
6419-6453 CA418693.1 1-35 c
FEATURES Location/Qualifiers
source 1..6453
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q22.2"
gene 1..6453
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/note="nuclear factor of activated T-cells, cytoplasmic,
calcineurin-dependent 3"
/db_xref="GeneID:4775"
/db_xref="HGNC:7777"
/db_xref="HPRD:04077"
/db_xref="MIM:602698"
exon 1..419
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
misc_feature 284..286
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/note="upstream in-frame stop codon"
CDS 317..3523
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/note="isoform 2 is encoded by transcript variant 2; T
cell transcription factor NFAT4; nuclear factor of
activated T-cells c3 isoform IE-Xa; NF-ATc3"
/codon_start=1
/product="nuclear factor of activated T-cells, cytoplasmic
3 isoform 2"
/protein_id="NP_004546.1"
/db_xref="GI:4758804"
/db_xref="CCDS:CCDS10862.1"
/db_xref="GeneID:4775"
/db_xref="HGNC:7777"
/db_xref="HPRD:04077"
/db_xref="MIM:602698"
/translation="
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDDQFISDLEHQPSGSAEKWPNHSVLSCPAPFWRI
"
misc_feature 320..322
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylthreonine; propagated from
UniProtKB/Swiss-Prot (Q12968.1); acetylation site"
misc_feature 641..658
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12968.1);
Region: Calcineurin-binding"
misc_feature 803..805
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:04206"
misc_feature 809..811
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:04206"
misc_feature 926..928
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02739"
misc_feature 935..1240
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12968.1);
Region: 3 X SP repeats"
misc_feature 935..937
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02739"
misc_feature 944..946
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02739"
misc_feature 947..949
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02739"
misc_feature 959..961
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02739"
misc_feature 1133..1141
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12968.1);
Region: Nuclear localization signal"
misc_feature 1577..2098
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/note="N-terminal sub-domain of the Rel homology domain
(RHD) of nuclear factor of activated T-cells (NFAT)
proteins; Region: RHD-n_NFAT; cd07881"
/db_xref="CDD:143641"
misc_feature order(1646..1648,1655..1657,1661..1666,1670..1678,
1817..1819,1940..1942,1946..1951,1991..1996,2000..2002,
2093..2095)
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:143641"
misc_feature 2111..2413
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/note="IPT domain of the NFAT family of transcription
factors. NFAT transcription complexes are a target of
calcineurin, a calcium dependent phosphatase, and activate
genes mainly involved in cell-cell-interaction; Region:
IPT_NFAT; cd01178"
/db_xref="CDD:28993"
misc_feature order(2183..2185,2375..2377)
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/note="DNA binding sites [nucleotide binding]"
/db_xref="CDD:28993"
misc_feature 2372..2380
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12968.1);
Region: Nuclear localization signal"
exon 420..1554
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 1555..1717
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 1718..1917
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 1918..2090
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 2091..2231
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 2232..2287
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 2288..2414
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 2415..3422
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 3423..3526
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
exon 3527..6436
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/inference="alignment:Splign:1.39.8"
STS 3558..3775
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="SHGC-35392"
/db_xref="UniSTS:46447"
STS 3636..3796
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="RH17654"
/db_xref="UniSTS:70905"
STS 3820..3944
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="RH78919"
/db_xref="UniSTS:7965"
STS 3926..4025
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="SHGC-60786"
/db_xref="UniSTS:3222"
STS 4720..4966
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="RH79943"
/db_xref="UniSTS:83977"
STS 4772..4915
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="RH64885"
/db_xref="UniSTS:87887"
STS 6184..6317
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="A002B46"
/db_xref="UniSTS:61142"
STS 6184..6317
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="G19908"
/db_xref="UniSTS:61141"
STS 6207..6383
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="RH16192"
/db_xref="UniSTS:10495"
variation complement(6232)
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/replace="a"
/replace="g"
/db_xref="dbSNP:11043"
STS 6291..6428
/gene="NFATC3"
/gene_synonym="NFAT4; NFATX"
/standard_name="SGC32906"
/db_xref="UniSTS:9489"
ORIGIN
cggcagggcgcgagagcgcacccgcggcggcggtggcggcgactgtgggggggcggcggggaacattggctaagccgacagtggaggcttaggcaccggtggcgggcggctgcggttcctggtgctgctcggcgcgcggccagctttcggaacggaacgctcggcgtcgcgggccccgcccggaaagtttgccgtggagtcgcgacctcttggcccgcgcggcccggcatgaagcggcgttgaggagctgctgccgccgcttgccgctgccgccgccgccgcctgaggaggagctgcagcaccctgggccacgccgatgactactgcaaactgtggcgcccacgacgagctcgacttcaaactcgtctttggcgaggacggggcgccggcgccgccgcccccgggctcgcggcctgcagatcttgagccagatgattgtgcatccatttacatctttaatgtagatccacctccatctactttaaccacaccactttgcttaccacatcatggattaccgtctcactcttctgttttgtcaccatcgtttcagctccaaagtcacaaaaactatgaaggaacttgtgagattcctgaatctaaatatagcccattaggtggtcccaaaccctttgagtgcccaagtattcaaattacatctatctctcctaactgtcatcaagaattagatgcacatgaagatgacctacagataaatgacccagaacgggaatttttggaaaggccttctagagatcatctctatcttcctcttgagccatcctaccgggagtcttctcttagtcctagtcctgccagcagcatctcttctaggagttggttctctgatgcatcttcttgtgaatcgctttcacatatttatgatgatgtggactcagagttgaatgaagctgcagcccgatttacccttggatcccctctgacttctcctggtggctctccagggggctgccctggagaagaaacttggcatcaacagtatggacttggacactcattatcacccaggcaatctccttgccactctcctagatccagtgtcactgatgagaattggctgagccccaggccagcctcaggaccctcatcaaggcccacatccccctgtgggaaacggaggcactccagtgctgaagtttgttatgctgggtccctttcaccccatcactcacctgttccttcacctggtcactcccccaggggaagtgtgacagaagatacgtggctcaatgcttctgtccatggtgggtcaggccttggccctgcagtttttccatttcagtactgtgtagagactgacatccctctcaaaacaaggaaaacttctgaagatcaagctgccatactaccaggaaaattagagctgtgttcagatgaccaagggagtttatcaccagcccgggagacttcaatagatgatggccttggatctcagtatcctttaaagaaagattcatgtggtgatcagtttctttcagttccttcaccctttacctggagcaaaccaaagcctggccacacccctatatttcgcacatcttcattacctccactagactggcctttaccagctcattttggacaatgtgaactgaaaatagaagtgcaacctaaaactcatcatcgagcccattatgaaactgaaggtagccgaggggcagtaaaagcatctactgggggacatcctgttgtgaagctcctgggctataacgaaaagccaataaatctacaaatgtttattgggacagcagatgatcgatatttacgacctcatgcattttaccaggtgcatcgaatcactgggaagacagtcgctactgcaagccaagagataataattgccagtacaaaagttctggaaattccacttcttcctgaaaataatatgtcagccagtattgattgtgcaggtattttgaaactccgcaattcagatatagaacttcgaaaaggagaaactgatattggcagaaagaatactagagtacgacttgtgtttcgtgtacacatcccacagcccagtggaaaagtcctttctctgcagatagcctctatacccgttgagtgctcccagcggtctgctcaagaacttcctcatattgagaagtacagtatcaacagttgttctgtaaatggaggtcatgaaatggttgtgactggatctaattttcttccagaatccaaaatcatttttcttgaaaaaggacaagatggacgacctcagtgggaggtagaagggaagataatcagggaaaaatgtcaaggggctcacattgtccttgaagttcctccatatcataacccagcagttacagctgcagtgcaggtgcacttttatctttgcaatggcaagaggaaaaaaagccagtctcaacgttttacttatacaccagttttgatgaagcaagaacacagagaagagattgatttgtcttcagttccatctttgcctgtgcctcatcctgctcagacccagaggccttcctctgattcagggtgttcacatgacagtgtactgtcaggacagagaagtttgatttgctccatcccacaaacatatgcatccatggtgacctcatcccatctgccacagttgcagtgtagagatgagagtgttagtaaagaacagcatatgattccttctccaattgtacaccagccttttcaagtcacaccaacacctcctgtggggtcttcctatcagcctatgcaaactaatgttgtgtacaatggaccaacttgtcttcctattaatgctgcctctagtcaagaatttgattcagttttgtttcagcaggatgcaactctttctggtttagtgaatcttggctgtcaaccactgtcatccataccatttcattcttcaaattcaggctcaacaggacatctcttagcccatacacctcattctgtgcataccctgcctcatctgcaatcaatgggatatcattgttcaaatacaggacaaagatctctttcttctccagtggctgaccagattacaggtcagccttcgtctcagttacaacctattacatatggtccttcacattcagggtctgctacaacagcttccccagcagcttctcatcccttggctagttcaccgctttctgggccaccatctcctcagcttcagcctatgccttaccaatctcctagctcaggaactgcctcatcaccgtctccagccaccagaatgcattctggacagcactcaactcaagcacaaagtacgggccaggggggtctttctgcaccttcatccttaatatgtcacagtttgtgtgatccagcgtcatttccacctgatggggcaactgtgagcattaaacctgaaccagaagatcgagagcctaactttgcaaccattggtctgcaggacatcactttagatgatgaccaatttatatctgacttggaacaccagccatcaggttcagcagagaaatggcctaaccacagtgtgctctcatgtccagctcctttctggagaatctagaggtgaacgagataattgggagagacatgtcccagatttctgtttcccaaggagcaggggtgagcaggcaggctcccctcccgagtcctgagtccctggatttaggaagatctgatgggctctaacagtgcttactgcagccttgtgtccaccaccaacttctcagcatgtttctctccttggaccttgggtttccaactctgcagccttcaggtctggggccaggagtgggacccaccatttgtggggaaagtagcattcctccacctcaggccttgggtagatttggcaaaagaacaggagcagcataggctgtttgagctttggggaaatgaactttgctttttatatttaactaggatacttttatatgatgggtgctttgagtgtgaatgcagcaggctctcttgtttccgaggtgctgcttttgcaggtgacctggttacttagctaggattggtgatttgtactgctttatggtcatttgaagggccctttagtttttatgataatttttaaaataggaacttttgataagaccttctagaagcaaaaaaaaaaaaaaaaaaaaaaaaaagaaaaaaaaagaaaagaaaaaaagaaaaagaaaaaaatatcccaagcccacacctatgcctcagaaagtcagcatgtgtcctgaagacgttcatagatttataggaaataaagccaaatgtagctcatacctctttataaaactaaactgttgttagataaaatgagaagagaccattccatcattgaagtgttggaatataaaaagacattccagagcatagccttttggtaactttctaggtaatcttgcaatctctccatactggctccatgttgaaattgctttttccctcaggaccctgggtaagatggctacatttaaggtgactctgaatggtggggttctagcttggtcactttcatttcttgccatcataaaaactagtaggctgtggagtgcgcttcctgtttgtgtcatctggtcgtagaaccttttccaaacagaagcatctgcctttggctgttctgtgacctttgaagccagtctcagtggtttaggcagctttgcagttctaactctagctagaggccaggctgtgtgcagagctaaagcacaaatgagcagtacatcagcatgggcagagaaaatacaggactccagatgggaaggttttaagagtcacactggcatggaaggcttatctgccattctatttatagcctgaaatgattctggcctaccctgtcctgtctgtatgatctaaaaaccagccttttccccagaaggctctgagcacatccagaagtgataacctgaccctccacaccaaagacaccctggtgctgctgctggtgagactggtgtccaaggcagggcccagcagaaactgcagcctgctgtctaccaaaggaggtacccgagttgggtactttaaaaaaaaaaaaaacctgcccttacccctctccctaatgggattttttttacctgttcctgggcccattacagagcctctgaagtttgcagtatgctttcaaatgaaataatatacttccattgattcaggaagcagattttttgagtgcctatatgtgagacagtgtgctggttgaaggcctgatgctgttattccaggagactgcaggcccttgatgccaggactctctctactaaggccagttcaggtctgggaaagggagctggcctattgcccaccacctgttgtcagtaggttaggagctgttgactcaggatgaggaagtatggtctttaaaaaaaacaaaatatattttagatttctcccctaaagttagttagagaaaaaggtctattcttcagcagatcactgtggcccctcttggagctgggtgttttcaaattttcttgaaaagtgagttgtgtcacagaatgtggatagtgagatttgcttctgggcctgtggttggacgcccacagcttcctttggaggggcaagaagttggcctctcggttgacattccagagaaatggccagacttgcccctacccttttgcccctggtgtagctgcctcacatgaggttattgcaagagttccccttgcaataccctttgtgccctcaagaattaaaagcctctatgatccagagttgctatgcaccaaattttgatgccttctaaataccttgatgcctgtagcactagaaatgctttcctatttaaaataaacattaaattttaaaatagagctttgtatactatgtaagcagttttatatcagctttgtaaaagctttggtgttaagagtcaatattttttggctttgtagataaagacttaaatttttgtgcaacatagtggtgttaaagcacacatccattggactatgcaaatcaatttctactagcagcactgagcaactgggcacgtgctagtacgcaccccctcctactctaactgtgctagctcttgggttgaggaatggaatgggtagccttctgcttactggagatgcacagagaaacatggctgaaaacagctttaaaaagaacatgtctttgggttcatgtgtggtgctgctgcccgggtgtaaactatccccacccagggccagccattatcaccagacctcttctgggcctggctgtgaagccctgtttttggtattcagaatggatctttaaggctcagatgggctcaaattgaaaccttgtgttttataaaatggatgtttagtaaaggaactggttctcagttatgtttacagcacttggaattgtgtgttcttgtacattttgtattttaaaaccttttatgggagtgcagtgctccttacacaaatacaaagggaagaagagccagcagttgaggctcctcagttttagtgctgaaataataaacagtgacaggtcaacagtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4775 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:4775 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:4775 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:4775 -> Biological process: GO:0001569 [patterning of blood vessels] evidence: IEA
GeneID:4775 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:4775 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:4775 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
GeneID:4775 -> Biological process: GO:0007507 [heart development] evidence: IEA
GeneID:4775 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:4775 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:4775 -> Biological process: GO:0045333 [cellular respiration] evidence: IEA
GeneID:4775 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4775 -> Biological process: GO:0051145 [smooth muscle cell differentiation] evidence: IEA
GeneID:4775 -> Biological process: GO:0055001 [muscle cell development] evidence: IEA
GeneID:4775 -> Biological process: GO:0071285 [cellular response to lithium ion] evidence: IEA
GeneID:4775 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:4775 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:4775 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:4775 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:4775 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:4775 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
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