Home |
Help |
Advanced search
2025-05-09 16:28:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004525 15735 bp mRNA linear PRI 31-MAY-2013
DEFINITION Homo sapiens low density lipoprotein receptor-related protein 2
(LRP2), mRNA.
ACCESSION NM_004525
VERSION NM_004525.2 GI:126012572
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 15735)
AUTHORS Dagil,R., O'Shea,C., Nykjaer,A., Bonvin,A.M. and Kragelund,B.B.
TITLE Gentamicin binds to the megalin receptor as a competitive inhibitor
using the common ligand binding motif of complement type repeats:
insight from the nmr structure of the 10th complement type repeat
domain alone and in complex with gentamicin
JOURNAL J. Biol. Chem. 288 (6), 4424-4435 (2013)
PUBMED 23275343
REMARK GeneRIF: Using NMR titration data in HADDOCK, we have generated a
three-dimensional model describing the complex between megalin and
gentamicin.
REFERENCE 2 (bases 1 to 15735)
AUTHORS Hamajima,N., Naito,M., Okada,R., Kawai,S., Yin,G., Morita,E.,
Higashibata,T., Tamura,T., Nakagawa,H., Matsuo,H., Mori,A. and
Wakai,K.
TITLE Significant interaction between LRP2 rs2544390 in intron 1 and
alcohol drinking for serum uric acid levels among a Japanese
population
JOURNAL Gene 503 (1), 131-136 (2012)
PUBMED 22565184
REMARK GeneRIF: This study confirmed that LRP2 rs2544390 C/T at intron 1
was associated with serum uric acid levels among Japanese males
with SLC22A12 258WW, SLC2A9 rs11722228C allele, ABCG2 126QQ and
141Q allele.
REFERENCE 3 (bases 1 to 15735)
AUTHORS Schreiber,A., Theilig,F., Schweda,F. and Hocherl,K.
TITLE Acute endotoxemia in mice induces downregulation of megalin and
cubilin in the kidney
JOURNAL Kidney Int. 82 (1), 53-59 (2012)
PUBMED 22437417
REMARK GeneRIF: Expression of megalin and cubilin is decreased during
experimental endotoxemia, which may contribute to an increase in
urine levels of albumin during acute renal failure.
REFERENCE 4 (bases 1 to 15735)
AUTHORS Ionita-Laza,I., Makarov,V. and Buxbaum,J.D.
CONSRTM ARRA Autism Sequencing Consortium
TITLE Scan-statistic approach identifies clusters of rare disease
variants in LRP2, a gene linked and associated with autism spectrum
disorders, in three datasets
JOURNAL Am. J. Hum. Genet. 90 (6), 1002-1013 (2012)
PUBMED 22578327
REMARK GeneRIF: analysis of rare disease variants in LRP2, a gene linked
and associated with autism spectrum disorders
REFERENCE 5 (bases 1 to 15735)
AUTHORS Wang,C., Hu,Y.M., He,J.W., Gu,J.M., Zhang,H., Hu,W.W., Yue,H.,
Gao,G., Xiao,W.J., Yu,J.B., Ke,Y.H., Hu,Y.Q., Li,M., Liu,Y.J.,
Fu,W.Z., Ren,Y. and Zhang,Z.L.
TITLE Association between low density lipoprotein receptor-related
protein 2 gene polymorphisms and bone mineral density variation in
Chinese population
JOURNAL PLoS ONE 6 (12), E28874 (2011)
PUBMED 22174918
REMARK GeneRIF: A total of 330 Chinese female-offspring nuclear families
with 1088 individuals and 400 Chinese male-offspring nuclear
families with 1215 individuals were genotyped at six tag single
nucleotide polymorphisms of the LRP2 gene.
REFERENCE 6 (bases 1 to 15735)
AUTHORS Farquhar,M.G.
TITLE The unfolding story of megalin (gp330): now recognized as a drug
receptor
JOURNAL J. Clin. Invest. 96 (3), 1184 (1995)
PUBMED 7657789
REMARK Review article
REFERENCE 7 (bases 1 to 15735)
AUTHORS Farquhar,M.G., Saito,A., Kerjaschki,D. and Orlando,R.A.
TITLE The Heymann nephritis antigenic complex: megalin (gp330) and RAP
JOURNAL J. Am. Soc. Nephrol. 6 (1), 35-47 (1995)
PUBMED 7579068
REMARK Review article
REFERENCE 8 (bases 1 to 15735)
AUTHORS Orlando,R.A. and Farquhar,M.G.
TITLE Functional domains of the receptor-associated protein (RAP)
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (8), 3161-3165 (1994)
PUBMED 7512726
REFERENCE 9 (bases 1 to 15735)
AUTHORS Christensen,E.I., Gliemann,J. and Moestrup,S.K.
TITLE Renal tubule gp330 is a calcium binding receptor for endocytic
uptake of protein
JOURNAL J. Histochem. Cytochem. 40 (10), 1481-1490 (1992)
PUBMED 1382088
REFERENCE 10 (bases 1 to 15735)
AUTHORS Raychowdhury,R., Niles,J.L., McCluskey,R.T. and Smith,J.A.
TITLE Autoimmune target in Heymann nephritis is a glycoprotein with
homology to the LDL receptor
JOURNAL Science 244 (4909), 1163-1165 (1989)
PUBMED 2786251
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA401915.1, U33837.1,
DA339827.1, AY265358.1, DA200673.1, CD673312.1, AC007556.3 and
AY265357.1.
This sequence is a reference standard in the RefSeqGene project.
On Feb 21, 2007 this sequence version replaced gi:6806918.
Summary: The protein encoded by this gene, low density
lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand
endocytic receptor that is expressed in many different tissues but
primarily in absorptive epithilial tissues such as the kidney. This
glycoprotein has a large amino-terminal extracellular domain, a
single transmembrane domain, and a short carboxy-terminal
cytoplasmic tail. The extracellular ligand-binding-domains bind
diverse macromolecules including albumin, apolipoproteins B and E,
and lipoprotein lipase. The LRP2 protein is critical for the
reuptake of numerous ligands, including lipoproteins, sterols,
vitamin-binding proteins, and hormones. This protein also has a
role in cell-signaling; extracellular ligands include parathyroid
horomones and the morphogen sonic hedgehog while cytosolic ligands
include MAP kinase scaffold proteins and JNK interacting proteins.
Recycling of this membrane receptor is regulated by phosphorylation
of its cytoplasmic domain. Mutations in this gene cause
Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal
syndrome (FOAR).[provided by RefSeq, Aug 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U33837.1, AY265358.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025083 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-109 DA401915.1 75-183
110-460 U33837.1 1-351
461-714 DA339827.1 339-592
715-2237 AY265358.1 566-2088
2238-2588 DA200673.1 91-441
2589-3281 U33837.1 2480-3172
3282-3422 CD673312.1 403-543
3423-3872 U33837.1 3314-3763
3873-3880 AC007556.3 150972-150979 c
3881-10715 AY265358.1 3732-10566
10716-12492 AY265357.1 10570-12346
12493-14306 U33837.1 12384-14197
14307-15735 AC007556.3 35125-36553 c
FEATURES Location/Qualifiers
source 1..15735
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q31.1"
gene 1..15735
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="low density lipoprotein receptor-related protein 2"
/db_xref="GeneID:4036"
/db_xref="HGNC:6694"
/db_xref="MIM:600073"
exon 1..292
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
misc_feature 49..51
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="upstream in-frame stop codon"
CDS 214..14181
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="megalin; glycoprotein 330; low-density lipoprotein
receptor-related protein 2; calcium sensor protein;
Heymann nephritis antigen homolog; LRP-2"
/codon_start=1
/product="low-density lipoprotein receptor-related protein
2 precursor"
/protein_id="NP_004516.2"
/db_xref="GI:126012573"
/db_xref="CCDS:CCDS2232.1"
/db_xref="GeneID:4036"
/db_xref="HGNC:6694"
/db_xref="MIM:600073"
/translation="
MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAIDRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV
"
sig_peptide 214..288
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 289..14178
/gene="LRP2"
/gene_synonym="DBS; GP330"
/product="low-density lipoprotein receptor-related protein
2"
misc_feature 295..399
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(310..312,334..336,367..372)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(346..348,355..357,367..369,385..390)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 376..390
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 535..639
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(550..552,574..576,607..612)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(586..588,595..597,607..609,625..630)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 616..630
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 658..750
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(661..663,685..687,718..723)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(697..699,706..708,718..720,736..741)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 727..741
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 760..864
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(775..777,799..801,832..837)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(811..813,820..822,832..834,850..855)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 841..855
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 877..981
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(892..894,916..918,949..954)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(928..930,937..939,949..951,967..972)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 958..972
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 1009..1113
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(1024..1026,1051..1053,1084..1089)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(1063..1065,1072..1074,1084..1086,1102..1107)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 1093..1107
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 1456..1584
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 1519..1647
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 1"
misc_feature 1594..1716
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 1648..1776
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 2"
misc_feature 1720..1857
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 1777..1917
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 3"
misc_feature 1864..1986
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 1918..2049
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 4"
misc_feature 2050..2172
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 5"
misc_feature 2470..2598
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 6"
misc_feature 2539..2667
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 2599..2724
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 7"
misc_feature 2725..2856
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 8"
misc_feature 2725..2850
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein receptor repeat class B;
Region: Ldl_recept_b; pfam00058"
/db_xref="CDD:200965"
misc_feature 2803..2925
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 2857..2988
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 9"
misc_feature 3289..3393
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(3304..3306,3328..3330,3361..3366)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(3340..3342,3349..3351,3361..3363,3379..3384)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 3370..3384
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 3412..3516
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(3427..3429,3451..3453,3484..3489)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(3463..3465,3472..3474,3484..3486,3502..3507)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 3493..3507
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 3538..3642
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(3553..3555,3577..3579,3610..3615)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(3589..3591,3598..3600,3610..3612,3628..3633)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 3619..3633
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 3658..3762
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(3673..3675,3697..3699,3730..3735)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(3709..3711,3718..3720,3730..3732,3748..3753)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 3739..3753
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 3772..3879
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(3787..3789,3814..3816,3847..3852)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(3826..3828,3835..3837,3847..3849,3865..3870)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 3856..3870
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 3901..4005
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(3916..3918,3943..3945,3976..3981)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(3955..3957,3964..3966,3976..3978,3994..3999)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 3985..3999
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 4024..4128
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(4039..4041,4063..4065,4096..4101)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(4075..4077,4084..4086,4096..4098,4114..4119)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 4105..4119
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 4144..4245
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein receptor domain class A;
Region: LDLa; smart00192"
/db_xref="CDD:197566"
misc_feature 4327..4392
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Complement Clr-like EGF-like; Region: cEGF;
pfam12662"
/db_xref="CDD:205000"
misc_feature 4381..4500
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(4381..4383,4390..4392,4429..4431)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 4594..4713
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 4645..4773
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 10"
misc_feature 4714..4842
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 4774..4902
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 11"
misc_feature 4846..4980
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 4909..5040
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 12"
misc_feature 4984..5109
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 5041..5175
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 13"
misc_feature 5176..5298
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 14"
misc_feature <5452..6288
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Uncharacterized conserved protein [Function
unknown]; Region: COG3391"
/db_xref="CDD:33198"
misc_feature 5581..5709
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 15"
misc_feature 5710..5859
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 16"
misc_feature 5860..6003
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 17"
misc_feature 5860..5997
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein receptor repeat class B;
Region: Ldl_recept_b; pfam00058"
/db_xref="CDD:200965"
misc_feature 5944..6072
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 6004..6126
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 18"
misc_feature 6127..6252
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 19"
misc_feature 6487..>7077
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Uncharacterized conserved protein [Function
unknown]; Region: COG3391"
/db_xref="CDD:33198"
misc_feature 6532..6681
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 20"
misc_feature 6622..6756
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 6682..6816
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 21"
misc_feature 6757..6888
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 6817..6948
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 22"
misc_feature 6892..7014
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 6949..7080
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 23"
misc_feature 7081..7206
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 24"
misc_feature 7504..7644
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 25"
misc_feature 7588..7713
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 7645..7767
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 26"
misc_feature 7711..7839
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 7768..7899
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 27"
misc_feature 7846..7968
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 7900..8022
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 28"
misc_feature 8023..8151
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 29"
misc_feature 8434..8538
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(8449..8451,8473..8475,8506..8511)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(8485..8487,8494..8496,8506..8508,8524..8529)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 8515..8529
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 8563..8664
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(8569..8571,8593..8595,8626..8631)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(8605..8607,8614..8616,8626..8628,8650..8655)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature order(8635..8640,8647..8655)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 8803..8898
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(8818..8820,8842..8844,8875..8880)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(8854..8856,8863..8865,8875..8877,8893..8898)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 8884..8898
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 8929..9027
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(8944..8946,8968..8970,9001..9006)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(8980..8982,8989..8991,9001..9003,9019..9024)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 9010..9024
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 9055..9177
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(9070..9072,9109..9111,9142..9147)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(9121..9123,9130..9132,9142..9144,9160..9165)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 9151..9165
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 9190..9294
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(9205..9207,9229..9231,9262..9267)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(9241..9243,9250..9252,9262..9264,9280..9285)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 9271..9285
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature <9337..9405
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(9346..9348,9379..9384)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(9358..9360,9367..9369,9379..9381,9397..9402)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 9388..9402
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 9436..9540
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(9451..9453,9475..9477,9508..9513)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(9487..9489,9496..9498,9508..9510,9526..9531)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 9517..9531
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 9607..9678
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Complement Clr-like EGF-like; Region: cEGF;
pfam12662"
/db_xref="CDD:205000"
misc_feature 9667..9786
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Calcium-binding EGF domain; Region: EGF_CA;
pfam07645"
/db_xref="CDD:148962"
misc_feature 9868..9993
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 9928..10056
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 30"
misc_feature 9997..10125
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 10057..10185
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 31"
misc_feature 10210..10341
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 32"
misc_feature 10210..10335
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein receptor repeat class B;
Region: Ldl_recept_b; pfam00058"
/db_xref="CDD:200965"
misc_feature 10285..10410
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 10342..10467
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 33"
misc_feature 10411..10536
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 10468..10593
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 34"
misc_feature 10747..10848
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(10762..10764,10789..10791,10822..10827)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(10801..10803,10810..10812,10822..10824,10840..10845)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 10831..10845
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 10870..10968
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(10885..10887,10909..10911,10942..10947)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(10921..10923,10930..10932,10942..10944,10960..10965)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 10951..10965
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 10993..>11055
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein receptor domain class A;
Region: LDLa; smart00192"
/db_xref="CDD:197566"
misc_feature 11116..11211
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(11131..11133,11155..11157,11188..11193)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(11167..11169,11176..11178,11188..11190,11206..11211)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 11197..11211
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 11257..11355
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(11263..11265,11290..11292,11323..11328)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(11302..11304,11311..11313,11323..11325,11341..11346)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 11332..11346
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 11368..11475
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(11386..11388,11410..11412,11443..11448)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(11422..11424,11431..11433,11443..11445,11461..11466)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 11452..11466
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 11488..11592
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(11503..11505,11527..11529,11560..11565)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(11539..11541,11548..11550,11560..11562,11578..11583)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 11569..11583
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 11605..11709
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; Region:
LDLa; cd00112"
/db_xref="CDD:29012"
misc_feature order(11620..11622,11644..11646,11677..11682)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="putative binding surface; other site"
/db_xref="CDD:29012"
misc_feature order(11656..11658,11665..11667,11677..11679,11695..11700)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="calcium-binding site [ion binding]; other site"
/db_xref="CDD:29012"
misc_feature 11686..11700
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="D-X-S-D-E motif; other site"
/db_xref="CDD:29012"
misc_feature 12232..12324
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(12232..12234,12241..12243,12280..12282)
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 12634..12741
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 12673..12801
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 35"
misc_feature 12802..12933
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 36"
misc_feature 12802..12927
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein receptor repeat class B;
Region: Ldl_recept_b; pfam00058"
/db_xref="CDD:200965"
misc_feature 12877..13005
/gene="LRP2"
/gene_synonym="DBS; GP330"
/note="Low-density lipoprotein-receptor YWTD domain;
Region: LY; smart00135"
/db_xref="CDD:197533"
misc_feature 12937..13062
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: LDL-receptor class B 37"
misc_feature 13483..13551
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
transmembrane region"
misc_feature 13570..13599
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: SH3-binding (Potential)"
misc_feature 13774..13791
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: Endocytosis signal (Potential)"
misc_feature 13978..14019
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: Interaction with DAB2"
misc_feature 13990..14007
/gene="LRP2"
/gene_synonym="DBS; GP330"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: NPXY motif"
misc_feature 14005..14016
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: SH2-binding (Potential)"
misc_feature 14044..14079
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98164.3);
Region: SH3-binding (Potential)"
exon 293..400
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 401..523
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 461
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229263"
variation 512
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:35642533"
exon 524..640
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 604
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:34592807"
variation 615
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="c"
/db_xref="dbSNP:34104660"
exon 641..751
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 752..865
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 852
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229266"
exon 866..982
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 983..1135
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 988
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="g"
/db_xref="dbSNP:34693334"
exon 1136..1255
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 1256..1384
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 1385..1554
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 1555..1778
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 1779..1985
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 1986..2188
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 2189..2329
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 2219
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:34291900"
exon 2330..2533
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 2534..2726
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 2645
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="g"
/replace="t"
/db_xref="dbSNP:17848140"
variation 2673
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:2241190"
exon 2727..2852
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 2853..2983
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 2939
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:36082715"
exon 2984..3121
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 3052
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:80338746"
exon 3122..3403
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 3147
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:17848143"
variation 3267
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="c"
/db_xref="dbSNP:2075249"
exon 3404..3643
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 3462
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="c"
/db_xref="dbSNP:2302691"
exon 3644..3763
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 3764..3880
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 3881..4258
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 4049
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="c"
/db_xref="dbSNP:17848149"
exon 4259..4507
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 4449
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="g"
/db_xref="dbSNP:34915742"
exon 4508..4719
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 4557
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="g"
/db_xref="dbSNP:35297090"
exon 4720..4904
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 4905..5133
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 5088
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229267"
exon 5134..5311
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 5312..5440
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 5313
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:2302694"
exon 5441..5607
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 5608..5751
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 5752..5861
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 5862..6039
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 6040..6253
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 6254..6493
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 6258
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:34834388"
variation 6319
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:34041086"
variation 6407
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228168"
variation 6480
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:2228169"
exon 6494..6682
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 6683..7603
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 6686
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="c"
/db_xref="dbSNP:34052957"
variation 6972
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:35114151"
variation 7023
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:2228170"
variation 7063
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:35413340"
variation 7167
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:34223099"
exon 7604..7769
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 7770..7928
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 7929..8218
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 8107
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:17848169"
variation 8131
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:34026778"
exon 8219..8422
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 8423..8665
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 8666..8791
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 8792..8911
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 8827
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2228171"
exon 8912..9043
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 9044..9245
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 9246..9541
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 9495
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:34813328"
exon 9542..10058
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 9626
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:35086590"
variation 9826
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:35734447"
exon 10059..10211
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 10127
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:3213760"
exon 10212..10382
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 10383..10606
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 10607..10784
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 10716
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229265"
exon 10785..10981
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 10860
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:17848184"
exon 10982..11227
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 11107
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:17848188"
exon 11228..11356
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 11305
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:34355135"
exon 11357..11476
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 11477..11593
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 11594..11710
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 11711..11848
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 11814
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229268"
exon 11849..11971
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 11972..12100
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 12101..12232
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 12233..12364
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 12365..12508
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 12493
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:2075252"
exon 12509..12674
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 12633
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:34663643"
exon 12675..12803
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 12804..13024
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 12938
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:35942532"
exon 13025..13201
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 13202..13321
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 13322..13412
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 13326
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="c"
/replace="t"
/db_xref="dbSNP:990626"
exon 13413..13480
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 13481..13601
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 13602..13731
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 13732..13833
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 13758
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:34029982"
exon 13834..13941
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 13942..14013
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
exon 14014..15735
/gene="LRP2"
/gene_synonym="DBS; GP330"
/inference="alignment:Splign:1.39.8"
variation 14016
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:34564141"
STS 14023..14656
/gene="LRP2"
/gene_synonym="DBS; GP330"
/standard_name="LRP2_7816"
/db_xref="UniSTS:467751"
STS 14331..14468
/gene="LRP2"
/gene_synonym="DBS; GP330"
/standard_name="WI-17537"
/db_xref="UniSTS:26882"
polyA_signal 14477..14482
/gene="LRP2"
/gene_synonym="DBS; GP330"
polyA_site 14494
/gene="LRP2"
/gene_synonym="DBS; GP330"
variation 15246
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace="a"
/replace="g"
/db_xref="dbSNP:1019334"
variation 15289
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace=""
/replace="gt"
/replace="tt"
/replace="ttt"
/db_xref="dbSNP:3083239"
variation 15310..15311
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace=""
/replace="tt"
/db_xref="dbSNP:3083240"
STS 15483..15638
/gene="LRP2"
/gene_synonym="DBS; GP330"
/standard_name="A009P03"
/db_xref="UniSTS:2385"
STS 15483..15638
/gene="LRP2"
/gene_synonym="DBS; GP330"
/standard_name="G32722"
/db_xref="UniSTS:117304"
STS 15495..15703
/gene="LRP2"
/gene_synonym="DBS; GP330"
/standard_name="RH45139"
/db_xref="UniSTS:26027"
variation 15581..15582
/gene="LRP2"
/gene_synonym="DBS; GP330"
/replace=""
/replace="gatg"
/db_xref="dbSNP:3083261"
polyA_signal 15714..15719
/gene="LRP2"
/gene_synonym="DBS; GP330"
polyA_site 15735
/gene="LRP2"
/gene_synonym="DBS; GP330"
ORIGIN
ggtctaaagggctttatgcactgtctggagggtggggactggcgcgggtagaaaacgggatgcctcgggcgtgggggcaggcttttggccactaggagctggcggaggtgcagacctaaaggagcgttcgctagcagaggcgctgccggtgcggtgtgctacgcgcgcccacctcccggggaaggaacggcgaggccggggaccgtcgcggagatggatcgcgggccggcagcagtggcgtgcacgctgctcctggctctcgtcgcctgcctagcgccggccagtggccaagaatgtgacagtgcgcattttcgctgtggaagtgggcattgcatccctgcagactggaggtgtgatgggaccaaagactgttcagatgacgcggatgaaattggctgcgctgttgtgacctgccagcagggctatttcaagtgccagagtgagggacaatgcatccccaactcctgggtgtgtgaccaagatcaagactgtgatgatggctcagatgaacgtcaagattgctcacaaagtacatgctcaagtcatcagataacatgctccaatggtcagtgtatcccaagtgaatacaggtgcgaccacgtcagagactgccccgatggagctgatgagaatgactgccagtacccaacatgtgagcagcttacttgtgacaatggggcctgctataacaccagtcagaagtgtgattggaaagttgattgcagggactcctcagatgaaatcaactgcactgagatatgcttgcacaatgagttttcatgtggcaatggagagtgtatccctcgtgcttatgtctgtgaccatgacaatgattgccaagacggcagtgacgaacatgcttgcaactatccgacctgcggtggttaccagttcacttgccccagtggccgatgcatttatcaaaactgggtttgtgatggagaagatgactgtaaagataatggagatgaagatggatgtgaaagcggtcctcatgatgttcataaatgttccccaagagaatggtcttgcccagagtcgggacgatgcatctccatttataaagtttgtgatgggattttagattgcccaggaagagaagatgaaaacaacactagtaccggaaaatactgtagtatgactctgtgctctgccttgaactgccagtaccagtgccatgagacgccgtatggaggagcgtgtttttgtcccccaggttatatcatcaaccacaatgacagccgtacctgtgttgagtttgatgattgccagatatggggaatttgtgaccagaagtgtgaaagccgacctggccgtcacctgtgccactgtgaagaagggtatatcttggagcgtggacagtattgcaaagctaatgattcctttggcgaggcctccattatcttctccaatggtcgggatttgttaattggtgatattcatggaaggagcttccggatcctagtggagtctcagaatcgtggagtggccgtgggtgtggctttccactatcacctgcaaagagttttttggacagacaccgtgcaaaataaggttttttcagttgacattaatggtttaaatatccaagaggttctcaatgtttctgttgaaaccccagagaacctggctgtggactgggttaataataaaatctatctagtggaaaccaaggtcaaccgcatagatatggtaaatttggatggaagctatcgggttacccttataactgaaaacttggggcatcctagaggaattgccgtggacccaactgttggttatttatttttctcagattgggagagcctttctggggaacctaagctggaaagggcattcatggatggcagcaaccgtaaagacttggtgaaaacaaagctgggatggcctgctggggtaactctggatatgatatcgaagcgtgtttactgggttgactctcggtttgattacattgaaactgtaacttatgatggaattcaaaggaagactgtagttcatggaggctccctcattcctcatccctttggagtaagcttatttgaaggtcaggtgttctttacagattggacaaagatggccgtgctgaaggcaaacaagttcacagagaccaacccacaagtgtactaccaggcttccctgaggccctatggagtgactgtttaccattccctcagacagccctatgctaccaatccgtgtaaagataacaatgggggctgtgagcaggtctgtgtcctcagccacagaacagataatgatggtttgggtttccgttgcaagtgcacattcggcttccaactggatacagatgagcgccactgcattgctgttcagaatttcctcattttttcatcccaagttgctattcgtgggatcccgttcaccttgtctacccaggaagatgtcatggttccagtttcggggaatccttctttctttgtcgggattgattttgacgcccaggacagcactatctttttttcagatatgtcaaaacacatgatttttaagcaaaagattgatggcacaggaagagaaattctcgcagctaacagggtggaaaatgttgaaagtttggcttttgattggatttcaaagaatctctattggacagactctcattacaagagtatcagtgtcatgaggctagctgataaaacgagacgcacagtagttcagtatttaaataacccacggtcggtggtagttcatccttttgccgggtatctattcttcactgattggttccgtcctgctaaaattatgagagcatggagtgacggatctcacctcttgcctgtaataaacactactcttggatggcccaatggcttggccatcgattgggctgcttcacgattgtactgggtagatgcctattttgataaaattgagcacagcacctttgatggtttagacagaagaagactgggccatatagagcagatgacacatccgtttggacttgccatctttggagagcatttattttttactgactggagactgggtgccattattcgagtcaggaaagcagatggtggagaaatgacagttatccgaagtggcattgcttacatactgcatttgaaatcgtatgatgtcaacatccagactggttctaacgcctgtaatcaacccacgcatcctaacggtgactgcagccacttctgcttcccggtgccaaatttccagcgagtgtgtgggtgcccttatggaatgaggctggcttccaatcacttgacatgcgagggggacccaaccaatgaaccacccacagagcagtgtggcttattttccttcccctgtaaaaatggcagatgtgtgcccaattactatctctgtgatggagtcgatgattgtcatgataacagtgatgagcaactatgtggcacacttaataatacctgttcatcttcggcgttcacctgtggccatggggagtgcattcctgcacactggcgctgtgacaaacgcaacgactgtgtggatggcagtgatgagcacaactgccccacccacgcacctgcttcctgccttgacacccaatacacctgtgataatcaccagtgtatctcaaagaactgggtctgtgacacagacaatgattgtggggatggatctgatgaaaagaactgcaattcgacagagacatgccaacctagtcagtttaattgccccaatcatcgatgtattgacctatcgtttgtctgtgatggtgacaaggattgtgttgatggatctgatgaggttggttgtgtattaaactgtactgcttctcaattcaagtgtgccagtggggataaatgtattggcgtcacaaatcgttgtgatggtgtttttgattgcagtgacaactcggatgaagcaggctgtccaaccaggcctcctggtatgtgccactcagatgaatttcagtgccaagaagatggtatctgcatcccgaacttctgggaatgtgatgggcatccagactgcctctatggatctgatgagcacaatgcctgtgtccccaagacttgcccttcatcatatttccactgtgacaacggaaactgcatccacagggcatggctctgtgatcgggacaatgactgcggggatatgagtgatgagaaggactgccctactcagccctttcgctgtcctagttggcaatggcagtgtcttggccataacatctgtgtgaatctgagtgtagtgtgtgatggcatctttgactgccccaatgggacagatgagtccccactttgcaatgggaacagctgctcagatttcaatggtggttgtactcacgagtgtgttcaagagccctttggggctaaatgcctatgtccattgggattcttacttgccaatgattctaagacctgtgaagacatagatgaatgtgatattctaggctcttgtagccagcactgttacaatatgagaggttctttccggtgctcgtgtgatacaggctacatgttagaaagtgatgggaggacttgcaaagttacagcatctgagagtctgctgttacttgtggcaagtcagaacaaaattattgccgacagtgtcacctcccaggtccacaatatctattcattggtcgagaatggttcttacattgtagctgttgattttgattcaattagtggtcgtatcttttggtctgatgcaactcagggtaaaacctggagtgcgtttcaaaatggaacggacagaagagtggtatttgacagtagcatcatcttgactgaaactattgcaatagattgggtaggtcgtaatctttactggacagactatgctctggaaacaattgaagtctccaaaattgatgggagccacaggactgtgctgattagtaaaaacctaacaaatccaagaggactagcattagatcccagaatgaatgagcatctactgttctggtctgactggggccaccaccctcgcatcgagcgagccagcatggacggcagcatgcgcactgtcattgtccaggacaagatcttctggccctgcggcttaactattgactaccccaacagactgctctacttcatggactcctatcttgattacatggacttttgtgattataatggacaccatcggagacaggtgatagccagtgatttgattatacggcacccctatgccctaactctctttgaagactctgtgtactggactgaccgtgctactcgtcgggttatgcgagccaacaagtggcatggagggaaccagtcagttgtaatgtataatattcaatggccccttgggattgttgcggttcatccttcgaaacaaccaaattccgtgaatccatgtgccttttcccgctgcagccatctctgcctgctttcctcacaggggcctcatttttactcctgtgtttgtccttcaggatggagtctgtctcctgatctcctgaattgcttgagagatgatcaacctttcttaataactgtaaggcaacatataatttttggaatctcccttaatcctgaggtgaagagcaatgatgctatggtccccatagcagggatacagaatggtttagatgttgaatttgatgatgctgagcaatacatctattgggttgaaaatccaggtgaaattcacagagtgaagacagatggcaccaacaggacagtatttgcttctatatctatggtggggccttctatgaacctggccttagattggatttcaagaaacctttattctaccaatcctagaactcagtcaatcgaggttttgacactccacggagatatcagatacagaaaaacattgattgccaatgatgggacagctcttggagttggctttccaattggcataactgttgatcctgctcgtgggaagctgtactggtcagaccaaggaactgacagtggggttcctgccaagatcgccagtgctaacatggatggcacatctgtgaaaactctctttactgggaacctcgaacacctggagtgtgtcactcttgacatcgaagagcagaaactctactgggcagtcactggaagaggagtgattgaaagaggaaacgtggatggaacagatcgaatgatcctggtacaccagctttcccacccctggggaattgcagtccatgattctttcctttattatactgatgaacagtatgaggtcattgaaagagttgataaggccactggggccaacaaaatagtcttgagagataatgttccaaatctgaggggtcttcaagtttatcacagacgcaatgccgccgaatcctcaaatggctgtagcaacaacatgaatgcctgtcagcagatttgcctgcctgtaccaggaggattgttttcctgcgcctgtgccactggatttaaactcaatcctgataatcggtcctgctctccatataactctttcattgttgtttcaatgctgtctgcaatcagaggctttagcttggaattgtcagatcattcagaaaccatggtgccggtggcaggccaaggacgaaacgcactgcatgtggatgtggatgtgtcctctggctttatttattggtgtgattttagcagctcagtggcatctgataatgcgatccgtagaattaaaccagatggatcttctctgatgaacattgtgacacatggaataggagaaaatggagtccggggtattgcagtggattgggtagcaggaaatctttatttcaccaatgcctttgtttctgaaacactgatagaagttctgcggatcaatactacttaccgccgtgttcttcttaaagtcacagtggacatgcctaggcatattgttgtagatcccaagaacagatacctcttctgggctgactatgggcagagaccaaagattgagcgttctttccttgactgtaccaatcgaacagtgcttgtgtcagagggcattgtcacaccacggggcttggcagtggaccgaagtgatggctacgtttattgggttgatgattctttagatataattgcaaggattcgtatcaatggagagaactctgaagtgattcgttatggcagtcgttacccaactccttatggcatcactgtttttgaaaattctatcatatgggtagataggaatttgaaaaagatcttccaagccagcaaggaaccagagaacacagagccacccacagtgataagagacaatatcaactggctaagagatgtgaccatctttgacaagcaagtccagccccggtcaccagcagaggtcaacaacaacccttgcttggaaaacaatggtgggtgctctcatctctgctttgctctgcctggattgcacaccccaaaatgtgactgtgcctttgggaccctgcaaagtgatggcaagaattgtgccatttcaacagaaaatttcctcatctttgccttgtctaattccttgagaagcttacacttggaccctgaaaaccatagcccacctttccaaacaataaatgtggaaagaactgtcatgtctctagactatgacagtgtaagtgatagaatctacttcacacaaaatttagcctctggagttggacagatttcctatgccaccctgtcttcagggatccatactccaactgtcattgcttcaggtatagggactgctgatggcattgcctttgactggattactagaagaatttattacagtgactacctcaaccagatgattaattccatggctgaagatgggtctaaccgcactgtgatagcccgcgttccaaaaccaagagcaattgtgttagatccctgccaagggtacctgtactgggctgactgggatacacatgccaaaatcgagagagccacattgggaggaaacttccgcgtacccattgtgaacagcagtctggtcatgcccagtgggctgactctggactatgaagaggaccttctctactgggtggatgctagtctgcagaggattgaacgcagcactctgacgggcgtggatcgtgaagtcattgtcaatgcagccgttcatgcttttggcttgactctctatggccagtatatttactggactgacttgtacacacaaagaatttaccgagctaacaaatatgacgggtcaggtcagattgcaatgaccacaaatttgctctcccagcccaggggaatcaacactgttgtgaagaaccagaaacaacagtgtaacaatccttgtgaacagtttaatgggggctgcagccatatctgtgcaccaggtccaaatggtgccgagtgccagtgtccacatgagggcaactggtatttggccaacaacaggaagcactgcattgtggacaatggtgaacgatgtggtgcatcttccttcacctgctccaatgggcgctgcatctcggaagagtggaagtgtgataatgacaacgactgtggggatggcagtgatgagatggaaagtgtctgtgcacttcacacctgctcaccgacagccttcacctgtgccaatgggcgatgtgtccaatactcttaccgctgtgattactacaatgactgtggtgatggcagtgatgaggcagggtgcctgttcagggactgcaatgccaccacggagtttatgtgcaataacagaaggtgcatacctcgtgagtttatctgcaatggtgtagacaactgccatgataataacacttcagatgagaaaaattgccctgatcgcacttgccagtctggatacacaaaatgtcataattcaaatatttgtattcctcgcgtttatttgtgtgacggagacaatgactgtggagataacagtgatgaaaaccctacttattgcaccactcacacgtgcagcagcagtgagttccaatgcgcatctgggcgctgtattcctcaacattggtattgtgatcaagaaacagattgttttgatgcctctgatgaacctgcctcttgtggtcactctgagcgaacatgcctagctgatgagttcaagtgtgatggtgggaggtgcatcccaagcgaatggatctgtgacggtgataatgactgtggggatatgagtgacgaggataaaaggcaccagtgtcagaatcaaaactgctcggattccgagtttctctgtgtaaatgacagacctccggacaggaggtgcattccccagtcttgggtctgtgatggcgatgtggattgtactgacggctacgatgagaatcagaattgcaccaggagaacttgctctgaaaatgaattcacctgtggttacggactgtgtatcccaaagatattcaggtgtgaccggcacaatgactgtggtgactatagcgacgagaggggctgcttataccagacttgccaacagaatcagtttacctgtcagaacgggcgctgcattagtaaaaccttcgtctgtgatgaggataatgactgtggagacggatctgatgagctgatgcacctgtgccacaccccagaacccacgtgtccacctcacgagttcaagtgtgacaatgggcgctgcatcgagatgatgaaactctgcaaccacctagatgactgtttggacaacagcgatgagaaaggctgtggcattaatgaatgccatgacccttcaatcagtggctgcgatcacaactgcacagacaccttaaccagtttctattgttcctgtcgtcctggttacaagctcatgtctgacaagcggacttgtgttgatattgatgaatgcacagagatgccttttgtctgtagccagaagtgtgagaatgtaataggctcctacatctgtaagtgtgccccaggctacctccgagaaccagatggaaagacctgccggcaaaacagtaacatcgaaccctatctcatttttagcaaccgttactatttgagaaatttaactatagatggctatttttactccctcatcttggaaggactggacaatgttgtggcattagattttgaccgagtagagaagagattgtattggattgatacacagaggcaagtcattgagagaatgtttctgaataagacaaacaaggagacaatcataaaccacagactaccagctgcagaaagtctggctgtagactgggtttccagaaagctctactggttggatgcccgcctggatggcctctttgtctctgacctcaatggtggacaccgccgcatgctggcccagcactgtgtggatgccaacaacaccttctgctttgataatcccagaggacttgcccttcaccctcaatatgggtacctctactgggcagactggggtcaccgcgcatacattgggagagtaggcatggatggaaccaacaagtctgtgataatctccaccaagttagagtggcctaatggcatcaccattgattacaccaatgatctactctactgggcagatgcccacctgggttacatagagtactctgatttggagggccaccatcgacacacggtgtatgatggggcactgcctcaccctttcgctattaccatttttgaagacactatttattggacagattggaatacaaggacagtggaaaagggaaacaaatatgatggatcaaatagacagacactggtgaacacaacacacagaccatttgacatccatgtgtaccatccatataggcagcccattgtgagcaatccctgtggtaccaacaatggtggctgttctcatctctgcctcatcaagccaggaggaaaagggttcacttgcgagtgtccagatgacttccgcacccttcagctgagtggcagcacctactgcatgcccatgtgctccagcacccagttcctgtgcgctaacaatgaaaagtgcattcctatctggtggaaatgtgatggacagaaagactgctcagatggctctgatgaactggccctttgcccgcagcgcttctgccgactgggacagttccagtgcagtgacggcaactgcaccagcccgcagactttatgcaatgctcaccaaaattgccctgatgggtctgatgaagaccgtcttctttgtgagaatcaccactgtgactccaatgaatggcagtgcgccaacaaacgttgcatcccagaatcctggcagtgtgacacatttaacgactgtgaggataactcagatgaagacagttcccactgtgccagcaggacctgccggccgggccagtttcggtgtgctaatggccgctgcatcccgcaggcctggaagtgtgatgtggataatgattgtggagaccactcggatgagcccattgaagaatgcatgagctctgcccatctctgtgacaacttcacagaattcagctgcaaaacaaattaccgctgcatcccaaagtgggccgtgtgcaatggtgtagatgactgcagggacaacagtgatgagcaaggctgtgaggagaggacatgccatcctgtgggggatttccgctgtaaaaatcaccactgcatccctcttcgttggcagtgtgatgggcaaaatgactgtggagataactcagatgaggaaaactgtgctccccgggagtgcacagagagcgagtttcgatgtgtcaatcagcagtgcattccctcgcgatggatctgtgaccattacaacgactgtggggacaactcagatgaacgggactgtgagatgaggacctgccatcctgaatattttcagtgtacaagtggacattgtgtacacagtgaactgaaatgcgatggatccgctgactgtttggatgcgtctgatgaagctgattgtcccacacgctttcctgatggtgcatactgccaggctactatgttcgaatgcaaaaaccatgtttgtatcccgccatattggaaatgtgatggcgatgatgactgtggcgatggttcagatgaagaacttcacctgtgcttggatgttccctgtaattcaccaaaccgtttccggtgtgacaacaatcgctgcatttatagtcatgaggtgtgcaatggtgtggatgactgtggagatggaactgatgagacagaggagcactgtagaaaaccgacccctaaaccttgtacagaatatgaatataagtgtggcaatgggcattgcattccacatgacaatgtgtgtgatgatgccgatgactgtggtgactggtccgatgaactgggttgcaataaaggaaaagaaagaacatgtgctgaaaatatatgcgagcaaaattgtacccaattaaatgaaggaggatttatctgctcctgtacagctgggttcgaaaccaatgtttttgacagaacctcctgtctagatatcaatgaatgtgaacaatttgggacttgtccccagcactgcagaaataccaaaggaagttatgagtgtgtctgtgctgatggcttcacgtctatgagtgaccgccctggaaaacgatgtgcagctgagggtagctctcctttgttgctactgcctgacaatgtccgaattcgaaaatataatctctcatctgagaggttctcagagtatcttcaagatgaggaatatatccaagctgttgattatgattgggatcccaaggacataggcctcagtgttgtgtattacactgtgcgaggggagggctctaggtttggtgctatcaaacgtgcctacatccccaactttgaatccggccgcaataatcttgtgcaggaagttgacctgaaactgaaatacgtaatgcagccagatggaatagcagtggactgggttggaaggcatatttactggtcagatgtcaagaataaacgcattgaggtggctaaacttgatggaaggtacagaaagtggctgatttccactgacctggaccaaccagctgctattgctgtgaatcccaaactagggcttatgttctggactgactggggaaaggaacctaaaatcgagtctgcctggatgaatggagaggaccgcaacatcctggttttcgaggaccttggttggccaactggcctttctatcgattatttgaacaatgaccgaatctactggagtgacttcaaggaggacgttattgaaaccataaaatatgatgggactgataggagagtcattgcaaaggaagcaatgaacccttacagcctggacatctttgaagaccagttatactggatatctaaggaaaagggagaagtatggaaacaaaataaatttgggcaaggaaagaaagagaaaacgctggtagtgaacccttggctcactcaagttcgaatctttcatcaactcagatacaataagtcagtgcccaacctttgcaaacagatctgcagccacctctgccttctgagacctggaggatacagctgtgcctgtccccaaggctccagctttatagaggggagcaccactgagtgtgatgcagccatcgaactgcctatcaacctgccccccccatgcaggtgcatgcacggaggaaattgctattttgatgagactgacctccccaaatgcaagtgtcctagcggctacaccggaaaatattgtgaaatggcgttttcaaaaggcatctctccaggaacaaccgcagtagctgtgctgttgacaatcctcttgatcgtcgtaattggagctctggcaattgcaggattcttccactatagaaggaccggctcccttttgcctgctctgcccaagctgccaagcttaagcagtctcgtcaagccctctgaaaatgggaatggggtgaccttcagatcaggggcagatcttaacatggatattggagtgtctggttttggacctgagactgctattgacaggtcaatggcaatgagtgaagactttgtcatggaaatggggaagcagcccataatatttgaaaacccaatgtactcagccagagacagtgctgtcaaagtggttcagccaatccaggtgactgtatctgaaaatgtggataataagaattatggaagtcccataaacccttctgagatagttccagagacaaacccaacttcaccagctgctgatggaactcaggtgacaaaatggaatctcttcaaacgaaaatctaaacaaactaccaactttgaaaatccaatctatgcacagatggagaacgagcaaaaggaaagtgttgctgcgacaccacctccatcaccttcgctccctgctaagcctaagcctccttcgagaagagacccaactccaacctattctgcaacagaagacacttttaaagacaccgcaaatcttgttaaagaagactctgaagtatagctataccagctatttagggaataattagaaacacacttttgcacatatattttttacaaacagatgaaaaaagttaacattcagtactttatgaaaaaaatatatttttccctgtttgcctatagttggaggtatcctgtgtgtctttttttacttatgccgtctcatatttttacaaataattatcacaatgtactatatgtatatctttgcactgaagttgtctgaaggtaatactataaatatattgtatatttgtaaattttggaaagattatcctgttactgaatttgctaataaagatgtctgctgatttggttggtgatcattatagtaaatgatccaacaagaaaaggaattgactggggacctttagccgtgtctaaagaagaggcaccactcatatttcctataaaattatctaggaaaggaatccaggccccgctcttgggtccatttttacacattagcacttaattaatgttcaatattacatgtcaatttgattaatggctatgttgataggggccactatgtgttgtatagacatctggacttgactgtagactcctcagataatacagaaggtaggaaaagcaattcagtttggcccttctgtgtgttggcattgtctaaccagaactctctgtttcatgtgtgttctctcactagctgccaagacaacatttttatttgtgatgtctatgaggaaatcccatatcattaagtgccagtgtcctgcattgagtttgtggttaattaaatgagctcttctgctgatggaccctggagcaatttctcccctcacctgacattcaaggtggtcacctgccctagtagttggagctcagtagctgaatttctgaaaccaaatctgtgtcttcataaaataaggtgcaaaaaaaaaaaataccagttaagtaaagcctcaactgggtttttgtttctatgaaaatatcattataatcactatttatttcctaagttgaacctgaatagaaagggaaaccattcttattaagctttttattaggccctgtggctaaatgtgtacatttatattagaatgtactgtacagtccagatcttttctttaattcttattggttttttttttttttttttttttagagatggagtcttgctatattgccaaggctgatcttgaagtcctgggctcaagtgatcctcccacctcagcctcctgagtggttggggttacgggcgtgagccactgtgcctggcttccagctctcctcttaaatagtgggtatagtctgcacaacaggaaccatggcaggaatatacactttcccatagcaaatagcatacctgactctctgtgctaatattgcacatttgttaaacaatgaatgaatggatggatggatggatggatgaatgaatgaaacatatactactgattattttattccagagttctcaaaatatttgttgctgatattttgagtgctgactgtaattactttgattagataaacaactggaaataatgctgctgaaaaagttctaataaatgtgtattttatcaga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4036 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:4036 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4036 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
GeneID:4036 -> Biological process: GO:0001523 [retinoid metabolic process] evidence: TAS
GeneID:4036 -> Biological process: GO:0006486 [protein glycosylation] evidence: TAS
GeneID:4036 -> Biological process: GO:0006629 [lipid metabolic process] evidence: TAS
GeneID:4036 -> Biological process: GO:0006897 [endocytosis] evidence: TAS
GeneID:4036 -> Biological process: GO:0006898 [receptor-mediated endocytosis] evidence: IEA
GeneID:4036 -> Biological process: GO:0007603 [phototransduction, visible light] evidence: TAS
GeneID:4036 -> Biological process: GO:0008202 [steroid metabolic process] evidence: TAS
GeneID:4036 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
GeneID:4036 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
GeneID:4036 -> Biological process: GO:0042359 [vitamin D metabolic process] evidence: TAS
GeneID:4036 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:4036 -> Cellular component: GO:0005764 [lysosome] evidence: TAS
GeneID:4036 -> Cellular component: GO:0005768 [endosome] evidence: IEA
GeneID:4036 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:4036 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
GeneID:4036 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:4036 -> Cellular component: GO:0005905 [coated pit] evidence: IEA
GeneID:4036 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:4036 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: ISS
GeneID:4036 -> Cellular component: GO:0030139 [endocytic vesicle] evidence: IEA
GeneID:4036 -> Cellular component: GO:0031526 [brush border membrane] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.