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2025-05-09 16:21:06, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003856 2542 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), transcript
variant 2, mRNA.
ACCESSION NM_003856
VERSION NM_003856.2 GI:27894327
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2542)
AUTHORS Chen,L.Q., de Lemos,J.A., Das,S.R., Ayers,C.R. and Rohatgi,A.
TITLE Soluble ST2 is associated with all-cause and cardiovascular
mortality in a population-based cohort: the Dallas Heart Study
JOURNAL Clin. Chem. 59 (3), 536-546 (2013)
PUBMED 23220272
REMARK GeneRIF: Soluble ST2 is associated with all-cause and
cardiovascular mortality in a population-based cohort.
REFERENCE 2 (bases 1 to 2542)
AUTHORS Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee
JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K,
Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z,
Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN,
Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A,
Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De
Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson
LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas
J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH,
Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees
CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W,
Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M,
Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber
S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M,
Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier
RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V,
Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD,
Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and
Cho JH.
CONSRTM International IBD Genetics Consortium (IIBDGC)
TITLE Host-microbe interactions have shaped the genetic architecture of
inflammatory bowel disease
JOURNAL Nature 491 (7422), 119-124 (2012)
PUBMED 23128233
REFERENCE 3 (bases 1 to 2542)
AUTHORS Hirota,T., Takahashi,A., Kubo,M., Tsunoda,T., Tomita,K.,
Sakashita,M., Yamada,T., Fujieda,S., Tanaka,S., Doi,S.,
Miyatake,A., Enomoto,T., Nishiyama,C., Nakano,N., Maeda,K.,
Okumura,K., Ogawa,H., Ikeda,S., Noguchi,E., Sakamoto,T., Hizawa,N.,
Ebe,K., Saeki,H., Sasaki,T., Ebihara,T., Amagai,M., Takeuchi,S.,
Furue,M., Nakamura,Y. and Tamari,M.
TITLE Genome-wide association study identifies eight new susceptibility
loci for atopic dermatitis in the Japanese population
JOURNAL Nat. Genet. 44 (11), 1222-1226 (2012)
PUBMED 23042114
REFERENCE 4 (bases 1 to 2542)
AUTHORS Salker,M.S., Nautiyal,J., Steel,J.H., Webster,Z., Sucurovic,S.,
Nicou,M., Singh,Y., Lucas,E.S., Murakami,K., Chan,Y.W., James,S.,
Abdallah,Y., Christian,M., Croy,B.A., Mulac-Jericevic,B., Quenby,S.
and Brosens,J.J.
TITLE Disordered IL-33/ST2 activation in decidualizing stromal cells
prolongs uterine receptivity in women with recurrent pregnancy loss
JOURNAL PLoS ONE 7 (12), E52252 (2012)
PUBMED 23300625
REMARK GeneRIF: Il-33/ST2 activation in HESCS drives an autoinflammatory
response that controls the temporal expression of receptivity genes
REFERENCE 5 (bases 1 to 2542)
AUTHORS Ramasamy A, Kuokkanen M, Vedantam S, Gajdos ZK, Couto Alves A, Lyon
HN, Ferreira MA, Strachan DP, Zhao JH, Abramson MJ, Brown MA, Coin
L, Dharmage SC, Duffy DL, Haahtela T, Heath AC, Janson C, Kahonen
M, Khaw KT, Laitinen J, Le Souef P, Lehtimaki T, Madden PA, Marks
GB, Martin NG, Matheson MC, Palmer CD, Palotie A, Pouta A,
Robertson CF, Viikari J, Widen E, Wjst M, Jarvis DL, Montgomery GW,
Thompson PJ, Wareham N, Eriksson J, Jousilahti P, Laitinen T,
Pekkanen J, Raitakari OT, O'Connor GT, Salomaa V, Jarvelin MR and
Hirschhorn JN.
CONSRTM Australian Asthma Genetics Consortium Collaborators
TITLE Genome-wide association studies of asthma in population-based
cohorts confirm known and suggested loci and identify an additional
association near HLA
JOURNAL PLoS ONE 7 (9), E44008 (2012)
PUBMED 23028483
REFERENCE 6 (bases 1 to 2542)
AUTHORS Lohning,M., Stroehmann,A., Coyle,A.J., Grogan,J.L., Lin,S.,
Gutierrez-Ramos,J.C., Levinson,D., Radbruch,A. and Kamradt,T.
TITLE T1/ST2 is preferentially expressed on murine Th2 cells, independent
of interleukin 4, interleukin 5, and interleukin 10, and important
for Th2 effector function
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (12), 6930-6935 (1998)
PUBMED 9618516
REFERENCE 7 (bases 1 to 2542)
AUTHORS Kumar,S., Tzimas,M.N., Griswold,D.E. and Young,P.R.
TITLE Expression of ST2, an interleukin-1 receptor homologue, is induced
by proinflammatory stimuli
JOURNAL Biochem. Biophys. Res. Commun. 235 (3), 474-478 (1997)
PUBMED 9207179
REFERENCE 8 (bases 1 to 2542)
AUTHORS Yanagisawa,K., Naito,Y., Kuroiwa,K., Arai,T., Furukawa,Y.,
Tomizuka,H., Miura,Y., Kasahara,T., Tetsuka,T. and Tominaga,S.
TITLE The expression of ST2 gene in helper T cells and the binding of ST2
protein to myeloma-derived RPMI8226 cells
JOURNAL J. Biochem. 121 (1), 95-103 (1997)
PUBMED 9058198
REFERENCE 9 (bases 1 to 2542)
AUTHORS Gayle,M.A., Slack,J.L., Bonnert,T.P., Renshaw,B.R., Sonoda,G.,
Taguchi,T., Testa,J.R., Dower,S.K. and Sims,J.E.
TITLE Cloning of a putative ligand for the T1/ST2 receptor
JOURNAL J. Biol. Chem. 271 (10), 5784-5789 (1996)
PUBMED 8621446
REFERENCE 10 (bases 1 to 2542)
AUTHORS Tominaga,S., Yokota,T., Yanagisawa,K., Tsukamoto,T., Takagi,T. and
Tetsuka,T.
TITLE Nucleotide sequence of a complementary DNA for human ST2
JOURNAL Biochim. Biophys. Acta 1171 (2), 215-218 (1992)
PUBMED 1482686
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC030975.1.
On Jan 24, 2003 this sequence version replaced gi:4507244.
Summary: The protein encoded by this gene is a member of the
interleukin 1 receptor family. Studies of the similar gene in mouse
suggested that this receptor can be induced by proinflammatory
stimuli, and may be involved in the function of helper T cells.
This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1
receptor, type II (IL1R2) and interleukin 1 receptor-like 2
(IL1RL2) form a cytokine receptor gene cluster in a region mapped
to chromosome 2q12. Alternative splicing of this gene results in
multiple transcript variants. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) differs in the 5' and 3' UTR,
compared to variant 1. The resulting isoform (2) has a distinct and
shorter C-terminus, as compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC030975.1, AK291578.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..2542
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q12"
gene 1..2542
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="interleukin 1 receptor-like 1"
/db_xref="GeneID:9173"
/db_xref="HGNC:5998"
/db_xref="MIM:601203"
exon 1..81
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
misc_feature 1..79
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="Region: the 5' UTR different from variant 1"
variation 11
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:7571371"
variation 61
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185771771"
exon 82..291
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
variation 159
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:13431828"
variation 160
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:77378267"
variation 169
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:370403265"
misc_feature 216..218
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="upstream in-frame stop codon"
variation 219
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372016897"
CDS 231..1217
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="isoform 2 precursor is encoded by transcript
variant 2; homolog of mouse growth stimulation-expressed;
interleukin 1 receptor-related protein; interleukin-1
receptor-like 1"
/codon_start=1
/product="interleukin-1 receptor-like 1 isoform 2
precursor"
/protein_id="NP_003847.2"
/db_xref="GI:27894328"
/db_xref="CCDS:CCDS2058.1"
/db_xref="GeneID:9173"
/db_xref="HGNC:5998"
/db_xref="MIM:601203"
/translation="
MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKECF
"
sig_peptide 231..284
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
misc_feature 276..542
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="First immunoglobulin (Ig)-like domain of
interleukin-1 receptor (IL1R) and similar proteins;
Region: Ig1_IL1R_like; cd05756"
/db_xref="CDD:143233"
misc_feature order(282..284,288..305)
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="antagonist binding site; other site"
/db_xref="CDD:143233"
mat_peptide 285..1214
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/product="interleukin-1 receptor-like 1 isoform 2"
misc_feature 582..842
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="Second immunoglobulin (Ig)-like domain of
interleukin-1 receptor (IL1R) and similar proteins;
Region: Ig2_IL1R_like; cd05757"
/db_xref="CDD:143234"
misc_feature order(582..587,591..602,618..620,633..635,639..641,
723..725,837..839)
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="antagonist binding site; other site"
/db_xref="CDD:143234"
variation 249
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:142516188"
variation 250
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201837678"
variation 257
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115399106"
variation 269
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200098412"
variation 283
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376279073"
exon 292..502
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
variation 335
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144435600"
variation 339
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146539272"
variation 365
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190188722"
variation 366
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:182781591"
variation 369
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201523855"
variation 374
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:147316935"
variation 403
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140931129"
variation 408
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146872465"
variation 414
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375754947"
variation 420
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:202037442"
variation 463
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1041973"
variation 468
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200028993"
variation 469
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34210856"
variation 487
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145568700"
variation 490
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369779260"
exon 503..677
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
variation 529
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141061248"
variation 536
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:148229923"
variation 543
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200221077"
variation 545
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:111382791"
variation 552
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:199800154"
variation 597
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:371207219"
variation 599
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140675864"
variation 614
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:376294785"
variation 629
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:149494752"
variation 637
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:143378674"
variation 658
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367674419"
variation 660
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141010284"
variation 677
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200484415"
exon 678..840
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
variation 688
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:114797672"
variation 713
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142878092"
variation 716
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:189627011"
variation 755
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200131845"
variation 756
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34225180"
variation 767
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368736748"
variation 769
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141101455"
variation 796
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:148867750"
variation 806
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112336397"
variation 814
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201973706"
variation 817
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200831341"
variation 821
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:368468978"
variation 826
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368053458"
variation 831
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137964169"
variation 832
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143458919"
variation 833
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201621624"
variation 834
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201365371"
exon 841..912
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
variation 873
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75320001"
variation 876
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111970215"
variation 880
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:188504053"
variation 882
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373122141"
exon 913..1054
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
variation 921
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75779188"
variation 974
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150894779"
variation 975
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:146105446"
variation 977
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372957266"
variation 982
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140073514"
exon 1055..2508
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/inference="alignment:Splign:1.39.8"
variation 1088
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199635856"
variation 1103
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35298562"
variation 1116
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:146406137"
variation 1120
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140301260"
variation 1121
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:373664545"
variation 1134
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150347157"
variation 1159
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368714053"
STS 1161..1325
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/standard_name="RH68200"
/db_xref="UniSTS:79528"
variation 1175
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372391703"
variation 1190
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202062299"
misc_feature 1201..2542
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/note="Region: 3' region different from variant 1"
STS 1266..1426
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/standard_name="D2S2552"
/db_xref="UniSTS:58525"
variation 1266
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375803902"
variation 1267
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:191129267"
variation 1301
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139756621"
variation 1332
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12905"
variation 1446
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:144457031"
variation 1534
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:184372967"
variation 1535
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:3771175"
variation 1584
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:114464599"
variation 1606
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:3821204"
variation 1641
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146609476"
variation 1711
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:192786331"
variation 1728
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368205427"
variation 1810
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:13001714"
variation 1812
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:13007174"
variation 1837
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:112204660"
variation 1838
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113456083"
variation 1858
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="t"
/db_xref="dbSNP:139845574"
variation 1909
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:12712142"
variation 1923
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:116953957"
variation 1926
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115600688"
variation 1952
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="g"
/db_xref="dbSNP:189187555"
variation 1957
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114564028"
variation 2042
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369264182"
variation 2069
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:113709807"
variation 2117
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:73004222"
variation 2132
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:181674853"
variation 2144
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:13007819"
variation 2149
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2160203"
variation 2176
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="g"
/replace="t"
/db_xref="dbSNP:114520889"
variation 2183
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184750440"
variation 2306
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149041524"
variation 2397
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189476163"
variation 2406
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:58758331"
variation 2430
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147861961"
polyA_signal 2487..2492
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
polyA_site 2508
/gene="IL1RL1"
/gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
gaggagggacctacaaagactggaaactattcttagctccgtcactgactccaagttcatcccctctgtctttcagtttggttgagatataggctactcttcccaactcagtcttgaagagtatcaccaactgcctcatgtgtggtgaccttcactgtcgtatgccagtgactcatctggagtaatctcaacaacgagttaccaatacttgctcttgattgataaacagaatggggttttggatcttagcaattctcacaattctcatgtattccacagcagcaaagtttagtaaacaatcatggggcctggaaaatgaggctttaattgtaagatgtcctagacaaggaaaacctagttacaccgtggattggtattactcacaaacaaacaaaagtattcccactcaggaaagaaatcgtgtgtttgcctcaggccaacttctgaagtttctaccagctgcagttgctgattctggtatttatacctgtattgtcagaagtcccacattcaataggactggatatgcgaatgtcaccatatataaaaaacaatcagattgcaatgttccagattatttgatgtattcaacagtatctggatcagaaaaaaattccaaaatttattgtcctaccattgacctctacaactggacagcacctcttgagtggtttaagaattgtcaggctcttcaaggatcaaggtacagggcgcacaagtcatttttggtcattgataatgtgatgactgaggacgcaggtgattacacctgtaaatttatacacaatgaaaatggagccaattatagtgtgacggcgaccaggtccttcacggtcaaggatgagcaaggcttttctctgtttccagtaatcggagcccctgcacaaaatgaaataaaggaagtggaaattggaaaaaacgcaaacctaacttgctctgcttgttttggaaaaggcactcagttcttggctgccgtcctgtggcagcttaatggaacaaaaattacagactttggtgaaccaagaattcaacaagaggaagggcaaaatcaaagtttcagcaatgggctggcttgtctagacatggttttaagaatagctgacgtgaaggaagaggatttattgctgcagtacgactgtctggccctgaatttgcatggcttgagaaggcacaccgtaagactaagtaggaaaaatccaagtaaggagtgtttctgagactttgatcacctgaactttctctagcaagtgtaagcagaatggagtgtggttccaagagatccatcaagacaatgggaatggcctgtgccataaaatgtgcttctcttcttcgggatgttgtttgctgtctgatctttgtagactgttcctgtttgctgggagcttctctgctgcttaaattgttcgtcctcccccactccctcctatcgttggtttgtctagaacactcagctgcttctttggtcatccttgttttctaactttatgaactccctctgtgtcactgtatgtgaaaggaaatgcaccaacaaccgtaaactgaacgtgttcttttgtgctcttttataacttgcattacatgttgtaagcatggtccgttctatacctttttctggtcataatgaacactcattttgttagcgagggtggtaaagtgaacaaaaaggggaagtatcaaactactgccatttcagtgagaaaatcctaggtgctactttataataagacatttgttaggccattcttgcattgatataaagaaatacctgagactgggtgatttatatgaaaagaggtttaattggctcacagttctgcaggctgtatgggaagcatggcggcatctgcttctggggacacctcaggagctttactcatggcagaaggcaaagcaaaggcaggcacttcacacagtaaaagcaggagcgagagagaggtgccacactgaaacagccagatctcatgagaagtcactcactattgcaaggacagcatcaaagagatggtgctaaaccattcatgatgaactcacccccatgatccaatcacctcccaccaggctccacctcgaatactggggattaccattcagcatgagatttgggcaggaacacagacccaaaccataccacacacattatcattgttaaactttgtaaagtatttaaggtacatggaacacacgggaagtctggtagctcagcccatttctttattgcatctgttattcaccatgtaattcaggtaccacgtattccagggagcctttcttggccctcagtttgcagtatacacactttccaagtactcttgtagcatcctgtttgtatcatagcactggtcacattgccttacctaaatctgtttgacagtctgctcaacacgactgcaagctccatgagggcagggacatcatctcttccatctttgggtccttagtgcaatacctggcagctagccagtgctcagctaaatatttgttgactgaataaatgaatgcacaaccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9173 -> Molecular function: GO:0002113 [interleukin-33 binding] evidence: IEA
GeneID:9173 -> Molecular function: GO:0002114 [interleukin-33 receptor activity] evidence: IEA
GeneID:9173 -> Molecular function: GO:0004896 [cytokine receptor activity] evidence: TAS
GeneID:9173 -> Molecular function: GO:0004908 [interleukin-1 receptor activity] evidence: IEA
GeneID:9173 -> Molecular function: GO:0005057 [receptor signaling protein activity] evidence: TAS
GeneID:9173 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9173 -> Biological process: GO:0002826 [negative regulation of T-helper 1 type immune response] evidence: IEA
GeneID:9173 -> Biological process: GO:0006955 [immune response] evidence: NAS
GeneID:9173 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:9173 -> Biological process: GO:0032689 [negative regulation of interferon-gamma production] evidence: IEA
GeneID:9173 -> Biological process: GO:0032754 [positive regulation of interleukin-5 production] evidence: IEA
GeneID:9173 -> Biological process: GO:0043032 [positive regulation of macrophage activation] evidence: IEA
GeneID:9173 -> Biological process: GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEA
GeneID:9173 -> Biological process: GO:0050729 [positive regulation of inflammatory response] evidence: IEA
GeneID:9173 -> Biological process: GO:0090197 [positive regulation of chemokine secretion] evidence: IEA
GeneID:9173 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:9173 -> Cellular component: GO:0009897 [external side of plasma membrane] evidence: IEA
GeneID:9173 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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