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2025-05-09 17:00:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002091 863 bp mRNA linear PRI 30-MAY-2013
DEFINITION Homo sapiens gastrin-releasing peptide (GRP), transcript variant 1,
mRNA.
ACCESSION NM_002091
VERSION NM_002091.3 GI:34222290
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 863)
AUTHORS Nordlund,M.S., Stieber,P., Brustugun,O.T., Warren,D.J. and Paus,E.
TITLE Characteristics and clinical validity of two immunoassays for
ProGRP
JOURNAL Tumour Biol. 33 (4), 1105-1113 (2012)
PUBMED 22399443
REMARK GeneRIF: Data indicate that progastrin-releasing peptide (proGRP)
assays with both time-resolved immunofluorometric assay (TR-IFMA)
and Advanced Life Science Institute (ALSI) ELISA showed good
clinical validity.
REFERENCE 2 (bases 1 to 863)
AUTHORS Ono,A., Naito,T., Ito,I., Watanabe,R., Shukuya,T., Kenmotsu,H.,
Tsuya,A., Nakamura,Y., Murakami,H., Kaira,K., Takahashi,T.,
Kameya,T., Nakajima,T., Endo,M. and Yamamoto,N.
TITLE Correlations between serial pro-gastrin-releasing peptide and
neuron-specific enolase levels, and the radiological response to
treatment and survival of patients with small-cell lung cancer
JOURNAL Lung Cancer 76 (3), 439-444 (2012)
PUBMED 22300752
REMARK GeneRIF: Percent changes in serum ProGRP showed better correlation
to the sum of the tumor diameters (SOD) and prognostic impact than
that of NSE.
REFERENCE 3 (bases 1 to 863)
AUTHORS Tattersall,M., Cordeaux,Y., Charnock-Jones,D.S. and Smith,G.C.
TITLE Expression of gastrin-releasing peptide is increased by prolonged
stretch of human myometrium, and antagonists of its receptor
inhibit contractility
JOURNAL J. Physiol. (Lond.) 590 (PT 9), 2081-2093 (2012)
PUBMED 22411014
REMARK GeneRIF: Tonic stretch of human myometrium increases contractility
and stimulates the expression of a known smooth muscle stimulatory
agonist, GRP. GRP receptor antagonists attenuate the effect of
stretch.
REFERENCE 4 (bases 1 to 863)
AUTHORS Patel,O., Clyde,D., Chang,M., Nordlund,M.S., Steel,R., Kemp,B.E.,
Pritchard,D.M., Shulkes,A. and Baldwin,G.S.
TITLE Pro-GRP-derived peptides are expressed in colorectal cancer cells
and tumors and are biologically active in vivo
JOURNAL Endocrinology 153 (3), 1082-1092 (2012)
PUBMED 22202166
REMARK GeneRIF: nonamidated peptides derived from the C terminus of
pro-GRP are expressed in significant quantities in colorectal
cancer cell lines
REFERENCE 5 (bases 1 to 863)
AUTHORS Kim,S.Y., Kim,J.S., Hwang,S.H., Park,H.K., Lee,J.H., Lee,D.H.,
Hah,S.S. and Park do,Y.
TITLE Progastrin-releasing peptide is a candidate marker for quality
control in clinical sample processing and storage
JOURNAL Am. J. Clin. Pathol. 137 (2), 277-282 (2012)
PUBMED 22261454
REMARK GeneRIF: Progastrin-releasing peptide cab be used as a marker for
quality control in clinical sample processing and storage.
REFERENCE 6 (bases 1 to 863)
AUTHORS Baraniuk,J.N., Lundgren,J.D., Shelhamer,J.H. and Kaliner,M.A.
TITLE Gastrin releasing peptide (GRP) binding sites in human bronchi
JOURNAL Neuropeptides 21 (2), 81-84 (1992)
PUBMED 1557184
REFERENCE 7 (bases 1 to 863)
AUTHORS Naylor,S.L., Sakaguchi,A.Y., Spindel,E. and Chin,W.W.
TITLE Human gastrin-releasing peptide gene is located on chromosome 18
JOURNAL Somat. Cell Mol. Genet. 13 (1), 87-91 (1987)
PUBMED 3027902
REFERENCE 8 (bases 1 to 863)
AUTHORS Lebacq-Verheyden,A.M., Bertness,V., Kirsch,I., Hollis,G.F.,
McBride,O.W. and Battey,J.
TITLE Human gastrin-releasing peptide gene maps to chromosome band 18q21
JOURNAL Somat. Cell Mol. Genet. 13 (1), 81-86 (1987)
PUBMED 3027901
REFERENCE 9 (bases 1 to 863)
AUTHORS Sausville,E.A., Lebacq-Verheyden,A.M., Spindel,E.R., Cuttitta,F.,
Gazdar,A.F. and Battey,J.F.
TITLE Expression of the gastrin-releasing peptide gene in human small
cell lung cancer. Evidence for alternative processing resulting in
three distinct mRNAs
JOURNAL J. Biol. Chem. 261 (5), 2451-2457 (1986)
PUBMED 3003116
REFERENCE 10 (bases 1 to 863)
AUTHORS Spindel,E.R., Zilberberg,M.D., Habener,J.F. and Chin,W.W.
TITLE Two prohormones for gastrin-releasing peptide are encoded by two
mRNAs differing by 19 nucleotides
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (1), 19-23 (1986)
PUBMED 3001723
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC004488.2.
On Aug 26, 2003 this sequence version replaced gi:31542859.
Summary: This gene encodes a member of the bombesin-like family of
gastrin-releasing peptides. Its preproprotein, following cleavage
of a signal peptide, is further processed to produce either the 27
aa gastrin-releasing peptide or the 10 aa neuromedin C. These
smaller peptides regulate numerous functions of the
gastrointestinal and central nervous systems, including release of
gastrointestinal hormones, smooth muscle cell contraction, and
epithelial cell proliferation. These peptides are also likely to
play a role in human cancers of the lung, colon, stomach, pancreas,
breast, and prostate. Alternative splicing results in multiple
transcript variants encoding different isoforms. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1). This variant has
also been identified as 'pro-gastrin releasing peptide type 1'.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC004488.2, BE791738.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..863
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21.1-q21.32"
gene 1..863
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/note="gastrin-releasing peptide"
/db_xref="GeneID:2922"
/db_xref="HGNC:4605"
/db_xref="HPRD:08845"
/db_xref="MIM:137260"
exon 1..237
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/inference="alignment:Splign:1.39.8"
CDS 99..545
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/note="isoform 1 preproprotein is encoded by transcript
variant 1; bombesin; neuromedin C; pre-progastrin
releasing peptide; prepro-GRP"
/codon_start=1
/product="gastrin-releasing peptide isoform 1
preproprotein"
/protein_id="NP_002082.2"
/db_xref="GI:31542860"
/db_xref="CCDS:CCDS11971.1"
/db_xref="GeneID:2922"
/db_xref="HGNC:4605"
/db_xref="HPRD:08845"
/db_xref="MIM:137260"
/translation="
MRGRELPLVLLALVLCLAPRGRAVPLPAGGGTVLTKMYPRGNHWAVGHLMGKKSTGESSSVSERGSLKQQLREYIRWEEAARNLLGLIEAKENRNHQPPQPKALGNQQPSWDSEDSSNFKDVGSKGKVGRLSAPGSQREGRNPQLNQQ
"
sig_peptide 99..167
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
proprotein 168..542
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/product="gastrin-releasing peptide proprotein"
mat_peptide 168..248
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/product="gastrin-releasing peptide"
misc_feature 207..209
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02667"
misc_feature 213..215
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02667"
misc_feature 216..218
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02667"
misc_feature 219..260
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/note="Bombesin-like peptide; Region: Bombesin; pfam02044"
/db_xref="CDD:110990"
mat_peptide 219..248
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/product="neuromedin C"
/exception="alternative processing"
misc_feature 222..224
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02666"
misc_feature 225..227
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02666"
misc_feature 228..230
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02666"
misc_feature 231..233
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02666"
misc_feature 240..242
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02666"
misc_feature 246..248
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/experiment="experimental evidence, no additional details
recorded"
/note="Methionine amide; propagated from
UniProtKB/Swiss-Prot (P07492.2); amidation site"
variation 108
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="c"
/db_xref="dbSNP:1062557"
variation 116
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:372288358"
variation 132
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="g"
/db_xref="dbSNP:35957920"
variation 149
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="g"
/db_xref="dbSNP:1042431"
exon 238..480
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/inference="alignment:Splign:1.39.8"
variation 242
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:199962860"
variation 247
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:368410424"
variation 261
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="g"
/db_xref="dbSNP:375754489"
variation 278
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:146673900"
variation 289
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="g"
/db_xref="dbSNP:143274265"
STS 300..493
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/standard_name="Grp"
/db_xref="UniSTS:498770"
variation 318
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="g"
/replace="t"
/db_xref="dbSNP:374866055"
variation 338
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="g"
/replace="t"
/db_xref="dbSNP:377146993"
variation 361
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:368021851"
variation 370
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="g"
/db_xref="dbSNP:371397932"
variation 407
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="c"
/db_xref="dbSNP:375963114"
variation 423
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:148328512"
variation 427
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:200302824"
variation 428
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="g"
/replace="t"
/db_xref="dbSNP:55796466"
variation 461
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:15526"
exon 481..848
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/inference="alignment:Splign:1.39.8"
variation 485
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:200574825"
variation 513..516
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace=""
/replace="gaag"
/db_xref="dbSNP:149962068"
variation 515
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="g"
/db_xref="dbSNP:185933795"
variation 554
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="g"
/replace="t"
/db_xref="dbSNP:376342645"
STS 557..831
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/standard_name="D18S1265"
/db_xref="UniSTS:68109"
STS 579..823
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/standard_name="STS-K02054"
/db_xref="UniSTS:9077"
variation 583
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:369600106"
variation 616
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:2742"
variation 762
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="c"
/replace="t"
/db_xref="dbSNP:144426024"
variation 769
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="t"
/db_xref="dbSNP:1803673"
variation 820
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="c"
/db_xref="dbSNP:3180482"
polyA_signal 822..827
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
variation 839
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
/replace="a"
/replace="g"
/db_xref="dbSNP:72956189"
polyA_site 848
/gene="GRP"
/gene_synonym="BN; GRP-10; preproGRP; proGRP"
ORIGIN
ccagcggctgcggcggcggagctcctccgaggtccgggtcaccagtctctgctcttcccagcctctccggcgcgctccaagggcttcccgtcgggaccatgcgcggccgtgagctcccgctggtcctgctggcgctggtcctctgcctggcgccccgggggcgagcggtcccgctgcctgcgggcggagggaccgtgctgaccaagatgtacccgcgcggcaaccactgggcggtggggcacttaatggggaaaaagagcacaggggagtcttcttctgtttctgagagagggagcctgaagcagcagctgagagagtacatcaggtgggaagaagctgcaaggaatttgctgggtctcatagaagcaaaggagaacagaaaccaccagccacctcaacccaaggccctgggcaatcagcagccttcgtgggattcagaggatagcagcaacttcaaagatgtaggttcaaaaggcaaagttggtagactctctgctccaggttctcaacgtgaaggaaggaacccccagctgaaccagcaatgataatgatggcctctctcaaaagagaaaaacaaaacccctaagagactgcgttctgcaagcatcagttctacggatcatcaacaagatttccttgtgcaaaatatttgactattctgtatctttcatccttgactaaattcgtgattttcaagcagcatcttctggtttaaacttgtttgctgtgaacaattgtcgaaaagagtcttccaattaatgcttttttatatctaggctacctgttggttagattcaaggccccgagctgttaccattcacaataaaagcttaaacacattgtccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2922 -> Molecular function: GO:0005102 [receptor binding] evidence: NAS
GeneID:2922 -> Molecular function: GO:0005184 [neuropeptide hormone activity] evidence: IDA
GeneID:2922 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:2922 -> Biological process: GO:0007218 [neuropeptide signaling pathway] evidence: IDA
GeneID:2922 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:2922 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
by
@meso_cacase at
DBCLS
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