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2025-05-09 16:48:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001935 3913 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens dipeptidyl-peptidase 4 (DPP4), mRNA.
ACCESSION NM_001935
VERSION NM_001935.3 GI:47078262
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3913)
AUTHORS Khurana,S., Margamuljana,L., Joseph,C., Schouteden,S., Buckley,S.M.
and Verfaillie,C.M.
TITLE Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism
in hematopoietic stem cell homing and maintenance
JOURNAL Blood 121 (14), 2587-2595 (2013)
PUBMED 23327927
REMARK GeneRIF: We identified tissue-factor pathway inhibitor (TFPI) as a
biological inhibitor of CD26 in murine and human hematopoietic stem
cells.
REFERENCE 2 (bases 1 to 3913)
AUTHORS Raj,V.S., Mou,H., Smits,S.L., Dekkers,D.H., Muller,M.A.,
Dijkman,R., Muth,D., Demmers,J.A., Zaki,A., Fouchier,R.A.,
Thiel,V., Drosten,C., Rottier,P.J., Osterhaus,A.D., Bosch,B.J. and
Haagmans,B.L.
TITLE Dipeptidyl peptidase 4 is a functional receptor for the emerging
human coronavirus-EMC
JOURNAL Nature 495 (7440), 251-254 (2013)
PUBMED 23486063
REMARK GeneRIF: identification of dipeptidyl peptidase 4 (DPP4; also known
as CD26) as a functional receptor for hCoV-EMC
REFERENCE 3 (bases 1 to 3913)
AUTHORS Higashibata,T., Naito,M., Mori,A., Ozawa,N., Furuta,M.,
Tsuchiya,R., Koyama,E., Morita,E., Kawai,S., Okada,R., Yin,G.,
Wakai,K. and Hamajima,N.
TITLE DPP4 genetic variants influence baseline prostate-specific antigen
levels: the J-MICC study
JOURNAL Nagoya J Med Sci 75 (1-2), 73-80 (2013)
PUBMED 23544270
REMARK GeneRIF: DPP4 genetic variants influence baseline PSA levels,
especially in men aged between 60 and 69.
REFERENCE 4 (bases 1 to 3913)
AUTHORS Mahmoudi,M., Hedayat,M., Aghamohammadi,A. and Rezaei,N.
TITLE Soluble CD26 and CD30 levels in patients with common variable
immunodeficiency
JOURNAL J Investig Allergol Clin Immunol 23 (2), 120-124 (2013)
PUBMED 23654079
REMARK GeneRIF: There is the association between high levels of soluble
serum CD26 and CD30 and disease severity.
REFERENCE 5 (bases 1 to 3913)
AUTHORS Marfella,R., Sasso,F.C., Rizzo,M.R., Paolisso,P., Barbieri,M.,
Padovano,V., Carbonara,O., Gualdiero,P., Petronella,P.,
Ferraraccio,F., Petrella,A., Canonico,R., Campitiello,F., Della
Corte,A., Paolisso,G. and Canonico,S.
TITLE Dipeptidyl peptidase 4 inhibition may facilitate healing of chronic
foot ulcers in patients with type 2 diabetes
JOURNAL Exp Diabetes Res 2012, 892706 (2012)
PUBMED 23197976
REMARK GeneRIF: DPP4 inhibition facilitated wound healing of chronic
diabetic foot ulcers in type 2 diabetics.
REFERENCE 6 (bases 1 to 3913)
AUTHORS Imai,K., Maeda,M., Fujiwara,H., Kariya,M., Takakura,K., Kanzaki,H.
and Mori,T.
TITLE Dipeptidyl peptidase IV as a differentiation marker of the human
endometrial glandular cells
JOURNAL Hum. Reprod. 7 (9), 1189-1194 (1992)
PUBMED 1362202
REFERENCE 7 (bases 1 to 3913)
AUTHORS Misumi,Y., Hayashi,Y., Arakawa,F. and Ikehara,Y.
TITLE Molecular cloning and sequence analysis of human dipeptidyl
peptidase IV, a serine proteinase on the cell surface
JOURNAL Biochim. Biophys. Acta 1131 (3), 333-336 (1992)
PUBMED 1352704
REFERENCE 8 (bases 1 to 3913)
AUTHORS Tanaka,T., Camerini,D., Seed,B., Torimoto,Y., Dang,N.H.,
Kameoka,J., Dahlberg,H.N., Schlossman,S.F. and Morimoto,C.
TITLE Cloning and functional expression of the T cell activation antigen
CD26
JOURNAL J. Immunol. 149 (2), 481-486 (1992)
PUBMED 1352530
REMARK Erratum:[J Immunol. 1993 Mar 1;150(5):2090. PMID: 8094732]
REFERENCE 9 (bases 1 to 3913)
AUTHORS Darmoul,D., Lacasa,M., Baricault,L., Marguet,D., Sapin,C.,
Trotot,P., Barbat,A. and Trugnan,G.
TITLE Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like
colon cancer cell lines HT-29 and Caco-2. Cloning of the complete
human coding sequence and changes of dipeptidyl peptidase IV mRNA
levels during cell differentiation
JOURNAL J. Biol. Chem. 267 (7), 4824-4833 (1992)
PUBMED 1347043
REFERENCE 10 (bases 1 to 3913)
AUTHORS Gorvel,J.P., Ferrero,A., Chambraud,L., Rigal,A., Bonicel,J. and
Maroux,S.
TITLE Expression of sucrase-isomaltase and dipeptidylpeptidase IV in
human small intestine and colon
JOURNAL Gastroenterology 101 (3), 618-625 (1991)
PUBMED 1677636
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC065265.1.
On May 7, 2004 this sequence version replaced gi:18765693.
Summary: The protein encoded by this gene is identical to adenosine
deaminase complexing protein-2, and to the T-cell activation
antigen CD26. It is an intrinsic membrane glycoprotein and a serine
exopeptidase that cleaves X-proline dipeptides from the N-terminus
of polypeptides. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC065265.1, X60708.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3913 BC065265.1 1-3913
FEATURES Location/Qualifiers
source 1..3913
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q24.3"
gene 1..3913
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/note="dipeptidyl-peptidase 4"
/db_xref="GeneID:1803"
/db_xref="HGNC:3009"
/db_xref="HPRD:02187"
/db_xref="MIM:102720"
exon 1..567
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
misc_feature 532..534
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/note="upstream in-frame stop codon"
CDS 562..2862
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/EC_number="3.4.14.5"
/note="dipeptidylpeptidase IV (CD26, adenosine deaminase
complexing protein 2); T-cell activation antigen CD26;
dipeptidylpeptidase 4; ADCP-2; DPP IV; dipeptidyl
peptidase IV"
/codon_start=1
/product="dipeptidyl peptidase 4"
/protein_id="NP_001926.2"
/db_xref="GI:18765694"
/db_xref="CCDS:CCDS2216.1"
/db_xref="GeneID:1803"
/db_xref="HGNC:3009"
/db_xref="HPRD:02187"
/db_xref="MIM:102720"
/translation="
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
"
misc_feature 580..645
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P27487.2);
transmembrane region"
misc_feature 883..1995
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
Region: DPPIV_N; pfam00930"
/db_xref="CDD:201511"
misc_feature <1753..2853
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/note="Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
[Amino acid transport and metabolism]; Region: DAP2;
COG1506"
/db_xref="CDD:31695"
misc_feature 2236..2850
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/note="Prolyl oligopeptidase family; Region: Peptidase_S9;
pfam00326"
/db_xref="CDD:201156"
exon 568..655
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
STS 570..1355
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/standard_name="GDB:207675"
/db_xref="UniSTS:156121"
variation 580
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="a"
/replace="g"
/db_xref="dbSNP:1129598"
variation 585
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="c"
/replace="t"
/db_xref="dbSNP:17574"
variation 642
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="a"
/replace="g"
/db_xref="dbSNP:17575"
exon 656..754
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 755..846
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 847..927
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 928..980
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 981..1053
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 1054..1174
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 1175..1335
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
STS 1277..1588
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/standard_name="GDB:456160"
/db_xref="UniSTS:157476"
exon 1336..1448
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 1449..1584
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 1585..1629
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 1630..1737
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
variation 1700
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="c"
/replace="g"
/db_xref="dbSNP:150619694"
exon 1738..1805
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 1806..1859
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 1860..1981
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
variation 1871
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1129599"
exon 1982..2029
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 2030..2128
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
variation 2036
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="a"
/replace="g"
/db_xref="dbSNP:17848907"
exon 2129..2198
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 2199..2393
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 2394..2448
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 2449..2548
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
variation 2496
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="c"
/replace="t"
/db_xref="dbSNP:17848910"
variation 2522
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="c"
/replace="t"
/db_xref="dbSNP:149643982"
exon 2549..2613
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 2614..2686
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 2687..2760
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
exon 2761..3900
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/inference="alignment:Splign:1.39.8"
STS 3025..3124
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/standard_name="RH47162"
/db_xref="UniSTS:15204"
STS 3054..3214
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/standard_name="SHGC-118"
/db_xref="UniSTS:9518"
variation 3108
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="g"
/replace="t"
/db_xref="dbSNP:13821"
STS 3211..3543
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/standard_name="SHGC-12694"
/db_xref="UniSTS:80816"
STS 3384..3582
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/standard_name="DPP4"
/db_xref="UniSTS:505438"
variation 3607
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/replace="a"
/replace="c"
/db_xref="dbSNP:11537990"
STS 3631..3796
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
/standard_name="RH17451"
/db_xref="UniSTS:672"
polyA_signal 3874..3879
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
polyA_site 3900
/gene="DPP4"
/gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
ORIGIN
ctttcactggcaagagacggagtcctgggtttcagttccagttgcctgcggtgggctgtgtgagtttgccaaagtcccctgccctctctgggtctcggttccctcgcctgtccacgtgaggttggaggagctgaacgccgacgtcatttttagctaagagggagcagggtccccgagtcgccggcccagggtctgcgcatccgaggccgcgcgccctttcccctcccccacggctcctccgggccccgcactctgcgccccggctgccgcccagcgccctacaccgccctcagggggccctcgcgggctccccccggccgggatgccagtgccccgcgccacgcgcgcctgctcccgcgccgcctgccctgcagcctgcccgcggcgcctttatacccagcgggctcggcgctcactaatgtttaactcggggccgaaacttgccagcggcgagtgactccaccgcccggagcagcggtgcaggacgcgcgtctccgccgcccgcggtgacttctgcctgcgctccttctctgaacgctcacttccgaggagacgccgacgatgaagacaccgtggaaggttcttctgggactgctgggtgctgctgcgcttgtcaccatcatcaccgtgcccgtggttctgctgaacaaaggcacagatgatgctacagctgacagtcgcaaaacttacactctaactgattacttaaaaaatacttatagactgaagttatactccttaagatggatttcagatcatgaatatctctacaaacaagaaaataatatcttggtattcaatgctgaatatggaaacagctcagttttcttggagaacagtacatttgatgagtttggacattctatcaatgattattcaatatctcctgatgggcagtttattctcttagaatacaactacgtgaagcaatggaggcattcctacacagcttcatatgacatttatgatttaaataaaaggcagctgattacagaagagaggattccaaacaacacacagtgggtcacatggtcaccagtgggtcataaattggcatatgtttggaacaatgacatttatgttaaaattgaaccaaatttaccaagttacagaatcacatggacggggaaagaagatataatatataatggaataactgactgggtttatgaagaggaagtcttcagtgcctactctgctctgtggtggtctccaaacggcacttttttagcatatgcccaatttaacgacacagaagtcccacttattgaatactccttctactctgatgagtcactgcagtacccaaagactgtacgggttccatatccaaaggcaggagctgtgaatccaactgtaaagttctttgttgtaaatacagactctctcagctcagtcaccaatgcaacttccatacaaatcactgctcctgcttctatgttgataggggatcactacttgtgtgatgtgacatgggcaacacaagaaagaatttctttgcagtggctcaggaggattcagaactattcggtcatggatatttgtgactatgatgaatccagtggaagatggaactgcttagtggcacggcaacacattgaaatgagtactactggctgggttggaagatttaggccttcagaacctcattttacccttgatggtaatagcttctacaagatcatcagcaatgaagaaggttacagacacatttgctatttccaaatagataaaaaagactgcacatttattacaaaaggcacctgggaagtcatcgggatagaagctctaaccagtgattatctatactacattagtaatgaatataaaggaatgccaggaggaaggaatctttataaaatccaacttagtgactatacaaaagtgacatgcctcagttgtgagctgaatccggaaaggtgtcagtactattctgtgtcattcagtaaagaggcgaagtattatcagctgagatgttccggtcctggtctgcccctctatactctacacagcagcgtgaatgataaagggctgagagtcctggaagacaattcagctttggataaaatgctgcagaatgtccagatgccctccaaaaaactggacttcattattttgaatgaaacaaaattttggtatcagatgatcttgcctcctcattttgataaatccaagaaatatcctctactattagatgtgtatgcaggcccatgtagtcaaaaagcagacactgtcttcagactgaactgggccacttaccttgcaagcacagaaaacattatagtagctagctttgatggcagaggaagtggttaccaaggagataagatcatgcatgcaatcaacagaagactgggaacatttgaagttgaagatcaaattgaagcagccagacaattttcaaaaatgggatttgtggacaacaaacgaattgcaatttggggctggtcatatggagggtacgtaacctcaatggtcctgggatcgggaagtggcgtgttcaagtgtggaatagccgtggcgcctgtatcccggtgggagtactatgactcagtgtacacagaacgttacatgggtctcccaactccagaagacaaccttgaccattacagaaattcaacagtcatgagcagagctgaaaattttaaacaagttgagtacctccttattcatggaacagcagatgataacgttcactttcagcagtcagctcagatctccaaagccctggtcgatgttggagtggatttccaggcaatgtggtatactgatgaagaccatggaatagctagcagcacagcacaccaacatatatatacccacatgagccacttcataaaacaatgtttctctttaccttagcacctcaaaataccatgccatttaaagcttattaaaactcatttttgttttcattatctcaaaactgcactgtcaagatgatgatgatctttaaaatacacactcaaatcaagaaacttaaggttacctttgttcccaaatttcatacctatcatcttaagtagggacttctgtcttcacaacagattattaccttacagaagtttgaattatccggtcgggttttattgtttaaaatcatttctgcatcagctgctgaaacaacaaataggaattgtttttatggaggctttgcatagattccctgagcaggattttaatctttttctaactggactggttcaaatgttgttctcttctttaaagggatggcaagatgtgggcagtgatgtcactagggcagggacaggataagagggattagggagagaagatagcagggcatggctgggaacccaagtccaagcataccaacacgagcaggctactgtcagctcccctcggagaagagctgttcacagccagactggcacagttttctgagaaagactattcaaacagtctcaggaaatcaaatatgcaaagcactgacttctaagtaaaaccacagcagttgaaaagactccaaagaaatgtaagggaaactgccagcaacgcaggcccccaggtgccagttatggctataggtgctacaaaaacacagcaagggtgatgggaaagcattgtaaatgtgcttttaaaaaaaaatactgatgttcctagtgaaagaggcagcttgaaactgagatgtgaacacatcagcttgccctgttaaaagatgaaaatatttgtatcacaaatcttaacttgaaggagtccttgcatcaatttttcttatttcatttctttgagtgtcttaattaaaagaatattttaacttccttggactcattttaaaaaatggaacataaaatacaatgttatgtattattattcccattctacatactatggaatttctcccagtcatttaataaatgtgccttcattttttcagaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1803 -> Molecular function: GO:0002020 [protease binding] evidence: IPI
GeneID:1803 -> Molecular function: GO:0004177 [aminopeptidase activity] evidence: IEA
GeneID:1803 -> Molecular function: GO:0004252 [serine-type endopeptidase activity] evidence: IEA
GeneID:1803 -> Molecular function: GO:0005102 [receptor binding] evidence: IPI
GeneID:1803 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1803 -> Molecular function: GO:0008236 [serine-type peptidase activity] evidence: IDA
GeneID:1803 -> Molecular function: GO:0008239 [dipeptidyl-peptidase activity] evidence: IDA
GeneID:1803 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:1803 -> Biological process: GO:0001666 [response to hypoxia] evidence: IDA
GeneID:1803 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:1803 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
GeneID:1803 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
GeneID:1803 -> Biological process: GO:0010716 [negative regulation of extracellular matrix disassembly] evidence: IDA
GeneID:1803 -> Biological process: GO:0031295 [T cell costimulation] evidence: IDA
GeneID:1803 -> Biological process: GO:0033632 [regulation of cell-cell adhesion mediated by integrin] evidence: IDA
GeneID:1803 -> Biological process: GO:0042110 [T cell activation] evidence: IDA
GeneID:1803 -> Biological process: GO:0043542 [endothelial cell migration] evidence: IDA
GeneID:1803 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:1803 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:1803 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:1803 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
GeneID:1803 -> Cellular component: GO:0030027 [lamellipodium] evidence: IDA
GeneID:1803 -> Cellular component: GO:0030139 [endocytic vesicle] evidence: IDA
GeneID:1803 -> Cellular component: GO:0031258 [lamellipodium membrane] evidence: IEA
GeneID:1803 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA
GeneID:1803 -> Cellular component: GO:0046581 [intercellular canaliculus] evidence: IEA
GeneID:1803 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
GeneID:1803 -> Cellular component: GO:0071438 [invadopodium membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001926 -> EC 3.4.14.5
by
@meso_cacase at
DBCLS
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