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2025-05-09 17:15:42, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001042482 2302 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens thiamin pyrophosphokinase 1 (TPK1), transcript variant
2, mRNA.
ACCESSION NM_001042482
VERSION NM_001042482.1 GI:110227856
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2302)
AUTHORS Mayr,J.A., Freisinger,P., Schlachter,K., Rolinski,B.,
Zimmermann,F.A., Scheffner,T., Haack,T.B., Koch,J., Ahting,U.,
Prokisch,H. and Sperl,W.
TITLE Thiamine pyrophosphokinase deficiency in encephalopathic children
with defects in the pyruvate oxidation pathway
JOURNAL Am. J. Hum. Genet. 89 (6), 806-812 (2011)
PUBMED 22152682
REMARK GeneRIF: Mutation analysis of TPK1 uncovered three missense, one
splice-site, and one frameshift mutation resulting in decreased TPK
protein levels
REFERENCE 2 (bases 1 to 2302)
AUTHORS Fradin,D. and Bougneres,P.
TITLE Three common intronic variants in the maternal and fetal thiamine
pyrophosphokinase gene (TPK1) are associated with birth weight
JOURNAL Ann. Hum. Genet. 71 (PT 5), 578-585 (2007)
PUBMED 17295612
REMARK GeneRIF: Genomic variations in either the fetal or maternal TPK1
gene could contribute to variability of birth weight in normal
humans.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 2302)
AUTHORS Onozuka,M., Konno,H., Akaji,K., Nishino,H. and Nosaka,K.
TITLE Molecular cloning and analysis of the 5'-flanking region of the
human thiamin pyrophosphokinase gene
JOURNAL J. Nutr. Sci. Vitaminol. 51 (4), 274-277 (2005)
PUBMED 16262001
REMARK GeneRIF: findings indicate the importance of the Sp1 transcription
factor cis-element in regulating the human thiamin
pyrophosphokinase gene (hTPK1) gene expression
REFERENCE 4 (bases 1 to 2302)
AUTHORS Toyoshima,M., Oka,A., Egi,Y., Yamamoto,T., Onozuka,M., Nosaka,K.,
Naito,E. and Yamada,K.
TITLE Thiamine-responsive congenital lactic acidosis: clinical and
biochemical studies
JOURNAL Pediatr. Neurol. 33 (2), 98-104 (2005)
PUBMED 16087053
REFERENCE 5 (bases 1 to 2302)
AUTHORS Bellyei,S., Szigeti,A., Boronkai,A., Szabo,Z., Bene,J., Janaky,T.,
Barna,L., Sipos,K., Minik,O., Kravjak,A., Ohmacht,R., Melegh,B.,
Zavodszky,P., Than,G.N., Sumegi,B., Bohn,H. and Than,N.G.
TITLE Cloning, sequencing, structural and molecular biological
characterization of placental protein 20 (PP20)/human thiamin
pyrophosphokinase (hTPK)
JOURNAL Placenta 26 (1), 34-46 (2005)
PUBMED 15664409
REFERENCE 6 (bases 1 to 2302)
AUTHORS Nosaka,K., Onozuka,M., Nishino,H., Nishimura,H., Kawasaki,Y. and
Ueyama,H.
TITLE Molecular cloning and expression of a mouse thiamin
pyrophosphokinase cDNA
JOURNAL J. Biol. Chem. 274 (48), 34129-34133 (1999)
PUBMED 10567383
REMARK GeneRIF: This is the first report on the primary sequence for
mammalian thiamin pyrophosphokinase, a protein that catalyzes the
pyrophosphorylation of thiamin with adenosine 5'-triphosphate to
form thiamin pyrophosphate.
REFERENCE 7 (bases 1 to 2302)
AUTHORS Egi,Y., Koyama,S., Shioda,T., Yamada,K. and Kawasaki,T.
TITLE Identification, purification and reconstitution of thiamin
metabolizing enzymes in human red blood cells
JOURNAL Biochim. Biophys. Acta 1160 (2), 171-178 (1992)
PUBMED 1332781
REFERENCE 8 (bases 1 to 2302)
AUTHORS Haas,R.H.
TITLE Thiamin and the brain
JOURNAL Annu. Rev. Nutr. 8, 483-515 (1988)
PUBMED 3060175
REMARK Review article
REFERENCE 9 (bases 1 to 2302)
AUTHORS Bohn,H. and Winckler,W.
TITLE Isolation and characterization of four new placental tissue
proteins (PP18, PP19, PP20, PP21)
JOURNAL Arch. Gynecol. 236 (4), 235-242 (1985)
PUBMED 3896163
REFERENCE 10 (bases 1 to 2302)
AUTHORS Iwashima,A., Kinugasa,A. and Nose,Y.
TITLE Radiometric assay for thiamine pyrophosphokinase activity in human
leukocytes
JOURNAL Acta Vitaminol. Enzymol. 5 (1), 41-45 (1983)
PUBMED 6303095
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA135998.1, BX446289.2,
BI770816.1, AC004534.1 and BC040555.1.
Summary: This gene encodes a protein, that exists as a homodimer,
which catalyzes the conversion of thiamine to thiamine
pyrophosphate. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized. [provided by RefSeq,
Jul 2008].
Transcript Variant: This variant (2) lacks an alternate in-frame
exon, compared to variant 1, resulting in a shorter protein
(isoform b), compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX446289.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-18 DA135998.1 1-18
19-235 BX446289.2 1-217
236-293 BI770816.1 152-209
294-354 BX446289.2 275-335
355-519 BI770816.1 269-433
520-933 BX446289.2 501-914
934-2074 AC004534.1 107534-108674 c
2075-2302 BC040555.1 2598-2825
FEATURES Location/Qualifiers
source 1..2302
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q34-q35"
gene 1..2302
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/note="thiamin pyrophosphokinase 1"
/db_xref="GeneID:27010"
/db_xref="HGNC:17358"
/db_xref="MIM:606370"
exon 1..87
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
variation complement(8)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:189728006"
variation complement(30..31)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="at"
/replace="ga"
/db_xref="dbSNP:34581809"
variation complement(37)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="g"
/replace="t"
/db_xref="dbSNP:185802456"
variation complement(68)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:181214483"
exon 88..146
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
misc_feature 95..97
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/note="upstream in-frame stop codon"
CDS 104..688
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/EC_number="2.7.6.2"
/note="isoform b is encoded by transcript variant 2;
placental protein 20; thiamine kinase; thiamine
diphosphokinase"
/codon_start=1
/product="thiamin pyrophosphokinase 1 isoform b"
/protein_id="NP_001035947.1"
/db_xref="GI:110227857"
/db_xref="CCDS:CCDS55178.1"
/db_xref="GeneID:27010"
/db_xref="HGNC:17358"
/db_xref="MIM:606370"
/translation="
MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS
"
misc_feature 161..673
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/note="Thiamine pyrophosphokinase; Region: TPK; cd07995"
/db_xref="CDD:153431"
misc_feature 164..679
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/note="thiamin pyrophosphokinase; Region: PLN02714"
/db_xref="CDD:178316"
misc_feature order(173..181,236..244,314..316,320..325,389..406,
560..562,566..568,602..613)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/note="active site"
/db_xref="CDD:153431"
misc_feature order(242..244,254..256,263..265,389..397,407..409,
449..451,500..502,506..508,512..514,518..523,599..601,
605..610,668..670)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:153431"
misc_feature order(314..316,389..400,560..562,566..568,602..613)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/note="thiamine binding site [chemical binding]; other
site"
/db_xref="CDD:153431"
variation complement(124)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201567119"
exon 147..218
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
variation complement(191)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="c"
/db_xref="dbSNP:150306900"
variation complement(200)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368467309"
variation complement(201)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:77358162"
variation complement(211)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375142717"
exon 219..288
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
variation 222
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:387906936"
variation complement(224)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199780530"
variation complement(241)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:138773679"
variation 251
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="c"
/db_xref="dbSNP:387906935"
variation complement(255)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:202038293"
variation complement(260)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201086987"
variation complement(267)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:373745325"
variation complement(271)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370527936"
variation complement(272)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200717734"
exon 289..361
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
variation complement(331)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:190902373"
variation complement(333)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145863885"
variation complement(334)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="t"
/db_xref="dbSNP:142178442"
exon 362..457
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
variation complement(429)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="t"
/db_xref="dbSNP:186564802"
exon 458..569
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
variation complement(466)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="g"
/db_xref="dbSNP:371701702"
variation complement(569)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:367833269"
exon 570..2292
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/inference="alignment:Splign:1.39.8"
variation complement(612)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371271054"
variation complement(619)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:113536847"
variation complement(620)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368458768"
variation complement(625)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:113056357"
variation complement(720)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375718551"
variation complement(777)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="c"
/db_xref="dbSNP:113719353"
variation complement(792)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="g"
/db_xref="dbSNP:115576202"
variation complement(803)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146756933"
variation complement(1149)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:142197214"
variation complement(1151)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:193069601"
variation complement(1316..1317)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace=""
/replace="gaaatgatgtgaaaga"
/db_xref="dbSNP:140880403"
variation complement(1317)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="g"
/replace="t"
/db_xref="dbSNP:200480908"
variation complement(1339)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="g"
/replace="t"
/db_xref="dbSNP:372934267"
variation complement(1347)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149043256"
variation complement(1379)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144891862"
variation complement(1452)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:61594332"
variation complement(1502)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:190747119"
variation complement(1517)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149912480"
variation complement(1597)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373133137"
variation complement(1662)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139543062"
variation complement(1663)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:114826691"
variation complement(1835)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369414591"
variation complement(1866)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147369616"
variation complement(1874)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:185049418"
variation complement(1877)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="g"
/replace="t"
/db_xref="dbSNP:369853323"
STS 1974..2084
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/standard_name="SHGC-52409"
/db_xref="UniSTS:19055"
variation complement(2028)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:117837628"
variation complement(2033)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:111378541"
variation complement(2053)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145581947"
STS 2092..2242
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/standard_name="RH103305"
/db_xref="UniSTS:97636"
variation complement(2129..2130)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace=""
/replace="gaat"
/db_xref="dbSNP:374194467"
variation complement(2155..2156)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace=""
/replace="t"
/db_xref="dbSNP:35199404"
variation complement(2180)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376632615"
variation complement(2246)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="c"
/replace="t"
/db_xref="dbSNP:193167794"
variation complement(2253)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="t"
/db_xref="dbSNP:1024482"
variation complement(2263)
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
/replace="a"
/replace="g"
/db_xref="dbSNP:77542038"
polyA_signal 2266..2271
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
polyA_site 2292
/gene="TPK1"
/gene_synonym="HTPK1; PP20; THMD5"
ORIGIN
aaggctcctcagccgagcgccgagcggtcgatcgccgtagctcccgcagcctgcgatctccagtctgtggctcctaccagccattgtaggccaataatccgttatggagcatgcctttaccccgttggagcccctgctttccactgggaatttgaagtactgccttgtaattcttaatcagcctttggacaactattttcgtcatctttggaacaaagctcttttaagagcctgtgccgatggaggtgccaaccgcttatatgatatcaccgaaggagagagagaaagctttttgcctgaattcatcaatggagactttgattctattaggcctgaagtcagagaatactatgctactaagggatgtgagctcatttcaactcctgatcaagaccacactgactttactaagtgccttaaaatgctccaaaagaagatagaagaaaaagacttaaagggaaagcacaggttgcatgtagacactggaatggagggtgattggtgtggccttattcctgttggacagccttgtatgcaggttacaaccacaggcctcaagtggaacctcacaaatgatgtgcttgcttttggaacattggtcagtacttccaatacctacgacgggtctggtgttgtgactgtggaaactgaccacccactcctctggaccatggccatcaaaagctaacctgttgactggcatccataagtgtgcctctgccttatctcatttctcaacagttcattgctcaacaagaacgattcacctgggtttgcaagaatctaaacctctctaggggaagcccactgggtttaaagatgttagtgtttagataatacaggtaacattataaatgacagatctcaattttatagtagtgggaaagatacatgctaagaaagcaaataagctctattatattcggttggaacctaatgggaatcattccactatacaattcagtactgattattcttcttacattattaatcattccatttatcctagaaaattgtttttaatttgaatcagagaaaactgttgaggttcctcttggagtctagaacatccttaaatgtctaacaacaagggctacctctgagtaccttttagtattagttttctgtatatgatatatattatcttatactgaaaaaaaattcctttcagattggggtgttagaagtgcaccaggtcactctgaccttattactgtctttggtattgtcttaaataaatcaagaatcattgacctaattgttaaatttaaaaataggtagttagcaataggtggaaagagaaatgatgtgaaagataaatgatgattcgtggagccctactcacacattaacccccaaattcaaaagtaagaatgcaaaagtctagagggggtaacagtctgcatcatcatcacaacctaaatggagaaagctgtgcagaggaaacttaagcataaaaattgaattcgtttctgacataccttagactgaaaaactgttggttcatccagaagtgtattcatattaccagaaaatgagtttgtctatggggatacatgaacttcatatactaaggagcctaactccaaagcctgcgttctcatcccagtctgatattcacctaagtttccggacccttttccttagctgtaaaatggaagcggttggactgatggtgtctgaggttctttcccacactgaaattctaaatattgacacttagcagtcatagggctgataatacacacagttactgacttagcctaaacaacctggtgcatcgaaatgtattcacctttcttttgtaaagagaccatcttctatcttctttccacctttctctgttttatgaaaccaactgttgacatacaaaccatgattgaaggagaacctgtccaacatgttttatgtacacaaatccctatgttgctataagaaaagtgaaagtaactgttttcttcttggtgctatgacagtgtgagactcaggttgtctgtagagaatgaaaggagcagtggcccgcgtgattgtggcatttaaggagcagtggcccatgtgactgtggcattttcggcacttttcattactttctgcttgaccggaagttgaggcttagctatgtttccatcttcagtttctgaagactagttatatattccttactagaaatatattcataatatataaaagaaatatatctgtgattttaaaattttgctaccaaagaatgcatgttctgtgtgccctgaaaatgttaccagtgttaataaatggatacttatcaaaaaagaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27010 -> Molecular function: GO:0004788 [thiamine diphosphokinase activity] evidence: TAS
GeneID:27010 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:27010 -> Molecular function: GO:0016301 [kinase activity] evidence: IEA
GeneID:27010 -> Biological process: GO:0006766 [vitamin metabolic process] evidence: TAS
GeneID:27010 -> Biological process: GO:0006767 [water-soluble vitamin metabolic process] evidence: TAS
GeneID:27010 -> Biological process: GO:0006772 [thiamine metabolic process] evidence: IEA
GeneID:27010 -> Biological process: GO:0009229 [thiamine diphosphate biosynthetic process] evidence: IEA
GeneID:27010 -> Biological process: GO:0042723 [thiamine-containing compound metabolic process] evidence: TAS
GeneID:27010 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:27010 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:27010 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001035947 -> EC 2.7.6.2
by
@meso_cacase at
DBCLS
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