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2025-05-09 16:54:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001037341 4309 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B),
transcript variant d, mRNA.
ACCESSION NM_001037341
VERSION NM_001037341.1 GI:82799485
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4309)
AUTHORS Yang,J.J., Cheng,C., Devidas,M., Cao,X., Campana,D., Yang,W.,
Fan,Y., Neale,G., Cox,N., Scheet,P., Borowitz,M.J., Winick,N.J.,
Martin,P.L., Bowman,W.P., Camitta,B., Reaman,G.H., Carroll,W.L.,
Willman,C.L., Hunger,S.P., Evans,W.E., Pui,C.H., Loh,M. and
Relling,M.V.
TITLE Genome-wide association study identifies germline polymorphisms
associated with relapse of childhood acute lymphoblastic leukemia
JOURNAL Blood 120 (20), 4197-4204 (2012)
PUBMED 23007406
REFERENCE 2 (bases 1 to 4309)
AUTHORS Lee,J., Komatsu,K., Lee,B.C., Lim,J.H., Jono,H., Xu,H., Kai,H.,
Zhang,Z.J., Yan,C. and Li,J.D.
TITLE Phosphodiesterase 4B mediates extracellular signal-regulated
kinase-dependent up-regulation of mucin MUC5AC protein by
Streptococcus pneumoniae by inhibiting cAMP-protein kinase
A-dependent MKP-1 phosphatase pathway
JOURNAL J. Biol. Chem. 287 (27), 22799-22811 (2012)
PUBMED 22610099
REMARK GeneRIF: PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC
by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
REFERENCE 3 (bases 1 to 4309)
AUTHORS Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
Laibson,D., Johannesson,M. and Visscher,P.M.
TITLE The genetic architecture of economic and political preferences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (21), 8026-8031 (2012)
PUBMED 22566634
REFERENCE 4 (bases 1 to 4309)
AUTHORS Kashiwagi,E., Shiota,M., Yokomizo,A., Itsumi,M., Inokuchi,J.,
Uchiumi,T. and Naito,S.
TITLE Downregulation of phosphodiesterase 4B (PDE4B) activates protein
kinase A and contributes to the progression of prostate cancer
JOURNAL Prostate 72 (7), 741-751 (2012)
PUBMED 22529021
REMARK GeneRIF: PDE4B was downregulated and the protein kinase A pathway
was activated in castration-resistant LNCaP prostate cancer cells.
PDE4B expression was reduced in advanced prostate cancer and PDE4B
knockdown promoted castration-resistant growth of LNCaP cells.
REFERENCE 5 (bases 1 to 4309)
AUTHORS Newburn,E.N., Hyde,T.M., Ye,T., Morita,Y., Weinberger,D.R.,
Kleinman,J.E. and Lipska,B.K.
TITLE Interactions of human truncated DISC1 proteins: implications for
schizophrenia
JOURNAL Transl Psychiatry 1, E30 (2011)
PUBMED 22832604
REMARK GeneRIF: Short Disrupted-in-Schizophrenia (DISC)1 splice variants
show reduced or no binding to nudE nuclear distribution E homolog
(NDEL)1 and PDE4B proteins but fully interact with
fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3
GSK3beta.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4309)
AUTHORS Szpirer,C., Szpirer,J., Riviere,M., Swinnen,J., Vicini,E. and
Conti,M.
TITLE Chromosomal localization of the human and rat genes (PDE4D and
PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4
JOURNAL Cytogenet. Cell Genet. 69 (1-2), 11-14 (1995)
PUBMED 7835077
REFERENCE 7 (bases 1 to 4309)
AUTHORS Bolger,G.B., Rodgers,L. and Riggs,M.
TITLE Differential CNS expression of alternative mRNA isoforms of the
mammalian genes encoding cAMP-specific phosphodiesterases
JOURNAL Gene 149 (2), 237-244 (1994)
PUBMED 7958996
REFERENCE 8 (bases 1 to 4309)
AUTHORS Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
TITLE A family of human phosphodiesterases homologous to the dunce
learning and memory gene product of Drosophila melanogaster are
potential targets for antidepressant drugs
JOURNAL Mol. Cell. Biol. 13 (10), 6558-6571 (1993)
PUBMED 8413254
REFERENCE 9 (bases 1 to 4309)
AUTHORS Obernolte,R., Bhakta,S., Alvarez,R., Bach,C., Zuppan,P.,
Mulkins,M., Jarnagin,K. and Shelton,E.R.
TITLE The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE
IV) reveals a multigene family
JOURNAL Gene 129 (2), 239-247 (1993)
PUBMED 8392015
REFERENCE 10 (bases 1 to 4309)
AUTHORS McLaughlin,M.M., Cieslinski,L.B., Burman,M., Torphy,T.J. and
Livi,G.P.
TITLE A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from
human brain. Cloning and expression of cDNA, biochemical
characterization of recombinant protein, and tissue distribution of
mRNA
JOURNAL J. Biol. Chem. 268 (9), 6470-6476 (1993)
PUBMED 8384210
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA103627.1, BC071607.1,
BC101480.1, BC046161.1 and AW519027.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene is a member of the type IV, cyclic AMP
(cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides are important second messengers that regulate
and mediate a number of cellular responses to extracellular
signals, such as hormones, light, and neurotransmitters. The cyclic
nucleotide phosphodiesterases (PDEs) regulate the cellular
concentrations of cyclic nucleotides and thereby play a role in
signal transduction. This gene encodes a protein that specifically
hydrolyzes cAMP. Altered activity of this protein has been
associated with schizophrenia and bipolar affective disorder.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (d) has a 5' UTR that is further
upstream than variant a. Both variants a and d encode the same
isoform (1, also referred to as PDE4B1 or Tm72).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC071607.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-4 DA103627.1 1-4
5-783 BC071607.1 1-779
784-2499 BC101480.1 679-2394
2500-3572 BC071607.1 2494-3566
3573-4147 BC046161.1 615-1189
4148-4309 AW519027.1 1-162 c
FEATURES Location/Qualifiers
source 1..4309
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p31"
gene 1..4309
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="phosphodiesterase 4B, cAMP-specific"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="MIM:600127"
exon 1..121
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 90
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:74085349"
exon 122..233
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 164
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:12038009"
misc_feature 165..167
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="upstream in-frame stop codon"
variation 181
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:138598652"
variation 185
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:368045878"
CDS 192..2402
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/EC_number="3.1.4.17"
/note="isoform 1 is encoded by transcript variant d;
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4
dunce homolog, Drosophila); dunce-like phosphodiesterase
E4; cAMP-specific 3',5'-cyclic phosphodiesterase 4B;
cAMP-specific phosphodiesterase-4 B isoform; PDE32"
/codon_start=1
/product="cAMP-specific 3',5'-cyclic phosphodiesterase 4B
isoform 1"
/protein_id="NP_001032418.1"
/db_xref="GI:82799486"
/db_xref="CCDS:CCDS632.1"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="MIM:600127"
/translation="
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
"
misc_feature 1404..1952
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(1419..1421,1527..1532,1881..1883)
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 1530..1532
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 1890..1892
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="non-experimental evidence, no additional
details recorded"
/note="Binds AMP, but not cAMP (By similarity); propagated
from UniProtKB/Swiss-Prot (Q07343.1); other site"
variation 218
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:200612585"
variation 226
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:12038033"
variation 230
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:144957956"
exon 234..472
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 266
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:138030327"
variation 347
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:79691733"
variation 383
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:147193846"
variation 470
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:367782903"
exon 473..667
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 480
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374255487"
variation 504
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:367809652"
variation 508
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:145072153"
variation 526
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:75398902"
variation 536
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:143755153"
variation 555
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:375693073"
variation 593
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:201506484"
variation 605
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:141704617"
variation 611
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:139030347"
variation 640
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370994595"
variation 641
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:143872916"
variation 662
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:115853607"
exon 668..704
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 671
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:372187760"
variation 673
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:374832183"
exon 705..775
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 737
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:369969167"
exon 776..825
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 779
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:192869700"
exon 826..938
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 849
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371423323"
variation 888
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116739380"
variation 908
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:140500253"
exon 939..1032
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 960
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376229903"
variation 963
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:145203756"
variation 988
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:199554373"
variation 1021
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371297521"
exon 1033..1211
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1074
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:138828553"
variation 1155
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:369849443"
variation 1158
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:372730987"
variation 1202
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377188281"
variation 1211
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:143554413"
exon 1212..1310
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1213
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141692815"
STS 1306..1412
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="RH64524"
/db_xref="UniSTS:59487"
exon 1311..1475
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1328
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:138407878"
variation 1377
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4322205"
variation 1415
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:146166974"
variation 1418
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115052833"
variation 1421
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:368002134"
variation 1435
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:371715752"
variation 1448
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:202021123"
exon 1476..1575
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1496
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:783036"
variation 1524
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:185687552"
variation 1542
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:116379917"
exon 1576..1730
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1583
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144798451"
exon 1731..1853
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1795
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:151031090"
variation 1812
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:34079300"
variation 1831
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116816923"
variation 1841
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:373028719"
variation 1845
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:142379593"
exon 1854..2036
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1860
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370349934"
variation 1861
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:116312841"
variation 1871
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:34492439"
variation 1886
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:367550787"
variation 1931
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141437989"
variation 1937
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200251647"
variation 1958
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286714"
variation 1971
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:201667673"
variation 1979
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114211692"
variation 1988
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370428408"
variation 1994
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373800241"
exon 2037..4303
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 2102
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:149054617"
variation 2111
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:41286716"
variation 2117
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:79722858"
variation 2118
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114393853"
variation 2135
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139001333"
variation 2146
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:200211480"
variation 2157
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371876952"
variation 2174
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:201727510"
variation 2186
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139374179"
variation 2187
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:149588422"
variation 2188
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144568843"
variation 2231
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3181494"
variation 2232
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:1042020"
variation 2235
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:34469235"
variation 2243
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373468487"
variation 2257
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370754936"
variation 2285
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:372714875"
variation 2292
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:150977853"
variation 2298
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:2227297"
variation 2299
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:375941228"
variation 2311
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:185910614"
variation 2332
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370636828"
variation 2346
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200854845"
variation 2355
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114387631"
STS 2420..3304
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="PDE4B_372"
/db_xref="UniSTS:277574"
variation 2423
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:374227067"
variation 2442
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115922110"
variation 2549
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:376708525"
variation 2605
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:57315098"
variation 2641
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286718"
variation 2726
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371856307"
variation 2774
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:783067"
variation 2854
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:138914808"
variation 2869
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804141"
variation 2942
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:141470428"
variation 3109
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:377201462"
variation 3119
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:181156834"
variation 3132
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200935637"
variation 3146
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:78315788"
variation 3366
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:150394636"
variation 3382
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4655837"
variation 3425..3426
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaca"
/db_xref="dbSNP:199875231"
variation 3446
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:186227828"
variation 3546
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:190701813"
STS 3604..3936
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="D1S2393"
/db_xref="UniSTS:66663"
variation 3637
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:371829302"
variation 3682
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:76335673"
variation 3684
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:112424842"
variation 3698
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3176927"
variation 3727
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138156061"
variation 3769
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:149577217"
variation 3798
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:144286936"
variation 3822
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:183451410"
STS 3850..3950
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="SGC30670"
/db_xref="UniSTS:79282"
variation 3894
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:186230480"
variation 3910
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:190745276"
variation 3925
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377465393"
variation 3933
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377626847"
polyA_signal 3977..3982
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
variation 3999
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:182887410"
polyA_site 4011
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/experiment="experimental evidence, no additional details
recorded"
variation 4028
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374581239"
variation 4145..4146
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tgggtt"
/db_xref="dbSNP:368800294"
variation 4145
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaccca"
/db_xref="dbSNP:16354"
variation 4146..4147
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="gg"
/replace="tgggtt"
/db_xref="dbSNP:71807410"
variation 4147..4148
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:141736339"
variation 4148..4149
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:71682925"
variation 4148
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:368211356"
variation 4149
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371168935"
variation 4151
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:374364770"
variation 4200
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376802391"
variation 4211
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138911836"
variation 4222..4223
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tat"
/db_xref="dbSNP:202242622"
polyA_signal 4279..4284
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
polyA_site 4303
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
ORIGIN
gtgcgtaatccttcagctctggtggtaagggagatgcagtgagctcccggctgggagagagggttattttgcaaaactcccctggtaccgtgcccgcggaatattgcaggaggtctgtgaggtattaaaaagtgtcagcaaactgcattgaataacagacatcctaagaggggatattttccacctctataatgaagaaaagcaggagtgtgatgacggtgatggctgatgataatgttaaagattattttgaatgtagcttgagtaaatcctacagttcttccagtaacacacttgggatcgacctctggagagggagaaggtgttgctcaggaaacttacagttaccaccactgtctcaaagacagagtgaaagggcaaggactcctgagggagatggtatttccaggccgaccacactgcctttgacaacgcttccaagcattgctattacaactgtaagccaggagtgctttgatgtggaaaatggcccttccccaggtcggagtccactggatccccaggccagctcttccgctgggctggtacttcacgccacctttcctgggcacagccagcgcagagagtcatttctctacagatcagacagcgactatgacttgtcaccaaaggcgatgtcgagaaactcttctcttccaagcgagcaacacggcgatgacttgattgtaactccttttgcccaggtccttgccagcttgcgaagtgtgagaaacaacttcactatactgacaaaccttcatggtacatctaacaagaggtccccagctgctagtcagcctcctgtctccagagtcaacccacaagaagaatcttatcaaaaattagcaatggaaacgctggaggaattagactggtgtttagaccagctagagaccatacagacctaccggtctgtcagtgagatggcttctaacaagttcaaaagaatgctgaaccgggagctgacacacctctcagagatgagccgatcagggaaccaggtgtctgaatacatttcaaatactttcttagacaagcagaatgatgtggagatcccatctcctacccagaaagacagggagaaaaagaaaaagcagcagctcatgacccagataagtggagtgaagaaattaatgcatagttcaagcctaaacaatacaagcatctcacgctttggagtcaacactgaaaatgaagatcacctggccaaggagctggaagacctgaacaaatggggtcttaacatctttaatgtggctggatattctcacaatagacccctaacatgcatcatgtatgctatattccaggaaagagacctcctaaagacattcagaatctcatctgacacatttataacctacatgatgactttagaagaccattaccattctgacgtggcatatcacaacagcctgcacgctgctgatgtagcccagtcgacccatgttctcctttctacaccagcattagacgctgtcttcacagatttggagatcctggctgccatttttgcagctgccatccatgacgttgatcatcctggagtctccaatcagtttctcatcaacacaaattcagaacttgctttgatgtataatgatgaatctgtgttggaaaatcatcaccttgctgtgggtttcaaactgctgcaagaagaacactgtgacatcttcatgaatctcaccaagaagcagcgtcagacactcaggaagatggttattgacatggtgttagcaactgatatgtctaaacatatgagcctgctggcagacctgaagacaatggtagaaacgaagaaagttacaagttcaggcgttcttctcctagacaactataccgatcgcattcaggtccttcgcaacatggtacactgtgcagacctgagcaaccccaccaagtccttggaattgtatcggcaatggacagaccgcatcatggaggaatttttccagcagggagacaaagagcgggagaggggaatggaaattagcccaatgtgtgataaacacacagcttctgtggaaaaatcccaggttggtttcatcgactacattgtccatccattgtgggagacatgggcagatttggtacagcctgatgctcaggacattctcgataccttagaagataacaggaactggtatcagagcatgatacctcaaagtccctcaccaccactggacgagcagaacagggactgccagggtctgatggagaagtttcagtttgaactgactctcgatgaggaagattctgaaggacctgagaaggagggagagggacacagctatttcagcagcacaaagacgctttgtgtgattgatccagaaaacagagattccctgggagagactgacatagacattgcaacagaagacaagtcccccgtggatacataatccccctctccctgtggagatgaacattctatccttgatgagcatgccagctatgtggtagggccagcccaccatgggggccaagacctgcacaggacaagggccacctggcctttcagttacttgagtttggagtcagaaagcaagaccaggaagcaaatagcagctcaggaaatcccacggttgacttgccttgatggcaagcttggtggagagggctgaagctgttgctgggggccgattctgatcaagacacatggcttgaaaatggaagacacaaaactgagagatcattctgcactaagtttcgggaacttatccccgacagtgactgaactcactgactaataacttcatttatgaatcttctcacttgtccctttgtctgccaacctgtgtgccttttttgtaaaacattttcatgtctttaaaatgcctgttgaatacctggagtttagtatcaacttctacacagataagctttcaaagttgacaaacttttttgactctttctggaaaagggaaagaaaatagtcttccttctttcttgggcaatatccttcactttactacagttacttttgcaaacagacagaaaggatacacttctaaccacattttacttccttcccctgttgtccagtccaactccacagtcactcttaaaacttctctctgtttgcctgcctccaacagtacttttaactttttgctgtaaacagaataaaattgaacaaattagggggtagaaaggagcagtggtgtcgttcaccgtgagagtctgcatagaactcagcagtgtgccctgctgtgtcttggaccctgccccccacaggagttgtacagtccctggccctgttccctacctcctctcttcaccccgttaggctgttttcaatgtaatgctgccgtccttctcttgcactgccttctgcgctaacacctccattcctgtttataaccgtgtatttattacttaatgtatataatgtaatgttttgtaagttattaatttatatatctaacattgcctgccaatggtggtgttaaatttgtgtagaaaactctgcctaagagttacgactttttcttgtaatgttttgtattgtgtattatataacccaaacgtcacttagtagagacatatggcccccttggcagagaggacaggggtgggcttttgttcaaagggtctgccctttccctgcctgagttgctacttctgcacaacccctttatgaaccagttttggaaacaatattctcacattagatactaaatggtttatactgagcttttacttttgtatagcttgataggggcagggggcaatgggatgtagtttttacccaggttctatccaaatctatgtgggcatgagttgggttataactggatcctactatcattgtggctttggttcaaaaggaaacactacatttgctcacagatgattcttctgaatgctcccgaactactgactttgaagaggtagcctcctgcctgccattaagcaggaatgtcatgttccagttcattacaaaagaaaacaataaaacaatgtgaatttttataataaaatgtgaactgatgtagcaaattacgcaaatgtgaagcctcttctgataacacttgttaggcctcttactgatgtcagtttcagtttgtaaaatatgtttcatgctttcagttcagcattgtgactcagtaattacagaaaatggcacaaatgtgcatgaccaatgtatgtctatgaacactgcattgtttcaggtggacattttatcattttcaaatgtttctcacaatgtatgttatagtattattattatatattgtgttcaaatgcattctaaagagacttttatatgaggtgaataaagaaaagcatgattagattaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5142 -> Molecular function: GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] evidence: ISS
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IDA
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IGI
GeneID:5142 -> Molecular function: GO:0030552 [cAMP binding] evidence: IGI
GeneID:5142 -> Molecular function: GO:0044325 [ion channel binding] evidence: ISS
GeneID:5142 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5142 -> Biological process: GO:0001780 [neutrophil homeostasis] evidence: ISS
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IDA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IGI
GeneID:5142 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: ISS
GeneID:5142 -> Biological process: GO:0032729 [positive regulation of interferon-gamma production] evidence: IMP
GeneID:5142 -> Biological process: GO:0032743 [positive regulation of interleukin-2 production] evidence: IMP
GeneID:5142 -> Biological process: GO:0035690 [cellular response to drug] evidence: ISS
GeneID:5142 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: IMP
GeneID:5142 -> Biological process: GO:0050900 [leukocyte migration] evidence: ISS
GeneID:5142 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS
GeneID:5142 -> Biological process: GO:0071872 [cellular response to epinephrine stimulus] evidence: ISS
GeneID:5142 -> Biological process: GO:0086004 [regulation of cardiac muscle cell contraction] evidence: ISS
GeneID:5142 -> Biological process: GO:1901841 [regulation of high voltage-gated calcium channel activity] evidence: ISS
GeneID:5142 -> Biological process: GO:1901898 [negative regulation of relaxation of cardiac muscle] evidence: ISS
GeneID:5142 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5142 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5142 -> Cellular component: GO:0005891 [voltage-gated calcium channel complex] evidence: ISS
GeneID:5142 -> Cellular component: GO:0030018 [Z disc] evidence: ISS
GeneID:5142 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001032418 -> EC 3.1.4.17
by
@meso_cacase at
DBCLS
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