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2025-05-09 16:47:06, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001037339 3882 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B),
transcript variant b, mRNA.
ACCESSION NM_001037339
VERSION NM_001037339.1 GI:82799481
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3882)
AUTHORS Yang,J.J., Cheng,C., Devidas,M., Cao,X., Campana,D., Yang,W.,
Fan,Y., Neale,G., Cox,N., Scheet,P., Borowitz,M.J., Winick,N.J.,
Martin,P.L., Bowman,W.P., Camitta,B., Reaman,G.H., Carroll,W.L.,
Willman,C.L., Hunger,S.P., Evans,W.E., Pui,C.H., Loh,M. and
Relling,M.V.
TITLE Genome-wide association study identifies germline polymorphisms
associated with relapse of childhood acute lymphoblastic leukemia
JOURNAL Blood 120 (20), 4197-4204 (2012)
PUBMED 23007406
REFERENCE 2 (bases 1 to 3882)
AUTHORS Lee,J., Komatsu,K., Lee,B.C., Lim,J.H., Jono,H., Xu,H., Kai,H.,
Zhang,Z.J., Yan,C. and Li,J.D.
TITLE Phosphodiesterase 4B mediates extracellular signal-regulated
kinase-dependent up-regulation of mucin MUC5AC protein by
Streptococcus pneumoniae by inhibiting cAMP-protein kinase
A-dependent MKP-1 phosphatase pathway
JOURNAL J. Biol. Chem. 287 (27), 22799-22811 (2012)
PUBMED 22610099
REMARK GeneRIF: PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC
by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
REFERENCE 3 (bases 1 to 3882)
AUTHORS Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
Laibson,D., Johannesson,M. and Visscher,P.M.
TITLE The genetic architecture of economic and political preferences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (21), 8026-8031 (2012)
PUBMED 22566634
REFERENCE 4 (bases 1 to 3882)
AUTHORS Kashiwagi,E., Shiota,M., Yokomizo,A., Itsumi,M., Inokuchi,J.,
Uchiumi,T. and Naito,S.
TITLE Downregulation of phosphodiesterase 4B (PDE4B) activates protein
kinase A and contributes to the progression of prostate cancer
JOURNAL Prostate 72 (7), 741-751 (2012)
PUBMED 22529021
REMARK GeneRIF: PDE4B was downregulated and the protein kinase A pathway
was activated in castration-resistant LNCaP prostate cancer cells.
PDE4B expression was reduced in advanced prostate cancer and PDE4B
knockdown promoted castration-resistant growth of LNCaP cells.
REFERENCE 5 (bases 1 to 3882)
AUTHORS Newburn,E.N., Hyde,T.M., Ye,T., Morita,Y., Weinberger,D.R.,
Kleinman,J.E. and Lipska,B.K.
TITLE Interactions of human truncated DISC1 proteins: implications for
schizophrenia
JOURNAL Transl Psychiatry 1, E30 (2011)
PUBMED 22832604
REMARK GeneRIF: Short Disrupted-in-Schizophrenia (DISC)1 splice variants
show reduced or no binding to nudE nuclear distribution E homolog
(NDEL)1 and PDE4B proteins but fully interact with
fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3
GSK3beta.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3882)
AUTHORS Szpirer,C., Szpirer,J., Riviere,M., Swinnen,J., Vicini,E. and
Conti,M.
TITLE Chromosomal localization of the human and rat genes (PDE4D and
PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4
JOURNAL Cytogenet. Cell Genet. 69 (1-2), 11-14 (1995)
PUBMED 7835077
REFERENCE 7 (bases 1 to 3882)
AUTHORS Bolger,G.B., Rodgers,L. and Riggs,M.
TITLE Differential CNS expression of alternative mRNA isoforms of the
mammalian genes encoding cAMP-specific phosphodiesterases
JOURNAL Gene 149 (2), 237-244 (1994)
PUBMED 7958996
REFERENCE 8 (bases 1 to 3882)
AUTHORS Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
TITLE A family of human phosphodiesterases homologous to the dunce
learning and memory gene product of Drosophila melanogaster are
potential targets for antidepressant drugs
JOURNAL Mol. Cell. Biol. 13 (10), 6558-6571 (1993)
PUBMED 8413254
REFERENCE 9 (bases 1 to 3882)
AUTHORS Obernolte,R., Bhakta,S., Alvarez,R., Bach,C., Zuppan,P.,
Mulkins,M., Jarnagin,K. and Shelton,E.R.
TITLE The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE
IV) reveals a multigene family
JOURNAL Gene 129 (2), 239-247 (1993)
PUBMED 8392015
REFERENCE 10 (bases 1 to 3882)
AUTHORS McLaughlin,M.M., Cieslinski,L.B., Burman,M., Torphy,T.J. and
Livi,G.P.
TITLE A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from
human brain. Cloning and expression of cDNA, biochemical
characterization of recombinant protein, and tissue distribution of
mRNA
JOURNAL J. Biol. Chem. 268 (9), 6470-6476 (1993)
PUBMED 8384210
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from M97515.1, L20971.1, BC046161.1
and AW519027.1.
Summary: This gene is a member of the type IV, cyclic AMP
(cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides are important second messengers that regulate
and mediate a number of cellular responses to extracellular
signals, such as hormones, light, and neurotransmitters. The cyclic
nucleotide phosphodiesterases (PDEs) regulate the cellular
concentrations of cyclic nucleotides and thereby play a role in
signal transduction. This gene encodes a protein that specifically
hydrolyzes cAMP. Altered activity of this protein has been
associated with schizophrenia and bipolar affective disorder.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (b) contains a distinct 5' UTR and
lacks an in-frame portion of the 5' coding region, compared to
variant a. The resulting isoform (2, also referred to as PDE4B2 or
PDE32) has a shorter and distinct N-terminus when compared to
isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M97515.1, L12686.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3 M97515.1 3-5
4-2816 L20971.1 489-3301
2817-2833 M97515.1 2817-2833
2834-2838 L20971.1 3321-3325
2839-3239 M97515.1 2839-3239
3240-3269 L20971.1 3726-3755
3270-3310 M97515.1 3271-3311
3311-3438 L20971.1 3797-3924
3439-3686 M97515.1 3439-3686
3687-3720 BC046161.1 1156-1189
3721-3762 M97515.1 3721-3762
3763-3871 BC046161.1 1238-1346
3872-3882 AW519027.1 1-11 c
FEATURES Location/Qualifiers
source 1..3882
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p31"
gene 1..3882
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="phosphodiesterase 4B, cAMP-specific"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="MIM:600127"
exon 1..511
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 39..42
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="agag"
/db_xref="dbSNP:17101822"
variation 124
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:369060694"
misc_feature 152..154
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="upstream in-frame stop codon"
variation 272
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376078522"
CDS 281..1975
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/EC_number="3.1.4.17"
/note="isoform 2 is encoded by transcript variant b;
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4
dunce homolog, Drosophila); dunce-like phosphodiesterase
E4; cAMP-specific 3',5'-cyclic phosphodiesterase 4B;
cAMP-specific phosphodiesterase-4 B isoform; PDE32"
/codon_start=1
/product="cAMP-specific 3',5'-cyclic phosphodiesterase 4B
isoform 2"
/protein_id="NP_001032416.1"
/db_xref="GI:82799482"
/db_xref="CCDS:CCDS30743.1"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="MIM:600127"
/translation="
MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
"
misc_feature 977..1525
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(992..994,1100..1105,1454..1456)
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 1103..1105
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
variation 290
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:146117440"
variation 305
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:201181666"
variation 313
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:151263754"
variation 314
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370407084"
variation 332
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:200202611"
variation 339
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:375930120"
variation 349
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:368502825"
variation 367
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:140445791"
variation 374
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200929311"
variation 422
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371423323"
variation 461
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116739380"
variation 481
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:140500253"
exon 512..605
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 533
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376229903"
variation 536
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:145203756"
variation 561
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:199554373"
variation 594
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371297521"
exon 606..784
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 647
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:138828553"
variation 728
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:369849443"
variation 731
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:372730987"
variation 775
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377188281"
variation 784
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:143554413"
exon 785..883
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 786
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141692815"
STS 879..985
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="RH64524"
/db_xref="UniSTS:59487"
exon 884..1048
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 901
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:138407878"
variation 950
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4322205"
variation 988
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:146166974"
variation 991
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115052833"
variation 994
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:368002134"
variation 1008
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:371715752"
variation 1021
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:202021123"
exon 1049..1148
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1069
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:783036"
variation 1097
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:185687552"
variation 1115
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:116379917"
exon 1149..1303
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1156
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144798451"
exon 1304..1426
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1368
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:151031090"
variation 1385
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:34079300"
variation 1404
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116816923"
variation 1414
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:373028719"
variation 1418
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:142379593"
exon 1427..1609
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1433
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370349934"
variation 1434
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:116312841"
variation 1444
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:34492439"
variation 1459
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:367550787"
variation 1504
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141437989"
variation 1510
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200251647"
variation 1531
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286714"
variation 1544
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:201667673"
variation 1552
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114211692"
variation 1561
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370428408"
variation 1567
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373800241"
exon 1610..3876
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1675
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:149054617"
variation 1684
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:41286716"
variation 1690
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:79722858"
variation 1691
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114393853"
variation 1708
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139001333"
variation 1719
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:200211480"
variation 1730
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371876952"
variation 1747
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:201727510"
variation 1759
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139374179"
variation 1760
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:149588422"
variation 1761
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144568843"
variation 1804
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3181494"
variation 1805
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:1042020"
variation 1808
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:34469235"
variation 1816
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373468487"
variation 1830
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370754936"
variation 1858
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:372714875"
variation 1865
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:150977853"
variation 1871
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:2227297"
variation 1872
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:375941228"
variation 1884
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:185910614"
variation 1905
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370636828"
variation 1919
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200854845"
variation 1928
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114387631"
STS 1993..2877
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="PDE4B_372"
/db_xref="UniSTS:277574"
variation 1996
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:374227067"
variation 2015
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115922110"
variation 2122
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:376708525"
variation 2178
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:57315098"
variation 2214
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286718"
variation 2299
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371856307"
variation 2347
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:783067"
variation 2427
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:138914808"
variation 2442
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804141"
variation 2515
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:141470428"
variation 2682
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:377201462"
variation 2692
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:181156834"
variation 2705
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200935637"
variation 2719
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:78315788"
variation 2939
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:150394636"
variation 2955
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4655837"
variation 2998..2999
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaca"
/db_xref="dbSNP:199875231"
variation 3019
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:186227828"
variation 3119
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:190701813"
STS 3177..3509
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="D1S2393"
/db_xref="UniSTS:66663"
variation 3210
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:371829302"
variation 3255
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:76335673"
variation 3257
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:112424842"
variation 3271
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3176927"
variation 3300
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138156061"
variation 3342
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:149577217"
variation 3371
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:144286936"
variation 3395
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:183451410"
STS 3423..3523
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="SGC30670"
/db_xref="UniSTS:79282"
variation 3467
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:186230480"
variation 3483
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:190745276"
variation 3498
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377465393"
variation 3506
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377626847"
polyA_signal 3550..3555
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
variation 3572
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:182887410"
polyA_site 3584
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/experiment="experimental evidence, no additional details
recorded"
variation 3601
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374581239"
variation 3718..3719
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tgggtt"
/db_xref="dbSNP:368800294"
variation 3718
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaccca"
/db_xref="dbSNP:16354"
variation 3719..3720
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="gg"
/replace="tgggtt"
/db_xref="dbSNP:71807410"
variation 3720..3721
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:141736339"
variation 3721..3722
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:71682925"
variation 3721
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:368211356"
variation 3722
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371168935"
variation 3724
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:374364770"
variation 3773
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376802391"
variation 3784
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138911836"
variation 3795..3796
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tat"
/db_xref="dbSNP:202242622"
polyA_signal 3852..3857
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
polyA_site 3876
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
ORIGIN
cacataccctaaagaaccctgggatgactaaggcagagagagtctgagaaaactctttggtgcttctgcctttagttttaggacacatttatgcagatgagcttataagagaccgttccctccgccttcttcctcagaggaagtttcttggtagatcaccgacacctcatccaggcggggggttggggggaaacttggcaccagccatcccaggcagagcaccactgtgatttgttctcctggtggagagagctggaaggaaggagccagcgtgcaaataatgaaggagcacgggggcaccttcagtagcaccggaatcagcggtggtagcggtgactctgctatggacagcctgcagccgctccagcctaactacatgcctgtgtgtttgtttgcagaagaatcttatcaaaaattagcaatggaaacgctggaggaattagactggtgtttagaccagctagagaccatacagacctaccggtctgtcagtgagatggcttctaacaagttcaaaagaatgctgaaccgggagctgacacacctctcagagatgagccgatcagggaaccaggtgtctgaatacatttcaaatactttcttagacaagcagaatgatgtggagatcccatctcctacccagaaagacagggagaaaaagaaaaagcagcagctcatgacccagataagtggagtgaagaaattaatgcatagttcaagcctaaacaatacaagcatctcacgctttggagtcaacactgaaaatgaagatcacctggccaaggagctggaagacctgaacaaatggggtcttaacatctttaatgtggctggatattctcacaatagacccctaacatgcatcatgtatgctatattccaggaaagagacctcctaaagacattcagaatctcatctgacacatttataacctacatgatgactttagaagaccattaccattctgacgtggcatatcacaacagcctgcacgctgctgatgtagcccagtcgacccatgttctcctttctacaccagcattagacgctgtcttcacagatttggagatcctggctgccatttttgcagctgccatccatgacgttgatcatcctggagtctccaatcagtttctcatcaacacaaattcagaacttgctttgatgtataatgatgaatctgtgttggaaaatcatcaccttgctgtgggtttcaaactgctgcaagaagaacactgtgacatcttcatgaatctcaccaagaagcagcgtcagacactcaggaagatggttattgacatggtgttagcaactgatatgtctaaacatatgagcctgctggcagacctgaagacaatggtagaaacgaagaaagttacaagttcaggcgttcttctcctagacaactataccgatcgcattcaggtccttcgcaacatggtacactgtgcagacctgagcaaccccaccaagtccttggaattgtatcggcaatggacagaccgcatcatggaggaatttttccagcagggagacaaagagcgggagaggggaatggaaattagcccaatgtgtgataaacacacagcttctgtggaaaaatcccaggttggtttcatcgactacattgtccatccattgtgggagacatgggcagatttggtacagcctgatgctcaggacattctcgataccttagaagataacaggaactggtatcagagcatgatacctcaaagtccctcaccaccactggacgagcagaacagggactgccagggtctgatggagaagtttcagtttgaactgactctcgatgaggaagattctgaaggacctgagaaggagggagagggacacagctatttcagcagcacaaagacgctttgtgtgattgatccagaaaacagagattccctgggagagactgacatagacattgcaacagaagacaagtcccccgtggatacataatccccctctccctgtggagatgaacattctatccttgatgagcatgccagctatgtggtagggccagcccaccatgggggccaagacctgcacaggacaagggccacctggcctttcagttacttgagtttggagtcagaaagcaagaccaggaagcaaatagcagctcaggaaatcccacggttgacttgccttgatggcaagcttggtggagagggctgaagctgttgctgggggccgattctgatcaagacacatggcttgaaaatggaagacacaaaactgagagatcattctgcactaagtttcgggaacttatccccgacagtgactgaactcactgactaataacttcatttatgaatcttctcacttgtccctttgtctgccaacctgtgtgccttttttgtaaaacattttcatgtctttaaaatgcctgttgaatacctggagtttagtatcaacttctacacagataagctttcaaagttgacaaacttttttgactctttctggaaaagggaaagaaaatagtcttccttctttcttgggcaatatccttcactttactacagttacttttgcaaacagacagaaaggatacacttctaaccacattttacttccttcccctgttgtccagtccaactccacagtcactcttaaaacttctctctgtttgcctgcctccaacagtacttttaactttttgctgtaaacagaataaaattgaacaaattagggggtagaaaggagcagtggtgtcgttcaccgtgagagtctgcatagaactcagcagtgtgccctgctgtgtcttggaccctgccccccacaggagttgtacagtccctggccctgttccctacctcctctcttcaccccgttaggctgttttcaatgtaatgctgccgtccttctcttgcactgccttctgcgctaacacctccattcctgtttataaccgtgtatttattacttaatgtatataatgtaatgttttgtaagttattaatttatatatctaacattgcctgccaatggtggtgttaaatttgtgtagaaaactctgcctaagagttacgactttttcttgtaatgttttgtattgtgtattatataacccaaacgtcacttagtagagacatatggcccccttggcagagaggacaggggtgggcttttgttcaaagggtctgccctttccctgcctgagttgctacttctgcacaacccctttatgaaccagttttggaaacaatattctcacattagatactaaatggtttatactgagcttttacttttgtatagcttgataggggcagggggcaatgggatgtagtttttacccaggttctatccaaatctatgtgggcatgagttgggttataactggatcctactatcattgtggctttggttcaaaaggaaacactacatttgctcacagatgattcttctgaatgctcccgaactactgactttgaagaggtagcctcctgcctgccattaagcaggaatgtcatgttccagttcattacaaaagaaaacaataaaacaatgtgaatttttataataaaatgtgaactgatgtagcaaattacgcaaatgtgaagcctcttctgataacacttgttaggcctcttactgatgtcagtttcagtttgtaaaatatgtttcatgctttcagttcagcattgtgactcagtaattacagaaaatggcacaaatgtgcatgaccaatgtatgtctatgaacactgcattgtttcaggtggacattttatcattttcaaatgtttctcacaatgtatgttatagtattattattatatattgtgttcaaatgcattctaaagagacttttatatgaggtgaataaagaaaagcatgattagattaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5142 -> Molecular function: GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] evidence: ISS
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IDA
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IGI
GeneID:5142 -> Molecular function: GO:0030552 [cAMP binding] evidence: IGI
GeneID:5142 -> Molecular function: GO:0044325 [ion channel binding] evidence: ISS
GeneID:5142 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5142 -> Biological process: GO:0001780 [neutrophil homeostasis] evidence: ISS
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IDA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IGI
GeneID:5142 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: ISS
GeneID:5142 -> Biological process: GO:0032729 [positive regulation of interferon-gamma production] evidence: IMP
GeneID:5142 -> Biological process: GO:0032743 [positive regulation of interleukin-2 production] evidence: IMP
GeneID:5142 -> Biological process: GO:0035690 [cellular response to drug] evidence: ISS
GeneID:5142 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: IMP
GeneID:5142 -> Biological process: GO:0050900 [leukocyte migration] evidence: ISS
GeneID:5142 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS
GeneID:5142 -> Biological process: GO:0071872 [cellular response to epinephrine stimulus] evidence: ISS
GeneID:5142 -> Biological process: GO:0086004 [regulation of cardiac muscle cell contraction] evidence: ISS
GeneID:5142 -> Biological process: GO:1901841 [regulation of high voltage-gated calcium channel activity] evidence: ISS
GeneID:5142 -> Biological process: GO:1901898 [negative regulation of relaxation of cardiac muscle] evidence: ISS
GeneID:5142 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5142 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5142 -> Cellular component: GO:0005891 [voltage-gated calcium channel complex] evidence: ISS
GeneID:5142 -> Cellular component: GO:0030018 [Z disc] evidence: ISS
GeneID:5142 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001032416 -> EC 3.1.4.17
by
@meso_cacase at
DBCLS
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