Home |
Help |
Advanced search
2025-05-09 16:35:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001017536 5060 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR),
transcript variant 3, mRNA.
ACCESSION NM_001017536
VERSION NM_001017536.1 GI:323714264
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5060)
AUTHORS Asano,L., Ito,I., Kuwabara,N., Waku,T., Yanagisawa,J., Miyachi,H.
and Shimizu,T.
TITLE Structural basis for vitamin D receptor agonism by novel
non-secosteroidal ligands
JOURNAL FEBS Lett. 587 (7), 957-963 (2013)
PUBMED 23462137
REMARK GeneRIF: Data indicate that ligands changed the conformation of the
vitamin D receptor (VDR), resulting in different hydrogen-bond
networks depending on the potency of the ligand.
REFERENCE 2 (bases 1 to 5060)
AUTHORS Li,L., Wu,B., Liu,J.Y. and Yang,L.B.
TITLE Vitamin D receptor gene polymorphisms and type 2 diabetes: a
meta-analysis
JOURNAL Arch. Med. Res. 44 (3), 235-241 (2013)
PUBMED 23506721
REMARK GeneRIF: meta-analysis suggests that the FokI polymorphism of the
VDR gene could be a risk factor for type 2 diabetes, especially in
an Asian population
REFERENCE 3 (bases 1 to 5060)
AUTHORS Tiosano,D., Wildbaum,G., Gepstein,V., Verbitsky,O., Weisman,Y.,
Karin,N. and Eztioni,A.
TITLE The role of vitamin D receptor in innate and adaptive immunity: a
study in hereditary vitamin D-resistant rickets patients
JOURNAL J. Clin. Endocrinol. Metab. 98 (4), 1685-1693 (2013)
PUBMED 23482605
REMARK GeneRIF: The role of vitamin D receptor in innate and adaptive
immunity in vitamin D-resistant rickets.
REFERENCE 4 (bases 1 to 5060)
AUTHORS Chesney,R.W. and Han,X.
TITLE Differential regulation of TauT by calcitriol and retinoic acid via
VDR/RXR in LLC-PK1 and MCF-7 cells
JOURNAL Adv. Exp. Med. Biol. 776, 291-305 (2013)
PUBMED 23392891
REMARK GeneRIF: Expression of TauT is differentially regulated by Vitamin
D(3) and retinoic acid via formation of VDR and RXR complexes in
the nuclei in a cell type-dependent manner.
REFERENCE 5 (bases 1 to 5060)
AUTHORS Pervin,S., Hewison,M., Braga,M., Tran,L., Chun,R., Karam,A.,
Chaudhuri,G., Norris,K. and Singh,R.
TITLE Down-regulation of vitamin D receptor in mammospheres: implications
for vitamin D resistance in breast cancer and potential for
combination therapy
JOURNAL PLoS ONE 8 (1), E53287 (2013)
PUBMED 23341935
REMARK GeneRIF: Inhibition of VDR expression by siRNA led to a significant
change in key epithelial mesenchymal transition-specific
transcription factors and increased the ability of these cells to
form mammospheres.
REFERENCE 6 (bases 1 to 5060)
AUTHORS Goto,H., Chen,K.S., Prahl,J.M. and DeLuca,H.F.
TITLE A single receptor identical with that from intestine/T47D cells
mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells
JOURNAL Biochim. Biophys. Acta 1132 (1), 103-108 (1992)
PUBMED 1324736
REFERENCE 7 (bases 1 to 5060)
AUTHORS Bugge,T.H., Pohl,J., Lonnoy,O. and Stunnenberg,H.G.
TITLE RXR alpha, a promiscuous partner of retinoic acid and thyroid
hormone receptors
JOURNAL EMBO J. 11 (4), 1409-1418 (1992)
PUBMED 1314167
REFERENCE 8 (bases 1 to 5060)
AUTHORS Szpirer,J., Szpirer,C., Riviere,M., Levan,G., Marynen,P.,
Cassiman,J.J., Wiese,R. and DeLuca,H.F.
TITLE The Sp1 transcription factor gene (SP1) and the
1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on
human chromosome arm 12q and rat chromosome 7
JOURNAL Genomics 11 (1), 168-173 (1991)
PUBMED 1662663
REFERENCE 9 (bases 1 to 5060)
AUTHORS Saijo,T., Ito,M., Takeda,E., Huq,A.H., Naito,E., Yokota,I.,
Sone,T., Pike,J.W. and Kuroda,Y.
TITLE A unique mutation in the vitamin D receptor gene in three Japanese
patients with vitamin D-dependent rickets type II: utility of
single-strand conformation polymorphism analysis for heterozygous
carrier detection
JOURNAL Am. J. Hum. Genet. 49 (3), 668-673 (1991)
PUBMED 1652893
REFERENCE 10 (bases 1 to 5060)
AUTHORS Yu,X.P., Mocharla,H., Hustmyer,F.G. and Manolagas,S.C.
TITLE Vitamin D receptor expression in human lymphocytes. Signal
requirements and characterization by western blots and DNA
sequencing
JOURNAL J. Biol. Chem. 266 (12), 7588-7595 (1991)
PUBMED 1850412
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA721726.1, BC060832.1,
AC004466.1 and BM685276.1.
Summary: This gene encodes the nuclear hormone receptor for vitamin
D3. This receptor also functions as a receptor for the secondary
bile acid lithocholic acid. The receptor belongs to the family of
trans-acting transcriptional regulatory factors and shows sequence
similarity to the steroid and thyroid hormone receptors. Downstream
targets of this nuclear hormone receptor are principally involved
in mineral metabolism though the receptor regulates a variety of
other metabolic pathways, such as those involved in the immune
response and cancer. Mutations in this gene are associated with
type II vitamin D-resistant rickets. A single nucleotide
polymorphism in the initiation codon results in an alternate
translation start site three codons downstream. Alternative
splicing results in multiple transcript variants encoding different
proteins. [provided by RefSeq, Feb 2011].
Transcript Variant: This variant (3) represents the longest
transcript and encodes the longer isoform (VDRB1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC060832.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-28 DA721726.1 10-37
29-3813 BC060832.1 1-3785
3814-4624 AC004466.1 48367-49177
4625-5060 BM685276.1 1-436 c
FEATURES Location/Qualifiers
source 1..5060
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13.11"
gene 1..5060
/gene="VDR"
/gene_synonym="NR1I1"
/note="vitamin D (1,25- dihydroxyvitamin D3) receptor"
/db_xref="GeneID:7421"
/db_xref="HGNC:12679"
/db_xref="MIM:601769"
exon 1..468
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 29
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574011"
misc_feature 318..320
/gene="VDR"
/gene_synonym="NR1I1"
/note="upstream in-frame stop codon"
CDS 402..1835
/gene="VDR"
/gene_synonym="NR1I1"
/note="isoform VDRB1 is encoded by transcript variant 3;
vitamin D3 receptor; vitamin D nuclear receptor variant 1;
1,25-dihydroxyvitamin D3 receptor; nuclear receptor
subfamily 1 group I member 1"
/codon_start=1
/product="vitamin D3 receptor isoform VDRB1"
/protein_id="NP_001017536.1"
/db_xref="GI:323714265"
/db_xref="CCDS:CCDS55820.1"
/db_xref="GeneID:7421"
/db_xref="HGNC:12679"
/db_xref="MIM:601769"
/translation="
MEWRNKKRSDWLSMVLRTAGVEEAFGSEVSVRPHRRAPLGSTYLPPAPSGMEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
"
misc_feature 597..917
/gene="VDR"
/gene_synonym="NR1I1"
/note="DNA-binding domain of vitamin D receptors (VDR) is
composed of two C4-type zinc fingers; Region: NR_DBD_VDR;
cd06955"
/db_xref="CDD:143513"
misc_feature order(621..623,630..632,672..674,681..683,729..731,
747..749,777..779,786..788)
/gene="VDR"
/gene_synonym="NR1I1"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:143513"
misc_feature order(651..659,675..680,684..686,696..701,768..773,
789..791,831..836,849..851)
/gene="VDR"
/gene_synonym="NR1I1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:143513"
misc_feature order(732..737,774..776,825..830)
/gene="VDR"
/gene_synonym="NR1I1"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:143513"
misc_feature 921..>1028
/gene="VDR"
/gene_synonym="NR1I1"
/note="The ligand binding domain of nuclear receptors, a
family of ligand-activated transcription regulators;
Region: NR_LBD; cl11397"
/db_xref="CDD:209301"
misc_feature 1218..1829
/gene="VDR"
/gene_synonym="NR1I1"
/note="The ligand binding domain of vitamin D receptors, a
member of the nuclear receptor superfamily; Region:
NR_LBD_VDR; cd06933"
/db_xref="CDD:132731"
misc_feature order(1230..1232,1239..1241,1248..1253,1260..1262,
1362..1364,1371..1376,1383..1385,1407..1409,1413..1415,
1449..1451,1458..1460,1464..1466,1740..1742,1752..1754,
1761..1763)
/gene="VDR"
/gene_synonym="NR1I1"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:132731"
misc_feature order(1275..1277,1287..1289,1305..1307,1320..1322,
1326..1331,1341..1343,1797..1802,1809..1814,1824..1829)
/gene="VDR"
/gene_synonym="NR1I1"
/note="coactivator recognition site [polypeptide binding];
other site"
/db_xref="CDD:132731"
exon 469..549
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 550..697
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 553
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2228570"
variation 608
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228572"
exon 698..828
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 829..1013
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 995
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229828"
exon 1014..1134
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 1135..1306
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 1239
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574090"
exon 1307..1458
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
STS 1321..1428
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDR"
/db_xref="UniSTS:503993"
exon 1459..1575
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 1460
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12721365"
exon 1576..5044
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 1601
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4987032"
variation 1607
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:731236"
variation 1636
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574115"
variation 1757
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:2229829"
STS 1775..2356
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU1"
/db_xref="UniSTS:463500"
variation 2019
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574116"
variation 2057
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574117"
variation 2244
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574118"
STS 2269..2880
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU2"
/db_xref="UniSTS:463501"
variation 2272
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574119"
variation 2363
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574120"
variation 2436
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574121"
variation 2483
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11574122"
variation 2524
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574123"
variation 2583
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574124"
variation 2628
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574125"
variation 2629
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574126"
variation 2727
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574127"
STS 2789..3413
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU3"
/db_xref="UniSTS:463502"
STS 3013..3155
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="WI-17447"
/db_xref="UniSTS:55150"
variation 3014..3015
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="a"
/db_xref="dbSNP:201007499"
variation 3014
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="a"
/db_xref="dbSNP:11574128"
variation 3061
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574129"
variation 3084..3085
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="ccagc"
/db_xref="dbSNP:11574130"
variation 3154
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574131"
variation 3312
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574132"
STS 3338..3926
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU4"
/db_xref="UniSTS:463503"
variation 3355
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11574133"
variation 3501
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11574134"
variation 3676
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:12088"
variation 3700
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11540149"
variation 3741
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:9729"
variation 3858
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574135"
STS 3861..4515
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU5"
/db_xref="UniSTS:463504"
STS 3861..4259
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU5-PoA"
/db_xref="UniSTS:463505"
variation 3972
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12721386"
variation 3978
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2853562"
variation 4061
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574136"
variation 4291
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574137"
variation 4428
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11168263"
variation 4626
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2853563"
variation 4662
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574138"
STS 4764..4936
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="RH17584"
/db_xref="UniSTS:5822"
variation 4809
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11574139"
polyA_signal 5022..5027
/gene="VDR"
/gene_synonym="NR1I1"
polyA_site 5044
/gene="VDR"
/gene_synonym="NR1I1"
ORIGIN
ctgcttgtcaaaaggcggcagcggagccgtgtgcgccgggagcgcggaacagcttgtccacccgccggccggaccaggtgcgaacccgggagcagcgggaaagggggtctcaggatagggactcggggtcggggcgtctgggataccggggcctgagcgcccggctgcgagcattagagtctaagtctcagcggtaaacttggctactgaggtccgggctgtcgtgccatgaggctgggacactaaggggcactgaggtttgagaaagctgaagttcgtgccaggctggcgaggggagcagcgacatcctcggcgcttaggagaaatgctccgctaacacagtgcttagcacttgggcaacaagaagtatttgtttccttcttctgtcggggcgccttggcatggagtggaggaataagaaaaggagcgattggctgtcgatggtgctcagaactgctggagtggaggaagcctttgggtctgaagtgtctgtgagacctcacagaagagcacccctgggctccacttacctgccccctgctccttcagggatggaggcaatggcggccagcacttccctgcctgaccctggagactttgaccggaacgtgccccggatctgtggggtgtgtggagaccgagccactggctttcacttcaatgctatgacctgtgaaggctgcaaaggcttcttcaggcgaagcatgaagcggaaggcactattcacctgccccttcaacggggactgccgcatcaccaaggacaaccgacgccactgccaggcctgccggctcaaacgctgtgtggacatcggcatgatgaaggagttcattctgacagatgaggaagtgcagaggaagcgggagatgatcctgaagcggaaggaggaggaggccttgaaggacagtctgcggcccaagctgtctgaggagcagcagcgcatcattgccatactgctggacgcccaccataagacctacgaccccacctactccgacttctgccagttccggcctccagttcgtgtgaatgatggtggagggagccatccttccaggcccaactccagacacactcccagcttctctggggactcctcctcctcctgctcagatcactgtatcacctcttcagacatgatggactcgtccagcttctccaatctggatctgagtgaagaagattcagatgacccttctgtgaccctagagctgtcccagctctccatgctgccccacctggctgacctggtcagttacagcatccaaaaggtcattggctttgctaagatgataccaggattcagagacctcacctctgaggaccagatcgtactgctgaagtcaagtgccattgaggtcatcatgttgcgctccaatgagtccttcaccatggacgacatgtcctggacctgtggcaaccaagactacaagtaccgcgtcagtgacgtgaccaaagccggacacagcctggagctgattgagcccctcatcaagttccaggtgggactgaagaagctgaacttgcatgaggaggagcatgtcctgctcatggccatctgcatcgtctccccagatcgtcctggggtgcaggacgccgcgctgattgaggccatccaggaccgcctgtccaacacactgcagacgtacatccgctgccgccacccgcccccgggcagccacctgctctatgccaagatgatccagaagctagccgacctgcgcagcctcaatgaggagcactccaagcagtaccgctgcctctccttccagcctgagtgcagcatgaagctaacgccccttgtgctcgaagtgtttggcaatgagatctcctgactaggacagcctgtggcggtgcctgggtggggctgctcctccagggccacgtgccaggcccggggctggcggctactcagcagccctcctcaccccgtctggggttcagcccctcctctgccacctcccctatccacccagcccattctctctcctgtccaacctaacccctttcctgcgggcttttccccggtcccttgagacctcagccatgaggagttgctgtttgtttgacaaagaaacccaagtgggggcagagggcagaggctggaggcagggccttgcccagagatgcctccaccgctgcctaagtggctgctgactgatgttgagggaacagacaggagaaatgcatccattcctcagggacagagacacctgcacctccccccactgcaggccccgcttgtccagcgcctagtggggtctccctctcctgcctactcacgataaataatcggcccacagctcccaccccacccccttcagtgcccaccaacatcccattgccctggttatattctcacgggcagtagctgtggtgaggtgggttttcttcccatcactggagcaccaggcacgaacccacctgctgagagacccaaggaggaaaaacagacaaaaacagcctcacagaagaatatgacagctgtccctgtcaccaagctcacagttcctcgccctgggtctaaggggttggttgaggtggaagccctccttccacggatccatgtagcaggactgaattgtccccagtttgcagaaaagcacctgccgacctcgtcctccccctgccagtgccttacctcctgcccaggagagccagccctccctgtcctcctcggatcaccgagagtagccgagagcctgctcccccaccccctccccaggggagagggtctggagaagcagtgagccgcatcttctccatctggcagggtgggatggaggagaagaattttcagaccccagcggctgagtcatgatctccctgccgcctcaatgtggttgcaaggccgctgttcacccacagggctaagagctagcgctgccgcaccccagagtgtgggaagggagagcggggcagtctcgggtggctagtcagagagagtgtttgggggttccgtgatgtagggtaaggtgccttcttattctcactccaccacccaaaagtcaaaaggtgcctgtgaggcaggggcggagtgatacaacttcaagtgcatgctctctgcagccagcccagcccagctggtgggaagcgtctgtccgtttactccaaggtggggtctttgtgagagtgagctgtaggtgtgcgggaccggtacagaaaggcgttcttcgaggtggatcacagaggcttcttcagatcagtgcttgagtttggggaatgcggccgcattccctgagtcaccaggaatgttaaagtcagtgggaacgtgactgccccaactcctggaagctgtgtccttgcacctgcatccgtagttccctgaaaacccagagaggaatcagacttcacactgcaagagccttggtgtccacctggccccatgtctctcagaattcttcaggtggaaaaacatctgaaagccacgttccttactgcagaatagcatatatatcgcttaatcttaaatttattagatatgagttgttttcagactcagactccatttgtattatagtctaatatacagggtagcaggtaccactgatttggagatatttatggggggagaacttacattgtgaaacttctgtacattaattattattgctgttgttattttacaagggtctagggagagacccttgtttgattttagctgcagaacgtattggtccagcttgctcttcagtgggagaaaacacttgtaagttgctaaacgagtcaatcccctcattcaggaaaactgacagaggagggcgtgactcacccaagcatatataactagctagaagtgggccaggacaggcccggcgcggtggctcacgcctgtaatcccagcagtttgggaggtcgaggtaggtggatcacctgaggtcgggagttcgagaccaacctgaccaacatggagaaaccctgtctctattaaaaatacaaaaaaaaaaaaaaaaaaaatagccgggcatggtggcgcaagcctgtaatcccagctactcaggaggctgaggcagaagaattgaacccaggaggtggaggttgcagtgagctgagatcgtgccgttactctccaacctggacaacaagagcgaaactccgtcttagaagtggaccaggacaggaccagattttggagtcatggtccggtgtccttttcactacaccatgtttgagctcagacccccactctcattccccaggtggctgacccagtccctgggggaagccctggatttcagaaagagcaagtctggatctgggaccctttccttccttccctggcttgtaactccaccaacccatcagaaggagaaggaaggagactcacctctgcctcaatgtgaatcagaccctaccccaccacgatgtggccctggcctgctgggctctccacctcagccttggataatgctgttgcctcatctataacatgcatttgtctttgtaatgtcaccaccttcccagctctccctctggccctgccttcttcggggaactcctggaaatatcagttactcagccctgggccccaccacctaggccactcctccaaaggaagtctaggagctgggaggaaaagaaaagaggggaaaatgagtttttatggggctgaacggggagaaaaggtcatcatcgattctactttagaatgagagtgtgaaatagacatttgtaaatgtaaaacttttaaggtatatcattataactgaaggagaaggtgccccaaaatgcaagattttccacaagattcccagagacaggaaaatcctctggctggctaactggaagcatgtaggagaatccaagcgaggtcaacagagaaggcaggaatgtgtggcagatttagtgaaagctagagatatggcagcgaaaggatgtaaacagtgcctgctgaatgatttccaaagagaaaaaaagtttgccagaagtttgtcaagtcaaccaatgtagaaagctttgcttatggtaataaaaatggctcatacttatatagcacttactttgttgcaagtactgctgtaaataaatgctttatgcaaaccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7421 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0003707 [steroid hormone receptor activity] evidence: IEA
GeneID:7421 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7421 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7421 -> Molecular function: GO:0008434 [calcitriol receptor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0038186 [lithocholic acid receptor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:7421 -> Molecular function: GO:0046965 [retinoid X receptor binding] evidence: IPI
GeneID:7421 -> Molecular function: GO:0070644 [vitamin D response element binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:1902098 [calcitriol binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:1902121 [lithocholic acid binding] evidence: IDA
GeneID:7421 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:7421 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IMP
GeneID:7421 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:7421 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7421 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:7421 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:7421 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
GeneID:7421 -> Biological process: GO:0010839 [negative regulation of keratinocyte proliferation] evidence: IMP
GeneID:7421 -> Biological process: GO:0010980 [positive regulation of vitamin D 24-hydroxylase activity] evidence: IDA
GeneID:7421 -> Biological process: GO:0038183 [bile acid signaling pathway] evidence: IDA
GeneID:7421 -> Biological process: GO:0045618 [positive regulation of keratinocyte differentiation] evidence: IMP
GeneID:7421 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:7421 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:7421 -> Biological process: GO:0046697 [decidualization] evidence: IEP
GeneID:7421 -> Biological process: GO:0060558 [regulation of calcidiol 1-monooxygenase activity] evidence: ISS
GeneID:7421 -> Biological process: GO:0070561 [vitamin D receptor signaling pathway] evidence: IDA
GeneID:7421 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7421 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.