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2025-05-09 16:45:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001017535 4791 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR),
transcript variant 2, mRNA.
ACCESSION NM_001017535
VERSION NM_001017535.1 GI:63054844
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4791)
AUTHORS Asano,L., Ito,I., Kuwabara,N., Waku,T., Yanagisawa,J., Miyachi,H.
and Shimizu,T.
TITLE Structural basis for vitamin D receptor agonism by novel
non-secosteroidal ligands
JOURNAL FEBS Lett. 587 (7), 957-963 (2013)
PUBMED 23462137
REMARK GeneRIF: Data indicate that ligands changed the conformation of the
vitamin D receptor (VDR), resulting in different hydrogen-bond
networks depending on the potency of the ligand.
REFERENCE 2 (bases 1 to 4791)
AUTHORS Li,L., Wu,B., Liu,J.Y. and Yang,L.B.
TITLE Vitamin D receptor gene polymorphisms and type 2 diabetes: a
meta-analysis
JOURNAL Arch. Med. Res. 44 (3), 235-241 (2013)
PUBMED 23506721
REMARK GeneRIF: meta-analysis suggests that the FokI polymorphism of the
VDR gene could be a risk factor for type 2 diabetes, especially in
an Asian population
REFERENCE 3 (bases 1 to 4791)
AUTHORS Tiosano,D., Wildbaum,G., Gepstein,V., Verbitsky,O., Weisman,Y.,
Karin,N. and Eztioni,A.
TITLE The role of vitamin D receptor in innate and adaptive immunity: a
study in hereditary vitamin D-resistant rickets patients
JOURNAL J. Clin. Endocrinol. Metab. 98 (4), 1685-1693 (2013)
PUBMED 23482605
REMARK GeneRIF: The role of vitamin D receptor in innate and adaptive
immunity in vitamin D-resistant rickets.
REFERENCE 4 (bases 1 to 4791)
AUTHORS Chesney,R.W. and Han,X.
TITLE Differential regulation of TauT by calcitriol and retinoic acid via
VDR/RXR in LLC-PK1 and MCF-7 cells
JOURNAL Adv. Exp. Med. Biol. 776, 291-305 (2013)
PUBMED 23392891
REMARK GeneRIF: Expression of TauT is differentially regulated by Vitamin
D(3) and retinoic acid via formation of VDR and RXR complexes in
the nuclei in a cell type-dependent manner.
REFERENCE 5 (bases 1 to 4791)
AUTHORS Pervin,S., Hewison,M., Braga,M., Tran,L., Chun,R., Karam,A.,
Chaudhuri,G., Norris,K. and Singh,R.
TITLE Down-regulation of vitamin D receptor in mammospheres: implications
for vitamin D resistance in breast cancer and potential for
combination therapy
JOURNAL PLoS ONE 8 (1), E53287 (2013)
PUBMED 23341935
REMARK GeneRIF: Inhibition of VDR expression by siRNA led to a significant
change in key epithelial mesenchymal transition-specific
transcription factors and increased the ability of these cells to
form mammospheres.
REFERENCE 6 (bases 1 to 4791)
AUTHORS Goto,H., Chen,K.S., Prahl,J.M. and DeLuca,H.F.
TITLE A single receptor identical with that from intestine/T47D cells
mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells
JOURNAL Biochim. Biophys. Acta 1132 (1), 103-108 (1992)
PUBMED 1324736
REFERENCE 7 (bases 1 to 4791)
AUTHORS Bugge,T.H., Pohl,J., Lonnoy,O. and Stunnenberg,H.G.
TITLE RXR alpha, a promiscuous partner of retinoic acid and thyroid
hormone receptors
JOURNAL EMBO J. 11 (4), 1409-1418 (1992)
PUBMED 1314167
REFERENCE 8 (bases 1 to 4791)
AUTHORS Szpirer,J., Szpirer,C., Riviere,M., Levan,G., Marynen,P.,
Cassiman,J.J., Wiese,R. and DeLuca,H.F.
TITLE The Sp1 transcription factor gene (SP1) and the
1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on
human chromosome arm 12q and rat chromosome 7
JOURNAL Genomics 11 (1), 168-173 (1991)
PUBMED 1662663
REFERENCE 9 (bases 1 to 4791)
AUTHORS Saijo,T., Ito,M., Takeda,E., Huq,A.H., Naito,E., Yokota,I.,
Sone,T., Pike,J.W. and Kuroda,Y.
TITLE A unique mutation in the vitamin D receptor gene in three Japanese
patients with vitamin D-dependent rickets type II: utility of
single-strand conformation polymorphism analysis for heterozygous
carrier detection
JOURNAL Am. J. Hum. Genet. 49 (3), 668-673 (1991)
PUBMED 1652893
REFERENCE 10 (bases 1 to 4791)
AUTHORS Yu,X.P., Mocharla,H., Hustmyer,F.G. and Manolagas,S.C.
TITLE Vitamin D receptor expression in human lymphocytes. Signal
requirements and characterization by western blots and DNA
sequencing
JOURNAL J. Biol. Chem. 266 (12), 7588-7595 (1991)
PUBMED 1850412
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC121338.6, CF138099.1,
BX355584.2, BC060832.1, AC004466.1, J03258.1, BM908433.1 and
BQ002808.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes the nuclear hormone receptor for vitamin
D3. This receptor also functions as a receptor for the secondary
bile acid lithocholic acid. The receptor belongs to the family of
trans-acting transcriptional regulatory factors and shows sequence
similarity to the steroid and thyroid hormone receptors. Downstream
targets of this nuclear hormone receptor are principally involved
in mineral metabolism though the receptor regulates a variety of
other metabolic pathways, such as those involved in the immune
response and cancer. Mutations in this gene are associated with
type II vitamin D-resistant rickets. A single nucleotide
polymorphism in the initiation codon results in an alternate
translation start site three codons downstream. Alternative
splicing results in multiple transcript variants encoding different
proteins. [provided by RefSeq, Feb 2011].
Transcript Variant: This variant (2) differs in the 5' UTR and
coding sequence compared to variant 3. The resulting isoform (VDRA)
is shorter at the N-terminus compared to isoform VDRB1. Variants 1
and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: J03258.1, AB307700.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-16 AC121338.6 15879-15894 c
17-77 CF138099.1 7-67
78-199 BX355584.2 62-183
200-280 CF138099.1 68-148
281-3544 BC060832.1 522-3785
3545-3545 AC004466.1 48367-48367
3546-3668 BC060832.1 3787-3909
3669-3688 J03258.1 3499-3518
3689-3976 J03258.1 3520-3807
3977-4028 J03258.1 3809-3860
4029-4100 J03258.1 3862-3933
4101-4525 BM908433.1 185-609
4526-4737 J03258.1 4356-4567
4738-4772 J03258.1 4569-4603
4773-4791 BQ002808.1 1-19 c
FEATURES Location/Qualifiers
source 1..4791
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13.11"
gene 1..4791
/gene="VDR"
/gene_synonym="NR1I1"
/note="vitamin D (1,25- dihydroxyvitamin D3) receptor"
/db_xref="GeneID:7421"
/db_xref="HGNC:12679"
/db_xref="HPRD:03463"
/db_xref="MIM:601769"
exon 1..77
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 29
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574011"
exon 78..199
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 102..103
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:17883984"
misc_feature 118..120
/gene="VDR"
/gene_synonym="NR1I1"
/note="upstream in-frame stop codon"
exon 200..280
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 281..428
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
CDS 283..1566
/gene="VDR"
/gene_synonym="NR1I1"
/note="isoform VDRA is encoded by transcript variant 2;
vitamin D3 receptor; vitamin D nuclear receptor variant 1;
1,25-dihydroxyvitamin D3 receptor; nuclear receptor
subfamily 1 group I member 1"
/codon_start=1
/product="vitamin D3 receptor isoform VDRA"
/protein_id="NP_001017535.1"
/db_xref="GI:63054845"
/db_xref="CCDS:CCDS8757.1"
/db_xref="GeneID:7421"
/db_xref="HGNC:12679"
/db_xref="HPRD:03463"
/db_xref="MIM:601769"
/translation="
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
"
misc_feature 292..294
/gene="VDR"
/gene_synonym="NR1I1"
/note="Region: alternate start codon"
misc_feature 328..648
/gene="VDR"
/gene_synonym="NR1I1"
/note="DNA-binding domain of vitamin D receptors (VDR) is
composed of two C4-type zinc fingers; Region: NR_DBD_VDR;
cd06955"
/db_xref="CDD:143513"
misc_feature order(352..354,361..363,403..405,412..414,460..462,
478..480,508..510,517..519)
/gene="VDR"
/gene_synonym="NR1I1"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:143513"
misc_feature order(382..390,406..411,415..417,427..432,499..504,
520..522,562..567,580..582)
/gene="VDR"
/gene_synonym="NR1I1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:143513"
misc_feature order(463..468,505..507,556..561)
/gene="VDR"
/gene_synonym="NR1I1"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:143513"
misc_feature 571..855
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Hinge"
misc_feature 652..>759
/gene="VDR"
/gene_synonym="NR1I1"
/note="The ligand binding domain of nuclear receptors, a
family of ligand-activated transcription regulators;
Region: NR_LBD; cl11397"
/db_xref="CDD:209301"
misc_feature 856..1563
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Ligand-binding"
misc_feature 904..906
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00277"
misc_feature 949..1560
/gene="VDR"
/gene_synonym="NR1I1"
/note="The ligand binding domain of vitamin D receptors, a
member of the nuclear receptor superfamily; Region:
NR_LBD_VDR; cd06933"
/db_xref="CDD:132731"
misc_feature order(961..963,970..972,979..984,991..993,1093..1095,
1102..1107,1114..1116,1138..1140,1144..1146,1180..1182,
1189..1191,1195..1197,1471..1473,1483..1485,1492..1494)
/gene="VDR"
/gene_synonym="NR1I1"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:132731"
misc_feature 961..993
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Vitamin D3 binding"
misc_feature order(1006..1008,1018..1020,1036..1038,1051..1053,
1057..1062,1072..1074,1528..1533,1540..1545,1555..1560)
/gene="VDR"
/gene_synonym="NR1I1"
/note="coactivator recognition site [polypeptide binding];
other site"
/db_xref="CDD:132731"
misc_feature 1093..1116
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Vitamin D3 binding"
variation 284
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2228570"
variation 339
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228572"
exon 429..559
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 560..744
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 726
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229828"
exon 745..865
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 866..1037
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 970
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574090"
exon 1038..1189
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
STS 1052..1159
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDR"
/db_xref="UniSTS:503993"
exon 1190..1306
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 1191
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12721365"
exon 1307..4775
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 1332
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4987032"
variation 1338
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:731236"
variation 1367
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574115"
variation 1488
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:2229829"
STS 1506..2087
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU1"
/db_xref="UniSTS:463500"
variation 1750
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574116"
variation 1788
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574117"
variation 1975
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574118"
STS 2000..2611
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU2"
/db_xref="UniSTS:463501"
variation 2003
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574119"
variation 2094
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574120"
variation 2167
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574121"
variation 2214
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11574122"
variation 2255
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574123"
variation 2314
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574124"
variation 2359
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574125"
variation 2360
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574126"
variation 2458
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574127"
STS 2520..3144
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU3"
/db_xref="UniSTS:463502"
STS 2744..2886
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="WI-17447"
/db_xref="UniSTS:55150"
variation 2745..2746
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="a"
/db_xref="dbSNP:201007499"
variation 2745
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="a"
/db_xref="dbSNP:11574128"
variation 2792
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574129"
variation 2815..2816
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="ccagc"
/db_xref="dbSNP:11574130"
variation 2885
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574131"
variation 3043
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574132"
STS 3069..3657
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU4"
/db_xref="UniSTS:463503"
variation 3086
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11574133"
variation 3232
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11574134"
variation 3407
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:12088"
variation 3431
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11540149"
variation 3472
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:9729"
variation 3589
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574135"
STS 3592..4246
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU5"
/db_xref="UniSTS:463504"
STS 3592..3990
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU5-PoA"
/db_xref="UniSTS:463505"
variation 3703
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12721386"
variation 3709
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2853562"
variation 3792
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574136"
variation 4022
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574137"
variation 4159
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11168263"
variation 4357
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2853563"
variation 4393
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574138"
STS 4495..4667
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="RH17584"
/db_xref="UniSTS:5822"
variation 4540
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11574139"
polyA_signal 4753..4758
/gene="VDR"
/gene_synonym="NR1I1"
polyA_site 4775
/gene="VDR"
/gene_synonym="NR1I1"
ORIGIN
ctgcttgtcaaaaggcggcagcggagccgtgtgcgccgggagcgcggaacagcttgtccacccgccggccggaccagggctcctgaacctagcccagctggacggagaaatggactctagcctcctctgatagcctcatgccaggccccgtgcacattgctttgcttgcctccctcaatcctcatagcttctctttgggaagcctttgggtctgaagtgtctgtgagacctcacagaagagcacccctgggctccacttacctgccccctgctccttcagggatggaggcaatggcggccagcacttccctgcctgaccctggagactttgaccggaacgtgccccggatctgtggggtgtgtggagaccgagccactggctttcacttcaatgctatgacctgtgaaggctgcaaaggcttcttcaggcgaagcatgaagcggaaggcactattcacctgccccttcaacggggactgccgcatcaccaaggacaaccgacgccactgccaggcctgccggctcaaacgctgtgtggacatcggcatgatgaaggagttcattctgacagatgaggaagtgcagaggaagcgggagatgatcctgaagcggaaggaggaggaggccttgaaggacagtctgcggcccaagctgtctgaggagcagcagcgcatcattgccatactgctggacgcccaccataagacctacgaccccacctactccgacttctgccagttccggcctccagttcgtgtgaatgatggtggagggagccatccttccaggcccaactccagacacactcccagcttctctggggactcctcctcctcctgctcagatcactgtatcacctcttcagacatgatggactcgtccagcttctccaatctggatctgagtgaagaagattcagatgacccttctgtgaccctagagctgtcccagctctccatgctgccccacctggctgacctggtcagttacagcatccaaaaggtcattggctttgctaagatgataccaggattcagagacctcacctctgaggaccagatcgtactgctgaagtcaagtgccattgaggtcatcatgttgcgctccaatgagtccttcaccatggacgacatgtcctggacctgtggcaaccaagactacaagtaccgcgtcagtgacgtgaccaaagccggacacagcctggagctgattgagcccctcatcaagttccaggtgggactgaagaagctgaacttgcatgaggaggagcatgtcctgctcatggccatctgcatcgtctccccagatcgtcctggggtgcaggacgccgcgctgattgaggccatccaggaccgcctgtccaacacactgcagacgtacatccgctgccgccacccgcccccgggcagccacctgctctatgccaagatgatccagaagctagccgacctgcgcagcctcaatgaggagcactccaagcagtaccgctgcctctccttccagcctgagtgcagcatgaagctaacgccccttgtgctcgaagtgtttggcaatgagatctcctgactaggacagcctgtggcggtgcctgggtggggctgctcctccagggccacgtgccaggcccggggctggcggctactcagcagccctcctcaccccgtctggggttcagcccctcctctgccacctcccctatccacccagcccattctctctcctgtccaacctaacccctttcctgcgggcttttccccggtcccttgagacctcagccatgaggagttgctgtttgtttgacaaagaaacccaagtgggggcagagggcagaggctggaggcagggccttgcccagagatgcctccaccgctgcctaagtggctgctgactgatgttgagggaacagacaggagaaatgcatccattcctcagggacagagacacctgcacctccccccactgcaggccccgcttgtccagcgcctagtggggtctccctctcctgcctactcacgataaataatcggcccacagctcccaccccacccccttcagtgcccaccaacatcccattgccctggttatattctcacgggcagtagctgtggtgaggtgggttttcttcccatcactggagcaccaggcacgaacccacctgctgagagacccaaggaggaaaaacagacaaaaacagcctcacagaagaatatgacagctgtccctgtcaccaagctcacagttcctcgccctgggtctaaggggttggttgaggtggaagccctccttccacggatccatgtagcaggactgaattgtccccagtttgcagaaaagcacctgccgacctcgtcctccccctgccagtgccttacctcctgcccaggagagccagccctccctgtcctcctcggatcaccgagagtagccgagagcctgctcccccaccccctccccaggggagagggtctggagaagcagtgagccgcatcttctccatctggcagggtgggatggaggagaagaattttcagaccccagcggctgagtcatgatctccctgccgcctcaatgtggttgcaaggccgctgttcacccacagggctaagagctagcgctgccgcaccccagagtgtgggaagggagagcggggcagtctcgggtggctagtcagagagagtgtttgggggttccgtgatgtagggtaaggtgccttcttattctcactccaccacccaaaagtcaaaaggtgcctgtgaggcaggggcggagtgatacaacttcaagtgcatgctctctgcagccagcccagcccagctggtgggaagcgtctgtccgtttactccaaggtggggtctttgtgagagtgagctgtaggtgtgcgggaccggtacagaaaggcgttcttcgaggtggatcacagaggcttcttcagatcagtgcttgagtttggggaatgcggccgcattccctgagtcaccaggaatgttaaagtcagtgggaacgtgactgccccaactcctggaagctgtgtccttgcacctgcatccgtagttccctgaaaacccagagaggaatcagacttcacactgcaagagccttggtgtccacctggccccatgtctctcagaattcttcaggtggaaaaacatctgaaagccacgttccttactgcagaatagcatatatatcgcttaatcttaaatttattagatatgagttgttttcagactcagactccatttgtattatagtctaatatacagggtagcaggtaccactgatttggagatatttatggggggagaacttacattgtgaaacttctgtacattaattattattgctgttgttattttacaagggtctagggagagacccttgtttgattttagctgcagaacgtattggtccagcttgctcttcagtgggagaaaacacttgtaagttgctaaacgagtcaatcccctcattcaggaaaactgacagaggagggcgtgactcacccaagcatatataactagctagaagtgggccaggacaggcccggcgcggtggctcacgcctgtaatcccagcagtttgggaggtcgaggtaggtggatcacctgaggtcgggagttcgagaccaacctgaccaacatggagaaaccctgtctctattaaaaatacaaaaaaaaaaaaaaaaaaaatagccgggcatggtggcgcaagcctgtaatcccagctactcaggaggctgaggcagaagaattgaacccaggaggtggaggttgcagtgagctgagatcgtgccgttactctccaacctggacaacaagagcgaaactccgtcttagaagtggaccaggacaggaccagattttggagtcatggtccggtgtccttttcactacaccatgtttgagctcagacccccactctcattccccaggtggctgacccagtccctgggggaagccctggatttcagaaagagcaagtctggatctgggaccctttccttccttccctggcttgtaactccaccaacccatcagaaggagaaggaaggagactcacctctgcctcaatgtgaatcagaccctaccccaccacgatgtggccctggcctgctgggctctccacctcagccttggataatgctgttgcctcatctataacatgcatttgtctttgtaatgtcaccaccttcccagctctccctctggccctgccttcttcggggaactcctggaaatatcagttactcagccctgggccccaccacctaggccactcctccaaaggaagtctaggagctgggaggaaaagaaaagaggggaaaatgagtttttatggggctgaacggggagaaaaggtcatcatcgattctactttagaatgagagtgtgaaatagacatttgtaaatgtaaaacttttaaggtatatcattataactgaaggagaaggtgccccaaaatgcaagattttccacaagattcccagagacaggaaaatcctctggctggctaactggaagcatgtaggagaatccaagcgaggtcaacagagaaggcaggaatgtgtggcagatttagtgaaagctagagatatggcagcgaaaggatgtaaacagtgcctgctgaatgatttccaaagagaaaaaaagtttgccagaagtttgtcaagtcaaccaatgtagaaagctttgcttatggtaataaaaatggctcatacttatatagcacttactttgttgcaagtactgctgtaaataaatgctttatgcaaaccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7421 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0003707 [steroid hormone receptor activity] evidence: IEA
GeneID:7421 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7421 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7421 -> Molecular function: GO:0008434 [calcitriol receptor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0038186 [lithocholic acid receptor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:7421 -> Molecular function: GO:0046965 [retinoid X receptor binding] evidence: IPI
GeneID:7421 -> Molecular function: GO:0070644 [vitamin D response element binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:1902098 [calcitriol binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:1902121 [lithocholic acid binding] evidence: IDA
GeneID:7421 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:7421 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IMP
GeneID:7421 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:7421 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7421 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:7421 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:7421 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
GeneID:7421 -> Biological process: GO:0010839 [negative regulation of keratinocyte proliferation] evidence: IMP
GeneID:7421 -> Biological process: GO:0010980 [positive regulation of vitamin D 24-hydroxylase activity] evidence: IDA
GeneID:7421 -> Biological process: GO:0038183 [bile acid signaling pathway] evidence: IDA
GeneID:7421 -> Biological process: GO:0045618 [positive regulation of keratinocyte differentiation] evidence: IMP
GeneID:7421 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:7421 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:7421 -> Biological process: GO:0046697 [decidualization] evidence: IEP
GeneID:7421 -> Biological process: GO:0060558 [regulation of calcidiol 1-monooxygenase activity] evidence: ISS
GeneID:7421 -> Biological process: GO:0070561 [vitamin D receptor signaling pathway] evidence: IDA
GeneID:7421 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7421 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
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