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2025-10-27 12:22:10, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000376 4669 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR),
transcript variant 1, mRNA.
ACCESSION NM_000376
VERSION NM_000376.2 GI:63054843
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4669)
AUTHORS Asano,L., Ito,I., Kuwabara,N., Waku,T., Yanagisawa,J., Miyachi,H.
and Shimizu,T.
TITLE Structural basis for vitamin D receptor agonism by novel
non-secosteroidal ligands
JOURNAL FEBS Lett. 587 (7), 957-963 (2013)
PUBMED 23462137
REMARK GeneRIF: Data indicate that ligands changed the conformation of the
vitamin D receptor (VDR), resulting in different hydrogen-bond
networks depending on the potency of the ligand.
REFERENCE 2 (bases 1 to 4669)
AUTHORS Li,L., Wu,B., Liu,J.Y. and Yang,L.B.
TITLE Vitamin D receptor gene polymorphisms and type 2 diabetes: a
meta-analysis
JOURNAL Arch. Med. Res. 44 (3), 235-241 (2013)
PUBMED 23506721
REMARK GeneRIF: meta-analysis suggests that the FokI polymorphism of the
VDR gene could be a risk factor for type 2 diabetes, especially in
an Asian population
REFERENCE 3 (bases 1 to 4669)
AUTHORS Tiosano,D., Wildbaum,G., Gepstein,V., Verbitsky,O., Weisman,Y.,
Karin,N. and Eztioni,A.
TITLE The role of vitamin D receptor in innate and adaptive immunity: a
study in hereditary vitamin D-resistant rickets patients
JOURNAL J. Clin. Endocrinol. Metab. 98 (4), 1685-1693 (2013)
PUBMED 23482605
REMARK GeneRIF: The role of vitamin D receptor in innate and adaptive
immunity in vitamin D-resistant rickets.
REFERENCE 4 (bases 1 to 4669)
AUTHORS Chesney,R.W. and Han,X.
TITLE Differential regulation of TauT by calcitriol and retinoic acid via
VDR/RXR in LLC-PK1 and MCF-7 cells
JOURNAL Adv. Exp. Med. Biol. 776, 291-305 (2013)
PUBMED 23392891
REMARK GeneRIF: Expression of TauT is differentially regulated by Vitamin
D(3) and retinoic acid via formation of VDR and RXR complexes in
the nuclei in a cell type-dependent manner.
REFERENCE 5 (bases 1 to 4669)
AUTHORS Pervin,S., Hewison,M., Braga,M., Tran,L., Chun,R., Karam,A.,
Chaudhuri,G., Norris,K. and Singh,R.
TITLE Down-regulation of vitamin D receptor in mammospheres: implications
for vitamin D resistance in breast cancer and potential for
combination therapy
JOURNAL PLoS ONE 8 (1), E53287 (2013)
PUBMED 23341935
REMARK GeneRIF: Inhibition of VDR expression by siRNA led to a significant
change in key epithelial mesenchymal transition-specific
transcription factors and increased the ability of these cells to
form mammospheres.
REFERENCE 6 (bases 1 to 4669)
AUTHORS Goto,H., Chen,K.S., Prahl,J.M. and DeLuca,H.F.
TITLE A single receptor identical with that from intestine/T47D cells
mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells
JOURNAL Biochim. Biophys. Acta 1132 (1), 103-108 (1992)
PUBMED 1324736
REFERENCE 7 (bases 1 to 4669)
AUTHORS Bugge,T.H., Pohl,J., Lonnoy,O. and Stunnenberg,H.G.
TITLE RXR alpha, a promiscuous partner of retinoic acid and thyroid
hormone receptors
JOURNAL EMBO J. 11 (4), 1409-1418 (1992)
PUBMED 1314167
REFERENCE 8 (bases 1 to 4669)
AUTHORS Szpirer,J., Szpirer,C., Riviere,M., Levan,G., Marynen,P.,
Cassiman,J.J., Wiese,R. and DeLuca,H.F.
TITLE The Sp1 transcription factor gene (SP1) and the
1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on
human chromosome arm 12q and rat chromosome 7
JOURNAL Genomics 11 (1), 168-173 (1991)
PUBMED 1662663
REFERENCE 9 (bases 1 to 4669)
AUTHORS Saijo,T., Ito,M., Takeda,E., Huq,A.H., Naito,E., Yokota,I.,
Sone,T., Pike,J.W. and Kuroda,Y.
TITLE A unique mutation in the vitamin D receptor gene in three Japanese
patients with vitamin D-dependent rickets type II: utility of
single-strand conformation polymorphism analysis for heterozygous
carrier detection
JOURNAL Am. J. Hum. Genet. 49 (3), 668-673 (1991)
PUBMED 1652893
REFERENCE 10 (bases 1 to 4669)
AUTHORS Yu,X.P., Mocharla,H., Hustmyer,F.G. and Manolagas,S.C.
TITLE Vitamin D receptor expression in human lymphocytes. Signal
requirements and characterization by western blots and DNA
sequencing
JOURNAL J. Biol. Chem. 266 (12), 7588-7595 (1991)
PUBMED 1850412
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC121338.6, CF138099.1,
BC060832.1, AC004466.1, J03258.1, BM908433.1 and BQ002808.1.
On May 5, 2005 this sequence version replaced gi:4507882.
Summary: This gene encodes the nuclear hormone receptor for vitamin
D3. This receptor also functions as a receptor for the secondary
bile acid lithocholic acid. The receptor belongs to the family of
trans-acting transcriptional regulatory factors and shows sequence
similarity to the steroid and thyroid hormone receptors. Downstream
targets of this nuclear hormone receptor are principally involved
in mineral metabolism though the receptor regulates a variety of
other metabolic pathways, such as those involved in the immune
response and cancer. Mutations in this gene are associated with
type II vitamin D-resistant rickets. A single nucleotide
polymorphism in the initiation codon results in an alternate
translation start site three codons downstream. Alternative
splicing results in multiple transcript variants encoding different
proteins. [provided by RefSeq, Feb 2011].
Transcript Variant: This variant (1) differs in the 5' UTR and
coding sequence compared to variant 3. The resulting isoform (VDRA)
is shorter at the N-terminus compared to isoform VDRB1. Variants 1
and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: J03258.1, AK225844.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-16 AC121338.6 15879-15894 c
17-158 CF138099.1 7-148
159-3422 BC060832.1 522-3785
3423-3423 AC004466.1 48367-48367
3424-3546 BC060832.1 3787-3909
3547-3566 J03258.1 3499-3518
3567-3854 J03258.1 3520-3807
3855-3906 J03258.1 3809-3860
3907-3978 J03258.1 3862-3933
3979-4403 BM908433.1 185-609
4404-4615 J03258.1 4356-4567
4616-4650 J03258.1 4569-4603
4651-4669 BQ002808.1 1-19 c
FEATURES Location/Qualifiers
source 1..4669
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13.11"
gene 1..4669
/gene="VDR"
/gene_synonym="NR1I1"
/note="vitamin D (1,25- dihydroxyvitamin D3) receptor"
/db_xref="GeneID:7421"
/db_xref="HGNC:12679"
/db_xref="HPRD:03463"
/db_xref="MIM:601769"
exon 1..77
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 29
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574011"
exon 78..158
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 159..306
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
CDS 161..1444
/gene="VDR"
/gene_synonym="NR1I1"
/note="isoform VDRA is encoded by transcript variant 1;
vitamin D3 receptor; vitamin D nuclear receptor variant 1;
1,25-dihydroxyvitamin D3 receptor; nuclear receptor
subfamily 1 group I member 1"
/codon_start=1
/product="vitamin D3 receptor isoform VDRA"
/protein_id="NP_000367.1"
/db_xref="GI:4507883"
/db_xref="CCDS:CCDS8757.1"
/db_xref="GeneID:7421"
/db_xref="HGNC:12679"
/db_xref="HPRD:03463"
/db_xref="MIM:601769"
/translation="
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
"
misc_feature 170..172
/gene="VDR"
/gene_synonym="NR1I1"
/note="Region: alternate start codon"
misc_feature 206..526
/gene="VDR"
/gene_synonym="NR1I1"
/note="DNA-binding domain of vitamin D receptors (VDR) is
composed of two C4-type zinc fingers; Region: NR_DBD_VDR;
cd06955"
/db_xref="CDD:143513"
misc_feature order(230..232,239..241,281..283,290..292,338..340,
356..358,386..388,395..397)
/gene="VDR"
/gene_synonym="NR1I1"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:143513"
misc_feature order(260..268,284..289,293..295,305..310,377..382,
398..400,440..445,458..460)
/gene="VDR"
/gene_synonym="NR1I1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:143513"
misc_feature order(341..346,383..385,434..439)
/gene="VDR"
/gene_synonym="NR1I1"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:143513"
misc_feature 449..733
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Hinge"
misc_feature 530..>637
/gene="VDR"
/gene_synonym="NR1I1"
/note="The ligand binding domain of nuclear receptors, a
family of ligand-activated transcription regulators;
Region: NR_LBD; cl11397"
/db_xref="CDD:209301"
misc_feature 734..1441
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Ligand-binding"
misc_feature 782..784
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00277"
misc_feature 827..1438
/gene="VDR"
/gene_synonym="NR1I1"
/note="The ligand binding domain of vitamin D receptors, a
member of the nuclear receptor superfamily; Region:
NR_LBD_VDR; cd06933"
/db_xref="CDD:132731"
misc_feature order(839..841,848..850,857..862,869..871,971..973,
980..985,992..994,1016..1018,1022..1024,1058..1060,
1067..1069,1073..1075,1349..1351,1361..1363,1370..1372)
/gene="VDR"
/gene_synonym="NR1I1"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:132731"
misc_feature 839..871
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Vitamin D3 binding"
misc_feature order(884..886,896..898,914..916,929..931,935..940,
950..952,1406..1411,1418..1423,1433..1438)
/gene="VDR"
/gene_synonym="NR1I1"
/note="coactivator recognition site [polypeptide binding];
other site"
/db_xref="CDD:132731"
misc_feature 971..994
/gene="VDR"
/gene_synonym="NR1I1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11473.1);
Region: Vitamin D3 binding"
variation 162
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2228570"
variation 217
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228572"
exon 307..437
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 438..622
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 604
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229828"
exon 623..743
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
exon 744..915
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 848
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574090"
exon 916..1067
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
STS 930..1037
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDR"
/db_xref="UniSTS:503993"
exon 1068..1184
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 1069
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12721365"
exon 1185..4653
/gene="VDR"
/gene_synonym="NR1I1"
/inference="alignment:Splign:1.39.8"
variation 1210
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4987032"
variation 1216
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:731236"
variation 1245
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574115"
variation 1366
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:2229829"
STS 1384..1965
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU1"
/db_xref="UniSTS:463500"
variation 1628
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574116"
variation 1666
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574117"
variation 1853
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574118"
STS 1878..2489
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU2"
/db_xref="UniSTS:463501"
variation 1881
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11574119"
variation 1972
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574120"
variation 2045
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574121"
variation 2092
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11574122"
variation 2133
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574123"
variation 2192
/gene="VDR"
/gene_synonym="NR1I1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11574124"
variation 2237
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574125"
variation 2238
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574126"
variation 2336
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574127"
STS 2398..3022
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU3"
/db_xref="UniSTS:463502"
STS 2622..2764
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="WI-17447"
/db_xref="UniSTS:55150"
variation 2623..2624
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="a"
/db_xref="dbSNP:201007499"
variation 2623
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="a"
/db_xref="dbSNP:11574128"
variation 2670
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574129"
variation 2693..2694
/gene="VDR"
/gene_synonym="NR1I1"
/replace=""
/replace="ccagc"
/db_xref="dbSNP:11574130"
variation 2763
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574131"
variation 2921
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574132"
STS 2947..3535
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU4"
/db_xref="UniSTS:463503"
variation 2964
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11574133"
variation 3110
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11574134"
variation 3285
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="g"
/db_xref="dbSNP:12088"
variation 3309
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11540149"
variation 3350
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:9729"
variation 3467
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574135"
STS 3470..4124
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU5"
/db_xref="UniSTS:463504"
STS 3470..3868
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="VDRU5-PoA"
/db_xref="UniSTS:463505"
variation 3581
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12721386"
variation 3587
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2853562"
variation 3670
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574136"
variation 3900
/gene="VDR"
/gene_synonym="NR1I1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574137"
variation 4037
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11168263"
variation 4235
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2853563"
variation 4271
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11574138"
STS 4373..4545
/gene="VDR"
/gene_synonym="NR1I1"
/standard_name="RH17584"
/db_xref="UniSTS:5822"
variation 4418
/gene="VDR"
/gene_synonym="NR1I1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11574139"
polyA_signal 4631..4636
/gene="VDR"
/gene_synonym="NR1I1"
polyA_site 4653
/gene="VDR"
/gene_synonym="NR1I1"
ORIGIN
ctgcttgtcaaaaggcggcagcggagccgtgtgcgccgggagcgcggaacagcttgtccacccgccggccggaccagaagcctttgggtctgaagtgtctgtgagacctcacagaagagcacccctgggctccacttacctgccccctgctccttcagggatggaggcaatggcggccagcacttccctgcctgaccctggagactttgaccggaacgtgccccggatctgtggggtgtgtggagaccgagccactggctttcacttcaatgctatgacctgtgaaggctgcaaaggcttcttcaggcgaagcatgaagcggaaggcactattcacctgccccttcaacggggactgccgcatcaccaaggacaaccgacgccactgccaggcctgccggctcaaacgctgtgtggacatcggcatgatgaaggagttcattctgacagatgaggaagtgcagaggaagcgggagatgatcctgaagcggaaggaggaggaggccttgaaggacagtctgcggcccaagctgtctgaggagcagcagcgcatcattgccatactgctggacgcccaccataagacctacgaccccacctactccgacttctgccagttccggcctccagttcgtgtgaatgatggtggagggagccatccttccaggcccaactccagacacactcccagcttctctggggactcctcctcctcctgctcagatcactgtatcacctcttcagacatgatggactcgtccagcttctccaatctggatctgagtgaagaagattcagatgacccttctgtgaccctagagctgtcccagctctccatgctgccccacctggctgacctggtcagttacagcatccaaaaggtcattggctttgctaagatgataccaggattcagagacctcacctctgaggaccagatcgtactgctgaagtcaagtgccattgaggtcatcatgttgcgctccaatgagtccttcaccatggacgacatgtcctggacctgtggcaaccaagactacaagtaccgcgtcagtgacgtgaccaaagccggacacagcctggagctgattgagcccctcatcaagttccaggtgggactgaagaagctgaacttgcatgaggaggagcatgtcctgctcatggccatctgcatcgtctccccagatcgtcctggggtgcaggacgccgcgctgattgaggccatccaggaccgcctgtccaacacactgcagacgtacatccgctgccgccacccgcccccgggcagccacctgctctatgccaagatgatccagaagctagccgacctgcgcagcctcaatgaggagcactccaagcagtaccgctgcctctccttccagcctgagtgcagcatgaagctaacgccccttgtgctcgaagtgtttggcaatgagatctcctgactaggacagcctgtggcggtgcctgggtggggctgctcctccagggccacgtgccaggcccggggctggcggctactcagcagccctcctcaccccgtctggggttcagcccctcctctgccacctcccctatccacccagcccattctctctcctgtccaacctaacccctttcctgcgggcttttccccggtcccttgagacctcagccatgaggagttgctgtttgtttgacaaagaaacccaagtgggggcagagggcagaggctggaggcagggccttgcccagagatgcctccaccgctgcctaagtggctgctgactgatgttgagggaacagacaggagaaatgcatccattcctcagggacagagacacctgcacctccccccactgcaggccccgcttgtccagcgcctagtggggtctccctctcctgcctactcacgataaataatcggcccacagctcccaccccacccccttcagtgcccaccaacatcccattgccctggttatattctcacgggcagtagctgtggtgaggtgggttttcttcccatcactggagcaccaggcacgaacccacctgctgagagacccaaggaggaaaaacagacaaaaacagcctcacagaagaatatgacagctgtccctgtcaccaagctcacagttcctcgccctgggtctaaggggttggttgaggtggaagccctccttccacggatccatgtagcaggactgaattgtccccagtttgcagaaaagcacctgccgacctcgtcctccccctgccagtgccttacctcctgcccaggagagccagccctccctgtcctcctcggatcaccgagagtagccgagagcctgctcccccaccccctccccaggggagagggtctggagaagcagtgagccgcatcttctccatctggcagggtgggatggaggagaagaattttcagaccccagcggctgagtcatgatctccctgccgcctcaatgtggttgcaaggccgctgttcacccacagggctaagagctagcgctgccgcaccccagagtgtgggaagggagagcggggcagtctcgggtggctagtcagagagagtgtttgggggttccgtgatgtagggtaaggtgccttcttattctcactccaccacccaaaagtcaaaaggtgcctgtgaggcaggggcggagtgatacaacttcaagtgcatgctctctgcagccagcccagcccagctggtgggaagcgtctgtccgtttactccaaggtggggtctttgtgagagtgagctgtaggtgtgcgggaccggtacagaaaggcgttcttcgaggtggatcacagaggcttcttcagatcagtgcttgagtttggggaatgcggccgcattccctgagtcaccaggaatgttaaagtcagtgggaacgtgactgccccaactcctggaagctgtgtccttgcacctgcatccgtagttccctgaaaacccagagaggaatcagacttcacactgcaagagccttggtgtccacctggccccatgtctctcagaattcttcaggtggaaaaacatctgaaagccacgttccttactgcagaatagcatatatatcgcttaatcttaaatttattagatatgagttgttttcagactcagactccatttgtattatagtctaatatacagggtagcaggtaccactgatttggagatatttatggggggagaacttacattgtgaaacttctgtacattaattattattgctgttgttattttacaagggtctagggagagacccttgtttgattttagctgcagaacgtattggtccagcttgctcttcagtgggagaaaacacttgtaagttgctaaacgagtcaatcccctcattcaggaaaactgacagaggagggcgtgactcacccaagcatatataactagctagaagtgggccaggacaggcccggcgcggtggctcacgcctgtaatcccagcagtttgggaggtcgaggtaggtggatcacctgaggtcgggagttcgagaccaacctgaccaacatggagaaaccctgtctctattaaaaatacaaaaaaaaaaaaaaaaaaaatagccgggcatggtggcgcaagcctgtaatcccagctactcaggaggctgaggcagaagaattgaacccaggaggtggaggttgcagtgagctgagatcgtgccgttactctccaacctggacaacaagagcgaaactccgtcttagaagtggaccaggacaggaccagattttggagtcatggtccggtgtccttttcactacaccatgtttgagctcagacccccactctcattccccaggtggctgacccagtccctgggggaagccctggatttcagaaagagcaagtctggatctgggaccctttccttccttccctggcttgtaactccaccaacccatcagaaggagaaggaaggagactcacctctgcctcaatgtgaatcagaccctaccccaccacgatgtggccctggcctgctgggctctccacctcagccttggataatgctgttgcctcatctataacatgcatttgtctttgtaatgtcaccaccttcccagctctccctctggccctgccttcttcggggaactcctggaaatatcagttactcagccctgggccccaccacctaggccactcctccaaaggaagtctaggagctgggaggaaaagaaaagaggggaaaatgagtttttatggggctgaacggggagaaaaggtcatcatcgattctactttagaatgagagtgtgaaatagacatttgtaaatgtaaaacttttaaggtatatcattataactgaaggagaaggtgccccaaaatgcaagattttccacaagattcccagagacaggaaaatcctctggctggctaactggaagcatgtaggagaatccaagcgaggtcaacagagaaggcaggaatgtgtggcagatttagtgaaagctagagatatggcagcgaaaggatgtaaacagtgcctgctgaatgatttccaaagagaaaaaaagtttgccagaagtttgtcaagtcaaccaatgtagaaagctttgcttatggtaataaaaatggctcatacttatatagcacttactttgttgcaagtactgctgtaaataaatgctttatgcaaaccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7421 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0003707 [steroid hormone receptor activity] evidence: IEA
GeneID:7421 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7421 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7421 -> Molecular function: GO:0008434 [calcitriol receptor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0038186 [lithocholic acid receptor activity] evidence: IDA
GeneID:7421 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:7421 -> Molecular function: GO:0046965 [retinoid X receptor binding] evidence: IPI
GeneID:7421 -> Molecular function: GO:0070644 [vitamin D response element binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:1902098 [calcitriol binding] evidence: IDA
GeneID:7421 -> Molecular function: GO:1902121 [lithocholic acid binding] evidence: IDA
GeneID:7421 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:7421 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IMP
GeneID:7421 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:7421 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7421 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:7421 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:7421 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
GeneID:7421 -> Biological process: GO:0010839 [negative regulation of keratinocyte proliferation] evidence: IMP
GeneID:7421 -> Biological process: GO:0010980 [positive regulation of vitamin D 24-hydroxylase activity] evidence: IDA
GeneID:7421 -> Biological process: GO:0038183 [bile acid signaling pathway] evidence: IDA
GeneID:7421 -> Biological process: GO:0045618 [positive regulation of keratinocyte differentiation] evidence: IMP
GeneID:7421 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:7421 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:7421 -> Biological process: GO:0046697 [decidualization] evidence: IEP
GeneID:7421 -> Biological process: GO:0060558 [regulation of calcidiol 1-monooxygenase activity] evidence: ISS
GeneID:7421 -> Biological process: GO:0070561 [vitamin D receptor signaling pathway] evidence: IDA
GeneID:7421 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7421 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
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