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2025-05-09 19:47:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015368 2782 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens pannexin 1 (PANX1), mRNA.
ACCESSION NM_015368
VERSION NM_015368.3 GI:39995063
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2782)
AUTHORS Lohman,A.W., Weaver,J.L., Billaud,M., Sandilos,J.K., Griffiths,R.,
Straub,A.C., Penuela,S., Leitinger,N., Laird,D.W., Bayliss,D.A. and
Isakson,B.E.
TITLE S-nitrosylation inhibits pannexin 1 channel function
JOURNAL J. Biol. Chem. 287 (47), 39602-39612 (2012)
PUBMED 23033481
REMARK GeneRIF: S-nitrosylation of Panx1 at Cys-40 and Cys-346 inhibits
Panx1 channel currents and ATP release.
REFERENCE 2 (bases 1 to 2782)
AUTHORS Xiao,F., Waldrop,S.L., Khimji,A.K. and Kilic,G.
TITLE Pannexin1 contributes to pathophysiological ATP release in
lipoapoptosis induced by saturated free fatty acids in liver cells
JOURNAL Am. J. Physiol., Cell Physiol. 303 (10), C1034-C1044 (2012)
PUBMED 22972801
REMARK GeneRIF: These results suggest that panx1 contributes to
pathophysiological ATP release in lipoapoptosis induced by
saturated FFA; panx1 may play a role in hepatic inflammation by
mediating an increase in extracellular ATP concentration in
lipotoxic liver injury.
REFERENCE 3 (bases 1 to 2782)
AUTHORS Penuela,S., Gyenis,L., Ablack,A., Churko,J.M., Berger,A.C.,
Litchfield,D.W., Lewis,J.D. and Laird,D.W.
TITLE Loss of pannexin 1 attenuates melanoma progression by reversion to
a melanocytic phenotype
JOURNAL J. Biol. Chem. 287 (34), 29184-29193 (2012)
PUBMED 22753409
REMARK GeneRIF: while Panx1 is present in skin melanocytes it is
up-regulated during melanoma tumor progression, and tumorigenesis
can be inhibited by the knockdown of Panx1 raising the possibility
that Panx1 may be a viable target for the treatment of melanoma.
REFERENCE 4 (bases 1 to 2782)
AUTHORS Cowan,K.N., Langlois,S., Penuela,S., Cowan,B.J. and Laird,D.W.
TITLE Pannexin1 and Pannexin3 exhibit distinct localization patterns in
human skin appendages and are regulated during keratinocyte
differentiation and carcinogenesis
JOURNAL Cell Commun. Adhes. 19 (3-4), 45-53 (2012)
PUBMED 22947051
REMARK GeneRIF: Panx1 level is modulated during keratinocyte
differentiation and carcinogenesis and reveal distinct localization
pattern for Panx1 in human adnexal structures.
REFERENCE 5 (bases 1 to 2782)
AUTHORS Sandilos,J.K., Chiu,Y.H., Chekeni,F.B., Armstrong,A.J., Walk,S.F.,
Ravichandran,K.S. and Bayliss,D.A.
TITLE Pannexin 1, an ATP release channel, is activated by caspase
cleavage of its pore-associated C-terminal autoinhibitory region
JOURNAL J. Biol. Chem. 287 (14), 11303-11311 (2012)
PUBMED 22311983
REMARK GeneRIF: mechanism of PANX1 channel regulation
REFERENCE 6 (bases 1 to 2782)
AUTHORS Locovei,S., Bao,L. and Dahl,G.
TITLE Pannexin 1 in erythrocytes: function without a gap
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (20), 7655-7659 (2006)
PUBMED 16682648
REMARK GeneRIF: Data show that erythrocytes express the gap junction
protein pannexin 1.
REFERENCE 7 (bases 1 to 2782)
AUTHORS Thompson,R.J., Zhou,N. and MacVicar,B.A.
TITLE Ischemia opens neuronal gap junction hemichannels
JOURNAL Science 312 (5775), 924-927 (2006)
PUBMED 16690868
REMARK GeneRIF: Pannexin-1 in pyramidal neurons is activated by ischemia
and may play an important role ionic dysregulation
REFERENCE 8 (bases 1 to 2782)
AUTHORS Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
Panchin,Y.
TITLE The mammalian pannexin family is homologous to the invertebrate
innexin gap junction proteins
JOURNAL Genomics 83 (4), 706-716 (2004)
PUBMED 15028292
REFERENCE 9 (bases 1 to 2782)
AUTHORS Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
TITLE Pannexins, a family of gap junction proteins expressed in brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (23), 13644-13649 (2003)
PUBMED 14597722
REFERENCE 10 (bases 1 to 2782)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC016931.1, AF398509.1,
AK074897.1, AY359023.1 and CA418094.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 17, 2003 this sequence version replaced gi:29837657.
Summary: The protein encoded by this gene belongs to the innexin
family. Innexin family members are the structural components of gap
junctions. This protein and pannexin 2 are abundantly expressed in
central nerve system (CNS) and are coexpressed in various neuronal
populations. Studies in Xenopus oocytes suggest that this protein
alone and in combination with pannexin 2 may form cell
type-specific gap junctions with distinct properties. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC016931.1, AK074897.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-21 BC016931.1 1-21
22-174 AF398509.1 20-172
175-399 AK074897.1 120-344
400-1676 AY359023.1 161-1437
1677-2758 AK074897.1 1622-2703
2759-2782 CA418094.1 1-24 c
FEATURES Location/Qualifiers
source 1..2782
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q21"
gene 1..2782
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/note="pannexin 1"
/db_xref="GeneID:24145"
/db_xref="HGNC:8599"
/db_xref="HPRD:10526"
/db_xref="MIM:608420"
exon 1..566
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="alignment:Splign:1.39.8"
variation 162..166
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace=""
/replace="cccgc"
/db_xref="dbSNP:72253125"
variation 182
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace=""
/replace="ccgcc"
/db_xref="dbSNP:57120261"
variation 252
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:78409697"
variation 256
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="c"
/db_xref="dbSNP:146477497"
variation 264
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:113788267"
variation 312
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:140930098"
misc_feature 314..316
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/note="upstream in-frame stop codon"
variation 352
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:201087780"
variation 353
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:376331286"
variation 362
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:370158352"
variation 365
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:77517764"
variation 368
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:370364319"
CDS 386..1666
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/note="innexin"
/codon_start=1
/product="pannexin-1"
/protein_id="NP_056183.2"
/db_xref="GI:39995064"
/db_xref="CCDS:CCDS8296.1"
/db_xref="GeneID:24145"
/db_xref="HGNC:8599"
/db_xref="HPRD:10526"
/db_xref="MIM:608420"
/translation="
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
"
misc_feature 506..568
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
transmembrane region"
misc_feature 704..766
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
transmembrane region"
misc_feature 1037..1099
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
transmembrane region"
misc_feature 1184..1246
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
transmembrane region"
variation 387
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:374023714"
variation 391
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:200382446"
variation 395
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="c"
/db_xref="dbSNP:17856519"
variation 400
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="c"
/db_xref="dbSNP:1138800"
variation 436
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:375516411"
variation 466
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:143890339"
variation 467
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:147278985"
variation 493
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:74613753"
variation 532
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:140681094"
exon 567..706
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="alignment:Splign:1.39.8"
variation 576
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:369757341"
variation 600
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:141406306"
variation 603
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:187445142"
variation 617
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:376684216"
variation 641
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:75339423"
variation 642
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:74961890"
variation 647
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:150832252"
variation 657
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="t"
/db_xref="dbSNP:1138799"
variation 658
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:369787689"
exon 707..930
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="alignment:Splign:1.39.8"
variation 731
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:139198736"
variation 735
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:184999372"
variation 756
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:199806267"
variation 757
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:376627227"
variation 766
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:200950145"
variation 768
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:200209193"
variation 772
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:371008778"
variation 773
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:201108551"
variation 812
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:202058238"
variation 839
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:111535626"
variation 844
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:377364972"
variation 850
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:149967628"
variation 857
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:145987256"
variation 864
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:371181159"
variation 865
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:201582998"
variation 929
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="t"
/db_xref="dbSNP:374405472"
exon 931..1586
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="alignment:Splign:1.39.8"
variation 941
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:181188850"
variation 985
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:374632686"
variation 1034
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:139920522"
variation 1035
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:143240087"
variation 1065
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:201905685"
variation 1066
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:372150104"
variation 1084
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:146698723"
variation 1093
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:140305953"
variation 1099
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:200067953"
variation 1112
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:142497626"
variation 1150
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:74832612"
variation 1176
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="c"
/db_xref="dbSNP:185625556"
variation 1193
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:375463776"
variation 1197
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:189649511"
variation 1199
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:12793348"
variation 1253
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:372103195"
variation 1267
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:375539925"
variation 1269
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:150484412"
variation 1312
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:138457061"
variation 1313
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:372606410"
variation 1347
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:201625424"
variation 1362
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:376071442"
variation 1423
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:369193430"
variation 1429
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:142555858"
variation 1465
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:373415904"
variation 1468
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:180948414"
variation 1475
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:185167261"
variation 1477
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:376644296"
variation 1499
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="t"
/db_xref="dbSNP:371006077"
variation 1501
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:191847249"
variation 1518
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:148324299"
variation 1555
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:74549886"
variation 1572
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:115773754"
variation 1573
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:369648726"
variation 1581
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:202124256"
variation 1584
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:199948423"
variation 1585
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:79692921"
exon 1587..2769
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/inference="alignment:Splign:1.39.8"
variation 1589
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:182654100"
variation 1595
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:200926531"
variation 1622
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="g"
/replace="t"
/db_xref="dbSNP:375269852"
variation 1637
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:187308377"
variation 1638
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:368311655"
variation 1681
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:202182737"
variation 1683
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:372065089"
variation 1760
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:12800562"
variation 1977
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:72972552"
variation 2074
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:4453199"
variation 2082
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046805"
variation 2109
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:13655"
variation 2264
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="g"
/db_xref="dbSNP:141960320"
variation 2340
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:1046812"
variation 2412
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:368833550"
STS 2554..2704
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/standard_name="WIAF-1483"
/db_xref="UniSTS:22488"
variation 2587
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:1070"
variation 2601
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="g"
/db_xref="dbSNP:191846383"
variation 2621
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="c"
/db_xref="dbSNP:1071"
variation 2717
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="t"
/db_xref="dbSNP:183658061"
variation 2719
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:146290949"
variation 2725
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:8830"
variation 2735
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="c"
/replace="t"
/db_xref="dbSNP:117849903"
polyA_signal 2738..2743
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
variation 2765
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
/replace="a"
/replace="t"
/db_xref="dbSNP:72972556"
polyA_site 2769
/gene="PANX1"
/gene_synonym="MRS1; PX1; UNQ2529"
ORIGIN
gggcggcgcggaggggcagggccagagggaagcgctttgttccgcgcgtggttcccgcgcctgggggtgcgcgggagaggcgcgaatccgagtgccgcgcgcggcccggggacttgcacgggcgtgcggggtggaaccgcaggaagcggagctctcgggttcccgccccgccccgccccgccggcggcggaggcagcgagcgcgagagcccagcggagtcgctgggagcctgaggcaccgagacacaaaggcaggcgggatgcgggagcaggcaaagggaaagcgaaagccgcgcgcccggccggtgactgggtgaaggcgccgcgcagctttcccgacgccggctgtacccggacctcctggtcgagcctggcgcgccgcagccatggccatcgctcaactggccacggagtacgtgttctcggatttcttgctgaaggagcccacggagcccaagttcaaggggctgcgactggagctggctgtggacaagatggtcacgtgcattgcggtggggctgcccctgctgctcatctcgctggccttcgcgcaggagatctcgattggtacacagataagctgtttctctccaagttctttctcctggcgtcaggctgcctttgtggattcatattgctgggcggctgttcagcagaagaactcactgcagagcgagtctggaaacctcccactgtggctgcataagtttttcccctacatcctgctgctctttgcgatcctcctgtacctgcccccgctgttctggcgtttcgcagctgctcctcatatttgctcagacttgaagtttatcatggaagaacttgacaaagtttacaaccgtgcaattaaggctgcaaagagtgcgcgtgaccttgacatgagagatggagcctgctcagttccaggtgttaccgagaacttagggcaaagtttgtgggaggtatctgaaagccacttcaagtacccaattgtggagcagtacttgaagacaaagaaaaattctaataatttaatcatcaagtacattagctgccgcctgctgacactcatcattatactgttagcgtgtatctacctgggctattacttcagcctctcctcactctcagacgagtttgtgtgcagcatcaaatcagggatcctgagaaacgacagcaccgtgcccgatcagtttcagtgcaaactcattgccgtgggcatcttccagttgctcagtgtcattaaccttgtggtttatgtcctgctggctcccgtggttgtctacacgctgtttgttccattccgacagaagacagatgttctcaaagtgtacgaaatcctccccacttttgatgttctgcatttcaaatctgaagggtacaacgatttgagcctctacaatctcttcttggaggaaaatataagtgaggtcaagtcatacaagtgtcttaaggtactggagaatattaagagcagtggtcaggggatcgacccaatgctactcctgacaaaccttggcatgatcaagatggatgttgttgatggcaaaactcccatgtctgcagagatgagagaggagcaggggaaccagacggcagagctccaaggtatgaacatagacagtgaaactaaagcaaataatggagagaagaatgcccgacagagacttctggattcttcttgctgatgatttttttccttgagctgtaaatctgtgacttctgcgacatgggatttaatttggctaaagcacccctgttggtttcacagctggtttgcaataaatggttcttggtggagatactgagcatgtcttattgagtccctaatggaaatggtgatcaacaaaaggttatggaagaatggtttatgaacttcccataggaagcacctgagagatagtaaactgcagcaagtaactatgtgtaagtcctcatcaaatgaaaagcagaaagacaagaacaattagtcaagagcagtagccctgtcagagcctcggagcaatacctttctgtacccgtggtgagacaagacccagagctactggaaaacaagcactttggaagatttgttttgttttcatggaataataatatgtcagggtataatttaacgtgagtttcttatgtgcccttaaagactgttagacaagaaaagcattcactggctaataatccataggtcgacctatgtcctaagttaggtgtaaggtccgatgccttggcccacactcgagctctctttacattgttagttgtcaaccttggctgatggaaatcccgtaaccactatttgttgcactgtgccttgaagggcagcaggcccaagtgctgctctgactgaaaactgagttaacaagatgaaatctaaaggatattcacagtgacttcaattcaggaagaatgcttccaaaagagcccagtggggaaatctgacatcacagaagacattaattcagtcactttcaaagagtttgtctacaggcggtttctctgttatcaaaggcatttgaaataggattttacttaaacaataatggaacacaggagtatttaaagtgaagaacactttgcctgaatgtgatcagggcacataagtgacattggcatgcttcatatggcgtgcttggagccagaaaaacttagcggtttattttgtttatatttaagcacagctttaaaaaattcattatcgtttattcagtgtccgaattgaggccatttgggaagaaaattctagcactggtggagaattatagaataaagattataaatggttggataagacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:24145 -> Molecular function: GO:0002020 [protease binding] evidence: IEA
GeneID:24145 -> Molecular function: GO:0005102 [receptor binding] evidence: IPI
GeneID:24145 -> Molecular function: GO:0005262 [calcium channel activity] evidence: IMP
GeneID:24145 -> Molecular function: GO:0022840 [leak channel activity] evidence: IMP
GeneID:24145 -> Molecular function: GO:0044325 [ion channel binding] evidence: IEA
GeneID:24145 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:24145 -> Molecular function: GO:0051015 [actin filament binding] evidence: IEA
GeneID:24145 -> Molecular function: GO:0055077 [gap junction hemi-channel activity] evidence: IDA
GeneID:24145 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IEA
GeneID:24145 -> Biological process: GO:0002931 [response to ischemia] evidence: IEA
GeneID:24145 -> Biological process: GO:0006812 [cation transport] evidence: IDA
GeneID:24145 -> Biological process: GO:0006816 [calcium ion transport] evidence: IMP
GeneID:24145 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:24145 -> Biological process: GO:0033198 [response to ATP] evidence: IEA
GeneID:24145 -> Biological process: GO:0034214 [protein hexamerization] evidence: IDA
GeneID:24145 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
GeneID:24145 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:24145 -> Biological process: GO:0050717 [positive regulation of interleukin-1 alpha secretion] evidence: IEA
GeneID:24145 -> Biological process: GO:0050718 [positive regulation of interleukin-1 beta secretion] evidence: IDA
GeneID:24145 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
GeneID:24145 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
GeneID:24145 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:24145 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:24145 -> Cellular component: GO:0005921 [gap junction] evidence: IEA
GeneID:24145 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:24145 -> Cellular component: GO:0032059 [bleb] evidence: IDA
GeneID:24145 -> Cellular component: GO:0043234 [protein complex] evidence: IEA
by
@meso_cacase at
DBCLS
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