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2025-11-15 11:03:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_024309 1993 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens TNFAIP3 interacting protein 2 (TNIP2), transcript
variant 1, mRNA.
ACCESSION NM_024309
VERSION NM_024309.3 GI:239787091
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1993)
AUTHORS Leotoing,L., Chereau,F., Baron,S., Hube,F., Valencia,H.J.,
Bordereaux,D., Demmers,J.A., Strouboulis,J. and Baud,V.
TITLE A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2
(ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase
alpha (IKKalpha)-mediated NF-kappaB transcriptional activity
JOURNAL J. Biol. Chem. 286 (37), 32277-32288 (2011)
PUBMED 21784860
REMARK GeneRIF: ABIN-2 acts as a positive regulator of NF-kappaB-dependent
transcription by activating IKKalpha.
REFERENCE 2 (bases 1 to 1993)
AUTHORS Dong,G., Chanudet,E., Zeng,N., Appert,A., Chen,Y.W., Au,W.Y.,
Hamoudi,R.A., Watkins,A.J., Ye,H., Liu,H., Gao,Z., Chuang,S.S.,
Srivastava,G. and Du,M.Q.
TITLE A20, ABIN-1/2, and CARD11 mutations and their prognostic value in
gastrointestinal diffuse large B-cell lymphoma
JOURNAL Clin. Cancer Res. 17 (6), 1440-1451 (2011)
PUBMED 21266526
REMARK GeneRIF: A20, ABIN-1/2, and CARD11 mutations have prognostic value
in gastrointestinal diffuse large B-cell lymphoma
REFERENCE 3 (bases 1 to 1993)
AUTHORS Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci
C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI,
Ardlie KG, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J,
Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding
B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner
DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW,
Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S,
Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma
IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, Altshuler D,
Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA,
Worthington J, Klareskog L, Gregersen PK, Daly MJ and Plenge RM.
CONSRTM BIRAC Consortium; YEAR Consortium
TITLE Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with
rheumatoid arthritis risk
JOURNAL Nat. Genet. 41 (12), 1313-1318 (2009)
PUBMED 19898481
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 1993)
AUTHORS Handoyo,H., Stafford,M.J., McManus,E., Baltzis,D., Peggie,M. and
Cohen,P.
TITLE IRAK1-independent pathways required for the
interleukin-1-stimulated activation of the Tpl2 catalytic subunit
and its dissociation from ABIN2
JOURNAL Biochem. J. 424 (1), 109-118 (2009)
PUBMED 19754427
REMARK GeneRIF: The IRAK1-, IKKbeta- and PP2-independent dissociation of
Tpl2 from ABIN2 is one of the two signalling events involved in
activation of the native Tpl2 complex by IL-1.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1993)
AUTHORS Verstrepen,L., Carpentier,I., Verhelst,K. and Beyaert,R.
TITLE ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling
JOURNAL Biochem. Pharmacol. 78 (2), 105-114 (2009)
PUBMED 19464428
REMARK GeneRIF: This review defines ABIN-2 based on three different
parameters: ability to bind A20; ability to inhibit NF-kappaB
activation upon overexpression; the presence of specific short
amino acid regions of strong homology, designated ABIN homology
domains.
Review article
REFERENCE 6 (bases 1 to 1993)
AUTHORS Liu,W.K., Chien,C.Y., Chou,C.K. and Su,J.Y.
TITLE An LKB1-interacting protein negatively regulates TNFalpha-induced
NF-kappaB activation
JOURNAL J. Biomed. Sci. 10 (2), 242-252 (2003)
PUBMED 12595760
REMARK GeneRIF: FLIP1 has a role in the regulation of NF-kappaB activity
related to the role of LKB1 in tumor suppression
REFERENCE 7 (bases 1 to 1993)
AUTHORS Wu,W.S., Xu,Z.X. and Chang,K.S.
TITLE The promyelocytic leukemia protein represses A20-mediated
transcription
JOURNAL J. Biol. Chem. 277 (35), 31734-31739 (2002)
PUBMED 12080044
REMARK GeneRIF: transcription repressed by promyelocytic leukemia protein
expression
REFERENCE 8 (bases 1 to 1993)
AUTHORS Van Huffel,S., Delaei,F., Heyninck,K., De Valck,D. and Beyaert,R.
TITLE Identification of a novel A20-binding inhibitor of nuclear
factor-kappa B activation termed ABIN-2
JOURNAL J. Biol. Chem. 276 (32), 30216-30223 (2001)
PUBMED 11390377
REFERENCE 9 (bases 1 to 1993)
AUTHORS Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
TITLE Functional redundancy of the zinc fingers of A20 for inhibition of
NF-kappaB activation and protein-protein interactions
JOURNAL FEBS Lett. 498 (1), 93-97 (2001)
PUBMED 11389905
REFERENCE 10 (bases 1 to 1993)
AUTHORS Heyninck,K., De Valck,D., Vanden Berghe,W., Van Criekinge,W.,
Contreras,R., Fiers,W., Haegeman,G. and Beyaert,R.
TITLE The zinc finger protein A20 inhibits TNF-induced
NF-kappaB-dependent gene expression by interfering with an RIP- or
TRAF2-mediated transactivation signal and directly binds to a novel
NF-kappaB-inhibiting protein ABIN
JOURNAL J. Cell Biol. 145 (7), 1471-1482 (1999)
PUBMED 10385526
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AF372839.1, AL110117.3 and BC002740.2.
On Jun 11, 2009 this sequence version replaced gi:34147369.
Summary: TNIP2 binds to the C-terminal zinc finger domain of A20
(TNFAIP3; MIM 191163) and is involved in activation of the ERK (see
MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van
Huffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006
[PubMed 16633345]).[supplied by OMIM, Mar 2008].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF372839.1, AK096296.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1361 AF372839.1 1-1361
1362-1362 AL110117.3 6761-6761
1363-1993 BC002740.2 1321-1951
FEATURES Location/Qualifiers
source 1..1993
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16.3"
gene 1..1993
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/note="TNFAIP3 interacting protein 2"
/db_xref="GeneID:79155"
/db_xref="HGNC:19118"
/db_xref="MIM:610669"
exon 1..363
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/inference="alignment:Splign:1.39.8"
CDS 88..1377
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/note="isoform 1 is encoded by transcript variant 1;
A20-binding inhibitor of NF-kappaB activation-2; fetal
liver LKB1-interacting protein; TNFAIP3-interacting
protein 2; A20-binding inhibitor of NF-kappa-B activation
2"
/codon_start=1
/product="TNFAIP3-interacting protein 2 isoform 1"
/protein_id="NP_077285.3"
/db_xref="GI:239787092"
/db_xref="CCDS:CCDS3362.1"
/db_xref="GeneID:79155"
/db_xref="HGNC:19118"
/db_xref="MIM:610669"
/translation="
MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAECCQ
"
misc_feature 727..831
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/note="TSG101 and ALIX binding domain of CEP55; Region:
EABR; pfam12180"
/db_xref="CDD:152615"
misc_feature 952..1128
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NFZ5.1);
Region: Ubiquitin-binding domain (UBD)"
exon 364..654
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/inference="alignment:Splign:1.39.8"
exon 655..744
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/inference="alignment:Splign:1.39.8"
exon 745..993
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/inference="alignment:Splign:1.39.8"
exon 994..1113
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/inference="alignment:Splign:1.39.8"
exon 1114..1974
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/inference="alignment:Splign:1.39.8"
variation 1274
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:2269495"
variation 1362
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:232712"
variation 1683
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:10587"
STS 1719..1926
/gene="TNIP2"
/gene_synonym="ABIN2; FLIP1; KLIP"
/standard_name="SHGC-68050"
/db_xref="UniSTS:5182"
ORIGIN
ggaaagttccgggaagggcggcagccggcggggcccgggcgcggaagttgccggcggccgcgcggcctcccgggcgggcctacagccatgtcccgggacccggggtcgggcggctgggaggaggccccgcgcgcagctgccgcgctctgcaccctgtaccacgaggccggacagcggctgcgccgcctgcaggaccagctcgctgcccgcgacgccctcatcgctcgcctccgcgcccgcctggccgcgctggagggggacgccgcgccgtccctagtggacgcgctgctggagcaggttgcgcgcttccgggagcagctgcgaaggcaggagggcggcgccgccgaggcccagatgcgccaggaaattgagaggctgactgagcgactagaagaaaaagagagggagatgcagcagctgctgagccagccccaacacgagcgagagaaggaagtcgtcctgctacggaggagcatggcagaaggggagcgcgcccgggccgccagtgacgtcctgtgccgctccttggccaacgagacccatcagctgcggaggacgctgaccgccaccgcccacatgtgtcagcatctggccaagtgtctggatgaacgacagcatgcacaaaggaatgtgggggagagaagtcctgaccagtcggaacacacagatgggcacacctctgtccagagtgttattgagaagttgcaggaagaaaatcgactgttaaaacagaaggtgactcacgttgaagacctcaatgccaagtggcagcgctacaacgccagcagggacgaatacgtgagggggctccatgcgcagctcagggggctgcagatcccccacgagcccgagctgatgaggaaggagatctcccggctcaacagacagttggaagagaaaataaatgactgtgccgaagtgaagcaggagctggcggcctccaggacggcccgggatgctgcgttggagcgggtgcagatgctggaacagcagattctcgcttacaaggatgacttcatgtcagaaagggccgatcgggaacgggctcaaagtaggattcaagaactggaggaaaaggtcgcctctttgctgcaccaggtgtcctggagacaggattctcgagagccagacgccggccggattcacgctgggagcaaaactgccaagtatttggccgccgacgcattagagcttatggtgcctggtggctggaggcctgggactgggtcccagcagccagaaccccctgcagagggcgggcatcctggcgcggcccagagaggccagggggaccttcagtgccctcactgcctgcagtgcttcagtgacgagcaaggggaagagctcctcaggcatgtggctgagtgctgccagtgaccgagactcacccgtgcccttgcggcctcctggcccggtgcagctgccctcagggacagggtgggtgctctcagatgccatgggttgagctctactgagagccaaggcccctagaatagttgcggggcactctgatcgttcactttggtccctttggctatggaacaggctgggtcacagggaactgccagtgaggctggaggctggaggtggagatggggtcaggaacatctggcagagggaggtcccagtctgtgtctccatcaggcttaagccagagctatctggtgctggtgtgccagcccctcccccagcctgcctagaaaggggtggctgcctgagggagtcacttgtatggtccccagggtgggagccccatcctgttctatggaataaagcgtcgcctctctgcctcgaaccagtcaaatggagtattgcggctgcacgtcacactagggtggccacccccgccattgcgagccacatgtctgcactgagaaactgcatttcagtagcatttgtcatccagccggaagttaaagcacacttactttattcacctatttttataataaacgttcttgctgctgtgactgcaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:79155 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:79155 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IDA
GeneID:79155 -> Molecular function: GO:0031593 [polyubiquitin binding] evidence: IDA
GeneID:79155 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:79155 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:79155 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:79155 -> Biological process: GO:0007249 [I-kappaB kinase/NF-kappaB cascade] evidence: IEA
GeneID:79155 -> Biological process: GO:0023035 [CD40 signaling pathway] evidence: ISS
GeneID:79155 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: ISS
GeneID:79155 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: ISS
GeneID:79155 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: ISS
GeneID:79155 -> Biological process: GO:0043032 [positive regulation of macrophage activation] evidence: ISS
GeneID:79155 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IDA
GeneID:79155 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:79155 -> Biological process: GO:0050821 [protein stabilization] evidence: ISS
GeneID:79155 -> Biological process: GO:0050871 [positive regulation of B cell activation] evidence: ISS
GeneID:79155 -> Biological process: GO:0070498 [interleukin-1-mediated signaling pathway] evidence: ISS
GeneID:79155 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS
GeneID:79155 -> Biological process: GO:2000352 [negative regulation of endothelial cell apoptotic process] evidence: IDA
GeneID:79155 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:79155 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
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@meso_cacase at
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