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2025-05-09 17:22:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_144709 3820 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens pseudouridylate synthase 10 (PUS10), mRNA.
ACCESSION NM_144709
VERSION NM_144709.2 GI:207113129
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3820)
AUTHORS Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee
JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K,
Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z,
Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN,
Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A,
Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De
Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson
LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas
J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH,
Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees
CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W,
Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M,
Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber
S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M,
Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier
RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V,
Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD,
Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and
Cho JH.
CONSRTM International IBD Genetics Consortium (IIBDGC)
TITLE Host-microbe interactions have shaped the genetic architecture of
inflammatory bowel disease
JOURNAL Nature 491 (7422), 119-124 (2012)
PUBMED 23128233
REFERENCE 2 (bases 1 to 3820)
AUTHORS Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
Peter,I.
TITLE A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
novel susceptibility loci
JOURNAL PLoS Genet. 8 (3), E1002559 (2012)
PUBMED 22412388
REFERENCE 3 (bases 1 to 3820)
AUTHORS Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
Weersma,R.K. and Rioux,J.D.
TITLE Meta-analysis identifies 29 additional ulcerative colitis risk
loci, increasing the number of confirmed associations to 47
JOURNAL Nat. Genet. 43 (3), 246-252 (2011)
PUBMED 21297633
REMARK Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE 4 (bases 1 to 3820)
AUTHORS Festen,E.A., Goyette,P., Green,T., Boucher,G., Beauchamp,C.,
Trynka,G., Dubois,P.C., Lagace,C., Stokkers,P.C., Hommes,D.W.,
Barisani,D., Palmieri,O., Annese,V., van Heel,D.A., Weersma,R.K.,
Daly,M.J., Wijmenga,C. and Rioux,J.D.
TITLE A meta-analysis of genome-wide association scans identifies
IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's
disease and celiac disease
JOURNAL PLoS Genet. 7 (1), E1001283 (2011)
PUBMED 21298027
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3820)
AUTHORS Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
Parkes,M.
TITLE Genome-wide meta-analysis increases to 71 the number of confirmed
Crohn's disease susceptibility loci
JOURNAL Nat. Genet. 42 (12), 1118-1125 (2010)
PUBMED 21102463
REFERENCE 6 (bases 1 to 3820)
AUTHORS Park,S.Y., Shin,J.N., Woo,H.N., Piya,S., Moon,A.R., Seo,Y.W.,
Seol,D.W. and Kim,T.H.
TITLE DOBI is cleaved by caspases during TRAIL-induced apoptotic cell
death
JOURNAL BMB Rep 42 (8), 511-515 (2009)
PUBMED 19712588
REMARK GeneRIF: These data suggest that the cleaved DOBI may acquire a new
function, possibly by cooperating with tBid in the mitochondrial
event of cell death caused by TRAIL.
REFERENCE 7 (bases 1 to 3820)
AUTHORS Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
and Wijmenga,C.
TITLE Coeliac disease-associated risk variants in TNFAIP3 and REL
implicate altered NF-kappaB signalling
JOURNAL Gut 58 (8), 1078-1083 (2009)
PUBMED 19240061
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 8 (bases 1 to 3820)
AUTHORS Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M,
Fisher SA, Gwilliam R, Jacob J, Nimmo ER, Drummond H, Lees CW,
Onnie CM, Hanson C, Blaszczyk K, Ravindrarajah R, Hunt S, Varma D,
Hammond N, Lewis G, Attlesey H, Watkins N, Ouwehand W, Strachan D,
McArdle W, Lewis CM, Lobo A, Sanderson J, Jewell DP, Deloukas P,
Mansfield JC, Mathew CG, Satsangi J and Parkes M.
CONSRTM Wellcome Trust Case Control Consortium
TITLE Investigation of Crohn's disease risk loci in ulcerative colitis
further defines their molecular relationship
JOURNAL Gastroenterology 136 (2), 523-529 (2009)
PUBMED 19068216
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 9 (bases 1 to 3820)
AUTHORS McCleverty,C.J., Hornsby,M., Spraggon,G. and Kreusch,A.
TITLE Crystal structure of human Pus10, a novel pseudouridine synthase
JOURNAL J. Mol. Biol. 373 (5), 1243-1254 (2007)
PUBMED 17900615
REMARK GeneRIF: crystal structure of Pus10 (previously denoted as
FLJ32312) at 2.0 A resolution and modeling studies describe protein
domains and active sites
REFERENCE 10 (bases 1 to 3820)
AUTHORS Aza-Blanc,P., Cooper,C.L., Wagner,K., Batalov,S., Deveraux,Q.L. and
Cooke,M.P.
TITLE Identification of modulators of TRAIL-induced apoptosis via
RNAi-based phenotypic screening
JOURNAL Mol. Cell 12 (3), 627-637 (2003)
PUBMED 14527409
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BP354604.1, AK056874.1, BC101680.1, AC010733.8 and AA878516.1.
On Sep 30, 2008 this sequence version replaced gi:21389306.
Summary: Pseudouridination, the isomerization of uridine to
pseudouridine, is the most common posttranscriptional nucleotide
modification found in RNA and is essential for biologic functions
such as spliceosome biogenesis. Pseudouridylate synthases, such as
PUS10, catalyze pseudouridination of structural RNAs, including
transfer, ribosomal, and splicing RNAs. These enzymes also act as
RNA chaperones, facilitating the correct folding and assembly of
tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by
OMIM, May 2009].
Sequence Note: The RefSeq transcript and protein were derived from
transcript and genomic sequence to make the sequence consistent
with the reference genome assembly. The genomic coordinates used
for the transcript record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK056874.1, BC101680.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-157 BP354604.1 10-166
158-859 AK056874.1 1-702
860-1905 BC101680.1 681-1726
1906-3597 AC010733.8 94081-95772 c
3598-3820 AA878516.1 1-223 c
FEATURES Location/Qualifiers
source 1..3820
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16.1"
gene 1..3820
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="pseudouridylate synthase 10"
/db_xref="GeneID:150962"
/db_xref="HGNC:26505"
/db_xref="MIM:612787"
exon 1..223
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
misc_feature 224..646
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST H17239 (NID:g883479) ym42f05.r1"
misc_feature <224..480
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST AA878516 (NID:g2987481) oj19b08.s1"
exon 224..364
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
misc_feature <224..360
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST AA813267 (NID:g2883252) aj44g04.s1"
misc_feature <224..252
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST BE883758 (NID:g10332534)"
misc_feature 227..229
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="upstream in-frame stop codon"
CDS 239..1828
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="pseudouridine synthase 10; coiled-coil domain
containing 139; psi55 synthase; tRNA-uridine isomerase;
tRNA pseudouridylate synthase; tRNA pseudouridine 55
synthase; coiled-coil domain-containing protein 139"
/codon_start=1
/product="putative tRNA pseudouridine synthase Pus10"
/protein_id="NP_653310.2"
/db_xref="GI:207113130"
/db_xref="CCDS:CCDS1865.1"
/db_xref="GeneID:150962"
/db_xref="HGNC:26505"
/db_xref="MIM:612787"
/translation="
MFPLTEENKHVAQLLLNTGTCPRCIFRFCGVDFHAPYKLPYKELLNELQKFLETEKDELILEVMNPPPKKIRLQELEDSIDNLSQNGEGRISVSHVGSTASKNSNLNVCNVCLGILQEFCEKDFIKKVCQKVEASGFEFTSLVFSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRDDIVQLKEAYKWITHPLFSEELGVPIDGKSLFEVSVVFAHPETVEDCHFLAAICPDCFKPAKNKQSVFTRMAVMKALNKIKEEDFLKQFPCPPNSPKAVCAVLEIECAHGAVFVAGRYNKYSRNLPQTPWIIDGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVHFTSQEIKELQQKINNSSNKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNKAIQKKDIEFLNDIKDLKIDQKTPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILELDVESVDVDWPPALDD
"
misc_feature 473..475
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q3MIT2.1); phosphorylation site"
misc_feature 488..490
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q3MIT2.1); phosphorylation site"
misc_feature <1100..1807
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="putative pseudouridylate synthase; Provisional;
Region: PRK14554"
/db_xref="CDD:184741"
misc_feature 1148..1189
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q3MIT2.1);
Region: RNA binding forefinger loop (Potential)"
misc_feature 1562..1609
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q3MIT2.1);
Region: RNA binding thumb loop (Potential)"
misc_feature 244..443
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST BF986046 (NID:g12392366)"
exon 365..619
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
misc_feature 397..605
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST BG111144 (NID:g12604650)"
misc_feature 537..1354
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST BG567982 (NID:g13575635)"
exon 620..706
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 707..741
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 742..853
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 854..915
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
misc_feature 866..1319
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST BG433736 (NID:g13340242)"
exon 916..961
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 962..1026
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 1027..1112
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 1113..1238
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
misc_feature 1213..>1915
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST BG546841 (NID:g13545506)"
exon 1239..1295
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 1296..1372
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 1373..1428
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 1429..1546
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 1547..1689
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
misc_feature 1571..>1915
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST AW295480 (NID:g6702116)"
misc_feature 1579..>1915
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST AV700540 (NID:g10302511)"
exon 1690..1789
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
exon 1790..3810
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/inference="alignment:Splign:1.39.8"
misc_feature 1877..>1915
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/note="match to EST AA213749 (NID:g1812367) zr93c02.r1"
STS 3230..3441
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/standard_name="WIAF-2118"
/db_xref="UniSTS:25257"
STS 3262..3397
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/standard_name="SHGC-56768"
/db_xref="UniSTS:7343"
variation 3358
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/replace="a"
/replace="c"
/db_xref="dbSNP:1206"
variation 3597
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/replace="c"
/replace="t"
/db_xref="dbSNP:1053862"
STS 3669..3796
/gene="PUS10"
/gene_synonym="CCDC139; DOBI"
/standard_name="WI-15536"
/db_xref="UniSTS:82826"
ORIGIN
gtggctggacaaatgccgctctcaactgctacagaccaaagtctacgctttaaagatagagaagccattctgtcaaagtgaaaacagaagcggtaggtaggaagccgcccccctttctttcaagcacagagacccagagagacgcccaggagctcccgaaaaaaacgttgctgattagagctgccgggtcagaaacagctgtgagacactaaagtccccactgttataattattcaatatgttcccactgactgaggaaaacaagcatgtggcccagttgttgctcaatactggtacttgtccaagatgtatcttcagattctgtggtgtggattttcatgcaccttacaaacttccatacaaggagttgctcaatgaactacagaaatttctggaaactgaaaaagatgaattaattttggaagttatgaacccacctcccaagaaaattcgactgcaagaactggaagatagtattgataatctaagtcaaaatggagagggaaggatctctgttagtcatgttggaagcactgcttccaagaactcaaatttaaatgtatgtaatgtatgcctaggaattcttcaagaattctgtgagaaagatttcattaaaaaggtgtgccaaaaggttgaggcctctgggtttgaattcaccagcttggtattttcagtctccttcccaccacaactatctgtaagagagcatgctgcatggttgctggtaaaacaggaaatgggaaagcagagtctgtcgctgggaagagatgatatagttcagctaaaagaagcctacaaatggataactcaccccctgttttcagaggaactgggtgttcccattgatggaaagagcttgtttgaagtgagtgtggtctttgctcacccagaaacagttgaggattgccacttcctagctgcgatatgcccagattgttttaagccagccaaaaacaaacagtctgtattcactagaatggcagttatgaaagccttgaataagataaaggaagaggatttccttaagcagtttccttgtcctccaaactcaccaaaggctgtatgcgctgttcttgaaattgaatgtgctcatggtgctgtttttgtggctgggagatataataaatactccaggaatctaccacaaactccttggataattgatggagaaaggaagctggaatcttcagtggaagaattaatttcagatcatctgttggcagtatttaaagcagagagttttaatttttcatcctctggaagagaagatgtagatgtgagaacattaggaaatggaaggccctttgcaattgagctggtgaatcctcatagagtacatttcacttcacaagaaattaaggaacttcagcagaaaattaataactcatctaacaaaatccaagtacgtgacttgcagcttgtcacaagagaggcaataggacatatgaaagaaggtgaagaagaaaagacaaagacctacagtgccttaatttggacaaataaagcgatacagaagaaagacattgaattcctaaatgacataaaggacttaaaaatcgaccagaaaacacctttgcgcgtccttcaccgaaggcccctggctgtgcgagctcgcgtcattcacttcatggagacacagtacgtggatgagcaccacttccgcctccacttgaaaactcaggctggcacctacattaaagagtttgtacatggagacttcgggagaaccaagccaaacattgggtccctgatgaatgtgactgcagacattctggagctggatgttgagtctgtagatgttgactggccacctgctctggatgactagctttcaaatttggagacaaagagtatggttttcctggcatgatgtggacatccatggagcacatgccgtaaaatggctgtttacccaccataacggtgtcttgaaaactatttggatcatgttgatctatataattgttaatttgttgtaacatctcaggatctatatatgtgtatattttgtgttaaattgttccaaggatgtcttaggatttttctcattccctctttcacccccacaaaccaaactatgaataatgaaataattctccttaattctttcatttagagaggtgcacaaacaggacacattctctgttaacctaagaagctgtaatttcagcaagatttccctccacaagagatataccacctttaaaatcatgttctaatttttgtaaattatctgaataaaagttatatctagatttatgcagcataatatcctataatagtctaagattgcaaatgcaaatctgacatcattattttccccaggaagcctcaaacaagctattaccaatgaagttcttttggctgtgatttgtcataaatcttaaccaaactatgaataatgaaataattctcattaatactttcattaagaaagaattttgacaatctaaaattgtcaatataggtttcctgtggagggaaagtaaaaccgtaggagccaaggcatgccatggtaggagcctttcataaatcttttaaataaggagaaacaagtgcctttaataacttcaatcccagggttaagaatttgaaaaattgagattgctaaacaaagacgaactggtattatttcagaatgcttcaatatattatccaattataaacattttaataataccttattaaagtagataggatattgtctccattttataaatatggaaaccaaagactagaagttaaatgacttatccaaaattgttagctacttctatattgaggactagaactgaagtttcttggtttctagggtctttctaataagccctattactgagcacctgtttgtgtgaaggggcagctatggatgccatttaaactcatgtaactgataattaacttttggaatgtagttaccaaatcaaagagcttaccaaaaaatagcccaagactatttaatacaatcttatatagttaccatttgttattaagttaaacctcagttggtattatgaagaggaaaaacattaagctaaacctaaaaaaaatgaatgggtcatttaagtttcagaaaggagcctcattacaatttcagatttgagtataatttccatcaccctaattcaactatttgagctttttttaagaatacatgtgacttgactagtattagattactaaccatttcccatctctatattaaacataaatcacagataccaagattcactttagatatgaggaaaatggttttaatggacacaaaggagtcagccacgttggaaccaacatagtttcataccacgttgaaaccatgtgtttgatatgcaaataacagcaaataattttttcactcttgtcaatgccaatgcattgaaaggcccagaaaatgagaaaaggataacaaacttttgataaaaaggtaagaatttctgtgtggatgttcctcagtttctgggaaaattttgctacaaaagagatttaaataatttaggaggcagtcttttgcatggtatttttggcttacctttgaatctagtggacctgtaatatgtaagaatgaagaatgtgcttagcaaactgaaatgagaagatttctatttcttaaatttctattcctgagattatataaaatttcacgcaaagagtaagcattagctttaaatacttcttccaaatgttcctagaattttgagacaaagattgttaaaaattaatgtatgtctttgttttaggcagaactggaaatattaagtagtgagagtactatagtttcccttttgcctacataaaagcattttaaaattaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:150962 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:150962 -> Molecular function: GO:0009982 [pseudouridine synthase activity] evidence: IEA
GeneID:150962 -> Biological process: GO:0001522 [pseudouridine synthesis] evidence: IEA
GeneID:150962 -> Biological process: GO:0008033 [tRNA processing] evidence: IEA
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