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2025-05-09 17:33:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_139160 2013 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant
2, mRNA.
ACCESSION NM_139160
VERSION NM_139160.2 GI:116256343
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2013)
AUTHORS Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
and Gessler,M.
TITLE A 7.5 Mb sequence-ready PAC contig and gene expression map of human
chromosome 11p13-p14.1
JOURNAL Genome Res. 9 (11), 1074-1086 (1999)
PUBMED 10568747
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC107939.5, AJ245600.1 and BC030970.1.
On Oct 17, 2006 this sequence version replaced gi:21040238.
Transcript Variant: This variant (2) includes a different segment
for the 5' UTR and 5' CDS, compared to variant 1. The resulting
protein (isoform 2) has a shorter and distinct N-terminus when it
is compared to isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AF447588.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-404 AC107939.5 43101-43504 c
405-1113 AJ245600.1 121-829
1114-1673 BC030970.1 875-1434
1674-2013 AJ245600.1 1390-1729
FEATURES Location/Qualifiers
source 1..2013
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p13"
gene 1..2013
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="DEP domain containing 7"
/db_xref="GeneID:91614"
/db_xref="HGNC:29899"
/db_xref="MIM:612294"
exon 1..404
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
misc_feature 137..139
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="upstream in-frame stop codon"
variation 173
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:111791472"
variation 324
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:371138729"
variation 329
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:374778072"
variation 345
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:367845306"
CDS 359..1867
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="isoform 2 is encoded by transcript variant 2; DEP
domain-containing protein 7; novel 58.3 KDA protein;
dJ85M6.4 (novel 58.3 KDA protein)"
/codon_start=1
/product="DEP domain-containing protein 7 isoform 2"
/protein_id="NP_631899.2"
/db_xref="GI:116256344"
/db_xref="CCDS:CCDS41633.1"
/db_xref="GeneID:91614"
/db_xref="HGNC:29899"
/db_xref="MIM:612294"
/translation="
MRGLCEFYWQEFGIKGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
"
misc_feature 446..730
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
found in DEPDC4-like proteins. DEPDC4 is a DEP domain
containing protein of unknown function; Region:
DEP_DEPDC4; cd04446"
/db_xref="CDD:80329"
misc_feature 911..1612
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein
[GAP] for Rho-like small GTPases) domain of BRCC3-like
proteins. This subgroup also contains two groups of
closely related proteins, BRCC3 and DEPDC7, which both
contain a C-terminal RhoGAP-like domain...; Region:
RhoGAP_BRCC3-like; cd04405"
/db_xref="CDD:63874"
misc_feature order(1094..1096,1250..1252,1262..1264,1472..1474,
1481..1486,1547..1549)
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="putative GTPase interaction site [polypeptide
binding]; other site"
/db_xref="CDD:63874"
misc_feature 1094..1096
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="catalytic residue [active]"
/db_xref="CDD:63874"
variation 379
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200779852"
exon 405..795
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 412
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375593314"
variation 437
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368794067"
variation 443
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:79199473"
variation 470
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200073795"
variation 503
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374733737"
variation 509
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:369053359"
variation 513
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200057806"
variation 528
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:138325318"
variation 568
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:74559182"
variation 619
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369355382"
variation 633
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372513278"
variation 702
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376814687"
variation 711
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371496330"
variation 721
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202173561"
variation 782
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374632275"
exon 796..923
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 823
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367903882"
variation 863
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200200424"
variation 877
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:17852860"
variation 882
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200498367"
variation 905
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:34161108"
exon 924..1113
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 927
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144655252"
variation 942
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:375290990"
variation 960
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201784282"
variation 964
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371231815"
variation 1021
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190343171"
variation 1031
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:374772959"
variation 1043
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199885269"
variation 1044
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148509454"
variation 1082
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373000064"
variation 1094
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:201199439"
variation 1109
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:369472957"
exon 1114..1325
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 1180
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:202124209"
STS 1191..1318
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/standard_name="AB070065"
/db_xref="UniSTS:480067"
variation 1195
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:36077875"
variation 1212
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370729400"
variation 1226
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75979055"
variation 1264..1265
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace=""
/replace="g"
/db_xref="dbSNP:35988670"
variation 1271
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377186754"
variation 1274
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370596448"
variation 1297
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:966191"
exon 1326..1468
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 1337
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:371828635"
variation 1339
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:183771544"
variation 1405
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375119204"
variation 1427
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:369520659"
exon 1469..1594
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 1515
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374663038"
exon 1595..1673
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 1635
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:373073447"
variation 1641
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376408973"
variation 1648
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370490867"
variation 1663
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:185768707"
exon 1674..1994
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
STS 1685..1870
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/standard_name="RH99094"
/db_xref="UniSTS:83970"
variation 1688
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148565354"
variation 1692
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:374445520"
variation 1703
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202020074"
variation 1716
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368852267"
variation 1722
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:17852859"
variation 1743
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374403792"
variation 1810
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:367948856"
variation 1819
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199502210"
variation 1824
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142956576"
variation 1834
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377079128"
variation 1863
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201413831"
variation 1882
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202246545"
variation 1891
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:151112215"
variation 1906
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:200612237"
variation 1944
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1059432"
variation 1951
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374578661"
polyA_signal 1974..1979
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
polyA_site 1994
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
ORIGIN
aacgcccccgccgagcgggcggatcgagttcctctctggctggtgggctgcaagcggcagagcccgcccgcacagcccagcttttttctttctacccagactctcaacttgaccgcgcgttggtctgtgcgcccgctaacgtgccaggcacgcgccggggagctccgggatatgctccgcggtgctaccggtgacaagtgtggtatctggaatttgtgtagttctttgccccctgtctcaaccacaaaccttgacgacacagtatggccaggggccgagctcctcccttgcccactttgttctccagactgctaggagtcaagagtcagcttgtctccccagactcttcctgggagggatgagaggtttatgtgagttctactggcaggaatttggcataaaaggtttcagtgtagctcagaagccatttggagccacgtatgtatggagcagcatcataaacactcttcaaacacaagtggaagtgaaaaaacgaaggcaccgtttaaaacgacataatgactgctttgttggttcagaagctgtggatgtcattttttctcacctaattcagaataagtattttggtgatgtagatattcctcgagccaaagtggtgagagtgtgtcaagcgcttatggactacaaagtatttgaagcagttccaaccaaagtctttggaaaagacaaaaaacctacatttgaagatagtagttgcagcctttatagattcaccacaatacctaaccaagacagtcagttaggcaaagagaacaaactatattcacctgccaggtatgcagatgcattatttaagtcatccgatatcagatcagccagtttagaggacctgtgggaaaatctgagtttaaagcctgccaactcccctcatgtaaatatctctgcaaccttgtctccacaagttattaatgaagtgtggcaagaagaaacaattgggcgtctactacaacttgtagaccttccacttcttgactccttactgaaacagcaagaggctgtacctaaaattcctcaacctaagaggcagtccaccatggtcaacagcagtaactatctggatcgagggattctcaaggcttatagtgactctcaggaagatgagtggctctcggcagcaattgactgtttagaataccttccagaccaaatggtggtggaaataagcagaagctttcctgagcaaccagaccgaacagacttagtgaaagaacttctgtttgatgccattggcagatattacagtagtagggaacctctgttaaatcacttatctgacgttcataatggaattgcagaactcttagtgaatgggaagacggaaatagctttagaagctacccagctccttctaaagcttttagatttccaaaatagagaagaatttagaagactactgtatttcatggctgttgcagcaaatccttctgagtttaaattacagaaagaaagtgacaaccgaatggttgtgaaaaggatattctcaaaagctattgttgacaataaaaatttatccaaaggcaaaacagatcttctggtactctttttaatggatcatcagaaagatgtttttaagattcctggaactctacataaaattgtaagtgttaagcttatggccatacagaacggaagagatccaaatagagatgcaggatatatttattgccagagaattgatcaacgtgactattccaacaatacagagaagacaaccaaagatgagctgttgaatttactaaaaactcttgatgaggattcaaaactttctgccaaagagaagaaaaaattgctaggtcaattctataagtgtcacccagacatctttattgagcattttggagactgagtttttaatatctgtatataagttgtgtattttaagaataaattatgtatcctaaatatccaatcacatttgtaagcgtggaagctctaaatttgaaactgtacttaataaaaatttttttgtataaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:91614 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:91614 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
GeneID:91614 -> Biological process: GO:0008150 [biological_process] evidence: ND
GeneID:91614 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: TAS
GeneID:91614 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:91614 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
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