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2025-05-09 16:20:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032139 4461 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens ankyrin repeat domain 27 (VPS9 domain) (ANKRD27),
mRNA.
ACCESSION NM_032139
VERSION NM_032139.2 GI:116063533
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4461)
CONSRTM GENDEP Investigators; MARS Investigators; STAR*D Investigators
TITLE Common genetic variation and antidepressant efficacy in major
depressive disorder: a meta-analysis of three genome-wide
pharmacogenetic studies
JOURNAL Am J Psychiatry 170 (2), 207-217 (2013)
PUBMED 23377640
REFERENCE 2 (bases 1 to 4461)
AUTHORS Schafer,I.B., Hesketh,G.G., Bright,N.A., Gray,S.R., Pryor,P.R.,
Evans,P.R., Luzio,J.P. and Owen,D.J.
TITLE The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically
inactive conformation
JOURNAL Nat. Struct. Mol. Biol. 19 (12), 1300-1309 (2012)
PUBMED 23104059
REMARK GeneRIF: VAMP7-SNARE motif is trapped between Varp and the VAMP7
longin domain, and hence Varp kinetically inhibits the ability of
VAMP7 to form SNARE complexes
REFERENCE 3 (bases 1 to 4461)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 4 (bases 1 to 4461)
AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 4461)
AUTHORS Burgo,A., Sotirakis,E., Simmler,M.C., Verraes,A., Chamot,C.,
Simpson,J.C., Lanzetti,L., Proux-Gillardeaux,V. and Galli,T.
TITLE Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in
neurite growth
JOURNAL EMBO Rep. 10 (10), 1117-1124 (2009)
PUBMED 19745841
REMARK GeneRIF: show that TI-VAMP interacts with the Vps9 domain and
ankyrin-repeat-containing protein Varp, a guanine nucleotide
exchange factor of the small GTPase Rab21, through a specific
domain herein called the interacting domain.
REFERENCE 6 (bases 1 to 4461)
AUTHORS Wang,F., Zhang,H., Zhang,X., Wang,Y., Ren,F., Zhang,X., Zhai,Y. and
Chang,Z.
TITLE Varp interacts with Rab38 and functions as its potential effector
JOURNAL Biochem. Biophys. Res. Commun. 372 (1), 162-167 (2008)
PUBMED 18477474
REMARK GeneRIF: Varp physically interacts with Rab38, and preferentially
binds to the active GTP-bound form of Rab38 both in vitro and in
vivo.
REFERENCE 7 (bases 1 to 4461)
AUTHORS Zhang,X., He,X., Fu,X.Y. and Chang,Z.
TITLE Varp is a Rab21 guanine nucleotide exchange factor and regulates
endosome dynamics
JOURNAL J. Cell. Sci. 119 (PT 6), 1053-1062 (2006)
PUBMED 16525121
REFERENCE 8 (bases 1 to 4461)
AUTHORS Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
Gu,J.
TITLE Large-scale cDNA transfection screening for genes related to cancer
development and progression
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (44), 15724-15729 (2004)
PUBMED 15498874
REMARK Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE 9 (bases 1 to 4461)
AUTHORS Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
TITLE Functional proteomics mapping of a human signaling pathway
JOURNAL Genome Res. 14 (7), 1324-1332 (2004)
PUBMED 15231748
REFERENCE 10 (bases 1 to 4461)
AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
Wiemann,S.
TITLE Systematic subcellular localization of novel proteins identified by
large-scale cDNA sequencing
JOURNAL EMBO Rep. 1 (3), 287-292 (2000)
PUBMED 11256614
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BI462844.1, AK054561.1 and AA903176.1.
On Oct 12, 2006 this sequence version replaced gi:14149802.
##Evidence-Data-START##
Transcript exon combination :: BC045605.1, AK054561.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-11 BI462844.1 10-20
12-4446 AK054561.1 1-4435
4447-4461 AA903176.1 1-15 c
FEATURES Location/Qualifiers
source 1..4461
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.11"
gene 1..4461
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="ankyrin repeat domain 27 (VPS9 domain)"
/db_xref="GeneID:84079"
/db_xref="HGNC:25310"
exon 1..126
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
misc_feature 124..126
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="upstream in-frame stop codon"
exon 127..258
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
CDS 157..3309
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="VPS9-ankyrin-repeat protein; Vps9 domain and
ankyrin-repeat-containing protein; VPS9 domain-containing
protein"
/codon_start=1
/product="ankyrin repeat domain-containing protein 27"
/protein_id="NP_115515.2"
/db_xref="GI:116063534"
/db_xref="CCDS:CCDS32986.1"
/db_xref="GeneID:84079"
/db_xref="HGNC:25310"
/translation="
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANALYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVSQGPEAAGPLSTPQEVSASRS
"
misc_feature 946..1245
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="Vacuolar sorting protein 9 (VPS9) domain; Region:
VPS9; pfam02204"
/db_xref="CDD:145388"
misc_feature 1342..1434
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 1"
misc_feature 1528..1911
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 1540..1629
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 2"
misc_feature 1555..1818
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 1639..1728
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 3"
misc_feature 1738..1836
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 4"
misc_feature 1741..1911
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="Ankyrin repeats (many copies); Region: Ank_4;
pfam13637"
/db_xref="CDD:205814"
misc_feature 1846..1935
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 5"
misc_feature 1849..>1974
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="Ankyrin repeats (many copies); Region: Ank_4;
pfam13637"
/db_xref="CDD:205814"
misc_feature 1945..2037
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 6"
misc_feature 2158..2250
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 7"
misc_feature 2173..2547
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 2368..2745
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 2383..2472
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 8"
misc_feature 2398..2676
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 2482..2571
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 9"
misc_feature 2581..2670
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 10"
misc_feature 2641..2805
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/note="Ankyrin repeats (many copies); Region: Ank_5;
pfam13857"
/db_xref="CDD:206028"
misc_feature 2680..2769
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NW4.2);
Region: ANK 11"
misc_feature 3223..3225
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q96NW4.2); phosphorylation site"
exon 259..369
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 370..526
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 527..681
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 682..741
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 742..795
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 796..861
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 862..938
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 939..1060
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 1061..1139
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 1140..1272
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 1273..1365
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 1366..1493
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
variation 1434
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="a"
/replace="c"
/db_xref="dbSNP:34938777"
exon 1494..1576
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 1577..1692
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 1693..1785
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
variation 1716
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="c"
/replace="t"
/db_xref="dbSNP:35109898"
exon 1786..1983
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
variation 1917
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="c"
/replace="t"
/db_xref="dbSNP:2302968"
exon 1984..2043
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 2044..2163
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
variation 2070
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="c"
/replace="t"
/db_xref="dbSNP:34174163"
variation 2125
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="a"
/replace="g"
/db_xref="dbSNP:2287669"
exon 2164..2208
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 2209..2331
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 2332..2529
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
variation 2438
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="c"
/replace="g"
/db_xref="dbSNP:2302970"
exon 2530..2649
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 2650..2811
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 2812..2923
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 2924..3002
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 3003..3075
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
exon 3076..4453
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/inference="alignment:Splign:1.39.8"
variation 3417
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="g"
/replace="t"
/db_xref="dbSNP:201881809"
variation 3821..3839
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace=""
/replace="tttgcaaagcaacactcga"
/db_xref="dbSNP:3217228"
variation 3994
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="a"
/replace="g"
/db_xref="dbSNP:2277927"
STS 4251..4408
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/standard_name="D19S661E"
/db_xref="UniSTS:150572"
variation 4319
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="c"
/replace="t"
/db_xref="dbSNP:10553"
variation 4348
/gene="ANKRD27"
/gene_synonym="PP12899; VARP"
/replace="g"
/replace="t"
/db_xref="dbSNP:3180584"
ORIGIN
gtaaggggtgggctatagggccagatcgccgcgcgagggtggtgggcatcgaggtcccagcagcggacgagggaggtgccgccgtcgcccaggatgggctgggaatgaagcgatgtagccttttaagagatttgctctgacccatctgaagtccatatggctctgtatgatgaagacctcctgaaaaatcctttctatctggctctgcaaaagtgccgccctgacttgtgcagcaaagtggcccaaatccatggcattgtcttagtaccctgcaaaggaagcctgtcgagcagcatccagtctacttgtcagtttgagtcctacattttgatacctgtggaagagcattttcagaccttaaatggaaaggatgtctttattcaagggaacaggattaaattaggagctggttttgcctgtcttctctcagtgcccattctctttgaagaaactttctacaatgaaaaagaagagagtttcagcatcctgtgtatagcccatcctttggaaaagagagagagttcagaagagcctttggcaccctcagatcccttttccctgaaaaccattgaagatgtgagagagttcttgggaagacactccgagcgatttgacaggaacatcgcctctttccatcgaacattccgagaatgcgagagaaagagcctccgtcaccacatagactcagcgaatgctctctacaccaaatgcctccagcagcttctgagggactctcacctgaaaatgctcgccaagcaggaggcccagatgaacctgatgaagcaggcagtggagatatacgtccatcatgaaatttacaacctgatctttaaatacgtggggaccatggaggcaagtgaggatgcggcctttaacaaaatcacaagaagccttcaagatcttcagcagaaagatattggtgtgaaaccggagttcagctttaacatacctcgtgccaaaagagagctggctcagctgaacaaatgcacctccccacagcagaagcttgtctgcttgcgaaaagtggtgcagctcattacacagtctccaagccagagagtgaacctggagaccatgtgtgctgatgatctgctatcagtcctgttatacttgcttgtgaaaacggagatccctaattggatggcaaatttgagttacatcaaaaacttcaggtttagcagcttggcaaaggatgaactgggatactgcctgacctcattcgaagctgccattgaatatattcggcaaggaagcctctctgctaaaccccctgagtctgagggatttggagacaggctgttccttaagcagagaatgagcttactctctcagatgacttcgtctcccaccgactgcctgtttaagcacattgcatcaggtaaccagaaagaagtggagagacttctgagccaagaggaccatgataaagataccgtccaaaagatgtgtcaccctctctgcttctgcgatgactgtgagaaactcgtctctgggaggttgaatgatccctcagttgtcactccattctccagagacgacagggggcacacccctctccatgtggctgctgtctgtgggcaggcatccctcatcgacctcctggtttccaagggcgccatggtaaatgccacagactaccatggagccactccgctccacctggcctgtcagaagggctaccagagcgtgacgctgctgctgctgcactacaaggccagcgcggaagtgcaggacaacaatgggaatacgccactccacctggcctgcacctacggccacgaggactgtgtgaaggctctggtttactacgacgtggagtcgtgcagacttgacattggcaatgagaaaggagacacccctctacacattgctgcccgctggggctaccaaggcgtcatagagacattgctgcagaacggagcgtccaccgagatccagaacagactgaaggagacgcccctcaagtgtgcattaaactcaaagattctgtctgtaatggaagcctatcacctgtccttcgagaggaggcagaagtcgtccgaggcccctgtgcagtccccgcagcgctccgtggactccatcagccaagagtcctccacttccagcttctcctccatgtcagccagctcaaggcaggaggagaccaagaaggactacagagaggtagaaaaacttttgagagcagttgctgatggagatctagaaatggtgcgttacctgttggaatggacagaggaggacctggaggatgcggaggacactgtcagtgcagcggaccccgaattctgtcacccgttgtgccagtgccccaagtgtgccccagctcagaagaggctggcgaaggttcctgccagtgggcttggtgtgaacgtgaccagccaggacggctcctccccgctgcatgtcgccgccctgcacggccgggcggacctcatccccctcctgctgaagcacggggccaacgcaggtgccaggaacgcagaccaagccgtcccgctccacctggcctgccagcagggccactttcaggtggtgaagtgtctgttagattcgaatgcaaaacccaataagaaggacctcagtggaaacacgcccctcatttacgcctgctccggtggccatcacgagcttgtggcactgctgctacagcacggggcctccattaacgcttctaacaataagggcaacacagcgctgcacgaggctgtgattgaaaagcacgtcttcgtggtagagctgcttctgctccacggagcgtcagttcaggtgctgaacaagcggcagcgcacggctgtagactgtgctgaacagaattcaaaaataatggaattgcttcaggtggtaccaagctgtgttgcttcattagatgatgtggctgaaactgaccgcaaggagtatgtcactgttaagatcaggaaaaaatggaactcaaaactgtatgatctaccagatgagccttttacaagacagttttactttgtccactcagctggtcagtttaagggaaagacttcaagggagattatggcaagagatagaagtgtccctaatttaaccgaaggttctttgcatgagccagggaggcaaagtgtcacactgagacagaataacctgccagctcagagtggatctcatgctgctgagaaaggcaacagcgactggccagagaggcctggactgacacagactggccctggacacagacggatgctgcggagacacacggtagaggatgcggtcgtgtcccagggcccggaggctgctggccccctctccactccccaagaggttagtgcttcccggtcctaacaggaatgaggagttgttgaacccactgctaggaagcaaggatgcaacaagatgatgctgagcgtgaacacatctgagaactaaatgtgcttccatgagactggcttgagaagtcttcagcaccaagttcctgaaagcttttctgtggcaggaaagaatgcaacaaaaaagttaaccaccaccatctctctcctcttcaaagctaatgaatacaattgaaacagacaaaaattccagtagcatccagatccttaagccagaggtgcatgcttctttttaagtatgagggtttgttggtcacagtgggagaggtttcaccaccgcattctgacctcctcctcccaaaaggtgctaaacctctctgacctgtgtacattcacaaaccacagctagaattcctccacctaggattaagctggagagaagtaagtaatttaggtttcatggtactgtagaggccaggctgaaatgtcatatctgaaggaagaaagcagcagctggacaatgtttctttgcaaagcaacactcgaaccaaaagatgcctcaatcccattttgatattcattttagtgaaaggatgcatcagacctgttccacatcatgcacatgggaaagggtggttatcattttccttctaacaagtaggtacagatattcggttactacacgtgcacctgtagcagtatttctagaaacatccctttttgttgagaacctcccttgaatgtctgtcacactcacacctgacgggatggttactggattagagagtagatttggcacatcttttcttagtcttttgattcaaattcaaaacttaacagcacaaaccaggtcagagttactttcggttagaatttattgccatttattcctttttataaatttctatagattatactgttatttttatgttattggcctagagctacacgtatatgggtttgtcctgagtccgttttcaaatgaccttgtgatagggaaatggttttgtccatgttcttggaaatacttgtgtatgtacagaaggaagggagggattatttttctacaaagtaatttatgatttctaattttctaatgtgccttggatatgtgccaaatgatggaaaagaaacagtaaactttatgattcttgactgtgaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84079 -> Molecular function: GO:0005085 [guanyl-nucleotide exchange factor activity] evidence: IDA
GeneID:84079 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IEA
GeneID:84079 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:84079 -> Biological process: GO:0045022 [early endosome to late endosome transport] evidence: IDA
GeneID:84079 -> Cellular component: GO:0005764 [lysosome] evidence: IDA
GeneID:84079 -> Cellular component: GO:0005769 [early endosome] evidence: IDA
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