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2025-05-09 17:22:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_024040 1203 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens CUE domain containing 2 (CUEDC2), mRNA.
ACCESSION NM_024040
VERSION NM_024040.2 GI:148596995
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1203)
AUTHORS Zhang,W.N., Wang,L., Wang,Q., Luo,X., Fang,D.F., Chen,Y., Pan,X.,
Man,J.H., Xia,Q., Jin,B.F., Li,W.H., Li,T., Liang,B., Chen,L.,
Gong,W.L., Yu,M., Li,A.L., Zhou,T. and Li,H.Y.
TITLE CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine
signaling 3) cooperate to negatively regulate Janus kinase 1/signal
transducers and activators of transcription 3 signaling
JOURNAL J. Biol. Chem. 287 (1), 382-392 (2012)
PUBMED 22084247
REMARK GeneRIF: a new biological activity for CUEDC2 as the regulator of
JAK1/STAT3 signaling and the mechanism by which SOCS3 has been
linked to suppression of the JAK/STAT pathway
REFERENCE 2 (bases 1 to 1203)
AUTHORS Gao,Y.F., Li,T., Chang,Y., Wang,Y.B., Zhang,W.N., Li,W.H., He,K.,
Mu,R., Zhen,C., Man,J.H., Pan,X., Li,T., Chen,L., Yu,M., Liang,B.,
Chen,Y., Xia,Q., Zhou,T., Gong,W.L., Li,A.L., Li,H.Y. and
Zhang,X.M.
TITLE Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation
and chromosomal instability
JOURNAL Nat. Cell Biol. 13 (8), 924-933 (2011)
PUBMED 21743465
REMARK GeneRIF: CUEDC2 is a cell-cycle regulator that promotes spindle
checkpoint inactivation and releases APC/C from checkpoint
inhibition. CUEDC2 is phosphorylated by Cdk1 during mitosis.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 1203)
AUTHORS Pan,X., Zhou,T., Tai,Y.H., Wang,C., Zhao,J., Cao,Y., Chen,Y.,
Zhang,P.J., Yu,M., Zhen,C., Mu,R., Bai,Z.F., Li,H.Y., Li,A.L.,
Liang,B., Jian,Z., Zhang,W.N., Man,J.H., Gao,Y.F., Gong,W.L.,
Wei,L.X. and Zhang,X.M.
TITLE Elevated expression of CUEDC2 protein confers endocrine resistance
in breast cancer
JOURNAL Nat. Med. 17 (6), 708-714 (2011)
PUBMED 21572428
REMARK GeneRIF: key factor in endocrine resistance in breast cancer
REFERENCE 4 (bases 1 to 1203)
AUTHORS Zhang,P.J., Zhao,J., Li,H.Y., Man,J.H., He,K., Zhou,T., Pan,X.,
Li,A.L., Gong,W.L., Jin,B.F., Xia,Q., Yu,M., Shen,B.F. and
Zhang,X.M.
TITLE CUE domain containing 2 regulates degradation of progesterone
receptor by ubiquitin-proteasome
JOURNAL EMBO J. 26 (7), 1831-1842 (2007)
PUBMED 17347654
REMARK GeneRIF: These results identify a key post-translational mechanism
that controls progesterone receptor protein levels and for the
first time provide an important insight into the function of CUEDC2
in breast cancer proliferation.
REFERENCE 5 (bases 1 to 1203)
AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
TITLE A scan of chromosome 10 identifies a novel locus showing strong
association with late-onset Alzheimer disease
JOURNAL Am. J. Hum. Genet. 78 (1), 78-88 (2006)
PUBMED 16385451
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 1203)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 7 (bases 1 to 1203)
AUTHORS Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
TITLE The DNA sequence and comparative analysis of human chromosome 10
JOURNAL Nature 429 (6990), 375-381 (2004)
PUBMED 15164054
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BM756951.1, BC000262.1, CX165866.1 and BF002772.1.
On Jun 5, 2007 this sequence version replaced gi:13128995.
##Evidence-Data-START##
Transcript exon combination :: BC000262.1, AL527504.3 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-70 BM756951.1 1-70
71-829 BC000262.1 1-759
830-904 CX165866.1 714-788
905-1192 BC000262.1 835-1122
1193-1203 BF002772.1 1-11 c
FEATURES Location/Qualifiers
source 1..1203
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24.32"
gene 1..1203
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/note="CUE domain containing 2"
/db_xref="GeneID:79004"
/db_xref="HGNC:28352"
/db_xref="MIM:614142"
exon 1..141
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
misc_feature 92..94
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/note="upstream in-frame stop codon"
exon 142..225
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
CDS 152..1015
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/codon_start=1
/product="CUE domain-containing protein 2"
/protein_id="NP_076945.2"
/db_xref="GI:148596996"
/db_xref="CCDS:CCDS41566.1"
/db_xref="GeneID:79004"
/db_xref="HGNC:28352"
/db_xref="MIM:614142"
/translation="
MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH
"
misc_feature 479..481
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H467.1); phosphorylation site"
misc_feature 596..709
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/note="CUE domain; Region: CUE; cl02655"
/db_xref="CDD:207689"
exon 226..369
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
exon 370..431
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
STS 392..789
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/standard_name="G73121"
/db_xref="UniSTS:231386"
exon 432..562
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
variation 502
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/replace="c"
/replace="t"
/db_xref="dbSNP:1044476"
variation 540
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/replace="c"
/replace="t"
/db_xref="dbSNP:11550025"
exon 563..745
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
exon 746..807
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
STS 770..1012
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/standard_name="MARC_7165-7166:996687578:1"
/db_xref="UniSTS:269719"
variation 799
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/replace="c"
/replace="t"
/db_xref="dbSNP:3210927"
exon 808..868
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
exon 869..1196
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/inference="alignment:Splign:1.39.8"
STS 990..1178
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/standard_name="RH47391"
/db_xref="UniSTS:81197"
variation 1044
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/replace="c"
/replace="t"
/db_xref="dbSNP:12558"
STS 1052..1181
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/standard_name="SGC33233"
/db_xref="UniSTS:9565"
STS 1052..1153
/gene="CUEDC2"
/gene_synonym="bA18I14.5; C10orf66"
/standard_name="SHGC-34547"
/db_xref="UniSTS:34389"
ORIGIN
aacttgcccttctcaaacatggccgccacggcgcctctggaagggaaccgctctgggccccgcctttgatctcgttggtggggctgggggatgagagctgcaccgcgcgggacaagtcgccggcggcgcccgacggagcagaagagagagcatggagctggagaggatcgtcagtgcagccctccttgcctttgtccagacacacctcccggaggccgacctcagtggcttggatgaggtcatcttctcctatgtgcttggggtcctggaggacctgggcccctcgggcccatcagaggagaacttcgatatggaggctttcactgagatgatggaggcctatgtgcctggcttcgcccacatccccaggggcacaataggggacatgatgcagaagctctcagggcagctgagcgatgccaggaacaaagagaacctgcaaccgcagagctctggtgtccaaggtcaggtgcccatctccccagagcccctgcagcggcccgaaatgctcaaagaagagactaggtcttcggctgctgctgctgcagacacccaagatgaggcaactggcgctgaggaggagcttctgccaggggtggatgtactcctggaggtgttccctacctgttcggtggagcaggcccagtgggtgctggccaaagctcggggggacttggaagaagctgtgcagatgctggtagagggaaaggaagaggggcctgcagcctgggagggccccaaccaggacctgcccagacgcctcagaggcccccaaaaggatgagctgaagtccttcatcctgcagaagtacatgatggtggatagcgcagaggatcagaagattcaccggcccatggctcccaaggaggcccccaagaagctgatccgatacatcgacaaccaggtagtgagcaccaaaggggagcgattcaaagatgtgcggaaccctgaggccgaggagatgaaggccacatacatcaacctcaagccagccagaaagtaccgcttccattgaggcactcgccggactctgcccgagccttctaggctcagatcccagagggatgcaggagccctatacccctacacaggggccccctaactcctgtcccccttctctactcctttgctccatagtgttaacctactctcggagctgcctccatgggcacagtaaaggtggcccaaggaaggtgaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:79004 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:79004 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:79004 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:79004 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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