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2025-05-09 17:14:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_020943 3279 bp mRNA linear PRI 19-APR-2013
DEFINITION Homo sapiens CWC22 spliceosome-associated protein homolog (S.
cerevisiae) (CWC22), mRNA.
ACCESSION NM_020943 XM_034594
VERSION NM_020943.2 GI:153792116
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3279)
AUTHORS Alexandrov,A., Colognori,D., Shu,M.D. and Steitz,J.A.
TITLE Human spliceosomal protein CWC22 plays a role in coupling splicing
to exon junction complex deposition and nonsense-mediated decay
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (52), 21313-21318 (2012)
PUBMED 23236153
REMARK GeneRIF: The essential splicing factor CWC22 has acquired functions
in exon junction complex assembly and nonsense-mediated decay
during evolution from single-celled to complex eukaryotes.
REFERENCE 2 (bases 1 to 3279)
AUTHORS Barbosa,I., Haque,N., Fiorini,F., Barrandon,C., Tomasetto,C.,
Blanchette,M. and Le Hir,H.
TITLE Human CWC22 escorts the helicase eIF4AIII to spliceosomes and
promotes exon junction complex assembly
JOURNAL Nat. Struct. Mol. Biol. 19 (10), 983-990 (2012)
PUBMED 22961380
REMARK GeneRIF: CWC22 escorts the helicase eIF4AIII to spliceosomes and
promotes exon junction complex assembly
REFERENCE 3 (bases 1 to 3279)
AUTHORS Steckelberg,A.L., Boehm,V., Gromadzka,A.M. and Gehring,N.H.
TITLE CWC22 connects pre-mRNA splicing and exon junction complex assembly
JOURNAL Cell Rep 2 (3), 454-461 (2012)
PUBMED 22959432
REMARK GeneRIF: CWC22 connects pre-mRNA splicing and exon junction complex
assembly.
REFERENCE 4 (bases 1 to 3279)
AUTHORS Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
TITLE A genome-wide search for loci interacting with known prostate
cancer risk-associated genetic variants
JOURNAL Carcinogenesis 33 (3), 598-603 (2012)
PUBMED 22219177
REFERENCE 5 (bases 1 to 3279)
AUTHORS Lehner,B. and Sanderson,C.M.
TITLE A protein interaction framework for human mRNA degradation
JOURNAL Genome Res. 14 (7), 1315-1323 (2004)
PUBMED 15231747
REFERENCE 6 (bases 1 to 3279)
AUTHORS Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
Moore,M.J.
TITLE Purification and characterization of native spliceosomes suitable
for three-dimensional structural analysis
JOURNAL RNA 8 (4), 426-439 (2002)
PUBMED 11991638
REFERENCE 7 (bases 1 to 3279)
AUTHORS Kelly,W.G., Xu,S., Montgomery,M.K. and Fire,A.
TITLE Distinct requirements for somatic and germline expression of a
generally expressed Caernorhabditis elegans gene
JOURNAL Genetics 146 (1), 227-238 (1997)
PUBMED 9136012
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC031216.1 and AB046824.1.
On Jul 25, 2007 this sequence version replaced gi:55749768.
##Evidence-Data-START##
Transcript exon combination :: BC031216.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1115 BC031216.1 1-1115
1116-3279 AB046824.1 935-3098
FEATURES Location/Qualifiers
source 1..3279
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q31.3"
gene 1..3279
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/note="CWC22 spliceosome-associated protein homolog (S.
cerevisiae)"
/db_xref="GeneID:57703"
/db_xref="HGNC:29322"
/db_xref="HPRD:17220"
/db_xref="MIM:615186"
exon 1..187
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
variation 108
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/replace="a"
/replace="g"
/db_xref="dbSNP:201574101"
exon 188..327
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
misc_feature 211..213
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/note="upstream in-frame stop codon"
CDS 301..3027
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/note="functional spliceosome-associated protein b;
nucampholin homolog"
/codon_start=1
/product="pre-mRNA-splicing factor CWC22 homolog"
/protein_id="NP_065994.1"
/db_xref="GI:55749769"
/db_xref="CCDS:CCDS46465.1"
/db_xref="GeneID:57703"
/db_xref="HGNC:29322"
/db_xref="HPRD:17220"
/db_xref="MIM:615186"
/translation="
MKSSVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGRSYDSSMESRNRDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSSAQDEPATKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAGSSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK
"
misc_feature 481..483
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HCG8.3); phosphorylation site"
misc_feature 880..1335
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/note="MIF4G domain; Region: MIF4G; pfam02854"
/db_xref="CDD:202432"
misc_feature 1663..1983
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/note="Domain in DAP-5, eIF4G, MA-3 and other proteins;
Region: MA3; smart00544"
/db_xref="CDD:128817"
misc_feature 2785..2787
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HCG8.3); phosphorylation site"
misc_feature 2785..2787
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 328..395
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 396..506
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 507..752
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 753..881
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 882..1050
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1051..1104
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1105..1240
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1241..1447
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1448..1510
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1511..1615
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1616..1697
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1698..1758
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1759..1836
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 1837..1989
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
STS 1923..2090
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/standard_name="RH65718"
/db_xref="UniSTS:89307"
exon 1990..2117
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 2118..2219
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 2220..2440
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
exon 2441..3279
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/inference="alignment:Splign:1.39.8"
variation 2681
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046356"
STS 2912..3059
/gene="CWC22"
/gene_synonym="EIF4GL; fSAPb; NCM"
/standard_name="RH102467"
/db_xref="UniSTS:96801"
ORIGIN
gtggagtccccgcaggcagagacgcggagtgggggtggcgggtcgccggatcgggtgggaagtaaaagacccccaggagtgggtgcgggctcactgatacggctgtgagcggcattggagtgtgcgtgggtcttctcgctacgctcgggcccgcaagaggggtgtgagagcggctaggtccaagcaggtgatgtttgcagacagaaaaagtaaactgtcaaggaattcagagcattgggtacttgttatttggaccagtttgaagcatctttgatttattggaccaactggcaacagaaaatgaaaagtagtgtggcacagataaaaccttcttctggtcatgacagaagggaaaaccttaattcatatcagaggaactcctctccagaagacagatatgaagaacaagaacgatccccccgggatagagattactttgattacagcagatcagactatgagcattcaagaagaggacgttcttatgatagtagcatggagtcacgaaacagggaccgagaaaaacgcagagaaagagaaagagatacggatcggaaaaggtctcggaaatccccatctcctgggaggagaaacccagaaacatcagtaactcagagttcctctgctcaggatgaacctgctacaaagaaaaagaaagatgagctggatcctcttcttactcgcactggtggagcatatattccccctgcaaagctcaggatgatgcaggaacagattacagataaaaacagcttagcataccagaggatgagttgggaggccctgaagaagtcaattaatggccttatcaacaaagtcaacatttccaacataagtattattattcaagagcttcttcaagaaaatatagttagaggaagaggactgctgtccaggtctgttttgcaagcacagagtgcttctccaatcttcacccatgtttatgcagcattagtggcaattatcaactcaaaatttccacaaattggagaattaatcctcaaaaggttaattcttaattttcgaaaaggctatcgaagaaatgacaagcaactttgcctgactgcttcaaaatttgtggcgcatcttattaaccaaaatgtggcacacgaagtattatgcttagagatgctcactttgctcctggaaagaccaacagatgatagcgttgaagtagctattggttttcttaaggaatgtggcctcaaattaacacaagtgtcaccaagaggaatcaatgctatatttgaacgccttcgaaacattctgcatgagtctgaaattgacaaaagagttcaatatatgattgaagtgatgtttgctgtacggaaagatggattcaaggaccaccccattatcctagaaggtcttgatttggtggaagaagatgatcaattcactcatatgctccctctggaggatgactataatccagaagatgttcttaatgttttcaagatggatcctaattttatggagaatgaagagaagtacaaagctattaagaaagaaattcttgatgagggagatactgactcgaacacagaccaggatgctgggagtagtgaagaggacgaggaagaagaagaggaagagggagaagaagatgaagaaggacaaaaagtaactattcatgacaaaacagaaattaacctggtctcatttcgtcgtacaatttatcttgctattcagtcaagtttagattttgaagaatgtgctcacaaattgctgaaaatggagtttcctgaaagccaaacaaaagaactctgcaacatgatacttgattgctgtgcccaacagaggacatacgaaaaattttttggcttattagctgggcgattttgcatgctaaagaaagagtacatggaatcctttgaaggtatattcaaagaacagtatgataccatccatcgcttggaaacaaacaagttgcgaaatgttgctaagatgtttgctcaccttttatacactgattcacttccatggagtgttcttgaatgtataaaactgagtgaagaaaccactacatcatccagtagaatttttgtcaaaatatttttccaggaactgtgtgaatacatgggtcttcctaaacttaatgcaagattaaaggatgaaactctgcagccattctttgaaggattattaccccgagataatccaagaaacactcggtttgccatcaacttctttacttctataggtcttggaggtttaacggatgaactgcgggagcatctcaaaaatacaccaaaggtcattgtggcgcagaaaccagatgttgagcaaaataaatcctccccatcctcttcctcttcagcgtcctcctcttcagagtctgactcatccgactctgattctgacagcagtgatagcagttcagagtcttccagtgaagagagcgactcttcatccatcagtagtcatagctctgcctcagctaatgatgtaagaaagaagggacatgggaagaccagaagtaaagaggtagataaattgatcagaaaccagcaaacaaatgataggaaacaaaaagaaagaagacaagaacacgggcaccaggaaacaaggactgagagagaaagaaggtcagaaaaacacagagatcaaaattcaagtggttcaaattggagagatcctataacaaagtacacatcagacaaagatgttccttctgaacgaaataactacagtagagttgcgaatgacagagaccaagaaatgcatatagatttggaaaataagcatggtgatcccaaaaagaagagaggagagagaagaaattctttttctgaaaatgagaagcatacacaccgaattaaagacagtgaaaatttcagaagaaaagatagatcaaagtcaaaggaaatgaatagaaagcactcaggctcaagaagtgatgaagatagatatcaaaatggtgccgagagacgatgggaaaaatctagcagatactctgaacaatccagagaatcaaagaaaaatcaggaccggcgaagagaaaagtctccagcaaaacaaaaataattctacaaaatgacataaactggacatgccttatattcagttgaaacaaattattttttactttgacgaactttatagagaattcttgtataaagtattggtttgtatttgtaaatttaaaaaatgttttcattttaacatgttttataattgatacatctcaaggccctacccataaaattatttgaaaactttcaccagaaagggatgtaagtctcgcttatattttgtgaataaaatgatcaaaagctc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:57703 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:57703 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
GeneID:57703 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: IC
GeneID:57703 -> Biological process: GO:0048024 [regulation of mRNA splicing, via spliceosome] evidence: IC
GeneID:57703 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:57703 -> Cellular component: GO:0005681 [spliceosomal complex] evidence: IDA
GeneID:57703 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:57703 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:57703 -> Cellular component: GO:0071013 [catalytic step 2 spliceosome] evidence: IDA
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@meso_cacase at
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