Home |
Help |
Advanced search
2025-05-09 17:19:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_020214 2631 bp mRNA linear PRI 04-MAY-2013
DEFINITION Homo sapiens poly (ADP-ribose) polymerase family, member 6 (PARP6),
mRNA.
ACCESSION NM_020214
VERSION NM_020214.2 GI:94536837
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2631)
AUTHORS Tuncel,H., Tanaka,S., Oka,S., Nakai,S., Fukutomi,R., Okamoto,M.,
Ota,T., Kaneko,H., Tatsuka,M. and Shimamoto,F.
TITLE PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of
cell proliferation, is involved in colorectal cancer development
JOURNAL Int. J. Oncol. 41 (6), 2079-2086 (2012)
PUBMED 23042038
REMARK GeneRIF: PARP6, a mono(ADP-ribosyl) transferase and a negative
regulator of cell proliferation, is involved in colorectal cancer
development, PARP6-positive colorectal cancer had a good prognosis.
REFERENCE 2 (bases 1 to 2631)
AUTHORS Ame,J.C., Spenlehauer,C. and de Murcia,G.
TITLE The PARP superfamily
JOURNAL Bioessays 26 (8), 882-893 (2004)
PUBMED 15273990
REMARK Review article
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from DB121441.1,
BC110902.1 and AK022547.1.
On May 4, 2006 this sequence version replaced gi:19482155.
##Evidence-Data-START##
CDS exon combination :: BC110902.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-422 DB121441.1 43-464
423-1052 BC110902.1 12-641
1053-1767 AK022547.1 817-1531
1768-2631 BC110902.1 1357-2220
FEATURES Location/Qualifiers
source 1..2631
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q23"
gene 1..2631
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/note="poly (ADP-ribose) polymerase family, member 6"
/db_xref="GeneID:56965"
/db_xref="HGNC:26921"
exon 1..265
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 266..462
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
misc_feature 445..447
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/note="upstream in-frame stop codon"
CDS 460..2352
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/EC_number="2.4.2.30"
/note="PARP-6; ADP-ribosyltransferase diphtheria
toxin-like 17"
/codon_start=1
/product="poly [ADP-ribose] polymerase 6"
/protein_id="NP_064599.2"
/db_xref="GI:94536838"
/db_xref="CCDS:CCDS10241.2"
/db_xref="GeneID:56965"
/db_xref="HGNC:26921"
/translation="
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
"
misc_feature 1123..1533
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/note="ADP_ribosylating enzymes catalyze the transfer of
ADP_ribose from NAD+ to substrates. Bacterial toxins are
cytoplasmic and catalyze the transfer of a single
ADP_ribose unit to eukaryotic elongation factor 2, halting
protein synthesis and killing the cell; Region:
ADP_ribosyl; cd01341"
/db_xref="CDD:238651"
misc_feature order(1129..1143,1150..1152,1162..1164,1183..1191,
1195..1197,1258..1266,1312..1314,1510..1512)
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/note="nad+ binding pocket [chemical binding]; other site"
/db_xref="CDD:238651"
misc_feature 1867..2241
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/note="ADP_ribosylating enzymes catalyze the transfer of
ADP_ribose from NAD+ to substrates. Bacterial toxins are
cytoplasmic and catalyze the transfer of a single
ADP_ribose unit to eukaryotic elongation factor 2, halting
protein synthesis and killing the cell; Region:
ADP_ribosyl; cd01341"
/db_xref="CDD:238651"
misc_feature order(1873..1887,1894..1896,1906..1908,1918..1926,
1930..1932,1978..1986,2014..2016,2197..2199)
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/note="nad+ binding pocket [chemical binding]; other site"
/db_xref="CDD:238651"
exon 463..540
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 541..635
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 636..696
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 697..787
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 788..854
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 855..1004
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1005..1215
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1216..1269
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1270..1365
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1366..1458
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1459..1584
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1585..1650
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1651..1718
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1719..1767
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1768..1877
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1878..1950
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 1951..2020
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 2021..2100
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 2101..2164
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 2165..2249
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
exon 2250..2626
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/inference="alignment:Splign:1.39.8"
variation 2397
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/replace="c"
/replace="t"
/db_xref="dbSNP:1044132"
variation 2487
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/replace="a"
/replace="g"
/db_xref="dbSNP:1044144"
variation 2533
/gene="PARP6"
/gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
/replace="c"
/replace="t"
/db_xref="dbSNP:1044151"
ORIGIN
caacagaaaccaagcagcaacagcccttggaaagaggctaaatttttcttgacttctgcagcaacaaagaccgtgaaaagttggcacttctggcctaacgctgccgtcatcctacccctcaccccagggcaacccaggctggacatttagtgcctccctctttattcctctgtgatcatccagatcagcacttgactgtttattttcaaatctcacgaacctcaccccaagatcttcacattctggatctcagctgctcttgaaggacagtgacttgttaccaccgcaacagcagagcctgccatccccaacagatcaccagttgtccctgacatcgtgccctaccttgtctccctttgtggtctcctaaatgcccatctcgttggccttggttcggctagtggtatggaggggtgctgcctagcactgacctgagagtgtgtgtgacccactgacccaatggacatcaaaggccagttctggaatgatgacgactcggagggagataatgaatcagaggaatttctctatggcgttcaggggagctgtgcagctgacctgtatcgacacccacagcttgatgcagacattgaagccgtgaaggagatctacagtgagaactctgtatccatcagagaatatggaactatcgatgacgtggacattgacctccacatcaacatcagcttcctcgatgaggaagtctctacagcctggaaggtcctccggacagaacctattgtgttgaggctgcgattttctctctcccagtacctagatggaccagaaccatccattgaggttttccagccatcaaataaggaaggatttgggctgggtcttcagttgaaaaagatcctgggtatgtttacatcccaacaatggaaacatctgagcaatgatttcttgaagacccagcaggagaagaggcacagttggttcaaggcaagtggtaccatcaagaagttccgagctggcctcagcatcttttcacccatccccaagtctcccagtttccctatcatacaggactccatgctgaaaggcaaactaggtgtaccagagcttcgggttgggcgcctcatgaaccgttccatctcctgtaccatgaagaaccccaaagtggaagtgtttggctaccctcccagcccccaggcaggtctcctgtgccctcagcacgtgggcctccctcccccagcacggacctctcctttggtcagtggtcactgcaagaacattcccactctggagtatggattcctcgttcagatcatgaagtatgcagaacagaggattccaacattgaatgagtactgtgtggtgtgtgatgagcagcatgtcttccaaaatggatctatgctgaagccagctgtctgtactcgtgaactatgcgttttctccttctacacactgggcgtcatgtctggagctgcagaggaggtggccactggagcagaggtggtggatctgctggtggccatgtgtagggcagctttagagtcccctagaaagagcatcatctttgagccttatccctctgtggtggaccccactgatcccaagactctggcctttaaccctaagaagaagaattatgagcggcttcagaaagctctggatagtgtgatgtctattcgggagatgacccagggctcatatttggaaatcaagaaacagatggacaagttggatcccctggcccatcctctcctgcagtggatcatctctagcaacaggtcacacattgtcaaactacctctcagcaggctgaagttcatgcacacctcacaccagttcctcctgctgagcagccctcctgccaaggaggctcggttccggaccgccaagaagctctatggcagcacctttgccttccatgggtcccacattgagaactggcattcgatcctgcgcaatgggctggtcaatgcatcctacaccaaactgcagctgcatggagcagcctatggcaaaggcatctacctgagccccatctccagtatttcctttggatactcaggaatgggaaaaggacagcacaggatgccctccaaggatgagctggtccagagatacaacaggatgaataccatcccccagacccgatccattcagtcacggttcctgcagagtcggaatctaaactgtatagcactttgtgaagtgattacatctaaggacctccagaagcatgggaacatctgggtgtgccctgtgtccgaccatgtctgcacaagattcttctttgtatatgaggatggtcaggtgggcgatgccaacattaatactcaggaccccaagatacagaaggaaatcatgcgtgtgatcggaactcaggtttacacaaactgagggggccccagccctcgtaccacccctgttaccccaggatccatctgccctcataaaagtgttcaggtacagcagctgaggctgccctgaggaatcaaggggccattaccaaggggcaggaaaaggatatgtaagaggtggccttcatggtagagcttgacccaagaactactccacattcggatggcccagactgactccatcccctgactttccctttgacttcaccctgtttgtaaataaaacaataaaatggaaggtgctgtggactggaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56965 -> Molecular function: GO:0003950 [NAD+ ADP-ribosyltransferase activity] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_064599 -> EC 2.4.2.30
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.