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2025-05-09 16:35:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018207 3865 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens tripartite motif containing 62 (TRIM62), mRNA.
ACCESSION NM_018207
VERSION NM_018207.2 GI:217035094
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3865)
AUTHORS Lott,S.T., Chen,N., Chandler,D.S., Yang,Q., Wang,L., Rodriguez,M.,
Xie,H., Balasenthil,S., Buchholz,T.A., Sahin,A.A., Chaung,K.,
Zhang,B., Olufemi,S.E., Chen,J., Adams,H., Band,V., El-Naggar,A.K.,
Frazier,M.L., Keyomarsi,K., Hunt,K.K., Sen,S., Haffty,B.,
Hewitt,S.M., Krahe,R. and Killary,A.M.
TITLE DEAR1 is a dominant regulator of acinar morphogenesis and an
independent predictor of local recurrence-free survival in
early-onset breast cancer
JOURNAL PLoS Med. 6 (5), E1000068 (2009)
PUBMED 19536326
REMARK GeneRIF: The evidence for the genetic alteration and loss of
expression of DEAR1 in breast cancer and for the functional role of
DEAR1 in the dominant regulation of acinar morphogenesis in 3D
culture
REFERENCE 2 (bases 1 to 3865)
AUTHORS Muthuswamy,S.K.
TITLE A new tumor suppressor that regulates tissue architecture
JOURNAL PLoS Med. 6 (5), E1000073 (2009)
PUBMED 19536324
REMARK GeneRIF: DEAR1 is a predictive biomarker for early onset breast
cancer.
REFERENCE 3 (bases 1 to 3865)
AUTHORS Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
TITLE Functional proteomics mapping of a human signaling pathway
JOURNAL Genome Res. 14 (7), 1324-1332 (2004)
PUBMED 15231748
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA338982.1, BM722392.1, BC007999.1, AK001621.1 and CX872720.1.
On Dec 10, 2008 this sequence version replaced gi:8922647.
##Evidence-Data-START##
Transcript exon combination :: BC001222.1, AK001621.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-558 DA338982.1 11-568
559-1009 BM722392.1 214-664
1010-2463 BC007999.1 405-1858
2464-2953 AK001621.1 2060-2549
2954-3305 CX872720.1 358-709
3306-3865 BC007999.1 2700-3259
FEATURES Location/Qualifiers
source 1..3865
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p35.1"
gene 1..3865
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="tripartite motif containing 62"
/db_xref="GeneID:55223"
/db_xref="HGNC:25574"
exon 1..1046
/gene="TRIM62"
/gene_synonym="DEAR1"
/inference="alignment:Splign:1.39.8"
misc_feature 264..266
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="upstream in-frame stop codon"
CDS 639..2066
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="ductal epithelium-associated RING Chromosome 1;
tripartite motif-containing 62"
/codon_start=1
/product="tripartite motif-containing protein 62"
/protein_id="NP_060677.2"
/db_xref="GI:217035095"
/db_xref="CCDS:CCDS376.1"
/db_xref="GeneID:55223"
/db_xref="HGNC:25574"
/translation="
MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
"
misc_feature 657..803
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature 669..809
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(669..671,678..680,714..716,720..722,729..731,
738..740,786..788,795..797)
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
misc_feature 900..1022
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="B-Box-type zinc finger; zinc binding domain
(CHC3H2); often present in combination with other motifs,
like RING zinc finger, NHL motif, coiled-coil or RFP
domain in functionally unrelated proteins, most likely
mediating protein-protein interaction; Region: BBOX;
cl00034"
/db_xref="CDD:206793"
misc_feature order(915..917,924..926,978..980,996..998)
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28905"
misc_feature 1044..1403
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="B-Box C-terminal domain; Region: BBC; smart00502"
/db_xref="CDD:128778"
misc_feature 1527..1676
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="SPRY-associated domain; Region: PRY; pfam13765"
/db_xref="CDD:205938"
misc_feature 1680..2012
/gene="TRIM62"
/gene_synonym="DEAR1"
/note="Domain in SPla and the RYanodine Receptor; Region:
SPRY; smart00449"
/db_xref="CDD:128725"
exon 1047..1142
/gene="TRIM62"
/gene_synonym="DEAR1"
/inference="alignment:Splign:1.39.8"
exon 1143..1399
/gene="TRIM62"
/gene_synonym="DEAR1"
/inference="alignment:Splign:1.39.8"
exon 1400..1515
/gene="TRIM62"
/gene_synonym="DEAR1"
/inference="alignment:Splign:1.39.8"
exon 1516..3841
/gene="TRIM62"
/gene_synonym="DEAR1"
/inference="alignment:Splign:1.39.8"
variation 1681
/gene="TRIM62"
/gene_synonym="DEAR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2335238"
variation 2611
/gene="TRIM62"
/gene_synonym="DEAR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:4045741"
variation 2684
/gene="TRIM62"
/gene_synonym="DEAR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4045742"
variation 2689
/gene="TRIM62"
/gene_synonym="DEAR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4045743"
variation 2771
/gene="TRIM62"
/gene_synonym="DEAR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4045744"
variation 2954..2955
/gene="TRIM62"
/gene_synonym="DEAR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4045745"
STS 3605..3744
/gene="TRIM62"
/gene_synonym="DEAR1"
/standard_name="D1S3575"
/db_xref="UniSTS:16848"
STS 3643..3775
/gene="TRIM62"
/gene_synonym="DEAR1"
/standard_name="SHGC-74539"
/db_xref="UniSTS:603"
ORIGIN
accggcagctcggattcggctggttccgggttgagaggctgcgctggaccgaagcggtggctgctaagctcgcgggggtaaggggtcgcgctgggccagggtttggggccgggatccggcagctgagcgggccggcacccctcctcttctctgccggtcacagccaatgtacggctcggcctggctgccccctcccccaggattccccatccccagcttctcgccctccccgcaccgcccccaccccgggatttcgacccccttaagggctccaccccgctccgggatccccttctcccagctcctatcccttaggactgccccgccccctagaacctccccgtcaggatctccgtccctcagccgctcacagcctcctcccagcgcccatcgccttgagctgcccactacctctagactgccctcccgggctggcgtcccacggagtctcagccgcgcaccccttcctcgcgttaccctccttccggacagcaccccctcccttctccggtagctcctacccctgcctgtgcgggcctcgtccccgcgcccagccctcggtgctgcctccgacagcgccgcgctctctcagccgcccccctgcccctcgggcccccctctctgctgcccctggcgccatggcgtgcagcctcaaggacgagctgctgtgctccatctgcctgagcatctaccaggacccggtgagcctgggctgcgagcattacttctgccgccgctgcatcacggagcactgggtgcggcaggaggcgcagggcgcccgcgactgccccgagtgccggcgcacgttcgccgagcccgcgctggcgcccagcctcaagctggccaacatcgtggagcgctacagctccttcccgctggacgccatcctcaacgcgcgccgcgccgcgcgaccctgccaggcgcacgacaaggtcaagctcttctgcctcacggaccgcgcgcttctctgcttcttctgcgacgagcctgcactgcacgagcagcatcaggtcaccggcatcgacgacgccttcgacgagctgcagagggagctgaaggaccaacttcaggcccttcaagacagcgagcgggaacacaccgaagcgctgcagctgctcaagcgacaactggcggagaccaagtcttccaccaagagcctgcggaccactatcggcgaggccttcgagcggctgcaccggctgctgcgtgaacgccagaaggccatgctagaggagctggaggcggacacggcccgcacgctgaccgacatcgagcagaaagtccagcgctacagccagcagctgcgcaaggtccaggagggagcccagatcctgcaggagcggctggctgaaaccgaccggcacaccttcctggctggggtggcctcactgtccgagcggctcaagggaaaaatccatgagaccaacctcacatatgaagacttcccgacctccaagtacacaggccccctgcagtacaccatctggaagtccctgttccaggacatccacccagtgccagccgccctaaccctggacccgggcacagcccaccagcgcctgatcctgtcggacgactgcaccattgtggcttacggcaacttgcacccacagccactgcaggactcgccaaagcgcttcgatgtggaggtgtcggtgctgggttctgaagccttcagtagtggcgtccactactgggaggtggtggtggcggagaagacccagtgggtgatcgggctggcacacgaagccgcaagccgcaagggcagcatccagatccagcccagccgcggcttctactgcatcgtgatgcacgatggcaaccagtacagcgcctgcacggagccctggacgcggcttaacgtccgggacaagcttgacaaggtgggtgtcttcctggactatgaccaaggcttgctcatcttctacaatgctgatgacatgtcctggctctacaccttccgcgagaagttccctggcaagctctgctcttacttcagccctggccagagccacgccaatggcaagaacgttcagccgctgcggatcaacaccgtccgcatctagtccaggcagaaggagaccacaacctcctgggaccactgccacctgcaagagccctgcccaggagatagaagacctggactccagcccaccgtggccactggagacctcaggccagttgtttaccctccagcctccagtctgtaaaatggaggttgcattccctacttcctaaactctcttccagcatcgatgttctgtagctctgaccttgatagggatacagctttgatccaaggatgtgacatggcttctcctcagggcaacccctgcccaaccctcatccccatcttctcaggggcaggggactaccttccagtgtctccctccagcccagccctgacctcaggaagtgtcagagcatggccagtagttggcagcccgaaagacacacagcaccctcttatgtcccatggcctaagacttacccctgaccaagctagtgatgggccatttacccttgaccccagtccacagtggtcacaggtagtacctggtcctagggttgcctgagagccaacctctcctgccacccccacaccaagaactatatggttcctacttctcccactgatctgctggtcagtgatgatgctgtggcctgtggaaggcacctggtagttgagtccacacattatagtcatgtgccaccaccttcctgcccacaggccgagggacagggtgagggtatacccaaagctgatgcagagcccattagcctaaaagcaactgcaggacaagcctccctggatgatcgaggtccccagtagctctgaacaagagtccagccaaccctcttcagccaggcctctgtgacctgctagggtgcaggaggcttccagaagcagttgttgtaattaggacccaagcactgggaggggctgttggctggaccccttgtcagacttggcatctatctcagttaggatcctgctgcagaaaacaagagccacttgtagctggtttaattagacaaggatttactacctggcccctggtggcttgcaaaattgttggaagagctggagaagcagactctgctgaatttccaggaactcccagcgccagattcatcatgtctgttgtgaccaggaaagctgcccccatctgcaggaagccactatgccagaaagctgctgactgcagaactaggctccctctgccacggtccgtgccagccaatagatgtcctgaggcctgcccctctcccacttcactcagttcccaaatctaaatttttacaagagattctgtttgggggaacttaagtcagatccagaaccttggctgcaagggagtctgggaaatgtcatttccctagaaggaagttagggtgggtggagcaagccccacctgcgtttttctgccacagcatccaatcgtgaagaactcgggagagggtggagtccacatctagggttgtcctgccccttggctctatccctgcccagaggtgggaactggaggagtgggctgcaagactgagcctaaatgtctccccggccttgacttttctttctagtcctggggcctagattctgcacttggggtctctgacacaacacaccatcccaaagtagccggaagagctaaacacagggggttcttaaaatggctgcccccgccacccgggcctcccttgggcaaaaggaattgtcagccctaccccaacccttcaactaccagaatctgggccaccccagcagtatttttatttaaaatgttgcccattttatgagttatgatcaatttgtattaaattaaagttacagatgtcaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55223 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:55223 -> Cellular component: GO:0005622 [intracellular] evidence: IEA
by
@meso_cacase at
DBCLS
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