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2025-05-09 16:49:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016953 9285 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens phosphodiesterase 11A (PDE11A), transcript variant 4,
mRNA.
ACCESSION NM_016953
VERSION NM_016953.3 GI:116536084
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9285)
AUTHORS Vezzosi,D., Libe,R., Baudry,C., Rizk-Rabin,M., Horvath,A., Levy,I.,
Rene-Corail,F., Ragazzon,B., Stratakis,C.A., Vandecasteele,G. and
Bertherat,J.
TITLE Phosphodiesterase 11A (PDE11A) gene defects in patients with
acth-independent macronodular adrenal hyperplasia (AIMAH):
functional variants may contribute to genetic susceptibility of
bilateral adrenal tumors
JOURNAL J. Clin. Endocrinol. Metab. 97 (11), E2063-E2069 (2012)
PUBMED 22996146
REMARK GeneRIF: PDE11A genetic variants may increase predisposition to
ACTH-independent macronodular adrenal hyperplasia.
REFERENCE 2 (bases 1 to 9285)
AUTHORS Uckert,S., Oelke,M., Albrecht,K., Breitmeier,D., Kuczyk,M.A. and
Hedlund,P.
TITLE Expression and distribution of key enzymes of the cyclic GMP
signaling in the human clitoris: relation to phosphodiesterase type
5 (PDE5)
JOURNAL Int. J. Impot. Res. 23 (5), 206-212 (2011)
PUBMED 21697861
REMARK GeneRIF: found in single nerve trunks in the clitoral stroma
REFERENCE 3 (bases 1 to 9285)
AUTHORS Libe,R., Horvath,A., Vezzosi,D., Fratticci,A., Coste,J.,
Perlemoine,K., Ragazzon,B., Guillaud-Bataille,M., Groussin,L.,
Clauser,E., Raffin-Sanson,M.L., Siegel,J., Moran,J.,
Drori-Herishanu,L., Faucz,F.R., Lodish,M., Nesterova,M.,
Bertagna,X., Bertherat,J. and Stratakis,C.A.
TITLE Frequent phosphodiesterase 11A gene (PDE11A) defects in patients
with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may
contribute to adrenal and testicular tumors in CNC as a modifier of
the phenotype
JOURNAL J. Clin. Endocrinol. Metab. 96 (1), E208-E214 (2011)
PUBMED 21047926
REMARK GeneRIF: We demonstrate, in a large cohort of Carney Complex
patients, a high frequency of PDE11A variants, suggesting that
PDE11A is a genetic modifying factor for the development of
testicular and adrenal tumors in patients with germline PRKAR1A
mutation.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 9285)
AUTHORS Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
TITLE Hundreds of variants clustered in genomic loci and biological
pathways affect human height
JOURNAL Nature 467 (7317), 832-838 (2010)
PUBMED 20881960
REFERENCE 5 (bases 1 to 9285)
AUTHORS DeWan,A.T., Triche,E.W., Xu,X., Hsu,L.I., Zhao,C., Belanger,K.,
Hellenbrand,K., Willis-Owen,S.A., Moffatt,M., Cookson,W.O.,
Himes,B.E., Weiss,S.T., Gauderman,W.J., Baurley,J.W., Gilliland,F.,
Wilk,J.B., O'Connor,G.T., Strachan,D.P., Hoh,J. and Bracken,M.B.
TITLE PDE11A associations with asthma: results of a genome-wide
association scan
JOURNAL J. Allergy Clin. Immunol. 126 (4), 871-873 (2010)
PUBMED 20920776
REMARK GeneRIF: PDE11A SNP assocaited with allergic asthma.
GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
REFERENCE 6 (bases 1 to 9285)
AUTHORS Hetman,J.M., Robas,N., Baxendale,R., Fidock,M., Phillips,S.C.,
Soderling,S.H. and Beavo,J.A.
TITLE Cloning and characterization of two splice variants of human
phosphodiesterase 11A
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (23), 12891-12895 (2000)
PUBMED 11050148
REFERENCE 7 (bases 1 to 9285)
AUTHORS Yuasa,K., Kotera,J., Fujishige,K., Michibata,H., Sasaki,T. and
Omori,K.
TITLE Isolation and characterization of two novel phosphodiesterase
PDE11A variants showing unique structure and tissue-specific
expression
JOURNAL J. Biol. Chem. 275 (40), 31469-31479 (2000)
PUBMED 10906126
REFERENCE 8 (bases 1 to 9285)
AUTHORS Fawcett,L., Baxendale,R., Stacey,P., McGrouther,C., Harrow,I.,
Soderling,S., Hetman,J., Beavo,J.A. and Phillips,S.C.
TITLE Molecular cloning and characterization of a distinct human
phosphodiesterase gene family: PDE11A
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (7), 3702-3707 (2000)
PUBMED 10725373
REFERENCE 9 (bases 1 to 9285)
AUTHORS Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B.,
Sonnenburg,W.K., Beavo,J.A. and Ferguson,K.
TITLE Isolation and characterization of cDNAs corresponding to two human
calcium, calmodulin-regulated, 3',5'-cyclic nucleotide
phosphodiesterases
JOURNAL J. Biol. Chem. 271 (2), 796-806 (1996)
PUBMED 8557689
REFERENCE 10 (bases 1 to 9285)
AUTHORS Beavo,J.A., Conti,M. and Heaslip,R.J.
TITLE Multiple cyclic nucleotide phosphodiesterases
JOURNAL Mol. Pharmacol. 46 (3), 399-405 (1994)
PUBMED 7935318
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AB036704.1, AC011998.8,
BC112393.1, AC073834.6 and AI919276.1.
On Oct 24, 2006 this sequence version replaced gi:19923439.
Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as
second messengers in a wide variety of signal transduction
pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)
catalyze the hydrolysis of cAMP and cGMP to the corresponding
5'-monophosphates and provide a mechanism to downregulate cAMP and
cGMP signaling. This gene encodes a member of the PDE protein
superfamily. Mutations in this gene are a cause of Cushing disease
and adrenocortical hyperplasia. Multiple transcript variants
encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (4) represents the longest
transcript and encodes the longest isoform (4).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB036704.1, BC112393.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-868 AB036704.1 1-868
869-1110 AC011998.8 120246-120487 c
1111-3081 BC112393.1 1102-3072
3082-3242 BC112393.1 3076-3236
3243-8974 AC073834.6 116649-122380 c
8975-9285 AI919276.1 1-311 c
FEATURES Location/Qualifiers
source 1..9285
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q31.2"
gene 1..9285
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="phosphodiesterase 11A"
/db_xref="GeneID:50940"
/db_xref="HGNC:8773"
/db_xref="MIM:604961"
exon 1..1230
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
misc_feature 2
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="major transcription initiation site"
misc_feature 253..255
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="upstream in-frame stop codon"
CDS 319..3120
/gene="PDE11A"
/gene_synonym="PPNAD2"
/EC_number="3.1.4.35"
/EC_number="3.1.4.17"
/note="isoform 4 is encoded by transcript variant 4; cAMP
and cGMP cyclic nucleotide phosphodiesterase 11A; dual
3',5'-cyclic-AMP and -GMP phosphodiesterase 11A"
/codon_start=1
/product="dual 3',5'-cyclic-AMP and -GMP phosphodiesterase
11A isoform 4"
/protein_id="NP_058649.3"
/db_xref="GI:116536085"
/db_xref="CCDS:CCDS33334.1"
/db_xref="GeneID:50940"
/db_xref="HGNC:8773"
/db_xref="MIM:604961"
/translation="
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
"
misc_feature 925..1464
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="FOG: GAF domain [Signal transduction mechanisms];
Region: FhlA; COG2203"
/db_xref="CDD:32385"
misc_feature 967..1458
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Domain present in phytochromes and cGMP-specific
phosphodiesterases; Region: GAF; smart00065"
/db_xref="CDD:197499"
misc_feature 1033..1035
/gene="PDE11A"
/gene_synonym="PPNAD2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HCR9.2); phosphorylation site"
misc_feature 1480..2028
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="FOG: GAF domain [Signal transduction mechanisms];
Region: FhlA; COG2203"
/db_xref="CDD:32385"
misc_feature 1522..2022
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Domain present in phytochromes and cGMP-specific
phosphodiesterases; Region: GAF; smart00065"
/db_xref="CDD:197499"
misc_feature 2236..3033
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCR9.2);
Region: Catalytic (By similarity)"
misc_feature 2305..2835
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(2320..2322,2428..2433,2764..2766)
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 2431..2433
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
variation 465
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:34556327"
variation 473
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:77972073"
variation 922
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77063376"
variation 983
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:78860696"
variation 1008
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:78496158"
variation 1110
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1435573"
variation 1112
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:77493999"
variation 1117
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:79233810"
variation 1211
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78328794"
exon 1231..1389
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1234
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:76865936"
variation 1363
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77477862"
exon 1390..1479
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 1480..1620
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1489
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78426895"
variation 1551
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77789692"
variation 1561
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:74460362"
variation 1569
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76725221"
exon 1621..1685
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1645
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75920749"
exon 1686..1818
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1716
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:78731210"
variation 1758
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77896877"
exon 1819..1894
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 1895..1962
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 1963..2055
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 2056..2106
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2075
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:78384547"
exon 2107..2253
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2131
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76110544"
variation 2143
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77934668"
variation 2157
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:75157857"
exon 2254..2361
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2291
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77597060"
variation 2295
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:77341035"
variation 2352
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78730670"
exon 2362..2471
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2404
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:74666005"
variation 2463
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35194777"
exon 2472..2562
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2551
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:79840971"
exon 2563..2663
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2616
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78690307"
exon 2664..2741
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2729
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75127279"
exon 2742..2805
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 2806..2880
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2815
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:75950476"
variation 2822
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:75226037"
variation 2836
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:79903863"
exon 2881..2964
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2894
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:79384192"
variation 2950
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:74357545"
exon 2965..9278
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 2965
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:79400048"
variation 2983
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:75437575"
variation 3040
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:80129029"
variation 3081..3082
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace=""
/replace="tcc"
/db_xref="dbSNP:3830637"
variation 3097
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:74326729"
STS 3843..4532
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="PDE11A_V281"
/db_xref="UniSTS:277573"
polyA_signal 4416..4421
/gene="PDE11A"
/gene_synonym="PPNAD2"
polyA_site 4444
/gene="PDE11A"
/gene_synonym="PPNAD2"
STS 4925..5269
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="RH79802"
/db_xref="UniSTS:88688"
STS 7508..7673
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="L30021"
/db_xref="UniSTS:3276"
STS 8831..8991
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="RH91242"
/db_xref="UniSTS:87167"
variation 8974
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:1047884"
STS 9127..9251
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="SHGC-37408"
/db_xref="UniSTS:1328"
polyA_signal 9258..9263
/gene="PDE11A"
/gene_synonym="PPNAD2"
polyA_site 9278
/gene="PDE11A"
/gene_synonym="PPNAD2"
ORIGIN
gcagcggcggcagccagaacaggagcagcgatagctcgggtttccggaacaggagccggggcagcggcggcagctcagtgctgggcacctgtgcggagcaggagtagcaggaccacggggtggggtcggcgccagccactctgagccagagaaggaaggggcatctcccagattccactgctgggaataatctccaggggaggtggcgctgaactgggaatactggtgggggtgaacatgtgcaggaacagctagaggcctcggggcaggaaaacatttggttcacgtgtaaacaggcaaggaaagctgtctgggaccatggcagcctcccgcctggactttggggaggtggaaactttcctggacaggcacccagagttgtttgaagattacttgatgcggaaggggaagcaggagatggttgaaaagtggctgcagaggcacagtcagggtcagggggctttaggtccaaggccctctttggctggtaccagcagcttggctcacagcacctgcagaggtggcagcagcgttggtggtggcactggaccaaatggctctgcccacagccagccccttcccggtggcggggactgtggtggggttcccttgagtcccagctgggccggtggcagcaggggcgatgggaacctgcagcggagagcttctcagaaagagctaaggaagagttttgcccgctccaaggccatccacgtgaacaggacctacgatgaacaggtgacctcccgggctcaggaacccctgagtagtgtacgacggagggcacttctccggaaggcaagctccctgccccccaccacagcccatattctcagtgcgctgctggaatcgagagtgaatctgcctcggtatccccctacagccatcgactacaagtgccatctgaaaaagcataatgagcgtcagttctttctggaattggtcaaagatatctccaatgaccttgacctcaccagcctgagctacaagattctcatctttgtctgccttatggtggatgctgaccgctgctctcttttcctggtggaaggggcagctgctggcaagaagaccttggtctccaaattctttgatgtgcatgcaggaacacctctgctgccttgcagcagcacagagaactcaaatgaggtgcaggtcccctggggcaaaggtatcattggctatgtcggggagcatggagaaacggtcaacattcctgatgcctaccaggatcgacgattcaatgatgaaatcgacaagctaactggatacaagacaaaatcattattgtgcatgcctatccgaagcagtgatggtgagattattggtgtggcccaagcgataaataagattcctgaaggagctccatttactgaagatgatgaaaaagttatgcagatgtatcttccattttgtggaatcgccatatctaacgctcagctctttgctgcctcaaggaaagaatatgaaagaagcagagctttgctagaggtggttaatgacctctttgaagaacagactgacctggagaaaattgtcaagaaaataatgcatcgggcccaaactctgctgaaatgtgaacgctgttctgttttactcctagaggacatcgaatcaccagtggtgaaatttaccaaatcctttgaattgatgtccccaaagtgcagtgctgatgctgagaacagtttcaaagaaagcatggagaaatcatcatactccgactggctaataaataacagcattgctgagctggttgcttcaacaggccttccagtgaacatcagtgatgcctaccaggatccgcgctttgatgcagaggcagaccagatatctggttttcacataagatctgttctttgtgtccctatttggaatagcaaccaccaaataattggagtggctcaagtgttaaacagacttgatgggaaaccttttgatgatgcagatcaacgactttttgaggcttttgtcatcttttgtggacttggcatcaacaacacaattatgtatgatcaagtgaagaagtcctgggccaagcagtctgtggctcttgatgtgctatcataccatgcaacatgttcaaaagctgaagttgacaagtttaaggcagccaacatccctctggtgtcagaacttgccatcgatgacattcattttgatgacttttctctcgacgttgatgccatgatcacagctgctctccggatgttcatggagctggggatggtacagaaatttaaaattgactatgagacactgtgtaggtggcttttgacagtgaggaaaaactatcggatggttctataccacaactggagacatgccttcaacgtgtgtcagctgatgttcgcgatgttaaccactgctgggtttcaagacattctgaccgaggtggaaattttagcggtgattgtgggatgcctgtgtcatgacctcgaccacaggggaaccaacaatgccttccaagctaagagtggctctgccctggcccaactctatggaacctctgctaccttggagcatcaccatttcaaccacgccgtgatgatccttcaaagtgagggtcacaatatctttgctaacctgtcctccaaggaatatagtgaccttatgcagcttttgaagcagtcaatattggcaacagacctcacgctgtactttgagaggagaactgaattctttgaacttgtcagtaaaggagaatacgattggaacatcaaaaaccatcgtgatatatttcgatcaatgttaatgacagcctgtgaccttggagccgtgaccaaaccgtgggagatctccagacaggtggcagaacttgtaaccagtgagttcttcgaacaaggagatcgggagagattagagctcaaactcactccttcagcaatttttgatcggaaccggaaggatgaactgcctcggttgcaactggagtggattgatagcatctgcatgcctttgtatcaggcactggtgaaggtcaacgtgaaactgaagccgatgctagattcagtagctacaaacagaagtaagtgggaagagctacaccaaaaacgactgctggcctcaactgcctcatcctcccctgccagtgttatggtagccaaggaagacaggaactaaacctccaggtcagctgcagctgcaaaatgactacagcctgaagggccattttcagtccagcaatgtcatccttttgttcttttagctcagaaagacctaacatctcaaggatgcactgggaagcatgcctgggctttcaccttgaagcatggtcagcagcagagagagcaacgggaaggacaaagaaagaggtggggcagggagcacaccccaggaccctcacttttccctaatgaacacgcatgggctgaaatgaaggctctgggtaggggactgttttggatccaaggacctgtggacagtcggcctacttactctgagctgagggaacactgaacagtaaaagcgtcattagcgctgcttcgttttgtatagggcttttctgtttgttacaagccaaacactgcctgtctttgcttcctgtccctgaatgcctttttgtgccagactgtcccaagaatcctaatttgtattccatagaggtattttatttttaatcctagagcttcttattgatggatcctttagaattgcctacctaaaaggtaaactatactatccttataaatactgatcaatcccagttctccccctaaaaatgaatacatagtaggactatagcaaatgtgtttgatgggtaattctagactgggactatggtacccttttccagagttttaaaattcaaccttcattacagacaaagttttctcccagaaggaatggattgatagattttgattaaagtaagggtggaaggaaatctgtagctggatttaccacaagtgacatctagaaactatagttcacaggacagagcagagccatggagactaagcattgactaccttgagttctcctagtgaggagttctggtataaaatttaagattactaccagtaaccaacttaaagcaaactataggggtccctaattttggatttttccttaagtgtaagaaacaatgcttcaaatgttaagaaataacagtctgggcaaagaacgcatattctataggaagccaggtttacaataggtaagaataaactgtattaagtagatgtaatgactagaaagctgctttgctccctatattgagaaattgtggacatggtatgtgttatccaaagaacattgggctagaagatagatttctatccttagctttggcattattgactggattgacttgaacaagtcacttaacttctacaagcttgtttccttatttgtcaaattagattacactaggaaacgattctcgaacatgttttaaccttacaactctttgttcaaataaatctttcaatgaatccccaacatataaaacgtcaaaaagctgaattcctatgtgaattataagcagggtttggacatccagagcacctacaaaccttcatctctttgattacgtacatgggggtccacagggactctgaagagtttgaaaatccctggcctagattaaacctgagagccattctagctcttaaaaaaatctgaaatttacaaaccatttttcttgttattgtttttgtttctttgtttgtttgttttttgagactgagttttcactcttgttgcccaggctggagtgcaatggcgtgatctcggcttactgcaacctctgcttcctgggttcaagcaattctccagcctcaacctcctgagaagctgggattacaggtgcctgccaccacgcctggctaatttttgtacttttagtagacacagggtttcaccatgtttgccaggctgatctcaaactcctgacctcaggtgagccacccacctctgcctccgaaagtgctgggattacaggcgtgagccaccgtacccggcccttgttattgttattaatcattatcaatcattaactttacagatattaaagaaataggggccatgttctacatgcgacattgttttcctggcacacagtagacaattcaggaaatgtctgaagaaggaatgggtaaaattaagataccaaaatggaattgaggggagagcaggtaattgtagagaaaaagactctttatggcaagaaacaaagtaaaagaaatgtatagaccgggcgcggtggctcacgcctgtaatcccagcaatttggaaggccgaggcgggcggatcacgaggtcaggagatcgagaccgtcctggctaacacggtgaaaccctgtctctactaaaaaacacaaaacaaattagccaggcgcggtggcaggcgtctgtagtcccagctactggggaggctgaggcaagagaatggcgggaacccgcgaggcggagcttgcagtgagtcgagatcacgtcactgccctccagcctgggcgaccagcgagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaagtataaaccagactaagaggggaataaaagcaagaagaaaaagaaacgtaagaacaccagtaaaggaaagacagggaccgagacaggtggttaagggaaatgaaaaaaaaaaaaaaaaggtgaaagtcaatccaaacaaagaaaaatggcacttccaaccaaaaaaaatgaaggtgtagaaccctgtcatcaattgctcagaaaagagagacacttgagcagggaggggtttgagaaaggggagaaggaaggagtgagagccctaaaaaataatgttcctagctaccctttacagctgtctctgcagggaagactggagaaagtagagggggaaatgaatgcaggaagaaactgcctctgcagagcaggtaagaggaggttgttcagatttatggattttattaagccagttttctgtatcactctgctataaaggaaaatagcttctgcagggctgtctctcctccttcaggtggggaacaaagggtgggtggagtcagggacagagtctggtctgcgagatcgtgacgtgtctgcagctccgaagcactgcaggtgtttctgggtaatgtgccacatcatgtttatatcacgaacgggaattgaaaatcagtctgtgtgaggcagagatgagcccacatctgttatcctccccaacaataaataaataaatagcccagacaaatggatgccagtccatctacagcaacattttaaagcatgtgctttatgacaaaactggacccagggtctgacagagactgcaggctgccgtgagcactgtagctatcctgaacattgatgctacatattgctaaggggaacataatttatagcataaaccctacaagcttccactaaggttgagttttcctctcattttcttgccgttttattggcttcactgcatggttgccaatagcaacatccactggtagcaaggggagttcaacaccattgcaatctgccatacagtggagccctgacaatgtcaaccatcaatctagtagctgtttgtaattgcctccatctatttctcctgtcttgaggtatctttcctattgtgggtcaagatttagaaactgctgactaatgccatgggtctgtgtctccatgactatgaagcagtggacaggaaggtagcagcttcctggtgccaacaaccccagaggttagaggttgaactcttgcgggtttcaggcgtttttaatcccttttctaaacaatttataattttgcaagaatgtgaggcatatgcagttatccatataatctgcttttccaaaaaagagaaaggaagtttcccagtccttattattaatgtttatttcctattggagaaagacatttgaaatatgagccttcttgtaaaaactcaaactgaccagattatgtttgcttcctcaggtctcttggcattaattgttgaaataacttcatcctactttttcgatgagatgtatttttttcagacatatttattcttactagtcactatgtagctattatgtgcacaatctacaatgtagtggcaatcctggtgggtagggacagcttcacatactgcaaagggtgccattcagtgcatagcagactggaactccctcctagcttggccaccagctgaacctgtaatcttaggactctccaagtcttagaatctccatctattacataaaagcactgacttttattcagtccccacaccaaaggaccaagacgtgtttagctttaaagaaattttccagataattttcttttttattcttctcaaataaaatagcaacaaacctaaagcagtcatcttcttaataaagacataataaaacttacatatatggggtagatgtaagcacaatcatactacagatgtatcttgagcctgtctctaattatgatgaaagatgtagtcatcaatacaatttaaaaaaagatatgtcctttttttgagacagggtcttgctctgtcacccaggctggagggcagtggcacaatcacagccactgcagccttgacctctccaacttaagtgatctttcctgcctcagcctcatgagtagctgggaccacaggtgtgcaccaccacacccagctaaattttgtattgtttgtaaagacgaggcctcactatgctgaccacactggtctcgaactcctgggctcaagcaatcctcctgccttggcctcccaaagtgttagggttagagatatgaaccaccacacccaccttatatgtccttttatttcataaaaaacaattttagattatctgatatcacacatatcccataaatggtagtcattaatttagaagtgaatttataaagttaagagaagttaaaattgcacatgcattttgtttctaaaatctgagatgtctatgcatttccaggtattgtatatttgcaaatacattgggttagaaatcatctttaacattttgtgttagtgtaataacaatattatctaatattaatgctgccagaatccagttgctttttctgtgtatcaaaatttatcataactttttccacttaacactaggtaattaaacagaatctgcccaatttattctgcagtaaaattattttaaaatctatttttcctgctgactcttagaaattgcagaaagacaaaaaccagtttcatctccagtaatagtgtgaaacaatttccttccagtgggacagaaacctagacatactagggaaagatttaaatataaagaaaaatgccttggctgaaaaaaaaaaaaaccaccaaaacacaaaaaggattcattaaagcaacagaacaaaacctaatttgggaccctaaaaactctggcaatgccactgtaatgaagtttcattatctgcttcagagtaacagtctctgaaattgttattctgctacatgctgtaaagaactcccaaaactcaaatgtatcaggaaatgtaaaggttaagtctgactacaagaaggccaaaattgcaccagcttcctaagtgaagaataatagaataaaacatatagagggcagaaataaaatgaggtgtatctggagaatttcatgatgagcatttagatttagcaatgcccaatgtcatgctgacactgtttgtcatgaccttgtcttcagctagtaatttggggttgtacttttttaaatttaattttgaatgttcttgcatgtttggtacctctctcctcactgctaaagataaattgtttatctgtataacataactacaccaatgtcatttttgtatacgctagtacacaaatgtgtttttttattaagtaatgaagtatttgctgtgaaaaatgtattatttgtgccaccgtttatatctgtgttcattttctgtgtgtatatgcgtgtgtattcgaatctcaatttttcttttactctagtttagattaagacatatttagatgaaattttaaaaataacattggaaataggaggctaagttttgttgagtctcattcccttggggggaaattgcttttgccattttattttcatgtacaataacctaaaaaggatctcctactgacttccttcctaattattattgttttacacgaaagaaaggaaatacgttttcaattgagttgtttgaaatcattcactttgtgtagatttcccagactgatgtttcattgtaagaatattacattatagacaggttggccatttcacaagcaactaatccatagttttggaagcccgctttaagagacctgaatatctttgtttttaataaaatacttagagtttaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:50940 -> Molecular function: GO:0004112 [cyclic-nucleotide phosphodiesterase activity] evidence: NAS
GeneID:50940 -> Molecular function: GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] evidence: TAS
GeneID:50940 -> Molecular function: GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] evidence: IDA
GeneID:50940 -> Molecular function: GO:0030552 [cAMP binding] evidence: IEA
GeneID:50940 -> Molecular function: GO:0030553 [cGMP binding] evidence: IDA
GeneID:50940 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:50940 -> Molecular function: GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] evidence: IEA
GeneID:50940 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:50940 -> Biological process: GO:0007165 [signal transduction] evidence: IEA
GeneID:50940 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:50940 -> Biological process: GO:0046069 [cGMP catabolic process] evidence: IEA
GeneID:50940 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:50940 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:50940 -> Cellular component: GO:0043204 [perikaryon] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_058649 -> EC 3.1.4.17
NP_058649 -> EC 3.1.4.35
by
@meso_cacase at
DBCLS
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