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2025-05-09 16:52:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016350 4388 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ninein (GSK3B interacting protein) (NIN), transcript
variant 6, mRNA.
ACCESSION NM_016350
VERSION NM_016350.4 GI:291167746
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4388)
AUTHORS Howng,S.L., Chou,A.K., Lin,C.C., Lin,Z.A., Wang,C.J., Loh,J.K.,
Lieu,A.S., Yen,J.H., Lee,C.I. and Hong,Y.R.
TITLE Autoimmunity against hNinein, a human centrosomal protein, in
patients with rheumatoid arthritis and systemic lupus erythematosus
JOURNAL Mol Med Rep 4 (5), 825-830 (2011)
PUBMED 21667027
REMARK GeneRIF: The prevalence of hNinein autoreactivity and its
specificity in 22 rheumatoid arthritis and 32 systemic lupus
erythematosus autoimmune disease sera.
REFERENCE 2 (bases 1 to 4388)
AUTHORS Ibi,M., Zou,P., Inoko,A., Shiromizu,T., Matsuyama,M., Hayashi,Y.,
Enomoto,M., Mori,D., Hirotsune,S., Kiyono,T., Tsukita,S., Goto,H.
and Inagaki,M.
TITLE Trichoplein controls microtubule anchoring at the centrosome by
binding to Odf2 and ninein
JOURNAL J. Cell. Sci. 124 (PT 6), 857-864 (2011)
PUBMED 21325031
REMARK GeneRIF: Trichoplein controls microtubule anchoring at the
centrosome by binding to Odf2 and ninein.
REFERENCE 3 (bases 1 to 4388)
AUTHORS Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
TITLE Centrosome-related genes, genetic variation, and risk of breast
cancer
JOURNAL Breast Cancer Res. Treat. 125 (1), 221-228 (2011)
PUBMED 20508983
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 4388)
AUTHORS Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
Gibson,G. and Goldstein,D.B.
TITLE Common genetic variation and performance on standardized cognitive
tests
JOURNAL Eur. J. Hum. Genet. 18 (7), 815-820 (2010)
PUBMED 20125193
REMARK Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE 5 (bases 1 to 4388)
AUTHORS Couch,F.J., Wang,X., Bamlet,W.R., de Andrade,M., Petersen,G.M. and
McWilliams,R.R.
TITLE Association of mitotic regulation pathway polymorphisms with
pancreatic cancer risk and outcome
JOURNAL Cancer Epidemiol. Biomarkers Prev. 19 (1), 251-257 (2010)
PUBMED 20056645
REMARK GeneRIF: Two single nucleotide polymorphisms in the APC and NIN
loci were significantly associated with pancreatic cancer risk
GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
REFERENCE 6 (bases 1 to 4388)
AUTHORS Dammermann,A. and Merdes,A.
TITLE Assembly of centrosomal proteins and microtubule organization
depends on PCM-1
JOURNAL J. Cell Biol. 159 (2), 255-266 (2002)
PUBMED 12403812
REFERENCE 7 (bases 1 to 4388)
AUTHORS Ou,Y.Y., Mack,G.J., Zhang,M. and Rattner,J.B.
TITLE CEP110 and ninein are located in a specific domain of the
centrosome associated with centrosome maturation
JOURNAL J. Cell. Sci. 115 (PT 9), 1825-1835 (2002)
PUBMED 11956314
REMARK GeneRIF: Ninein is essential for the reformation of specific
aspects of the interphase centrosome architecture following mitosis
as well as being required for the centrosome to function as a MTOC.
REFERENCE 8 (bases 1 to 4388)
AUTHORS Hong,Y.R., Chen,C.H., Chuo,M.H., Liou,S.Y. and Howng,S.L.
TITLE Genomic organization and molecular characterization of the human
ninein gene
JOURNAL Biochem. Biophys. Res. Commun. 279 (3), 989-995 (2000)
PUBMED 11162463
REFERENCE 9 (bases 1 to 4388)
AUTHORS Hong,Y.R., Chen,C.H., Chang,J.H., Wang,S., Sy,W.D., Chou,C.K. and
Howng,S.L.
TITLE Cloning and characterization of a novel human ninein protein that
interacts with the glycogen synthase kinase 3beta
JOURNAL Biochim. Biophys. Acta 1492 (2-3), 513-516 (2000)
PUBMED 11004522
REFERENCE 10 (bases 1 to 4388)
AUTHORS Mack,G.J., Rees,J., Sandblom,O., Balczon,R., Fritzler,M.J. and
Rattner,J.B.
TITLE Autoantibodies to a group of centrosomal proteins in human
autoimmune sera reactive with the centrosome
JOURNAL Arthritis Rheum. 41 (3), 551-558 (1998)
PUBMED 9506584
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF302773.2 and BC090932.1.
On Mar 17, 2010 this sequence version replaced gi:33946312.
Summary: This gene encodes one of the proteins important for
centrosomal function. This protein is important for positioning and
anchoring the microtubules minus-ends in epithelial cells.
Localization of this protein to the centrosome requires three
leucine zippers in the central coiled-coil domain. Multiple
alternatively spliced transcript variants that encode different
isoforms have been reported. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (6) lacks an alternate in-frame
exon in the central coding region and uses a distinct 3' coding
region and 3' UTR, compared to variant 2. The resulting isoform (6)
lacks an internal segment and has a shorter and distinct
C-terminus, compared to isoform 2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: BC090932.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-156 AF302773.2 1-156
157-3025 BC090932.1 1-2869
3026-3026 AF302773.2 5165-5165
3027-3688 BC090932.1 2871-3532
3689-3689 AF302773.2 5828-5828
3690-4388 BC090932.1 3534-4232
FEATURES Location/Qualifiers
source 1..4388
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q22.1"
gene 1..4388
/gene="NIN"
/gene_synonym="SCKL7"
/note="ninein (GSK3B interacting protein)"
/db_xref="GeneID:51199"
/db_xref="HGNC:14906"
/db_xref="MIM:608684"
exon 1..116
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 117..170
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 171..374
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
CDS 192..4325
/gene="NIN"
/gene_synonym="SCKL7"
/note="isoform 6 is encoded by transcript variant 6;
ninein centrosomal protein; glycogen synthase kinase 3
beta-interacting protein; hNinein"
/codon_start=1
/product="ninein isoform 6"
/protein_id="NP_057434.4"
/db_xref="GI:291167747"
/db_xref="CCDS:CCDS32078.2"
/db_xref="GeneID:51199"
/db_xref="HGNC:14906"
/db_xref="MIM:608684"
/translation="
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH
"
misc_feature <1266..2228
/gene="NIN"
/gene_synonym="SCKL7"
/note="chromosome segregation protein SMC, common
bacterial type; Region: SMC_prok_B; TIGR02168"
/db_xref="CDD:162739"
misc_feature 2658..>3521
/gene="NIN"
/gene_synonym="SCKL7"
/note="Chromosome segregation ATPases [Cell division and
chromosome partitioning]; Region: Smc; COG1196"
/db_xref="CDD:31389"
exon 375..456
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 457..626
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 627..666
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 667..857
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 858..1004
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1005..1172
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1173..1309
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1310..1450
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1451..1625
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1626..1736
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1737..1826
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1827..1965
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 1966..2087
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 2088..2590
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 2591..2716
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 2717..2786
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 2787..3002
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 3003..3116
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 3117..3239
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 3240..3353
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 3354..3500
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 3501..3680
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 3681..3827
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
variation 3689
/gene="NIN"
/gene_synonym="SCKL7"
/replace="a"
/replace="g"
/db_xref="dbSNP:11376"
exon 3828..3929
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
variation 3896
/gene="NIN"
/gene_synonym="SCKL7"
/replace="a"
/replace="g"
/db_xref="dbSNP:1055883"
exon 3930..4130
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
exon 4131..4369
/gene="NIN"
/gene_synonym="SCKL7"
/inference="alignment:Splign:1.39.8"
STS 4152..4272
/gene="NIN"
/gene_synonym="SCKL7"
/standard_name="RH104252"
/db_xref="UniSTS:98577"
polyA_signal 4346..4351
/gene="NIN"
/gene_synonym="SCKL7"
polyA_site 4369
/gene="NIN"
/gene_synonym="SCKL7"
ORIGIN
ccgagccgggagccgagcgcgctgggcgcggccgtcccgctgccgccgccaagcccggagtgcgccagcggccatggttcccgcggcggcgccgggcgcctgagccccgggacgcaagcgctggaggcgggctgccggctgtgcgggcgctccggagagaccgacagaaggtgagcactgtgggctatgggatggatgaggtggagcaggaccagcatgaggcccgactcaaggagctgtttgacagttttgacacgacgggcacagggtccctggggcaggaggaactcaccgacctttgccacatgttgagcttggaggaggtggccccagtgctgcagcagacattacttcaggacaacctcttgggcagggtacattttgaccaatttaaagaagcattaatactcatcttgtccagaactctgtcaaatgaagaacactttcaagaaccagactgctcactagaagctcagcccaaatatgttagaggtgggaagcgttacggacgaaggtccttgcccgagttccaagagtccgtggaggagtttcctgaagtgacggtgattgagccactggatgaagaagcgcggccttcacacatcccagccggtgactgcagtgagcactggaagacgcaacgcagtgaggagtatgaagcggaaggccagttaaggttttggaacccagatgacttgaatgcttcacagagtggatcttcccctccccaagactggatagaagagaaactgcaagaagtttgtgaagatttggggatcacccgtgatggtcacctgaaccggaagaagctggtctccatctgtgagcagtatggtttacagaatgtggatggagagatgctcgaggaagtattccataatcttgatcctgacggtacaatgagtgtagaagattttttctatggtttgtttaaaaatggaaaatctcttacaccatcagcatctactccatatagacaactaaaaaggcacctttccatgcagtctttcgatgagagtggacgacgtaccacaacctcatcagcaatgacaagtaccattggctttcgggtcttctcctgcctggatgatgggatgggccatgcatctgtggagagaatactggacacctggcaggaagagggcattgagaacagccaggagatcctgaaggccttggatttcagcctcgatggaaacatcaatttgacagaattaacactggcccttgaaaatgaacttttggttaccaagaacagcattcaccaggcggctctggccagctttaaggctgaaatccggcatttgttggaacgagttgatcaggtggtcagagaaaaagagaagctacggtcagatctggacaaggccgagaagctcaagtctttaatggcctcggaggtggatgatcaccatgcggccatagagcggcggaatgagtacaacctcaggaaactggatgaagagtacaaggagcgaatagcagccttaaaaaatgaactccgaaaagagagagagcagatcctgcagcaggcaggcaagcagcgtttagaacttgaacaggaaattgaaaaggcaaaaacagaagagaactatatccgggaccgccttgccctctctttaaaggaaaacagtcgtctggaaaatgagcttctagaaaatgcagagaagttggcagaatatgagaatctgacaaacaaacttcagagaaatttggaaaatgtgttagcagaaaagtttggtgacctcgatcctagcagtgctgagttcttcctgcaagaagagagactgacacagatgagaaatgaatatgagcggcagtgcagggtactacaagaccaagtagatgaactccagtctgagctggaagaatatcgtgcacaaggcagagtgctcaggcttccgttgaagaactcaccgtcagaagaagttgaggctaacagcggtggcattgagcccgaacacgggctcggttctgaagaatgcaatccattgaatatgagcattgaggcagagctggtcattgaacagatgaaagaacaacatcacagggacatatgttgcctcagactggagctcgaagataaagtgcgccattatgaaaagcagctggacgaaaccgtggtcagctgcaagaaggcacaggagaacatgaagcaaaggcatgagaacgaaacgcacaccttagaaaaacaaataagtgaccttaaaaatgaaattgctgaacttcaggggcaagcagcagtgctcaaggaggcacatcatgaggccacttgcaggcatgaggaggagaaaaaacaactgcaagtgaagcttgaggaggaaaagactcacctgcaggagaagctgaggctgcaacatgagatggagctcaaggctagactgacacaggctcaagcaagctttgagcgggagagggaaggccttcagagtagcgcctggacagaagagaaggtgagaggcttgactcaggaactagagcagtttcaccaggagcagctgacaagcctggtggagaaacacactcttgagaaagaggagttaagaaaagagctcttggaaaagcaccaaagggagcttcaggagggaagatatgaatctgaaaagcttcaacaggaaaattctattttgagaaatgaaattactactttaaatgaagaagatagcatttctaacctgaaattagggacattaaatggatctcaggaagaaatgtggcaaaaaacggaaactgtaaaacaagaaaatgctgcagttcagaagatggttgaaaatttaaagaaacagatttcagaattaaaaatcaaaaaccaacaattggatttggaaaatacagaacttagccaaaagaactctcaaaaccaggaaaaactgcaagaacttaatcaacgtctaacagaaatgctatgccagaaggaaaaagagccaggaaacagtgcattggaggaacgggaacaagagaagtttaatctgaaagaagaactggaacgttgtaaagtgcagtcctccactttagtgtcttctctggaggcggagctctctgaagttaaaatacagacccatattgtgcaacaggaaaaccaccttctcaaagatgaactggagaaaatgaaacagctgcacagatgtcccgatctctctgacttccagcaaaaaatctctagtgttctaagctacaacgaaaaactgctgaaagaaaaggaagctctgagtgaggaattaaatagctgtgtcgataagttggcaaaatcaagtcttttagagcatagaattgcgacgatgaagcaggaacagaaatcctgggaacatcagagtgcgagcttaaagtcacagctggtggcttctcaggaaaaggttcagaatttagaagacaccgtgcagaatgtaaacctgcaaatgtcccggatgaaatctgacctacgagtgactcagcaggaaaaggaggctttaaaacaagaagtgatgtctttacataagcaacttcagaatgctggtggcaagagctgggccccagagatagctactcatccatcagggctccataaccagcagaaaaggctgtcctgggacaagttggatcatctgatgaatgaggaacagcagctgctttggcaagagaatgagaggctccagaccatggtacagaacaccaaagccgaactcacgcactcccgggagaaggtccgtcagttggaatccaatcttcttcccaagcaccaaaaacatctaaacccatcaggtaccatgaatcccacagagcaagaaaaattgagcttaaagagagagtgtgatcagtttcagaaagaacaatctcctgctaacaggaaggtcagtcagatgaattcccttgaacaagaattagaaacaattcatttggaaaatgaaggcctgaaaaagaaacaagtaaaactggatgagcagctcatggagatgcagcacctgaggtccactgcgacgcctagcccgtcccctcatgcttgggatttgcagctgctccagcagcaagcctgtccgatggtgcccagggagcagtttctgcagcttcaacgccagctgctgcaggcagaaaggataaaccagcacctgcaggaggaacttgaaaacaggacctccgaaaccaacacaccacagggaaaccaggaacaactggtaactgtcatggaggaacgaatgatagaagttgaacagaaactgaaactagtgaaaaggcttcttcaagagaaagtgaatcagctcaaagaacaagtgagcctacccggtcatctctgttcacccacctcacattccagctttaactccagttttacatccctttattgccattaactcgttaacttatgttgtctaataaaggcaaattctattataaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:51199 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:51199 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:51199 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:51199 -> Biological process: GO:0034454 [microtubule anchoring at centrosome] evidence: IEA
GeneID:51199 -> Biological process: GO:0051642 [centrosome localization] evidence: TAS
GeneID:51199 -> Biological process: GO:0090222 [centrosome-templated microtubule nucleation] evidence: IEA
GeneID:51199 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:51199 -> Cellular component: GO:0005814 [centriole] evidence: IEA
GeneID:51199 -> Cellular component: GO:0005874 [microtubule] evidence: IEA
by
@meso_cacase at
DBCLS
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