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2025-05-09 16:25:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014246 11389 bp mRNA linear PRI 11-MAY-2013
DEFINITION Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 1
(CELSR1), mRNA.
ACCESSION NM_014246
VERSION NM_014246.1 GI:7656966
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 11389)
AUTHORS Allache,R., De Marco,P., Merello,E., Capra,V. and Kibar,Z.
TITLE Role of the planar cell polarity gene CELSR1 in neural tube defects
and caudal agenesis
JOURNAL Birth Defects Res. Part A Clin. Mol. Teratol. 94 (3), 176-181
(2012)
PUBMED 22371354
REMARK GeneRIF: CELSR1 is a risk factor for neural tube defects or caudal
agenesis via pathogenic role of planar cell polarity signaling in
these malformations.
REFERENCE 2 (bases 1 to 11389)
AUTHORS Robinson,A., Escuin,S., Doudney,K., Vekemans,M., Stevenson,R.E.,
Greene,N.D., Copp,A.J. and Stanier,P.
TITLE Mutations in the planar cell polarity genes CELSR1 and SCRIB are
associated with the severe neural tube defect craniorachischisis
JOURNAL Hum. Mutat. 33 (2), 440-447 (2012)
PUBMED 22095531
REMARK GeneRIF: Missense variants in CELSR1 may represent a cause of
craniorachischisis in humans, as in mice, with defective planar
cell polarity protein trafficking to the plasma membrane a likely
pathogenic mechanism.
REFERENCE 3 (bases 1 to 11389)
AUTHORS Gouveia,L.O., Sobral,J., Vicente,A.M., Ferro,J.M. and Oliveira,S.A.
TITLE Replication of the CELSR1 association with ischemic stroke in a
Portuguese case-control cohort
JOURNAL Atherosclerosis 217 (1), 260-262 (2011)
PUBMED 21511255
REMARK GeneRIF: CELSR1 may have a role in ischemic stroke, as shown in a
Portuguese case-control cohort
REFERENCE 4 (bases 1 to 11389)
AUTHORS Yates,L.L., Schnatwinkel,C., Murdoch,J.N., Bogani,D.,
Formstone,C.J., Townsend,S., Greenfield,A., Niswander,L.A. and
Dean,C.H.
TITLE The PCP genes Celsr1 and Vangl2 are required for normal lung
branching morphogenesis
JOURNAL Hum. Mol. Genet. 19 (11), 2251-2267 (2010)
PUBMED 20223754
REMARK GeneRIF: The planar cell polarity genes Celsr1 and Vangl2 are
required for normal lung branching morphogenesis.
REFERENCE 5 (bases 1 to 11389)
AUTHORS Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
TITLE Association of genetic variants with hemorrhagic stroke in Japanese
individuals
JOURNAL Int. J. Mol. Med. 25 (4), 649-656 (2010)
PUBMED 20198315
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 11389)
AUTHORS Nollet,F., Kools,P. and van Roy,F.
TITLE Phylogenetic analysis of the cadherin superfamily allows
identification of six major subfamilies besides several solitary
members
JOURNAL J. Mol. Biol. 299 (3), 551-572 (2000)
PUBMED 10835267
REMARK Review article
REFERENCE 7 (bases 1 to 11389)
AUTHORS Wu,Q. and Maniatis,T.
TITLE Large exons encoding multiple ectodomains are a characteristic
feature of protocadherin genes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (7), 3124-3129 (2000)
PUBMED 10716726
REFERENCE 8 (bases 1 to 11389)
AUTHORS Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
al.
TITLE The DNA sequence of human chromosome 22
JOURNAL Nature 402 (6761), 489-495 (1999)
PUBMED 10591208
REMARK Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE 9 (bases 1 to 11389)
AUTHORS Wu,Q. and Maniatis,T.
TITLE A striking organization of a large family of human neural
cadherin-like cell adhesion genes
JOURNAL Cell 97 (6), 779-790 (1999)
PUBMED 10380929
REFERENCE 10 (bases 1 to 11389)
AUTHORS Hadjantonakis,A.K., Sheward,W.J., Harmar,A.J., de Galan,L.,
Hoovers,J.M. and Little,P.F.
TITLE Celsr1, a neural-specific gene encoding an unusual seven-pass
transmembrane receptor, maps to mouse chromosome 15 and human
chromosome 22qter
JOURNAL Genomics 45 (1), 97-104 (1997)
PUBMED 9339365
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF231024.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: The protein encoded by this gene is a member of the
flamingo subfamily, part of the cadherin superfamily. The flamingo
subfamily consists of nonclassic-type cadherins; a subpopulation
that does not interact with catenins. The flamingo cadherins are
located at the plasma membrane and have nine cadherin domains,
seven epidermal growth factor-like repeats and two laminin A G-type
repeats in their ectodomain. They also have seven transmembrane
domains, a characteristic unique to this subfamily. It is
postulated that these proteins are receptors involved in
contact-mediated communication, with cadherin domains acting as
homophilic binding regions and the EGF-like domains involved in
cell adhesion and receptor-ligand interactions. This particular
member is a developmentally regulated, neural-specific gene which
plays an unspecified role in early embryogenesis. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF231024.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..11389
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q13.3"
gene 1..11389
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="cadherin, EGF LAG seven-pass G-type receptor 1"
/db_xref="GeneID:9620"
/db_xref="HGNC:1850"
/db_xref="HPRD:05160"
/db_xref="MIM:604523"
CDS 1..9045
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="protocadherin flamingo 2; cadherin, EGF LAG
seven-pass G-type receptor 1 (flamingo homolog,
Drosophila); flamingo homolog 2; cadherin family member 9"
/codon_start=1
/product="cadherin EGF LAG seven-pass G-type receptor 1
precursor"
/protein_id="NP_055061.1"
/db_xref="GI:7656967"
/db_xref="CCDS:CCDS14076.1"
/db_xref="GeneID:9620"
/db_xref="HGNC:1850"
/db_xref="HPRD:05160"
/db_xref="MIM:604523"
/translation="
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVRLRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLTLTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVRTGSAQADGSDSEKP
"
sig_peptide 1..75
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 748..1047
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(766..771,934..936,940..942,1033..1035,1039..1044)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1069..1365
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1090..1095,1246..1248,1252..1254,1351..1353,
1357..1362)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1390..1683
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1408..1413,1567..1569,1573..1575,1669..1671,
1675..1680)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1705..2049
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1726..1731,1936..1938,1942..1944,2035..2037,
2041..2046)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 2071..2355
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(2092..2097,2251..2253,2257..2259,2341..2343,
2347..2352)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 2377..2664
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(2398..2403,2551..2553,2557..2559,2650..2652,
2656..2661)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 2689..2985
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(2707..2712,2869..2871,2875..2877,2971..2973,
2977..2982)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 3007..3291
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(3028..3033,3187..3189,3193..3195,3277..3279,
3283..3288)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 3349..3594
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature 4087..4197
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(4087..4089,4096..4098,4138..4140)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 4219..4323
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature 4330..4881
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; Region: LamG; cd00110"
/db_xref="CDD:29010"
misc_feature 4951..5055
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(4954..4956,4996..4998)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 5080..5538
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; Region: LamG; cd00110"
/db_xref="CDD:29010"
misc_feature 5611..5724
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(5611..5613,5620..5622,5665..5667)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 5722..5838
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(5728..5730,5770..5772)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 6004..>6120
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Laminin-type epidermal growth factor-like domain;
laminins are the major noncollagenous components of
basement membranes that mediate cell adhesion, growth
migration, and differentiation; the laminin-type epidermal
growth factor-like module occurs in...; Region: EGF_Lam;
cd00055"
/db_xref="CDD:28937"
misc_feature 6007..6144
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Laminin-type epidermal growth factor-like domai;
Region: EGF_Lam; smart00180"
/db_xref="CDD:197558"
misc_feature order(6007..6009,6013..6015,6043..6045,6064..6066,
6070..6072,6097..6099)
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="EGF-like motif; other site"
/db_xref="CDD:28937"
misc_feature 6154..6339
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Domain present in hormone receptors; Region: HormR;
smart00008"
/db_xref="CDD:197465"
misc_feature 6364..7146
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="Domain of unknown function (DUF3497); Region:
DUF3497; pfam12003"
/db_xref="CDD:204805"
misc_feature 7219..7380
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="G-protein-coupled receptor proteolytic site domain;
Region: GPS; smart00303"
/db_xref="CDD:197639"
misc_feature 7396..8091
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/note="7 transmembrane receptor (Secretin family); Region:
7tm_2; pfam00002"
/db_xref="CDD:200919"
misc_feature 7408..7470
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NYQ6.1);
transmembrane region"
misc_feature 7504..7566
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NYQ6.1);
transmembrane region"
misc_feature 7582..7644
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NYQ6.1);
transmembrane region"
misc_feature 7717..7779
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NYQ6.1);
transmembrane region"
misc_feature 7834..7896
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NYQ6.1);
transmembrane region"
misc_feature 7966..8028
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NYQ6.1);
transmembrane region"
misc_feature 8050..8112
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NYQ6.1);
transmembrane region"
misc_feature 8290..8292
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NYQ6.1); phosphorylation site"
misc_feature 8599..8601
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 1..3544
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
variation 355
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/replace="c"
/replace="g"
/db_xref="dbSNP:926287"
variation 1666
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/replace="c"
/replace="g"
/db_xref="dbSNP:11575871"
exon 3545..4183
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 4184..4406
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 4407..4522
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 4523..4611
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 4612..4769
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 4770..4933
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 4934..5059
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 5060..5226
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 5227..5412
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 5413..5526
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 5527..5701
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 5702..5843
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 5844..5964
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 5965..6148
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 6149..6250
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 6251..6345
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 6346..6555
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 6556..6739
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 6740..6883
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 6884..7088
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 7089..7256
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 7257..7383
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 7384..7584
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 7585..7759
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 7760..7872
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 7873..7952
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 7953..8079
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 8080..8205
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 8206..8300
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 8301..8404
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 8405..8554
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 8555..8779
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 8780..9035
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
exon 9036..11389
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/inference="alignment:Splign:1.39.8"
variation 10247
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201772740"
STS 11044..11173
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/standard_name="RH93715"
/db_xref="UniSTS:92944"
variation 11132
/gene="CELSR1"
/gene_synonym="CDHF9; FMI2; HFMI2; ME2"
/replace="c"
/replace="t"
/db_xref="dbSNP:15023"
ORIGIN
atggcgccgccgccgccgcccgtgctgcccgtgctgctgctcctggccgccgccgccgccctgccggcgatggggctgcgagcggccgcctgggagccgcgcgtacccggcgggacccgcgccttcgccctccggcccggctgtacctacgcggtgggcgccgcttgcacgccccgggcgccgcgggagctgctggacgtgggccgcgatgggcggctggcaggacgtcggcgcgtctcgggcgcggggcgcccgctgccgctgcaagtccgcttggtggcccgcagtgccccgacggcgctgagccgccgcctgcgggcgcgcacgcaccttcccggctgcggagcccgtgcccggctctgcggaaccggtgcccggctctgcggggcgctctgcttccccgtccccggcggctgcgcggccgcgcagcattcggcgctcgcagctccgaccaccttacccgcctgccgctgcccgccgcgccccaggccccgctgtcccggccgtcccatctgcctgccgccgggcggctcggtccgcctgcgtctgctgtgcgccctgcggcgcgcggctggcgccgtccgggtgggactggcgctggaggccgccaccgcggggacgccctccgcgtcgccatccccatcgccgcccctgccgccgaacttgcccgaagcccgggcggggccggcgcgacgggcccggcggggcacgagcggcagagggagcctgaagtttccgatgcccaactaccaggtggcgttgtttgagaacgaaccggcgggcaccctcatcctccagctgcacgcgcactacaccatcgagggcgaggaggagcgcgtgagctattacatggaggggctgttcgacgagcgctcccggggctacttccgaatcgactctgccacgggcgccgtgagcacggacagcgtactggaccgcgagaccaaggagacgcacgtcctcagggtgaaagccgtggactacagtacgccgccgcgctcggccaccacctacatcactgtcttggtcaaagacaccaacgaccacagcccggtcttcgagcagtcggagtaccgcgagcgcgtgcgggagaacctggaggtgggctacgaggtgctgaccatccgcgccagcgaccgcgactcgcccatcaacgccaacttgcgttaccgcgtgttggggggcgcgtgggacgtcttccagctcaacgagagctctggcgtggtgagcacacgggcggtgctggaccgggaggaggcggccgagtaccagctcctggtggaggccaacgaccaggggcgcaatccgggcccgctcagtgccacggccaccgtgtacatcgaggtggaggacgagaacgacaactacccccagttcagcgagcagaactacgtggtccaggtgcccgaggacgtggggctcaacacggctgtgctgcgagtgcaggccacggaccgggaccagggccagaacgcggccattcactacagcatcctcagcgggaacgtggccggccagttctacctgcactcgctgagcgggatcctggatgtgatcaaccccttggatttcgaggatgtccagaaatactcgctgagcattaaggcccaggatgggggccggcccccgctcatcaattcttcaggggtggtgtctgtgcaggtgctggatgtcaacgacaacgagcctatctttgtgagcagccccttccaggccacggtgctggagaatgtgcccctgggctaccccgtggtgcacattcaggcggtggacgcggactctggagagaacgcccggctgcactatcgcctggtggacacggcctccacctttctggggggcggcagcgctgggcctaagaatcctgcccccacccctgacttccccttccagatccacaacagctccggttggatcacagtgtgtgccgagctggaccgcgaggaggtggagcactacagcttcggggtggaggcggtggaccacggctcgccccccatgagctcctccaccagcgtgtccatcacggtgctggacgtgaatgacaacgacccggtgttcacgcagcccacctacgagcttcgtctgaatgaggatgcggccgtggggagcagcgtgctgaccctgcaggcccgcgaccgtgacgccaacagtgtgattacctaccagctcacaggcggcaacacccggaaccgctttgcactcagcagccagagagggggcggcctcatcaccctggcgctacctctggactacaagcaggagcagcagtacgtgctggcggtgacagcatccgacggcacacggtcgcacactgcgcatgtcctaatcaacgtcactgatgccaacacccacaggcctgtctttcagagctcccattacacagtgagtgtcagtgaggacaggcctgtgggcacctccattgctaccctcagtgccaacgatgaggacacaggagagaatgcccgcatcacctacgtgattcaggaccccgtgccgcagttccgcattgaccccgacagtggcaccatgtacaccatgatggagctggactatgagaaccaggtcgcctacacgctgaccatcatggcccaggacaacggcatcccgcagaaatcagacaccaccaccctagagatcctcatcctcgatgccaatgacaatgcaccccagttcctgtgggatttctaccagggttccatctttgaggatgctccaccctcgaccagcatcctccaggtctctgccacggaccgggactcaggtcccaatgggcgtctgctgtacaccttccagggtggggacgacggcgatggggacttctacatcgagcccacgtccggtgtgattcgcacccagcgccggctggaccgggagaatgtggccgtgtacaacctttgggctctggctgtggatcggggcagtcccactccccttagcgcctcggtagaaatccaggtgaccatcttggacattaatgacaatgcccccatgtttgagaaggacgaactggagctgtttgttgaggagaacaacccagtggggtcggtggtggcaaagattcgtgctaacgaccctgatgaaggccctaatgcccagatcatgtatcagattgtggaaggggacatgcggcatttcttccagctggacctgctcaacggggacctgcgtgccatggtggagctggactttgaggtccggcgggagtatgtgctggtggtgcaggccacgtcggctccgctggtgagccgagccacggtgcacatccttctcgtggaccagaatgacaacccgcctgtgctgcccgacttccagatcctcttcaacaactatgtcaccaacaagtccaacagtttccccaccggcgtgatcggctgcatcccggcccatgaccccgacgtgtcagacagcctcaactacaccttcgtgcagggcaacgagctgcgcctgttgctgctggaccccgccacgggcgaactgcagctcagccgcgacctggacaacaaccggccgctggaggcgctcatggaggtgtctgtgtctgatggcatccacagcgtcacggccttctgcaccctgcgtgtcaccatcatcacggacgacatgctgaccaacagcatcactgtccgcctggagaacatgtcccaggagaagttcctgtccccgctgctggccctcttcgtggagggggtggccgccgtgctgtccaccaccaaggacgacgtcttcgtcttcaacgtccagaacgacaccgacgtcagctccaacatcctgaacgtgaccttctcggcgctgctgcctggcggcgtccgcggccagttcttcccgtcggaggacctgcaggagcagatctacctgaatcggacgctgctgaccaccatctccacgcagcgcgtgctgcccttcgacgacaacatctgcctgcgcgagccctgcgagaactacatgaagtgcgtgtccgttctgcgattcgacagctccgcgcccttcctcagctccaccaccgtgctcttccggcccatccaccccatcaacggcctgcgctgccgctgcccgcccggcttcaccggcgactactgcgagacggagatcgacctctgctactccgacccgtgcggcgccaacggccgctgccgcagccgcgagggcggctacacctgcgagtgcttcgaggacttcactggagagcactgtgaggtggatgcccgctcaggccgctgtgccaacggggtgtgcaagaacgggggcacctgcgtgaacctgctcatcggcggcttccactgcgtgtgtcctcctggcgagtatgagaggccctactgtgaggtgaccaccaggagcttcccgccccagtccttcgtcaccttccggggcctgagacagcgcttccacttcaccatctccctcacgtttgccactcaggaaaggaacggcttgcttctctacaacggccgcttcaatgagaagcacgacttcatcgccctggagatcgtggacgagcaggtgcagctcaccttctctgcaggcgagacaacaacgaccgtggcaccgaaggttcccagtggtgtgagtgacgggcggtggcactctgtgcaggtgcagtactacaacaagcccaatattggccacctgggcctgccccatgggccgtccggggaaaagatggccgtggtgacagtggatgattgtgacacaaccatggctgtgcgctttggaaaggacatcgggaactacagctgcgctgcccagggcactcagaccggctccaagaagtccctggatctgaccggccctctactcctggggggtgtccccaacctgccagaagacttcccagtgcacaaccggcagttcgtgggctgcatgcggaacctgtcagtcgacggcaaaaatgtggacatggccggattcatcgccaacaatggcacccgggaaggctgcgctgctcggaggaacttctgcgatgggaggcggtgtcagaatggaggcacctgtgtcaacaggtggaatatgtatctgtgtgagtgtccactccgattcggcgggaagaactgtgagcaagccatgcctcacccccagctcttcagcggtgagagcgtcgtgtcctggagtgacctgaacatcatcatctctgtgccctggtacctggggctcatgttccggacccggaaggaggacagcgttctgatggaggccaccagtggtgggcccaccagctttcgcctccagatcctgaacaactacctccagtttgaggtgtcccacggcccctccgatgtggagtccgtgatgctgtccgggttgcgggtgaccgacggggagtggcaccacctgctgatcgagctgaagaatgttaaggaggacagtgagatgaagcacctggtcaccatgaccttggactatgggatggaccagaacaaggcagatatcgggggcatgcttcccgggctgacggtaaggagcgtggtggtcggaggcgcctctgaagacaaggtctccgtgcgccgtggattccgaggctgcatgcagggagtgaggatgggggggacgcccaccaacgtcgccaccctgaacatgaacaacgcactcaaggtcagggtgaaggacggctgtgatgtggacgacccctgtacctcgagcccctgtccccccaatagccgctgccacgacgcctgggaggactacagctgcgtctgtgacaaagggtaccttggaataaactgtgtggatgcctgtcacctgaacccctgcgagaacatgggggcctgcgtgcgctcccccggctccccgcagggctacgtgtgcgagtgtgggcccagtcactacgggccgtactgtgagaacaaactcgaccttccgtgccccagaggctggtgggggaaccccgtctgtggaccctgccactgtgccgtcagcaaaggctttgatcccgactgtaataagaccaacggccagtgccaatgcaaggagaattactacaagctcctagcccaggacacctgtctgccctgcgactgcttcccccatggctcccacagccgcacttgcgacatggccaccgggcagtgtgcctgcaagcccggcgtcatcggccgccagtgcaaccgctgcgacaacccgtttgccgaggtcaccacgctcggctgtgaagtgatctacaatggctgtcccaaagcatttgaggccggcatctggtggccacagaccaagttcgggcagccggctgcggtgccatgccctaagggatccgttggaaatgcggtccgacactgcagcggggagaagggctggctgcccccagagctctttaactgtaccaccatctccttcgtggacctcagggccatgaatgagaagctgagccgcaatgagacgcaggtggacggcgccagggccctgcagctggtgagggcgctgcgcagtgctacacagcacacgggcacgctctttggcaatgacgtgcgcacggcctaccagctgctgggccacgtccttcagcacgagagctggcagcagggcttcgacctggcagccacgcaggacgccgactttcacgaggacgtcatccactcgggcagcgccctcctggccccagccaccagggcggcgtgggagcagatccagcggagcgagggcggcacggcacagctgctccggcgcctcgagggctacttcagcaacgtggcacgcaacgtgcggcggacgtacctgcggcccttcgtcatcgtcaccgccaacatgattcttgctgtcgacatctttgacaagttcaactttacgggagccagggtcccgcgattcgacaccatccatgaagagttccccagggagctggagtcctccgtctccttcccagccgacttcttcagaccacctgaagaaaaagaaggccccctgctgaggccggctggccggaggaccaccccgcagaccacgcgcccggggcctggcaccgagagggaggccccgatcagcaggcggaggcgacaccctgatgacgctggccagttcgccgtcgctctggtcatcatttaccgcaccctggggcagctcctgcccgagcgctacgaccccgaccgtcgcagcctccggttgcctcaccggcccatcattaataccccgatggtgagcacgctggtgtacagcgagggggctccgctcccgagacccctggagaggcccgtcctggtggagttcgccctgctggaggtggaggagcgaaccaagcctgtctgcgtgttctggaaccactccctggccgttggtgggacgggagggtggtctgcccggggctgcgagctcctgtccaggaaccggacacatgtcgcctgccagtgcagccacacagccagctttgcggtgctcatggatatctccaggcgtgagaacggggaggtcctgcctctgaagattgtcacctatgccgctgtgtccttgtcactggcagccctgctggtggccttcgtcctcctgagcctggtccgcatgctgcgctccaacctgcacagcattcacaagcacctcgccgtggcgctcttcctctctcagctggtgttcgtgattgggatcaaccagacggaaaacccgtttctgtgcacagtggttgccatcctcctccactacatctacatgagcacctttgcctggaccctcgtggagagcctgcatgtctaccgcatgctgaccgaggtgcgcaacatcgacacggggcccatgcggttctactacgtcgtgggctggggcatcccggccattgtcacaggactggcggtcggcctggacccccagggctacgggaaccccgacttctgctggctgtcgcttcaagacaccctgatttggagctttgcggggcccatcggagctgttataatcatcaacacagtcacttctgtcctatctgcaaaggtttcctgccaaagaaagcaccattattatgggaaaaaagggatcgtctccctgctgaggaccgcattcctcctgctgctgctcatcagcgccacctggctgctggggctgctggctgtgaaccgcgatgcactgagctttcactacctcttcgccatcttcagcggcttacagggccccttcgtcctccttttccactgcgtgctcaaccaggaggtccggaagcacctgaagggcgtgctcggcgggaggaagctgcacctggaggactccgccaccaccagggccaccctgctgacgcgctccctcaactgcaacaccaccttcggtgacgggcctgacatgctgcgcacagacttgggcgagtccaccgcctcgctggacagcatcgtcagggatgaagggatccagaagctcggcgtgtcctctgggctggtgaggggcagccacggagagccagacgcgtccctcatgcccaggagctgcaaggatccccctggccacgattccgactcagatagcgagctgtccctggatgagcagagcagctcttacgcctcctcacactcgtcagacagcgaggacgatggggtgggagctgaggaaaaatgggacccggccaggggcgccgtccacagcacccccaaaggggacgctgtggccaaccacgttccggccggctggcccgaccagagcctggctgagagtgacagtgaggaccccagcggcaagccccgcctgaaggtggagaccaaggtcagcgtggagctgcaccgcgaggagcagggcagtcaccgtggagagtaccccccggaccaggagagcgggggcgcagccaggcttgctagcagccagcccccagagcagaggaaaggcatcttgaaaaataaagtcacctacccgccgccgctgacgctgacggagcagacgctgaagggccggctccgggagaagctggccgactgtgagcagagccccacatcctcgcgcacgtcttccctgggctctggcggccccgactgcgccatcacagtcaagagccctgggagggagccggggcgtgaccacctcaacggggtggccatgaatgtgcgcactgggagcgcccaggccgatggctccgactctgagaaaccgtgaggcaagcccgtcaccccacacaggctgcggcatcaccctcagaccttggagcccaaggggccactgcccttgaagtggagtgggcccagagtgtggcggtccccatggtggcagccccccgactgatcatccagacacaaaggtcttggttctcccaggagctcagggcctgtcagacctggtgacaagtgccaaaggccacaggcatgagggaggcgtggaccactgggccagcaccgctgagtcctaagactgcagtcaaagccagaactgagaggggaccccagactgggcccagaggctggccagagttcaggaacgccgggcacagaccaaagaccgcggtccagccccgcccaggcgggcatctcatggcagtgcggacccgtggctggcagcccgggcagtcctttgcaaaggcaccccttgtcttaaaatcacttcgctatgtgggaaaggtggagatacttttatatatttgtatgggactctgaggaggtgcaacctgtatatatattgcattcgtgctgactttgttatcccgagagatccatgcaatgatctcttgctgtcttctctgtcaagattgcacagttgtacttgaatctggcatgtgttgacgaaactggtgccccagcagatcaaaggtgggaaatacgtcagcagtggggctaaaaccaagcggctagaagccctacagctgccttcggccaggaagtgaggatggtgtgggccctccccgccggccccctgggtccccagtgttcgctgtgtgtgcgtttgtcctctgctgccatctgccccggctgtgtgaattcaagacagggcagtgcagcactaggcaggtgtgaggagccctgctgaggtcactgtggggcacggttgccacacggctgtcatttttcacctggtcattctgtgaccaccaccccctcccctcaccgcctcccaggtggcccgggagctgcaggtggggatggctttgtcctttgctcctgctccccgtgggacctgggaccttaaagcgttgcaggttcctgatttggacagaggtgtggggccttccaggccgttacatacctcctgccaattctctaactctctgagactgcgaggatctccaggcagggttctcccctctggagtctgaccaattacttcattttgcttcaaatggccaattgtgcagagggacaaagccacagccacactcttcaacggttaccaaactgtttttggaaattcacaccaaggtcgggcccactgcaggcagctggcacagcgtggcccgaggggctgtggaacgggtcccggaactgtcagacatgtttgattttagcgtttcctttgttcttcaaatcaggtgcccaaataagtgatcagcacagctgcttccaaataggagaaaccataaaataggatgaaaatcaagtaaaatgcaaagatgtccacactgttttaaacttgaccctgatgaaaatgtgagcactgttagcagatgcctatgggagaggaaaagcgtatctgaaaatggtccaggacaggaggatgaaatgagatcccagagtcctcacacctgaatgaattatacatgtgccttaccaggtgagtggtctttcgaagataaaaaactctagtccctttaaacgtttgcccctggcgtttcctaagtacgaaaaggtttttaagtcttcgaacagtctcctttcatgactttaacaggattctgccccctgaggtgtaatttttttgttctatttttttccacgtactccacagccaacatcacgaggtgtaatttttaatttgatcagaactgttaccaaaaaacaactgtcagttttattgagatgggaaaaatgtaaacctatttttattacttaagactttatgggagagattagacactggaggtttttaacagaacgtgtatttattaatgttcaaaacactggaattacaaatgagaagagtctacaataaattaagatttttgaatttgtacttctgcggtgctggtttttctccacaaacacccccgcccctccccatgcccagggtggccgtggaagggacggtttacggacgtgcagctgagctgtccgtgtcccatgctccctcagccagtggaacgtgccggaactttttgtccattccctagtaggcctgccacagcctagatgggcagtttttgtctttcaccaaatttgaggactttttttttttgccattatttcttcagttttcttttcttgcactgatctttctcctctccttctgtgactccagtgactcagacgttagacctcttgatgttttcccactggtccctgaggctctgttc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9620 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: NAS
GeneID:9620 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: NAS
GeneID:9620 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:9620 -> Molecular function: GO:0046983 [protein dimerization activity] evidence: NAS
GeneID:9620 -> Biological process: GO:0001736 [establishment of planar polarity] evidence: ISS
GeneID:9620 -> Biological process: GO:0001764 [neuron migration] evidence: IEA
GeneID:9620 -> Biological process: GO:0001843 [neural tube closure] evidence: ISS
GeneID:9620 -> Biological process: GO:0001942 [hair follicle development] evidence: IEA
GeneID:9620 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: IEA
GeneID:9620 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: NAS
GeneID:9620 -> Biological process: GO:0007218 [neuropeptide signaling pathway] evidence: IEA
GeneID:9620 -> Biological process: GO:0007266 [Rho protein signal transduction] evidence: IEA
GeneID:9620 -> Biological process: GO:0007417 [central nervous system development] evidence: NAS
GeneID:9620 -> Biological process: GO:0007417 [central nervous system development] evidence: TAS
GeneID:9620 -> Biological process: GO:0007626 [locomotory behavior] evidence: IEA
GeneID:9620 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
GeneID:9620 -> Biological process: GO:0032956 [regulation of actin cytoskeleton organization] evidence: IEA
GeneID:9620 -> Biological process: GO:0042060 [wound healing] evidence: IEA
GeneID:9620 -> Biological process: GO:0042249 [establishment of planar polarity of embryonic epithelium] evidence: IEA
GeneID:9620 -> Biological process: GO:0042472 [inner ear morphogenesis] evidence: IEA
GeneID:9620 -> Biological process: GO:0045176 [apical protein localization] evidence: IEA
GeneID:9620 -> Biological process: GO:0048105 [establishment of body hair planar orientation] evidence: IEA
GeneID:9620 -> Biological process: GO:0060488 [orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis] evidence: IEA
GeneID:9620 -> Biological process: GO:0060489 [planar dichotomous subdivision of terminal units involved in lung branching morphogenesis] evidence: IEA
GeneID:9620 -> Biological process: GO:0060490 [lateral sprouting involved in lung morphogenesis] evidence: IEA
GeneID:9620 -> Biological process: GO:0090179 [planar cell polarity pathway involved in neural tube closure] evidence: IEA
GeneID:9620 -> Biological process: GO:0090251 [protein localization involved in establishment of planar polarity] evidence: IEA
GeneID:9620 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:9620 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS
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