2025-05-09 16:38:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014175 1749 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens mitochondrial ribosomal protein L15 (MRPL15), mRNA. ACCESSION NM_014175 VERSION NM_014175.3 GI:169403971 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1749) AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M., Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D., Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J. TITLE Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression JOURNAL PLoS ONE 5 (9), E12862 (2010) PUBMED 20877624 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only REFERENCE 2 (bases 1 to 1749) AUTHORS Zhang,Z. and Gerstein,M. TITLE Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome JOURNAL Genomics 81 (5), 468-480 (2003) PUBMED 12706105 REFERENCE 3 (bases 1 to 1749) AUTHORS Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S., Watanabe,K. and Tanaka,T. TITLE The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders JOURNAL Genomics 77 (1-2), 65-70 (2001) PUBMED 11543634 REFERENCE 4 (bases 1 to 1749) AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and Wiemann,S. TITLE Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing JOURNAL EMBO Rep. 1 (3), 287-292 (2000) PUBMED 11256614 REFERENCE 5 (bases 1 to 1749) AUTHORS O'Brien,T.W., Fiesler,S.E., Denslow,N.D., Thiede,B., Wittmann-Liebold,B., Mougey,E.B., Sylvester,J.E. and Graack,H.R. TITLE Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences JOURNAL J. Biol. Chem. 274 (51), 36043-36051 (1999) PUBMED 10593885 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000891.1, DA504537.1 and BM510276.1. On Mar 5, 2008 this sequence version replaced gi:21265077. Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BC000891.1, AF161494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1131 BC000891.1 1-1131 1132-1460 DA504537.1 241-569 1461-1749 BM510276.1 147-435 FEATURES Location/Qualifiers source 1..1749 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="8" /map="8q11.2-q13" gene 1..1749 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /note="mitochondrial ribosomal protein L15" /db_xref="GeneID:29088" /db_xref="HGNC:14054" /db_xref="HPRD:14742" /db_xref="MIM:611828" exon 1..171 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /inference="alignment:Splign:1.39.8" variation 26 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:200873877" variation 30 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="t" /db_xref="dbSNP:373295729" variation 38 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="g" /db_xref="dbSNP:199847553" misc_feature 40..42 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /note="upstream in-frame stop codon" variation 41 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:115113743" variation 54 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:375824584" CDS 64..954 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /codon_start=1 /product="39S ribosomal protein L15, mitochondrial" /protein_id="NP_054894.1" /db_xref="GI:7661806" /db_xref="CCDS:CCDS6158.1" /db_xref="GeneID:29088" /db_xref="HGNC:14054" /db_xref="HPRD:14742" /db_xref="MIM:611828" /translation="
MAGPLQGGGARALDLLRGLPRVSLANLKPNPGSKKPERRPRGRRRGRKCGRGHKGERQRGTRPRLGFEGGQTPFYIRIPKYGFNEGHSFRRQYKPLSLNRLQYLIDLGRVDPSQPIDLTQLVNGRGVTIQPLKRDYGVQLVEEGADTFTAKVNIEVQLASELAIAAIEKNGGVVTTAFYDPRSLDIVCKPVPFFLRGQPIPKRMLPPEELVPYYTDAKNRGYLADPAKFPEARLELARKYGYILPDITKDELFKMLCTRKDPRQIFFGLAPGWVVNMADKKILKPTDENLLKYYTS
" misc_feature 133..588 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /note="50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592" /db_xref="CDD:180155" variation 66 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:367818357" variation 68 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:202131264" variation 113 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:200980911" variation 116 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:185602304" variation 127 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:369951746" variation 136 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:147114545" variation 146 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="t" /db_xref="dbSNP:200528523" variation 157 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:375605064" variation 159 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="c" /db_xref="dbSNP:369347994" exon 172..326 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /inference="alignment:Splign:1.39.8" variation 178 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="c" /db_xref="dbSNP:140659512" variation 186 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:376894590" variation 190 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:116167634" variation 191 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:374236252" variation 199 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="g" /db_xref="dbSNP:200301483" variation 213 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:187177795" variation 232 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:117264028" variation 248 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:191944170" variation 252 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:143290279" variation 254 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:368659643" variation 289 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:201010270" exon 327..492 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /inference="alignment:Splign:1.39.8" variation 334 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:372905836" variation 373 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="g" /db_xref="dbSNP:375531818" variation 378 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:138469741" variation 385 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:149600755" variation 386 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:144260791" variation 400 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:148719420" variation 438 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:201300444" variation 443 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:200821635" variation 475 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:200254262" variation 484 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:146037612" exon 493..616 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /inference="alignment:Splign:1.39.8" variation 518 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:139986837" variation 521 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="t" /db_xref="dbSNP:201428141" variation 522 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:143467923" variation 536 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:146739374" variation 544 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="g" /db_xref="dbSNP:140295154" variation 581 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:149906233" variation 590 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:144928483" exon 617..1749 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /inference="alignment:Splign:1.39.8" variation 637 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="c" /db_xref="dbSNP:143041082" variation 649 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:377066222" variation 656 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:192445048" variation 675 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:369873163" variation 680 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:184808605" variation 688 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:373468980" STS 692..1209 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /standard_name="MRPL15_3130" /db_xref="UniSTS:462349" variation 705 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:374098857" variation 717 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="g" /db_xref="dbSNP:376969993" variation 815 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:147766742" variation 835 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:375896512" variation 868 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:370538622" variation 897 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:187322525" variation 909 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:141899859" variation 929 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:147113313" variation 950 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="c" /db_xref="dbSNP:201769943" STS 992..1117 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /standard_name="WI-12392" /db_xref="UniSTS:81837" polyA_signal 1102..1107 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" polyA_site 1128 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" polyA_site 1132 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" polyA_site 1136 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" polyA_site 1140 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" variation 1155 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:193172419" variation 1302 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="g" /replace="t" /db_xref="dbSNP:184639828" variation 1342 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:77920229" variation 1384 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="c" /replace="t" /db_xref="dbSNP:77180248" variation 1389 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="g" /db_xref="dbSNP:369074158" variation 1561 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="c" /db_xref="dbSNP:138433944" variation 1686 /gene="MRPL15" /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7" /replace="a" /replace="t" /db_xref="dbSNP:189861801" ORIGIN
cccgagaccacgtggcctccgagcagctcagggcgcccttgaaagttcttggatctgcgggttatggccggtcccttgcagggcggtggggcccgggccctggacctactccggggcctgccgcgtgtgagcctggccaacttaaagccgaatcccggctccaagaaaccggagagaagaccaagaggtcggagaagaggtagaaaatgtggcagaggccataaaggagaaaggcaaagaggaacccggccccgcttgggctttgagggaggccagactccattttacatccgaatcccaaaatacgggtttaacgaaggacatagtttcagacgccagtataagcctttgagtctcaatagactgcagtatcttattgatttgggtcgtgttgatcctagtcaacctattgacttaacccagcttgtcaatgggagaggtgtgaccatccagccacttaaaagggattatggtgtccagctggttgaggagggtgctgacacctttacggcaaaagttaatattgaagtacagttggcttcagaactagctattgctgccattgaaaaaaatggtggtgttgttactacagccttctatgatccaagaagtctggacattgtatgcaaacctgttccattctttcttcgtggacaacccattccaaaaagaatgcttccaccagaagaactggtaccatattacactgatgcaaagaaccgtgggtacctggcggatcctgccaaatttcctgaagcacgacttgaactcgccaggaagtatggttatatcttacctgatatcactaaagatgaactcttcaaaatgctctgtactaggaaggatccaaggcagattttctttggtcttgctccaggatgggtggtgaatatggccgataagaaaatcctaaaacctacagatgaaaatctccttaagtattatacctcatgaattcccgtccaaggaagcagagttgttaaagagtactggaataggggctgaaggatctatattcccttattgcattttccttatgtataattttccagatggtgatgttacttttcagtgtactcatatgtctcattttcatctaaaattaaatggcaggaaacaaggactgcatagagaaactgagtctgtgtgggttctgtctcaaagatacaaactccctgatagtctatggaaggaaaatgacaactattttagaatatttctagtttgttttttcagtgatcttttcatccaggccttgttactgttacagatcagaatgaaatgcacaagtggaatgggattgacctgtaggcctgctctgccgagatgagagcagatggaatgagttggtgacccctcttaatctgtagcctcagggaaacacggctacccaatgccaagatggtaaaccctcaactcgaagagtaagatcaggacgtatgcttaaggtgtaaggctgaggagtagctggtaggcagtatgtttgccagtgacattgaaggtgagagaaacaaaaattacaaatgaatttattttctcaattctgtggtagaagtgttacaggcaggcctttgttcttagagctcccaagatggtggtggccactcccaagatggcagcaagccttttgttctctgacctggggttcttggcctcacggattccaaagaatggaaccttgggccatgtggtcagtgttatagctctagtagaagtcatgggtcacggaagagaactgtggaacccagt
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:29088 -> Molecular function: GO:0003735 [structural constituent of ribosome] evidence: IEA GeneID:29088 -> Biological process: GO:0006412 [translation] evidence: IEA GeneID:29088 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:29088 -> Cellular component: GO:0015934 [large ribosomal subunit] evidence: IEA
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