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2025-05-09 16:53:03, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012381 2586 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens origin recognition complex, subunit 3 (ORC3),
transcript variant 2, mRNA.
ACCESSION NM_012381
VERSION NM_012381.3 GI:308737001
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2586)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 2 (bases 1 to 2586)
AUTHORS Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
Schreiber,S. and Nebel,A.
TITLE Investigation of genetic susceptibility factors for human longevity
- a targeted nonsynonymous SNP study
JOURNAL Mutat. Res. 694 (1-2), 13-19 (2010)
PUBMED 20800603
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 2586)
AUTHORS Enjuanes,A., Benavente,Y., Bosch,F., Martin-Guerrero,I.,
Colomer,D., Perez-Alvarez,S., Reina,O., Ardanaz,M.T., Jares,P.,
Garcia-Orad,A., Pujana,M.A., Montserrat,E., de Sanjose,S. and
Campo,E.
TITLE Genetic variants in apoptosis and immunoregulation-related genes
are associated with risk of chronic lymphocytic leukemia
JOURNAL Cancer Res. 68 (24), 10178-10186 (2008)
PUBMED 19074885
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 2586)
AUTHORS DeRosse,P., Lencz,T., Burdick,K.E., Siris,S.G., Kane,J.M. and
Malhotra,A.K.
TITLE The genetics of symptom-based phenotypes: toward a molecular
classification of schizophrenia
JOURNAL Schizophr Bull 34 (6), 1047-1053 (2008)
PUBMED 18628273
REMARK GeneRIF: Lifetime severity of positive symptoms was significantly
(P = 2.50 x 10(-5)) associated with a SNP within the origin
recognition complex subunit 3-like (ORC3L) gene, a gene implicated
in synaptic plasticity.
REFERENCE 5 (bases 1 to 2586)
AUTHORS Siddiqui,K. and Stillman,B.
TITLE ATP-dependent assembly of the human origin recognition complex
JOURNAL J. Biol. Chem. 282 (44), 32370-32383 (2007)
PUBMED 17716973
REFERENCE 6 (bases 1 to 2586)
AUTHORS Izumi,M., Yanagi,K., Mizuno,T., Yokoi,M., Kawasaki,Y., Moon,K.Y.,
Hurwitz,J., Yatagai,F. and Hanaoka,F.
TITLE The human homolog of Saccharomyces cerevisiae Mcm10 interacts with
replication factors and dissociates from nuclease-resistant nuclear
structures in G(2) phase
JOURNAL Nucleic Acids Res. 28 (23), 4769-4777 (2000)
PUBMED 11095689
REFERENCE 7 (bases 1 to 2586)
AUTHORS Thome,K.C., Dhar,S.K., Quintana,D.G., Delmolino,L., Shahsafaei,A.
and Dutta,A.
TITLE Subsets of human origin recognition complex (ORC) subunits are
expressed in non-proliferating cells and associate with non-ORC
proteins
JOURNAL J. Biol. Chem. 275 (45), 35233-35241 (2000)
PUBMED 10954718
REFERENCE 8 (bases 1 to 2586)
AUTHORS Herbig,U., Marlar,C.A. and Fanning,E.
TITLE The Cdc6 nucleotide-binding site regulates its activity in DNA
replication in human cells
JOURNAL Mol. Biol. Cell 10 (8), 2631-2645 (1999)
PUBMED 10436018
REFERENCE 9 (bases 1 to 2586)
AUTHORS Pinto,S., Quintana,D.G., Smith,P., Mihalek,R.M., Hou,Z.H.,
Boynton,S., Jones,C.J., Hendricks,M., Velinzon,K.,
Wohlschlegel,J.A., Austin,R.J., Lane,W.S., Tully,T. and Dutta,A.
TITLE latheo encodes a subunit of the origin recognition complex and
disrupts neuronal proliferation and adult olfactory memory when
mutant
JOURNAL Neuron 23 (1), 45-54 (1999)
PUBMED 10402192
REMARK GeneRIF: Functional studies of the Drosophila homolog
REFERENCE 10 (bases 1 to 2586)
AUTHORS Tugal,T., Zou-Yang,X.H., Gavin,K., Pappin,D., Canas,B.,
Kobayashi,R., Hunt,T. and Stillman,B.
TITLE The Orc4p and Orc5p subunits of the Xenopus and human origin
recognition complex are related to Orc1p and Cdc6p
JOURNAL J. Biol. Chem. 273 (49), 32421-32429 (1998)
PUBMED 9829972
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC395106.1, AF125507.1 and
BM971022.1.
On Oct 15, 2010 this sequence version replaced gi:32483366.
Summary: The origin recognition complex (ORC) is a highly conserved
six subunits protein complex essential for the initiation of the
DNA replication in eukaryotic cells. Studies in yeast demonstrated
that ORC binds specifically to origins of replication and serves as
a platform for the assembly of additional initiation factors such
as Cdc6 and Mcm proteins. The protein encoded by this gene is a
subunit of the ORC complex. Studies of a similar gene in Drosophila
suggested a possible role of this protein in neuronal proliferation
and olfactory memory. Alternatively spliced transcript variants
encoding distinct isoforms have been reported for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) lacks three nts in an
alternate splicing site in the 3' coding, as compared to variant 1.
The translation reading frame remains the same, and the resulting
isoform (2) lacks an internal aa, as compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF093535.1, AK222795.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-67 DC395106.1 1-67
68-2563 AF125507.1 1-2496
2564-2586 BM971022.1 1-23 c
FEATURES Location/Qualifiers
source 1..2586
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q14.3-q16.1"
gene 1..2586
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/note="origin recognition complex, subunit 3"
/db_xref="GeneID:23595"
/db_xref="HGNC:8489"
/db_xref="HPRD:05398"
/db_xref="MIM:604972"
exon 1..126
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 21
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307387"
misc_feature 28..30
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/note="upstream in-frame stop codon"
variation 35
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:146601654"
variation 68
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:201438682"
variation 88..89
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace=""
/replace="ag"
/db_xref="dbSNP:28381461"
variation 91..92
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace=""
/replace="gt"
/db_xref="dbSNP:2307367"
variation 101
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:2307368"
CDS 103..2238
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/note="isoform 2 is encoded by transcript variant 2;
origin recognition complex, subunit 3 honolog; homolog of
latheo, Drosophila; origin recognition complex subunit
Latheo"
/codon_start=1
/product="origin recognition complex subunit 3 isoform 2"
/protein_id="NP_036513.2"
/db_xref="GI:32483367"
/db_xref="CCDS:CCDS43486.1"
/db_xref="GeneID:23595"
/db_xref="HGNC:8489"
/db_xref="HPRD:05398"
/db_xref="MIM:604972"
/translation="
MATSSMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
"
misc_feature 157..1134
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/note="Origin recognition complex (ORC) subunit 3
N-terminus; Region: ORC3_N; pfam07034"
/db_xref="CDD:148572"
misc_feature 169..171
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UBD5.1); phosphorylation site"
misc_feature 724..726
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1648..1650
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UBD5.1); phosphorylation site"
misc_feature 1648..1650
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 114
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:376418108"
variation 116
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:375214415"
variation 120
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:149941248"
exon 127..181
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 159
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201861328"
variation 168
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:144122164"
variation 178
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148696846"
exon 182..279
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 234
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:371874111"
variation 235
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142044709"
variation 258
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146668920"
variation 267
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:200996438"
exon 280..424
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 304
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:144040713"
variation 343
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:78910923"
variation 347
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:368053556"
variation 356
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:371584444"
variation 365
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:112186214"
variation 378
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:74364970"
variation 379
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201924978"
variation 382
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:2307365"
variation 410
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:150252172"
exon 425..529
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 429
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:145851270"
variation 431
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="t"
/db_xref="dbSNP:149010963"
variation 457
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373085430"
variation 464
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:78632433"
variation 465
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:143632999"
variation 466
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:202154049"
variation 479
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:2307371"
variation 481
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:143881974"
variation 489
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:369815671"
variation 491
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:77689062"
variation 507
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373119034"
variation 517
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146526621"
variation 521
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:141851921"
exon 530..681
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 533
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:141721711"
variation 570
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:150567304"
variation 611
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:112741742"
variation 613
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:61756140"
variation 616
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:139602020"
variation 650
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:149324991"
variation 655..656
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace=""
/replace="c"
/db_xref="dbSNP:35309297"
exon 682..815
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 686
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:146286747"
variation 687
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:369385539"
variation 745
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:199698250"
variation 751
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:2307389"
variation 775
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:200682425"
variation 781
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:199789475"
variation 802
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:367552239"
exon 816..975
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 841
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:2307374"
variation 852
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:377330226"
variation 884
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146446780"
variation 891
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201301884"
variation 912
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:367965463"
variation 933
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148643475"
variation 962
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307381"
variation 969
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:151302588"
exon 976..1089
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1049
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:140577831"
variation 1070
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:150481408"
variation 1089
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:2307363"
exon 1090..1223
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1096
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:61753612"
variation 1112
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:147755470"
variation 1134
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:368361212"
variation 1165
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200762592"
exon 1224..1287
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1227
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:200082103"
variation 1238
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="t"
/db_xref="dbSNP:142333103"
variation 1243
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201077859"
variation 1259
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:146416983"
variation 1264
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:200211835"
variation 1267
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:2307372"
exon 1288..1404
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1289
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:376650812"
variation 1295
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:371509958"
variation 1378
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:138599697"
exon 1405..1484
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1420
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201209204"
variation 1444
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:139108147"
variation 1476
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:143108637"
exon 1485..1618
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1493
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:371508516"
variation 1501
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:148245971"
variation 1544
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:9353493"
variation 1553
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:202114121"
variation 1594
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307393"
variation 1608
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201278306"
variation 1610
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146268634"
exon 1619..1695
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1630
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200525076"
variation 1639
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:369225174"
variation 1640
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:199578553"
variation 1647
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373490954"
variation 1651
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:199748447"
variation 1686
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201594291"
exon 1696..1793
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1697
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:138153363"
variation 1756
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142321378"
exon 1794..1935
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1827
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:370934198"
variation 1864
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307370"
variation 1886
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:61747273"
variation 1933
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:375586431"
exon 1936..2052
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 1954
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:370143904"
variation 1961
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:139494209"
STS 1970..2110
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/standard_name="STS-H99257"
/db_xref="UniSTS:38099"
variation 1978
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:28381545"
variation 1982
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201741907"
variation 2007
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:144517793"
exon 2053..2132
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 2053
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:374112561"
variation 2101
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148557057"
variation 2130
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:200865515"
exon 2133..2569
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/inference="alignment:Splign:1.39.8"
variation 2138
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:188446659"
STS 2149..2568
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/standard_name="ORC3L_9379"
/db_xref="UniSTS:471702"
variation 2194
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:146518052"
STS 2200..2370
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/standard_name="RH68856"
/db_xref="UniSTS:39128"
variation 2263
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="g"
/replace="t"
/db_xref="dbSNP:376580990"
variation 2269
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="c"
/db_xref="dbSNP:368993527"
variation 2278
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="t"
/db_xref="dbSNP:371602431"
variation 2321
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="g"
/db_xref="dbSNP:2307380"
variation 2339
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:190350143"
variation 2343
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307392"
variation 2380
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307369"
variation 2426
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:149980633"
variation 2446
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="c"
/replace="t"
/db_xref="dbSNP:28381552"
variation 2450
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="t"
/db_xref="dbSNP:145220662"
polyA_signal 2539..2544
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
variation 2540
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:74984361"
variation 2549
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
/replace="a"
/replace="g"
/db_xref="dbSNP:149159300"
polyA_site 2569
/gene="ORC3"
/gene_synonym="LAT; LATHEO; ORC3L"
ORIGIN
caatcaaggagccgtgtggctcgccactaacctctgccctgcagccgcgagggcgcgcgggaaatcccgagtgcatctggaatacgcagagtcagtaagaccatggctacgtcctcgatgtctaagggttgctttgtttttaagccaaactccaaaaagagaaagatctctctgccaatagaggactattttaacaaagggaaaaatgagcctgaggacagtaagcttcgattcgaaacttatcagttgatatggcagcagatgaaatctgaaaatgagcgactacaagaggaattaaataaaaacttgtttgacaatctgattgaatttctgcaaaaatcacattctggattccagaagaattcaagagacttgggcggtcaaataaaactcagagaaattccaactgctgctcttgttcttggtgtgaatgtcacagatcatgatttgacattcggaagtctaacagaggcccttcagaataatgtcacaccatatgtagtctcattgcaagctaaagattgtccagatatgaaacattttttgcaaaagttgatctcacagttgatggactgctgtgtagatataaaatccaaagaggaggaaagtgttcacgtcacccaaagaaagacacattattcaatggattcactttccagttggtatatgactgtcacacagaagacggacccaaaaatgctaagcaaaaaaaggactacttctagccaatggcagtctcctcctgttgtcgttatcttgaaggatatggaaagctttgccacaaaagtactacaagacttcataattatcagcagtcaacatctccatgaatttccactaatactcatttttggaatagccacatctcctattatcatccaccgattgcttcctcatgcagtatcatctctattgtgcatagaactgttccaatctttgtcttgtaaggagcacctgactacggtactcgataagctacttcttacaactcagtttccctttaaaataaatgaaaaagtattacaggttctgaccaacatctttttgtatcatgatttctcagttcaaaactttataaaaggacttcagctttctctattagagcatttctattcccagcccttaagtgtcctgtgctgtaatcttccagaagccaaaagaagaataaattttttatcaaataatcaatgtgaaaacatccgacgtctaccatcttttaggaggtacgtggaaaagcaagcttcagaaaagcaagttgcgctcttgaccaatgagagatatttgaaggaggaaacacaattattactagaaaacctgcatgtttatcatatgaattacttcctggttttgagatgtcttcataagttcacctcttctcttcccaagtatccactaggtcgacagatcagagagttgtactgtacatgtttagaaaagaacatatgggattcagaggagtatgcatcagtcttgcagctgctgaggatgttggcaaaggatgaactgatgaccatacttgagaaatgtttcaaggtttttaagtcttattgtgaaaaccaccttggcagcacagctaagagaatagaggagttcctggcccagtttcagagcctcgatgaaaccaaagaggaagaagatgcttctgggtcacagccaaaggggcttcagaagacagacctctatcatcttcagaagtccttattggaaatgaaggagttaagaagaagtaagaagcaaaccaaatttgaagtactcagagaaaatgttgtgaacttcattgactgtctagtgagagaataccttctgcctcctgagacacagcctctccatgaggtggtgtacttcagtgctgcccatgcccttcgtgagcatttaaatgctgctccgcgaattgccctccatactgcactcaacaatccttactattatctcaagaatgaagcactgaaaagcgaagaaggctgcattccgaatatcgccccagacatctgcatagcatacaaactgcacctagagtgtagcaggctcatcaacctcgtggactggtcagaggcttttgcaacagttgtgacagctgctgaaaaaatggatgcaaattctgcaacctcagaagaaatgaatgaaattatccatgctcggtttattagagctgtttctgaactagaacttttaggatttataaaacctaccaaacagaagactgaccatgtggcaagactaacatggggaggctgctagaaagcaaataagcaaagccagaactatcacatttagcttaagagaaaaaggtgaccagtcatatttacatatattagaggagcctgttttgttgagaagataaatgtgtaacccccattgatgtttaaccagaaaagtacattgctaaccccaaacaggcatgtatcaaaacacctgtggagtactttagactccaacaaataataatgtaactaaaactgctcacacattttactgtactttccaaagtcattactaaattgtgagtaaatcattcttgaacttagagtatgtaaatgtaataaattccgttatccaggagtataaattaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23595 -> Molecular function: GO:0003688 [DNA replication origin binding] evidence: TAS
GeneID:23595 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23595 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:23595 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:23595 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:23595 -> Cellular component: GO:0000808 [origin recognition complex] evidence: IDA
GeneID:23595 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:23595 -> Cellular component: GO:0005664 [nuclear origin of replication recognition complex] evidence: IDA
by
@meso_cacase at
DBCLS
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