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2025-05-09 16:51:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012115 6821 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript
variant 1, mRNA.
ACCESSION NM_012115
VERSION NM_012115.3 GI:212549780
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6821)
AUTHORS Yang,X.C., Sabath,I., Debski,J., Kaus-Drobek,M., Dadlez,M.,
Marzluff,W.F. and Dominski,Z.
TITLE A complex containing the CPSF73 endonuclease and other
polyadenylation factors associates with U7 snRNP and is recruited
to histone pre-mRNA for 3'-end processing
JOURNAL Mol. Cell. Biol. 33 (1), 28-37 (2013)
PUBMED 23071092
REMARK GeneRIF: FLASH/Lsm11 complex bind a unique combination of
polyadenylation factors
REFERENCE 2 (bases 1 to 6821)
AUTHORS Lee,K.D., Pai,M.Y., Hsu,C.C., Chen,C.C., Chen,Y.L., Chu,P.Y.,
Lee,C.H., Chen,L.T., Chang,J.Y., Huang,T.H., Hsiao,S.H. and
Leu,Y.W.
TITLE Targeted Casp8AP2 methylation increases drug resistance in
mesenchymal stem cells and cancer cells
JOURNAL Biochem. Biophys. Res. Commun. 422 (4), 578-585 (2012)
PUBMED 22595458
REMARK GeneRIF: These data demonstrate that methylation within the
Casp8AP2 promoter correlates with the development of drug
resistance and might serve as a biomarker and treatment target for
drug resistance in cancer cells.
REFERENCE 3 (bases 1 to 6821)
AUTHORS De Cola,A., Bongiorno-Borbone,L., Bianchi,E., Barcaroli,D.,
Carletti,E., Knight,R.A., Di Ilio,C., Melino,G., Sette,C. and De
Laurenzi,V.
TITLE FLASH is essential during early embryogenesis and cooperates with
p73 to regulate histone gene transcription
JOURNAL Oncogene 31 (5), 573-582 (2012)
PUBMED 21725362
REMARK GeneRIF: Data show that show that the transcription factor p73
binds to Flice-Associated Huge Protein (FLASH) and is part of the
complex that regulates histone gene transcription.
REFERENCE 4 (bases 1 to 6821)
AUTHORS Chen,S., Evans,H.G. and Evans,D.R.
TITLE FLASH knockdown sensitizes cells to Fas-mediated apoptosis via
down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip
short
JOURNAL PLoS ONE 7 (3), E32971 (2012)
PUBMED 22427918
REMARK GeneRIF: FLASH knockdown in HT1080 mutant cells defective in p53
did not significantly accelerate Fas mediated apoptosis indicating
that the effect was dependent on functional p53.
REFERENCE 5 (bases 1 to 6821)
AUTHORS Hummon,A.B., Pitt,J.J., Camps,J., Emons,G., Skube,S.B., Huppi,K.,
Jones,T.L., Beissbarth,T., Kramer,F., Grade,M.,
Difilippantonio,M.J., Ried,T. and Caplen,N.J.
TITLE Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional
deregulation of the replication-dependent histone genes and
extensive effects on the transcriptome of colorectal cancer cells
JOURNAL Mol. Cancer 11, 1 (2012)
PUBMED 22216762
REMARK GeneRIF: This study further defines the role CASP8AP2/FLASH plays
in the regulating expression of the replication-dependent histones
and shows that its LOF results in broad and reproducible effects on
the transcriptome of colorectal cancer cells
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6821)
AUTHORS Jun,J.I., Chung,C.W., Lee,H.J., Pyo,J.O., Lee,K.N., Kim,N.S.,
Kim,Y.S., Yoo,H.S., Lee,T.H., Kim,E. and Jung,Y.K.
TITLE Role of FLASH in caspase-8-mediated activation of NF-kappaB:
dominant-negative function of FLASH mutant in NF-kappaB signaling
pathway
JOURNAL Oncogene 24 (4), 688-696 (2005)
PUBMED 15592525
REMARK GeneRIF: endogenous caspase-8 mediates tumor necrosis
factor-alpha-induced activation of NF-kappaB via FLASH
REFERENCE 7 (bases 1 to 6821)
AUTHORS Kino,T. and Chrousos,G.P.
TITLE Tumor necrosis factor alpha receptor- and Fas-associated FLASH
inhibit transcriptional activity of the glucocorticoid receptor by
binding to and interfering with its interaction with p160 type
nuclear receptor coactivators
JOURNAL J. Biol. Chem. 278 (5), 3023-3029 (2003)
PUBMED 12477726
REFERENCE 8 (bases 1 to 6821)
AUTHORS Choi,Y.H., Kim,K.B., Kim,H.H., Hong,G.S., Kwon,Y.K., Chung,C.W.,
Park,Y.M., Shen,Z.J., Kim,B.J., Lee,S.Y. and Jung,Y.K.
TITLE FLASH coordinates NF-kappa B activity via TRAF2
JOURNAL J. Biol. Chem. 276 (27), 25073-25077 (2001)
PUBMED 11340079
REFERENCE 9 (bases 1 to 6821)
AUTHORS Koonin,E.V., Aravind,L., Hofmann,K., Tschopp,J. and Dixit,V.M.
TITLE Apoptosis. Searching for FLASH domains
JOURNAL Nature 401 (6754), 662 (1999)
PUBMED 10537104
REFERENCE 10 (bases 1 to 6821)
AUTHORS Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
Yonehara,S.
TITLE The CED-4-homologous protein FLASH is involved in Fas-mediated
activation of caspase-8 during apoptosis
JOURNAL Nature 398 (6730), 777-785 (1999)
PUBMED 10235259
REMARK Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP363682.1, BC132830.1 and
AF154415.1.
On Nov 13, 2008 this sequence version replaced gi:16306505.
Summary: This protein is highly similar to FLASH, a mouse apoptotic
protein identified by its interaction with the death-effector
domain (DED) of caspase 8. Studies of FLASH protein suggested that
this protein may be a component of the death-inducing signaling
complex that includes Fas receptor, Fas-binding adapter FADD, and
caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
Alternative splicing results in multiple transcript variants
encoding the same protein.[provided by RefSeq, Nov 2008].
Transcript Variant: This variant (1) represents the longest
transcript.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF154415.1, BC132830.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025084 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-153 BP363682.1 1-153
154-6722 BC132830.1 1-6569
6723-6821 AF154415.1 6684-6782
FEATURES Location/Qualifiers
source 1..6821
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q15"
gene 1..6821
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="caspase 8 associated protein 2"
/db_xref="GeneID:9994"
/db_xref="HGNC:1510"
/db_xref="HPRD:06048"
/db_xref="MIM:606880"
variation 4
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375731771"
variation 10
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:368340936"
variation 24
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:183190155"
variation 46
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:150333903"
variation 65
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:73752810"
variation 70
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:137975335"
variation 92
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:143660157"
variation 105
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:367700022"
variation 183
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:113121473"
misc_feature 212..214
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="upstream in-frame stop codon"
variation 227
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:371341158"
CDS 236..6184
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="FLICE associated huge; CASP8 associated protein 2;
FLICE-associated huge protein; human FLASH; FLASH homolog
RIP25"
/codon_start=1
/product="CASP8-associated protein 2"
/protein_id="NP_036247.1"
/db_xref="GI:6912288"
/db_xref="GeneID:9994"
/db_xref="HGNC:1510"
/db_xref="HPRD:06048"
/db_xref="MIM:606880"
/translation="
MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQTQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLPNTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSKCR
"
misc_feature 239..241
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (Q9UKL3.1); acetylation site"
misc_feature 293..295
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKL3.1); phosphorylation site"
misc_feature 4067..4069
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 5282..5296
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: SUMO interaction motif 1 (SIM), mediates the
binding to polysumoylated substrates (By similarity)"
misc_feature 5360..6181
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: NCOA2-binding"
misc_feature 5444..5458
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: SUMO interaction motif 2 (SIM), mediates the
binding to polysumoylated substrates (By similarity)"
misc_feature 5615..5629
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: SUMO interaction motif 3 (SIM), mediates the
binding to polysumoylated substrates (By similarity)"
misc_feature 5981..6175
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="Caspase 8-associated protein 2 myb-like domain;
Region: CASP8AP2; cd12202"
/db_xref="CDD:213401"
variation 244
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:371635635"
variation 283
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:35891026"
variation 286
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376288172"
variation 311
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377117590"
variation 380
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:138471825"
variation 397
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374871939"
variation 409
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369309364"
variation 514
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369328"
variation 583
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375845338"
variation 586
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:370454326"
variation 730
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:191794738"
variation 746
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:375746744"
variation 752
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371046529"
variation 827
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:79485882"
variation 867
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:199979891"
variation 888
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:115337779"
variation 890
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374867724"
variation 898
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:182729426"
variation 907
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372111972"
variation 921
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:377049861"
variation 944
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:368353175"
variation 945
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:202238236"
variation 963
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376835324"
variation 980
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369918159"
variation 1005
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:371653827"
variation 1006
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:116832209"
variation 1023
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200917530"
variation 1045
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:201596073"
variation 1047
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369118984"
variation 1105
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:3734656"
variation 1106
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:376169756"
variation 1107
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369927994"
variation 1129
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:373400557"
variation 1144
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377422956"
variation 1214
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:200248550"
variation 1236
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374722055"
variation 1264
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:9444715"
variation 1282
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370574439"
variation 1292
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375447849"
variation 1340
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:368346657"
variation 1351
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:372317117"
variation 1399
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374277382"
variation 1495
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:75673851"
variation 1539
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:74395498"
variation 1572
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:187658864"
variation 1577
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372268202"
variation 1578
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374708182"
variation 1587
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:202104748"
variation 1591
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:34701151"
variation 1607
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201785439"
variation 1666
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:192787612"
variation 1759
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369303003"
variation 1785
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200323558"
variation 1841
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376777596"
variation 1847
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370049023"
variation 1853
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374581994"
variation 1903
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:377395999"
variation 1913
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370348129"
variation 1951
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370445193"
variation 1953
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200220681"
variation 1975
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:377095494"
variation 2025
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370562618"
variation 2103
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:375044202"
variation 2105
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368459977"
variation 2151
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:372157483"
variation 2173
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374796247"
variation 2174
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:139622677"
variation 2198
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:367672377"
variation 2200
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:371194420"
variation 2215
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375013992"
variation 2221
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368221756"
variation 2237
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201489639"
variation 2257
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376398807"
variation 2290
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369747236"
variation 2305
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374435750"
variation 2347
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:373095386"
variation 2371
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:185478571"
variation 2385
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369938492"
variation 2438
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:199531988"
variation 2482
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:376213760"
variation 2502
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:370683344"
variation 2532
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:189475790"
variation 2607
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:118038939"
variation 2619
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:377330360"
variation 2626
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:3799895"
variation 2632
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370853193"
variation 2642
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:374310883"
variation 2667
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:373335807"
variation 2758
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:191911199"
variation 2767
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201271265"
variation 2773
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:368553205"
variation 2799
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371069501"
variation 2838
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:184335133"
variation 2858
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:201494268"
variation 2912
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:202224866"
variation 2952
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:137945652"
variation 2985
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:199818755"
variation 3089
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:201306147"
variation 3104
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:368026528"
variation 3124..3125
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="c"
/db_xref="dbSNP:34572105"
variation 3150
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:117850701"
variation 3174
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:149473817"
variation 3191
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201974982"
variation 3195
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376299045"
variation 3214
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:369795421"
variation 3231
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:114897724"
variation 3297
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:375785540"
variation 3363
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369132664"
variation 3394
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370730058"
STS 3623..3779
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/standard_name="STS-H50583"
/db_xref="UniSTS:2284"
variation 3638
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:373329038"
variation 3675
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064002"
variation 3703
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:143076875"
variation 3740
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:182864217"
variation 3867
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:41273333"
variation 3893
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:116614248"
variation 3947
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201597048"
variation 3949
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:199918891"
variation 3951
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:73752819"
variation 3954
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:201506096"
variation 3982
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376295745"
variation 3989
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:200866261"
variation 3990
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374748337"
variation 4006
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369576046"
variation 4036
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:367664392"
variation 4049
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370073401"
variation 4051
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374343288"
variation 4079
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:186180164"
variation 4086
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:148256815"
variation 4095
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375610839"
variation 4102
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:141249173"
variation 4128
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372787304"
variation 4129
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375991831"
variation 4172
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370120781"
variation 4192
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:371257885"
variation 4198
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374774067"
variation 4251
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:369180336"
variation 4257
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:78396072"
variation 4288
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:147437828"
variation 4295
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376211225"
variation 4372
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369714914"
variation 4405
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:373655186"
variation 4540
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376852526"
variation 4622
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:139736386"
variation 4623
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:143016644"
variation 4627
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371559146"
variation 4661
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:190118214"
variation 4773
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:75601500"
variation 4828
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:60966143"
variation 4876
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:200433993"
variation 4933..4950
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="gacatctttgcccagaca"
/db_xref="dbSNP:202116886"
variation 4938
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:202101805"
variation 4940
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:200213073"
variation 4946
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201189413"
variation 4949
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:202111256"
variation 4951
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:199694900"
variation 4952
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200862023"
variation 4953
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201534830"
variation 4954
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:199515704"
variation 5073
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:139983441"
variation 5102
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:150022229"
variation 5126
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:369757511"
variation 5152
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:368260598"
variation 5170
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:371881005"
variation 5183
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:111766212"
variation 5202
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:375182927"
variation 5210
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:3799896"
variation 5213
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:372893351"
variation 5270..5271
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="t"
/db_xref="dbSNP:34373654"
variation 5277
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374695928"
variation 5285
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200556402"
variation 5357
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369072391"
variation 5358
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:371594163"
variation 5373
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:199714955"
variation 5377
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369451328"
variation 5395
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200853389"
variation 5418
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:377357235"
variation 5439
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369858460"
variation 5441
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:117650507"
variation 5461
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377396142"
variation 5472
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370442854"
variation 5533
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:374893112"
variation 5539
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377482246"
variation 5544
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:73752820"
variation 5554
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374232968"
variation 5561
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368605777"
variation 5571
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:371085535"
variation 5602
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374618973"
variation 5635
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:368658707"
STS 5637..5874
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/standard_name="SHGC-52865"
/db_xref="UniSTS:38874"
variation 5656
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:371166110"
variation 5660
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200564116"
variation 5750
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201549866"
variation 5753
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:200157861"
variation 5841
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:1062121"
variation 5886
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:199771380"
variation 5912
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:182937785"
variation 5933
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:367942163"
variation 5967
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372229978"
variation 6050
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369939894"
variation 6066
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200753477"
variation 6100
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:374433157"
variation 6185
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370975833"
variation 6210
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376095529"
variation 6220
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:367794675"
variation 6257
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:11752373"
variation 6324
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368628751"
variation 6332
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:112756481"
variation 6370
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:371344448"
variation 6529
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:372563597"
variation 6549
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:370145460"
STS 6578..6719
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/standard_name="RH47433"
/db_xref="UniSTS:49695"
variation 6659
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:142161883"
variation 6726..6727
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="tt"
/db_xref="dbSNP:71864478"
polyA_signal 6785..6790
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
polyA_site 6811
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
ORIGIN
aaaggaaccgggttgtcttgggccgggcagggcgggtaagttgtcgtaggggcccggtccgtgagggactgctaaggaagaggctgcatggcgcggtagtcccccgagtggaggtcggctgcccctgggaaaccagagagtcggagggagtccatctggagcggccaagtaggtcggggaagggccgcgcctgacgtctggccgcaggtggtgactctcaaaaggaaataggatcatggcagcagatgatgacaatggtgatggaacaagtttatttgatgtcttttctgcttctcctcttaagaacaatgatgaaggctcactggacatatacgctgggttggacagtgctgtttctgacagcgcttccaaatcctgtgtaccatcaagaaattgtttggacttatatgaagagatcctgactgaagaaggaactgcaaaggaggcaacatataatgatttgcaagtagaatatggaaaatgtcaactacaaatgaaagagctgatgaaaaaatttaaagaaatacagacacagaatttcagcttaataaacgaaaaccagtctcttaagaagaatatttcagcacttatcaaaactgccagagtggaaataaaccgcaaggatgaagaaataagtaatcttcaccaaagattgtctgagtttccacattttcgaaataatcataaaactgcaaggacatttgatacagttaaaacaaaagatcttaaatctagatctccacatttggatgattgttcaaagactgatcacagagctaaaagtgatgtttctaaagatgtacatcatagcacttcactgccaaatctggaaaaggaaggaaaaccacattctgataaaaggagtacttcacatttacctacatctgttgagaaacactgcactaatggtgtttggtcacgttctcattatcaggttggcgagggtagctcaaatgaggatagtagaagaggaagaaaagatattagacatagccagtttaacagaggaactgaaagagtacgaaaagacttaagtactggctgtggtgatggtgaaccaaggatattggaggctagtcaaaggctacaaggacatcctgagaaatatggtaaaggtgaaccaaagactgaaagcaaaagttcgaagtttaaaagtaactcagattctgactataaaggtgaacgcattaactcttcttgggagaaagagacccctggagaaaggtcacacagtcgagtagactctcaaagtgacaaaaaactagaaagacaaagtgaaagatcacaaaatataaataggaaagaagttaaatcacaagacaaagaagaaagaaaagttgatcaaaaacctaaatcagtagtaaaggaccaagatcactggagaagatctgaacgagcatcacttcctcattccaagaatgaaataacattttctcataattcaagtaaataccatctagaagagagaagaggatgggaagattgtaaaagagacaagagtgtaaacagtcatagttttcaagatggaagatgtccatcttctctttcaaacagtagaactcacaaaaacattgactctaaggaagttgatgccatgcatcagtgggaaaatacacctttaaaagcagaaagacatagaactgaagataagaggaaaagagaacaagaaagcaaagaagaaaataggcatattagaaatgaaaaaagagtacctacagaacatttgcagaagactaataaggaaactaagaaaaccactactgatttaaagaaacagaatgaaccaaagactgataagggagaagtccttgataatggtgtttctgaaggagcagataataaagagcttgcaatgaaagctgagagtggtccaaatgaaacaaaaaacaaggacctaaaattgagttttatgaaaaaattgaacttaactctttctcctgctaaaaagcaacctgtttcccaggataatcagcataaaataactgatattcccaagtccagtggtgtatgtgattcagagtcttcaatgcaagttaaaacagtggcatatgttccctccataagtgaacatatcttgggggaagcagctgtcagtgaacataccatgggggaaaccaagtcaacgttattggaaccaaaggttgctcttctagcagtgactgaacccaggatcggtatctcagaaaccaacaaggaagacgaaaatagtttgttagttaggtctgttgacaatactatgcattgtgaagagcccatttgtggtacagagacttccttcccatctcctatggaaatacaacagacagaatccttgtttccatcaacaggaatgaaacaaaccattaataatggaagggcagcagctcctgtggtaatggatgtattacaaacagatgtgtctcaaaactttggcttggaattggataccaaaagaaatgataattcagattattgtggtatttctgaaggtatggagatgaaggtggcactttcaacaacagtgagtgaaaccactgaaagcattttgcagccttcaattgaggaagctgatattttgccaataatgctttcagaagataataacccaaaatttgagccttctgttatagttacaccactggttgagagtaagtcgtgtcatctggagccttgcttacctaaagagactctagattcttcacttcagcagactgagttaatggaccacagaatggcaactggtgaaacaaactcagtatatcatgatgatgataactcggttttgagcattgaccttaatcacctgagacctattccagaagccatcagtcctctgaatagtccagtgagacctgtagcaaaagttcttagaaatgaaagcccacctcaagttccagtgtataataacagtcataaagatgtgtttttaccaaattcagctcattctacctctaagagtcagtctgatctcaataaggaaaatcaaaagccaatttacaaatctgacaaatgtacagaagcagacacatgtaagaattcaccattagatgaattagaagaaggagaaattagaagtgatagtgaaacatctaaaccacaagaaagttttgaaaaaaattccaaacgtagagtgtcagctgatgtgcggaagtcaaagactatcccacgacgtgggaaaagtactgtgtgtttagataaagacagtaggaaaacacatgtaagaatccatcagaccaataacaaatggaataaaagacctgataaatctagcagatcttcaaaaacagagaagaaagataaagtgatgagcacttccagcttggaaaaaatagttccaattattgctgtaccctcttctgaacaagagatcatgcacatgttacgaatgataagaaaacatgtaagaaaaaattatatgaaattcaaggcaaaattttcattaatacaatttcacagaattattgagtcagcaattttgagttttacatctttaattaaacatctcaacttacacaaaatctctaagtcagtgactaccttacagaagaatctctgtgatattatagagtctaaacttaagcaagttaaaaagaatggcatagttgatcgtttatttgaacagcaactaccagatatgaaaaaaaaattgtggaagtttgtagatgaccaacttgattatttgtttgcaaagcttaagaaaatcttagtatgtgattccaaaagctttggaagagatagtgatgaaggcaaacttgaaaaaacaagtaaacagaatgcacagtattcaaatagtcagaaaaggagtgtggacaactccaacagagaattgctgaaagaaaaattatcaaaatcagaagaccctgttcattataagtctttagtgggatgtaaaaaatctgaggaaaattatcaagaccaaaataactccagtattaacactgtaaagcatgacattaaaaaaaattttaacatctgctttgataatataaagaactctcaatccgaagagcgctccttggaagtacactgtccaagcaccccaaagtcagaaaaaaacgaaggaagcagcatagaggatgcacagacatcccagcatgcaactttgaagccagaacgaagtttcgagattcttaccgaacagcaagcatcgagccttacttttaatttagtgagtgatgcacaaatgggtgaaatatttaaaagtttgttgcaaggttctgatcttttagacagcagtgttaactgtactgaaaaaagtgagtgggagttaaagactccagagaagcagctgctagagactcttaagtgcgagtctataccagcttgtacaacagaagagctagtttcaggggtggcttctccatgtcctaaaatgattagtgatgataattggtcattattatcatctgaaaaaggtccatctctgtcttcagggctttcattgccggttcatcctgatgtgttggatgaaagttgtatgtttgaagtgtctactaacctacctttaagtaaagataatgtgtgtagtgtagaaaagagcaagccctgcgtttcttccatacttcttgaagatctagcagtctctttaacagtaccatcgcctctgaagtcagatggtcatctcagttttttaaagcctgatatgtcgtccagttcaactcctgaagaagtcattagtgctcattttagtgaagatgccttacttgaggaagaggatgcatctgagcaagatattcatttagctctggagtctgataattcaagcagtaaatcaagttgttcttcttcctggacaagccgatctgttgctccaggctttcagtaccaccctaatctacctatgcatgccgtcataatggaaaagtccaatgatcatttcattgtgaaaatacgacgtgcaacaccatctacctcttctggccttaaacagagtatgatgcctgatgaattattgacatctttgcccagacatggaaaggaagctgatgaaggaccagagaaagaatatatttcatgtcagaacacagtttttaaatctgtggaggaattggaaaactccaacaaaaatgttgatggcagcaagtcaactcatgaagaacagagctctatgatacaaacacaggttcctgatatatatgaatttcttaaagatgcttcagataagatgggtcatagtgatgaagtggctgatgaatgtttcaaattgcatcaagtatgggaaacaaaagtgcctgaaagcattgaagaattgccttcaatggaagaaatctcacactctgttggggaacatcttccaaacacatacgtagatctaacgaaagatccagtcactgaaaccaaaaacttgggggaattcatagaagtaacagttttacatattgatcagttgggatgttctggaggcaatttaaatcagagtgctcaaatattagacaattctttgcaggctgatactgtaggtgcttttattgatttgacacaagatgcttcaagtgaggctaaaagtgaaggtaatcatcctgcattagctgtggaagacttgggatgtggggtgatacaggtagatgaagataattgtaaggaagaaaaggcacaagtggcaaacaggcctttaaaatgcattgttgaggaaacctatatcgacttgaccacagaatctcccagttcatgtgaagtaaaaaaagatgagttaaaatcagagccaggatcaaattgtgataactcggagttgcctgggactttgcataattctcacaaaaagagaagaaacatttctgatctaaatcatcctcataaaaaacaaagaaaggaaacagacttaactaataaggaaaagaccaagaaacctacccaagattcttgtgagaatactgaagctcaccaaaagaaagccagtaagaagaaggcccctcctgtgactaaagatccctcatcattaaaggcaaccccagggattaaggattcatcagcagcacttgccacttctacaagtctttctgcaaaaaatgttattaaaaagaagggagaaattatcattttatggacaagaaatgatgaccgggaaattttattggagtgtcagaaaagagggccatcatttaaaacatttgcatatttagccgccaagttggataaaaatccaaatcaggtctcagaaagattccagcagctaatgaagctctttgaaaagtcaaaatgcagataagttgctgaattcctgggactcttaactgatattgcatactacacagaagcttcaaattcctcatgttttaaatgagcactagagggaggtttatcacctttttggttaccagatgataatctatatttgttattactcagtgactctctaatttcacatcagcatgttcagcttgtgctagtcatcattctgatttgcttatctgtttttggtcaaaatatttatttttaaacatgttagaacttaccaaaatgaaagcaacagtgatgtattgaaatcttagttttgatattttaaagaaatgactttctagattaaaaaaatagttttgtagcattttaaacttagtgactatttagttcaattgttcatccattttttatttgcttttataattgcctccttgttttggtatattgtaaaataatttaaataatgtatttataaatatgtataattatgatgtaaaataccgtgtgtatatgtatgtatgtgtgtttctgtatatgcacacacataaacggctttgcctagccaaggattttttttatctgtataaaactttttgtataaagtttgctttcaataacagtaatgtataataaaaccatgtaaagttttgttgtaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9994 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:9994 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
GeneID:9994 -> Molecular function: GO:0005123 [death receptor binding] evidence: TAS
GeneID:9994 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9994 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: ISS
GeneID:9994 -> Molecular function: GO:0016505 [peptidase activator activity involved in apoptotic process] evidence: ISS
GeneID:9994 -> Molecular function: GO:0032184 [SUMO polymer binding] evidence: IDA
GeneID:9994 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:9994 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IMP
GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: ISS
GeneID:9994 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:9994 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: IMP
GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: ISS
GeneID:9994 -> Biological process: GO:0036337 [Fas signaling pathway] evidence: IMP
GeneID:9994 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:9994 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:9994 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9994 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:9994 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:9994 -> Cellular component: GO:0016605 [PML body] evidence: IDA
by
@meso_cacase at
DBCLS
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