2025-05-09 16:46:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006461 3824 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens sperm associated antigen 5 (SPAG5), mRNA. ACCESSION NM_006461 VERSION NM_006461.3 GI:73623034 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3824) AUTHORS Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M., Vierkant,R.A., Cerhan,J.R. and Couch,F.J. TITLE Centrosome-related genes, genetic variation, and risk of breast cancer JOURNAL Breast Cancer Res. Treat. 125 (1), 221-228 (2011) PUBMED 20508983 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 2 (bases 1 to 3824) AUTHORS Manning,A.L., Bakhoum,S.F., Maffini,S., Correia-Melo,C., Maiato,H. and Compton,D.A. TITLE CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity JOURNAL EMBO J. 29 (20), 3531-3543 (2010) PUBMED 20852589 REMARK GeneRIF: Data show that CLASP1-astrin-Kif2b complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments. REFERENCE 3 (bases 1 to 3824) AUTHORS Liu,L., Akhter,S., Bae,J.B., Mukhopadhyay,S.S., Richie,C.T., Liu,X. and Legerski,R. TITLE SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint JOURNAL Cell Cycle 8 (4), 628-638 (2009) PUBMED 19197158 REMARK GeneRIF: Results suggest that SNM1B/Apollo and Astrin function together to enforce the prophase checkpoint in response to spindle stress. REFERENCE 4 (bases 1 to 3824) AUTHORS Du,J., Jablonski,S., Yen,T.J. and Hannon,G.J. TITLE Astrin regulates Aurora-A localization JOURNAL Biochem. Biophys. Res. Commun. 370 (2), 213-219 (2008) PUBMED 18361916 REMARK GeneRIF: Astrin acts upstream of Aurora-A to regulate its mitotic spindle localization. REFERENCE 5 (bases 1 to 3824) AUTHORS Cheng,T.S., Hsiao,Y.L., Lin,C.C., Yu,C.T., Hsu,C.M., Chang,M.S., Lee,C.I., Huang,C.Y., Howng,S.L. and Hong,Y.R. TITLE Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin JOURNAL J. Biol. Chem. 283 (4), 2454-2464 (2008) PUBMED 18055457 REMARK GeneRIF: GSK3beta interacts with and phosphorylates the spindle-associated protein Astrin, resulting in targeting Astrin to the spindle microtubules and kinetochores. REFERENCE 6 (bases 1 to 3824) AUTHORS Yang,Y.C., Hsu,Y.T., Wu,C.C., Chen,H.T. and Chang,M.S. TITLE Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells JOURNAL Biochem. Biophys. Res. Commun. 343 (2), 428-434 (2006) PUBMED 16546135 REMARK GeneRIF: These findings suggest that the silencing of astrin induce a p53-dependent apoptosis and has an additive effect on paclitaxel treatment. REFERENCE 7 (bases 1 to 3824) AUTHORS Le,X.F., Lammayot,A., Gold,D., Lu,Y., Mao,W., Chang,T., Patel,A., Mills,G.B. and Bast,R.C. Jr. TITLE Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling JOURNAL J. Biol. Chem. 280 (3), 2092-2104 (2005) PUBMED 15504738 REFERENCE 8 (bases 1 to 3824) AUTHORS Gruber,J., Harborth,J., Schnabel,J., Weber,K. and Hatzfeld,M. TITLE The mitotic-spindle-associated protein astrin is essential for progression through mitosis JOURNAL J. Cell. Sci. 115 (PT 21), 4053-4059 (2002) PUBMED 12356910 REFERENCE 9 (bases 1 to 3824) AUTHORS Mack,G.J. and Compton,D.A. TITLE Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (25), 14434-14439 (2001) PUBMED 11724960 REFERENCE 10 (bases 1 to 3824) AUTHORS Chang,M.S., Huang,C.J., Chen,M.L., Chen,S.T., Fan,C.C., Chu,J.M., Lin,W.C. and Yang,Y.C. TITLE Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins JOURNAL Biochem. Biophys. Res. Commun. 287 (1), 116-121 (2001) PUBMED 11549262 REMARK GeneRIF: hMap126 is abundantly expressed in testis and localized in mitotic spindle and may be involved in the functional and dynamic regulation of mitotic spindles. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI459711.1, BC000322.2 and BQ773438.1. On Aug 19, 2005 this sequence version replaced gi:46399193. Summary: This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF063308.1, AF399910.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-300 BI459711.1 4-303 301-3797 BC000322.2 261-3757 3798-3824 BQ773438.1 1-27 c FEATURES Location/Qualifiers source 1..3824 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q11.2" gene 1..3824 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /note="sperm associated antigen 5" /db_xref="GeneID:10615" /db_xref="HGNC:13452" exon 1..143 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" misc_feature 36..38 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /note="upstream in-frame stop codon" CDS 93..3674 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /note="mitotic spindle coiled-coil related protein; astrin; mitotic spindle associated protein p126; mitotic spindle-associated protein p126" /codon_start=1 /product="sperm-associated antigen 5" /protein_id="NP_006452.3" /db_xref="GI:73623035" /db_xref="CCDS:CCDS32594.1" /db_xref="GeneID:10615" /db_xref="HGNC:13452" /translation="
MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFLS
" misc_feature 219..221 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 276..278 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 276..278 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 288..290 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 288..290 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 423..425 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 495..497 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 495..497 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 837..839 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1092..1094 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 1092..1094 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1098..1100 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 1113..1115 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 1113..1115 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1149..1151 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1176..1178 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96R06.2); phosphorylation site" misc_feature 1176..1178 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1182..1184 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1221..1223 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1257..1259 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1281..1283 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1284..1286 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1293..1295 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1536..2642 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q96R06.2); Region: Interaction with KNSTRN" misc_feature <1869..>2678 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /note="chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168" /db_xref="CDD:162739" misc_feature 2901..2903 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 144..269 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" variation 165 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /replace="c" /replace="t" /db_xref="dbSNP:11540040" exon 270..1354 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" STS 734..976 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /standard_name="RH79796" /db_xref="UniSTS:89253" exon 1355..1529 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 1530..1604 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 1605..1697 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 1698..1832 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 1833..1952 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 1953..2045 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 2046..2159 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" STS 2153..3447 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /standard_name="D1S3690" /db_xref="UniSTS:474268" exon 2160..2253 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 2254..2401 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 2402..2504 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 2505..2638 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" variation 2519 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /replace="a" /replace="g" /db_xref="dbSNP:11540041" exon 2639..2777 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 2778..2889 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 2890..2976 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 2977..3097 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 3098..3209 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 3210..3290 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 3291..3446 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 3447..3521 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" STS 3499..3669 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /standard_name="RH102973" /db_xref="UniSTS:97307" exon 3522..3602 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" exon 3603..3808 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /inference="alignment:Splign:1.39.8" STS 3653..3780 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /standard_name="G21480" /db_xref="UniSTS:76245" polyA_signal 3780..3785 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" polyA_site 3799 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" /experiment="experimental evidence, no additional details recorded" polyA_site 3808 /gene="SPAG5" /gene_synonym="DEEPEST; hMAP126; MAP126" ORIGIN
ggaagcgcagagcaggttcaaacacagacggcgggtgaacatggcgtcctcgacttggtctgagacgtgataggcctgccttctggttgaagatgtggcgagtgaaaaaactgagcctcagcctgtcgccttcgccccagacgggaaaaccatctatgagaactcctctccgtgaacttaccctgcagcccggtgccctcaccaactctggaaaaagatcccccgcttgctcctcgctgaccccatcactgtgcaagctggggctgcaggaaggcagcaacaactcatctccagtggattttgtaaataacaagaggacagacttatcttcagaacatttcagtcattcctcaaagtggctagaaacttgtcagcatgaatcagatgagcagcctctagatccaattccccaaattagctctactcctaaaacgtctgaggaagcagtagacccactgggcaattatatggttaaaaccatcgtccttgtaccatctccactggggcagcaacaagacatgatatttgaggcccgtttagataccatggcagagacaaacagcatatctttaaatggacctttgagaacagacgatctggtgagagaggaggtggcaccctgcatgggagacaggttttcagaagttgctgctgtatctgagaaacctatctttcaggaatctccgtcccatctcttagaggagtctccaccaaatccctgttctgaacaactacattgctccaaggaaagcctgagcagtagaactgaggctgtgcgtgaggacttagtaccttctgaaagtaacgccttcttgccttcctctgttctctggctttccccttcaactgccttggcagcagatttccgtgtcaatcatgtggacccagaggaggaaattgtagagcatggagctatggaggaaagagaaatgaggtttcccacacatcctaaggagtctgaaacagaagatcaagcacttgtctcaagtgtggaagatattctgtccacatgcctgacaccaaatctagtagaaatggaatcccaagaagctccaggcccagcagtagaagatgttggtaggattcttggctctgatacagagtcttggatgtccccactggcctggctggaaaaaggtgtaaatacctccgtcatgctggaaaatctccgccaaagcttatcccttccctcgatgcttcgggatgctgcaattggcactacccctttctctacttgctcggtggggacttggtttactccttcagcaccacaggaaaagagtacaaacacatcccagacaggcctggttggcaccaagcacagtacttctgagacagagcagctcctgtgtggccggcctccagatctgactgccttgtctcgacatgacttggaagataacctgctgagctctcttgtcattctggaggttctctcccgccagcttcgggactggaagagccagctggctgtccctcacccagaaacccaggacagtagcacacagactgacacatctcacagtgggataactaataaacttcagcatcttaaggagagccatgagatgggacaggccctacagcaggccagaaatgtcatgcaatcatgggtgcttatctctaaagagctgatatccttgcttcacctatccctgttgcatttagaagaagataagactactgtgagtcaggagtctcggcgtgcagaaacattggtctgttgctgttttgatttgctgaagaaattgagggcaaagctccagagcctcaaagcagaaagggaggaggcaaggcacagagaggaaatggctctcagaggcaaggatgcggcagagatagtgttggaggctttctgtgcacacgccagccagcgcatcagccagctggaacaggacctagcatccatgcgggaattcagaggccttctgaaggatgcccagacccaactggtagggcttcatgccaagcaagaagagctggttcagcagacagtgagtcttacttctaccttgcaacaagactggaggtccatgcaactggattatacaacatggacagctttgctgagtcggtcccgacaactcacagagaaactcacagtcaagagccagcaagccctgcaggaacgtgatgtggcaattgaggaaaagcaggaggtttctagggtgctggaacaagtctctgcccagttagaggagtgcaaaggccaaacagaacaactggagttggaaaacagtcgtctagcaacagatctccgggctcagttgcagattctggccaacatggacagccagctaaaagagctacagagtcagcatacccattgtgcccaggacctggctatgaaggatgagttactctgccagcttacccagagcaatgaggagcaggctgctcaatggcaaaaggaagagatggcactaaaacacatgcaggcagaactgcagcagcaacaagctgtcctggccaaagaggtgcgggacctgaaagagaccttggagtttgcagaccaggagaatcaggttgctcacctggagctgggtcaggttgagtgtcaattgaaaaccacactggaagtgctccgggagcgcagcttgcagtgtgagaacctcaaggacactgtagagaacctaacggctaaactggccagcaccatagcagataaccaggagcaagatctggagaaaacacggcagtactctcaaaagctagggctgctgactgagcaactacagagcctgactctctttctacagacaaaactaaaggagaagactgaacaagagacccttctgctgagtacagcctgtcctcccacccaggaacaccctctgcctaatgacaggaccttcctgggaagcatcttgacagcagtggcagatgaagagccagaatcaactcctgtgcccttgcttggaagtgacaagagtgctttcacccgagtagcatcaatggtttcccttcagcccgcagagaccccaggcatggaggagagcctggcagaaatgagtattatgactactgagcttcagagtctttgttccctgctacaagagtctaaagaagaagccatcaggactctgcagcgaaaaatttgtgagctgcaagctaggctgcaggcccaggaagaacagcatcaggaagtccagaaggcaaaagaagcagacatagagaagctgaaccaggccttgtgcttgcgctacaagaatgaaaaggagctccaggaagtgatacagcagcagaatgagaagatcctagaacagatagacaagagtggcgagctcataagccttagagaggaggtgacccaccttacccgctcacttcggcgtgcggagacagagaccaaagtgctccaggaggccctggcaggccagctggactccaactgccagcctatggccaccaattggatccaggagaaagtgtggctctctcaggaggtggacaaactgagagtgatgttcctggagatgaaaaatgagaaggaaaaactcatgatcaagttccagagccatagaaatatcctagaggagaaccttcggcgctctgacaaggagttagaaaaactagatgacattgttcagcatatttataagaccctgctctctattccagaggtggtgaggggatgcaaagaactacagggattgctggaatttctgagctaagaaactgaaagccagaatctgcttcacctctttttacctgcaatacccccttaccccaataccaagaccaactggcatagagccaactgagataaatgctatttaaataaagtgtatttaatgaatttctccaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:10615 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:10615 -> Biological process: GO:0000070 [mitotic sister chromatid segregation] evidence: IMP GeneID:10615 -> Biological process: GO:0000090 [mitotic anaphase] evidence: IMP GeneID:10615 -> Biological process: GO:0007049 [cell cycle] evidence: NAS GeneID:10615 -> Biological process: GO:0007051 [spindle organization] evidence: IMP GeneID:10615 -> Biological process: GO:0007051 [spindle organization] evidence: NAS GeneID:10615 -> Biological process: GO:0007059 [chromosome segregation] evidence: IMP GeneID:10615 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: NAS GeneID:10615 -> Biological process: GO:0051301 [cell division] evidence: IEA GeneID:10615 -> Biological process: GO:0051988 [regulation of attachment of spindle microtubules to kinetochore] evidence: IMP GeneID:10615 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA GeneID:10615 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IEA GeneID:10615 -> Cellular component: GO:0000922 [spindle pole] evidence: IEA GeneID:10615 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:10615 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:10615 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:10615 -> Cellular component: GO:0005876 [spindle microtubule] evidence: IEA GeneID:10615 -> Cellular component: GO:0035371 [microtubule plus end] evidence: IDA GeneID:10615 -> Cellular component: GO:0072686 [mitotic spindle] evidence: IDA
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