2025-05-09 16:30:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005441 2297 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens chromatin assembly factor 1, subunit B (p60) (CHAF1B), mRNA. ACCESSION NM_005441 VERSION NM_005441.2 GI:45827788 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2297) AUTHORS Staibano,S., Mascolo,M., Rocco,A., Lo Muzio,L., Ilardi,G., Siano,M., Pannone,G., Vecchione,M.L., Nugnes,L., Califano,L., Zamparese,R., Bufo,P. and De Rosa,G. TITLE The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours JOURNAL Oncol. Rep. 25 (1), 13-22 (2011) PUBMED 21109952 REMARK GeneRIF: Overexpression of CAF-1/p60, on histological and/or cytological samples, characterizes malignant salivary gland tumours with aggressive behaviour REFERENCE 2 (bases 1 to 2297) AUTHORS Polo,S.E., Theocharis,S.E., Grandin,L., Gambotti,L., Antoni,G., Savignoni,A., Asselain,B., Patsouris,E. and Almouzni,G. TITLE Clinical significance and prognostic value of chromatin assembly factor-1 overexpression in human solid tumours JOURNAL Histopathology 57 (5), 716-724 (2010) PUBMED 21083601 REMARK GeneRIF: CAF-1 is a proliferation marker in various malignant tumours with prognostic value in renal, endometrial and cervical carcinomas, which supports the value of CAF-1 as a clinical marker of cancer progression. REFERENCE 3 (bases 1 to 2297) AUTHORS Mascolo,M., Vecchione,M.L., Ilardi,G., Scalvenzi,M., Molea,G., Di Benedetto,M., Nugnes,L., Siano,M., De Rosa,G. and Staibano,S. TITLE Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients JOURNAL BMC Cancer 10, 63 (2010) PUBMED 20178651 REMARK GeneRIF: Chromatin Assembly Factor-1/p60 may have a role in progression and metastasis of melanoma Publication Status: Online-Only REFERENCE 4 (bases 1 to 2297) AUTHORS Loyola,A., Tagami,H., Bonaldi,T., Roche,D., Quivy,J.P., Imhof,A., Nakatani,Y., Dent,S.Y. and Almouzni,G. TITLE The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin JOURNAL EMBO Rep. 10 (7), 769-775 (2009) PUBMED 19498464 REMARK GeneRIF: The histone H3K9 methyltransferase SetDB1 associates with the specific heterochromatin protein 1alpha (HP1alpha)-chromatin assembly factor 1 (CAF1) chaperone complex. REFERENCE 5 (bases 1 to 2297) AUTHORS Staibano,S., Mascolo,M., Mancini,F.P., Kisslinger,A., Salvatore,G., Di Benedetto,M., Chieffi,P., Altieri,V., Prezioso,D., Ilardi,G., De Rosa,G. and Tramontano,D. TITLE Overexpression of chromatin assembly factor-1 (CAF-1) p60 is predictive of adverse behaviour of prostatic cancer JOURNAL Histopathology 54 (5), 580-589 (2009) PUBMED 19309489 REMARK GeneRIF: overexpression of CAF-1/p60 characterized prostatic cancers with a worse prognosis REFERENCE 6 (bases 1 to 2297) AUTHORS Verreault,A., Kaufman,P.D., Kobayashi,R. and Stillman,B. TITLE Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4 JOURNAL Cell 87 (1), 95-104 (1996) PUBMED 8858152 REFERENCE 7 (bases 1 to 2297) AUTHORS Katsanis,N. and Fisher,E.M. TITLE The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome JOURNAL Hum. Genet. 98 (4), 497-499 (1996) PUBMED 8792829 REFERENCE 8 (bases 1 to 2297) AUTHORS Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and Westendorf,J.M. TITLE Identification of novel M phase phosphoproteins by expression cloning JOURNAL Mol. Biol. Cell 7 (9), 1455-1469 (1996) PUBMED 8885239 REFERENCE 9 (bases 1 to 2297) AUTHORS Blouin,J.L., Duriaux-Sail,G., Chen,H., Gos,A., Morris,M.A., Rossier,C. and Antonarakis,S.E. TITLE Mapping of the gene for the p60 subunit of the human chromatin assembly factor (CAF1A) to the Down syndrome region of chromosome 21 JOURNAL Genomics 33 (2), 309-312 (1996) PUBMED 8660983 REFERENCE 10 (bases 1 to 2297) AUTHORS Kaufman,P.D., Kobayashi,R., Kessler,N. and Stillman,B. TITLE The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication JOURNAL Cell 81 (7), 1105-1114 (1995) PUBMED 7600578 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL711314.1, BC001143.1 and BC021218.2. On Mar 30, 2004 this sequence version replaced gi:4885104. Summary: Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313152.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025082, ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-24 AL711314.1 5-28 25-68 BC001143.1 1-44 69-2297 BC021218.2 1-2229 FEATURES Location/Qualifiers source 1..2297 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="21" /map="21q22.13" gene 1..2297 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /note="chromatin assembly factor 1, subunit B (p60)" /db_xref="GeneID:8208" /db_xref="HGNC:1911" /db_xref="HPRD:03147" /db_xref="MIM:601245" exon 1..61 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 40..43 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="" /replace="ctga" /db_xref="dbSNP:371096914" exon 62..264 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" misc_feature 85..87 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /note="upstream in-frame stop codon" variation 99 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:368209090" variation 116 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:372478630" CDS 139..1818 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /note="human chromatin assembly factor-I p60 subunit; chromatin assembly factor I p60 subunit; CAF-1 subunit B; CAF-I 60 kDa subunit; M-phase phosphoprotein 7; CAF-I p60" /codon_start=1 /product="chromatin assembly factor 1 subunit B" /protein_id="NP_005432.1" /db_xref="GI:4885105" /db_xref="CCDS:CCDS13644.1" /db_xref="GeneID:8208" /db_xref="HGNC:1911" /db_xref="HPRD:03147" /db_xref="MIM:601245" /translation="
MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELRPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRPRLDENKGGTESLDP
" misc_feature <142..771 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /note="FOG: WD40 repeat [General function prediction only]; Region: COG2319" /db_xref="CDD:32473" misc_feature 169..300 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13112.1); Region: WD 1" misc_feature <175..891 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567" /db_xref="CDD:207648" misc_feature order(235..237,250..252,268..273,331..333,382..384, 397..399,415..417,481..483,517..522,574..576,586..588, 604..609,643..648,697..699,712..714,730..735,781..783, 823..825,889..891) /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /note="structural tetrad; other site" /db_xref="CDD:29257" misc_feature 328..447 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13112.1); Region: WD 2" misc_feature 418..>1299 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /note="FOG: WD40 repeat [General function prediction only]; Region: COG2319" /db_xref="CDD:32473" misc_feature 517..636 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13112.1); Region: WD 3" misc_feature 643..762 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13112.1); Region: WD 4" misc_feature 820..975 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13112.1); Region: WD 5" misc_feature 1033..1158 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13112.1); Region: WD 6" misc_feature 1168..1293 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13112.1); Region: WD 7" misc_feature 1363..1365 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13112.1); phosphorylation site" misc_feature 1363..1365 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1393..1395 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q13112.1); phosphorylation site" misc_feature 1402..1404 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1423..1425 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13112.1); phosphorylation site" misc_feature 1423..1425 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1435..1437 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q13112.1); phosphorylation site" misc_feature 1510..1512 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13112.1); phosphorylation site" misc_feature 1510..1512 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1618..1620 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q13112.1); acetylation site" misc_feature 1750..1752 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13112.1); phosphorylation site" misc_feature 1750..1752 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" variation 183 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:376058259" variation 185 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:143543321" variation 220 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:142093091" variation 243 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:369391435" variation 244 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="g" /replace="t" /db_xref="dbSNP:373045673" exon 265..397 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 303 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:150756912" variation 326 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:62229404" variation 341 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:145043768" variation 366 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:376476845" variation 384 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="t" /db_xref="dbSNP:370681660" exon 398..515 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 403 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:372344270" variation 498 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:374395395" variation 511 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:56118104" exon 516..619 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 537 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:371404730" variation 546 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:375376353" variation 566 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:199719028" variation 567 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:369456414" variation 571 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:201731956" exon 620..716 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 632 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:147952403" variation 634 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:140630794" variation 640 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:150455108" variation 678 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:372761555" variation 681 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="g" /replace="t" /db_xref="dbSNP:145372971" variation 701 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:377214460" exon 717..801 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 720 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:375539352" variation 733 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:149193400" variation 748 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:201339256" exon 802..895 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 825 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:138882376" variation 828 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:373907249" variation 846 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:114386479" variation 873 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:139980774" variation 891 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="g" /replace="t" /db_xref="dbSNP:371289350" exon 896..965 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 933 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:200436991" variation 940 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:201944985" exon 966..1057 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 1000 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:193921141" variation 1012 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:140663225" variation 1050 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:148060266" exon 1058..1199 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 1089 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:113388736" variation 1116 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:199657347" variation 1117 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:150591609" variation 1120 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:377324005" variation 1158 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:370336150" variation 1185 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:200144938" exon 1200..1631 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 1207 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:140609932" variation 1236 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="g" /replace="t" /db_xref="dbSNP:376882750" variation 1239 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:200643242" variation 1251 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:142817288" variation 1302 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:147369174" variation 1311 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:139594054" variation 1382 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:115050809" variation 1383 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:376013076" variation 1396 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:201581262" variation 1397 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:375927375" variation 1404 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:369251042" variation 1409 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:376201329" variation 1418 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:148582638" variation 1440 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:142952612" variation 1520 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:368621019" variation 1521 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:201486922" variation 1529 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:372352704" variation 1535 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:375860533" variation 1556 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:185949588" variation 1575 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:114018584" variation 1578 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:374268527" variation 1596 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:141027936" variation 1630 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:143837442" exon 1632..1726 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 1645 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:375302132" variation 1654 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:74900401" variation 1658 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:115392153" variation 1671 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:145634790" variation 1673 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:369040613" variation 1697 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:200840491" variation 1703 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:375381530" exon 1727..2279 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /inference="alignment:Splign:1.39.8" variation 1749 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:138120217" variation 1750 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:377266252" variation 1755 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="c" /db_xref="dbSNP:149139435" variation 1770 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="g" /replace="t" /db_xref="dbSNP:143171594" variation 1780 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:376573502" variation 1795 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:200304218" variation 1799 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:201964602" STS 1811..2008 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /standard_name="STS-U20980" /db_xref="UniSTS:9190" variation 1814 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:148277419" variation 1843 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="g" /db_xref="dbSNP:181653099" variation 1846 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:377724094" variation 1856 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:377511926" variation 1857 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="g" /replace="t" /db_xref="dbSNP:202093155" variation 1858 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:371122870" variation 1864 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:374622617" variation 1999 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:113542793" STS 2014..2164 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /standard_name="D21S1939" /db_xref="UniSTS:63591" variation 2034 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="g" /db_xref="dbSNP:8596" variation 2073 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="c" /replace="t" /db_xref="dbSNP:185095355" STS 2092..2275 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /standard_name="G34657" /db_xref="UniSTS:78156" variation 2099 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="g" /replace="t" /db_xref="dbSNP:376663242" variation 2153 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" /replace="a" /replace="t" /db_xref="dbSNP:372828379" polyA_signal 2262..2267 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" polyA_site 2279 /gene="CHAF1B" /gene_synonym="CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7" ORIGIN
cgggaagcggcgcgcgctgcgcgggaggtgacggtgcctctgactgtccgggtccctccagcattttgcagctttctcctgtcttgaagaagtagaacggtgcccgagaaacgtttttccccttcgagactcaggaggatgaaagtcatcacttgtgaaatagcctggcacaacaaggagcccgtgtacagcctggacttccagcatgggacggctgggaggatccacagactggcgtctgccggcgtggacaccaatgtcaggatctggaaggtagaaaagggaccagatggaaaagccatcgtggaatttttgtccaatcttgctcgtcataccaaagccgtcaatgttgtgcgtttttctccaactggggaaattttagcatcgggaggagatgatgctgtcatcctattgtggaaggtgaatgataacaaggagccggagcagatcgcttttcaggatgaggacgaggcccagctgaacaaggagaactggacggttgtgaagactctgcggggccacttagaagatgtgtatgatatttgctgggcaactgatgggaatttaatggcttctgcctctgtggataacacagccatcatatgggatgtcagcaaaggacaaaagatatcaatttttaatgaacataaaagttatgtccaaggagtaacctgggaccctttgggtcaatatgttgctactctgagctgtgacagggtgctgcgagtatacagtatacagaagaagcgtgtggctttcaatgtttcgaagatgctgtctggaataggggctgaaggagaggcaagaagctaccggatgtttcacgacgacagcatgaagtctttcttccgtagactgagtttcactcccgacggatctttgcttctcacgccagctggatgtgtggaatctggtgaaaatgtaatgaataccacttatgttttctccaggaagaatcttaaaaggcccatcgctcatcttccatgtcctggaaaagccactcttgctgttcgctgctgtccggtctactttgaactgaggccagtggtggaaacaggtgtggagctgatgagtctgccctaccgcctggtgtttgctgtggcctcggaggattccgtgcttctgtatgacacccagcagtccttcccttttggttacgtgtctaatatacattaccacaccctcagtgacatttcatggtccagcgatggtgccttcctggccatttcttccacggacggttactgctcatttgtgacatttgagaaagatgaacttggaattcctttgaaagagaagccagttttgaacatgagaactcctgatacagcaaagaaaaccaagagtcagacacatcgagggtcttcgccaggacccagaccggtagagggaacccctgccagcagaacccaagaccccagcagccccggcacgactccccctcaggccagacaggccccagccccaacagtcatcagggaccctccctccatcactcctgctgtcaaaagccccttgccggggccttcggaggagaagaccctgcagcccagtagtcaaaacacaaaagcccacccatcccggagggtcactctgaacacactgcaagcctggagcaagacaacaccccggagaataaacttaacacccttaaagacggacactccaccaagttctgtaccaaccagtgtgatttccaccccttctacagaagaaattcagtcagagacgcctggagacgctcagggcagtcccccagagctaaagcggcccagactcgatgaaaacaaaggaggcacggaaagtctggacccttgatgggacctcggcttctgctcgaagcctaccaggctcccggtgtgtgcagggagacggtaaagctggaggtgcctgagaccagggcttccatggagcgggacacactgtaaatggatttctataacagaagtgacatgtgtactgatttttctccagaaatatggatgctgttgtattcagtatccatttttaacttgggacatgaacgttttaacgtagtaaatcctctttttgatgagtttctgaaactggagcggttcaacgttatccagtgtgaaaatcagtgagtcctccctggcatcctcgtgaaagtgcacacacttcatggagggactccttttcaataagaattaggaagatgagaaagtaatttgagattttactctgtcgaattttagagtatttgaagtgattgttagatttcacttctaaggagttgattgattaaactttggaaggtaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:8208 -> Molecular function: GO:0003682 [chromatin binding] evidence: TAS GeneID:8208 -> Molecular function: GO:0042393 [histone binding] evidence: NAS GeneID:8208 -> Molecular function: GO:0051082 [unfolded protein binding] evidence: TAS GeneID:8208 -> Biological process: GO:0006260 [DNA replication] evidence: IEA GeneID:8208 -> Biological process: GO:0006281 [DNA repair] evidence: IEA GeneID:8208 -> Biological process: GO:0006335 [DNA replication-dependent nucleosome assembly] evidence: TAS GeneID:8208 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA GeneID:8208 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA GeneID:8208 -> Biological process: GO:0006461 [protein complex assembly] evidence: TAS GeneID:8208 -> Biological process: GO:0007049 [cell cycle] evidence: IEA GeneID:8208 -> Biological process: GO:0031497 [chromatin assembly] evidence: IDA GeneID:8208 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:8208 -> Cellular component: GO:0005634 [nucleus] evidence: NAS GeneID:8208 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA GeneID:8208 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:8208 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS GeneID:8208 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:8208 -> Cellular component: GO:0033186 [CAF-1 complex] evidence: IDA
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@meso_cacase at
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