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2025-05-09 16:48:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005347 3973 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein,
78kDa) (HSPA5), mRNA.
ACCESSION NM_005347
VERSION NM_005347.4 GI:305855105
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3973)
AUTHORS Gray,M.J., Mhawech-Fauceglia,P., Yoo,E., Yang,W., Wu,E., Lee,A.S.
and Lin,Y.G.
TITLE AKT inhibition mitigates GRP78 (glucose-regulated protein)
expression and contribution to chemoresistance in endometrial
cancers
JOURNAL Int. J. Cancer 133 (1), 21-30 (2013)
PUBMED 23280503
REMARK GeneRIF: GRP78 is an important mediator in Endometrial Cancer (EC)
cell survival and is associated with malignant disease.
Furthermore, GRP78 contributes to cisplatin resistance, a critical
aspect of disease progression in EC.
REFERENCE 2 (bases 1 to 3973)
AUTHORS Hammadi,M., Oulidi,A., Gackiere,F., Katsogiannou,M., Slomianny,C.,
Roudbaraki,M., Dewailly,E., Delcourt,P., Lepage,G., Lotteau,S.,
Ducreux,S., Prevarskaya,N. and Van Coppenolle,F.
TITLE Modulation of ER stress and apoptosis by endoplasmic reticulum
calcium leak via translocon during unfolded protein response:
involvement of GRP78
JOURNAL FASEB J. 27 (4), 1600-1609 (2013)
PUBMED 23322163
REMARK GeneRIF: Expression of GRP78, an ER stress marker, increased
following treatment with puromycin (a translocon opener) and was
suppressed by anisomycin, confirming a primary role of translocon
in ER stress induction.
REFERENCE 3 (bases 1 to 3973)
AUTHORS Liu,S., Li,K., Li,T., Xiong,X., Yao,S., Chen,Z., Wang,C. and
Zhao,B.
TITLE Association between promoter polymorphisms of the GRP78 gene and
risk of type 2 diabetes in a Chinese Han population
JOURNAL DNA Cell Biol. 32 (3), 119-124 (2013)
PUBMED 23402331
REMARK GeneRIF: No associations of GRP78 polymorphisms with type 2
diabetes were observed in genotypic analyses in a Chinese Han
population.
REFERENCE 4 (bases 1 to 3973)
AUTHORS Ryu,J., Park,S.G., Lee,P.Y., Cho,S., Lee do,H., Kim,G.H., Kim,J.H.
and Park,B.C.
TITLE Dimerization of pro-oncogenic protein Anterior Gradient 2 is
required for the interaction with BiP/GRP78
JOURNAL Biochem. Biophys. Res. Commun. 430 (2), 610-615 (2013)
PUBMED 23220234
REMARK GeneRIF: this study showed that dimerization of AGR2 attenuates ER
stress induced cell death and its dimerization is required for the
interaction with BiP/GRP78.
REFERENCE 5 (bases 1 to 3973)
AUTHORS Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
Coulombe,B.
TITLE A newly uncovered group of distantly related lysine
methyltransferases preferentially interact with molecular
chaperones to regulate their activity
JOURNAL PLoS Genet. 9 (1), E1003210 (2013)
PUBMED 23349634
REMARK GeneRIF: Evidence of trimethylation at Lys-585 by METTL21A
REFERENCE 6 (bases 1 to 3973)
AUTHORS Chao,C.C. and Lin-Chao,S.
TITLE A direct-repeat sequence of the human BiP gene is required for
A23187-mediated inducibility and an inducible nuclear factor
binding
JOURNAL Nucleic Acids Res. 20 (24), 6481-6485 (1992)
PUBMED 1480470
REFERENCE 7 (bases 1 to 3973)
AUTHORS Dawson,S.J. and White,L.A.
TITLE Treatment of Haemophilus aphrophilus endocarditis with
ciprofloxacin
JOURNAL J. Infect. 24 (3), 317-320 (1992)
PUBMED 1602151
REFERENCE 8 (bases 1 to 3973)
AUTHORS Suzuki,C.K., Bonifacino,J.S., Lin,A.Y., Davis,M.M. and
Klausner,R.D.
TITLE Regulating the retention of T-cell receptor alpha chain variants
within the endoplasmic reticulum: Ca(2+)-dependent association with
BiP
JOURNAL J. Cell Biol. 114 (2), 189-205 (1991)
PUBMED 1649196
REFERENCE 9 (bases 1 to 3973)
AUTHORS Dana,R.C., Welch,W.J. and Deftos,L.J.
TITLE Heat shock proteins bind calcitonin
JOURNAL Endocrinology 126 (1), 672-674 (1990)
PUBMED 2294010
REFERENCE 10 (bases 1 to 3973)
AUTHORS Ting,J. and Lee,A.S.
TITLE Human gene encoding the 78,000-dalton glucose-regulated protein and
its pseudogene: structure, conservation, and regulation
JOURNAL DNA 7 (4), 275-286 (1988)
PUBMED 2840249
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA549454.1, BC020235.1,
X87949.1 and AA433933.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 3, 2010 this sequence version replaced gi:194097371.
Summary: The protein encoded by this gene is a member of the heat
shock protein 70 (HSP70) family. It is localized in the lumen of
the endoplasmic reticulum (ER), and is involved in the folding and
assembly of proteins in the ER. As this protein interacts with many
ER proteins, it may play a key role in monitoring protein transport
through the cell.[provided by RefSeq, Sep 2010].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC020235.1, X87949.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088, ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-264 DA549454.1 107-370
265-2445 BC020235.1 208-2388
2446-2579 X87949.1 2404-2537
2580-2735 BC020235.1 2523-2678
2736-3965 BC020235.1 2680-3909
3966-3973 AA433933.1 1-8 c
FEATURES Location/Qualifiers
source 1..3973
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q33.3"
gene 1..3973
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="heat shock 70kDa protein 5 (glucose-regulated
protein, 78kDa)"
/db_xref="GeneID:3309"
/db_xref="HGNC:5238"
/db_xref="HPRD:00682"
/db_xref="MIM:138120"
exon 1..383
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
variation 10..11
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace=""
/replace="g"
/db_xref="dbSNP:35938784"
STS 40..261
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/standard_name="PMC108893P1"
/db_xref="UniSTS:270143"
misc_feature 73..75
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="upstream in-frame stop codon"
variation 76
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:34899577"
variation 138
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="g"
/db_xref="dbSNP:35757312"
variation 208
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542737"
CDS 262..2226
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="78 kDa glucose-regulated protein; immunoglobulin
heavy chain-binding protein; endoplasmic reticulum lumenal
Ca(2+)-binding protein grp78"
/codon_start=1
/product="78 kDa glucose-regulated protein precursor"
/protein_id="NP_005338.1"
/db_xref="GI:16507237"
/db_xref="CCDS:CCDS6863.1"
/db_xref="GeneID:3309"
/db_xref="HGNC:5238"
/db_xref="HPRD:00682"
/db_xref="MIM:138120"
/translation="
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
"
sig_peptide 262..315
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 316..2223
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/product="78 kDa glucose-regulated protein"
misc_feature 343..1437
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="Nucleotide-binding domain of human HSPA5 and
similar proteins; Region: HSPA5-like_NBD; cd10241"
/db_xref="CDD:212681"
misc_feature 349..2166
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="Hsp70 protein; Region: HSP70; pfam00012"
/db_xref="CDD:200927"
misc_feature order(361..363,367..378,547..549,778..780,862..864,
931..948,952..954,1024..1029,1138..1140,1147..1152,
1348..1356,1360..1365,1432..1434)
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="nucleotide binding site [chemical binding]; other
site"
/db_xref="CDD:212681"
misc_feature order(430..432,481..483,493..495,502..507,736..741,
1108..1110,1117..1122,1129..1131,1141..1143,1183..1185,
1189..1194)
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="putative NEF/HSP70 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:212681"
misc_feature order(793..798,802..807,850..855,859..861,985..996)
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/note="SBD interface [polypeptide binding]; other site"
/db_xref="CDD:212681"
misc_feature 1813..1815
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P11021.2); phosphorylation site"
misc_feature 2212..2223
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P11021.2);
Region: Prevents secretion from ER"
variation 270
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="g"
/db_xref="dbSNP:35866338"
variation 364
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3189684"
exon 384..615
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
variation 429
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542736"
exon 616..753
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
exon 754..866
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
exon 867..1257
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
variation 1030
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="g"
/replace="t"
/db_xref="dbSNP:11542738"
exon 1258..1495
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
variation 1295
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="a"
/replace="t"
/db_xref="dbSNP:11542739"
exon 1496..1663
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
exon 1664..3970
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/inference="alignment:Splign:1.39.8"
STS 1759..2557
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/standard_name="HSPA5_988"
/db_xref="UniSTS:277334"
variation 1888
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="a"
/replace="c"
/db_xref="dbSNP:35356639"
STS 2331..2540
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/standard_name="D2Wsu17e"
/db_xref="UniSTS:142375"
STS 2357..2531
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/standard_name="D9S1138"
/db_xref="UniSTS:48897"
variation 2364
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:7922"
variation 2446
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:8759"
polyA_signal 2553..2558
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
polyA_site 2582
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
variation 2814
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:35228219"
variation 2901
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:35130081"
variation 2971..2972
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="a"
/replace="t"
/db_xref="dbSNP:35875709"
variation 2972..2973
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace=""
/replace="t"
/db_xref="dbSNP:35204075"
STS 3444..3536
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/standard_name="D10S275"
/db_xref="UniSTS:147992"
variation 3505
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1140763"
STS 3740..3917
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/standard_name="RH102504"
/db_xref="UniSTS:96838"
variation 3789
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35189333"
variation 3794
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:12009"
polyA_signal 3946..3951
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
polyA_site 3970
/gene="HSPA5"
/gene_synonym="BIP; GRP78; MIF2"
ORIGIN
gggctgggggagggtatataagccgagtaggcgacggtgaggtcgacgccggccaagacagcacagacagattgacctattggggtgtttcgcgagtgtgagagggaagcgccgcggcctgtatttctagacctgcccttcgcctggttcgtggcgccttgtgaccccgggcccctgccgcctgcaagtcggaaattgcgctgtgctcctgtgctacggcctgtggctggactgcctgctgctgcccaactggctggcaagatgaagctctccctggtggccgcgatgctgctgctgctcagcgcggcgcgggccgaggaggaggacaagaaggaggacgtgggcacggtggtcggcatcgacctggggaccacctactcctgcgtcggcgtgttcaagaacggccgcgtggagatcatcgccaacgatcagggcaaccgcatcacgccgtcctatgtcgccttcactcctgaaggggaacgtctgattggcgatgccgccaagaaccagctcacctccaaccccgagaacacggtctttgacgccaagcggctcatcggccgcacgtggaatgacccgtctgtgcagcaggacatcaagttcttgccgttcaaggtggttgaaaagaaaactaaaccatacattcaagttgatattggaggtgggcaaacaaagacatttgctcctgaagaaatttctgccatggttctcactaaaatgaaagaaaccgctgaggcttatttgggaaagaaggttacccatgcagttgttactgtaccagcctattttaatgatgcccaacgccaagcaaccaaagacgctggaactattgctggcctaaatgttatgaggatcatcaacgagcctacggcagctgctattgcttatggcctggataagagggagggggagaagaacatcctggtgtttgacctgggtggcggaaccttcgatgtgtctcttctcaccattgacaatggtgtcttcgaagttgtggccactaatggagatactcatctgggtggagaagactttgaccagcgtgtcatggaacacttcatcaaactgtacaaaaagaagacgggcaaagatgtcaggaaagacaatagagctgtgcagaaactccggcgcgaggtagaaaaggccaaacgggccctgtcttctcagcatcaagcaagaattgaaattgagtccttctatgaaggagaagacttttctgagaccctgactcgggccaaatttgaagagctcaacatggatctgttccggtctactatgaagcccgtccagaaagtgttggaagattctgatttgaagaagtctgatattgatgaaattgttcttgttggtggctcgactcgaattccaaagattcagcaactggttaaagagttcttcaatggcaaggaaccatcccgtggcataaacccagatgaagctgtagcgtatggtgctgctgtccaggctggtgtgctctctggtgatcaagatacaggtgacctggtactgcttgatgtatgtccccttacacttggtattgaaactgtgggaggtgtcatgaccaaactgattccaaggaacacagtggtgcctaccaagaagtctcagatcttttctacagcttctgataatcaaccaactgttacaatcaaggtctatgaaggtgaaagacccctgacaaaagacaatcatcttctgggtacatttgatctgactggaattcctcctgctcctcgtggggtcccacagattgaagtcacctttgagatagatgtgaatggtattcttcgagtgacagctgaagacaagggtacagggaacaaaaataagatcacaatcaccaatgaccagaatcgcctgacacctgaagaaatcgaaaggatggttaatgatgctgagaagtttgctgaggaagacaaaaagctcaaggagcgcattgatactagaaatgagttggaaagctatgcctattctctaaagaatcagattggagataaagaaaagctgggaggtaaactttcctctgaagataaggagaccatggaaaaagctgtagaagaaaagattgaatggctggaaagccaccaagatgctgacattgaagacttcaaagctaagaagaaggaactggaagaaattgttcaaccaattatcagcaaactctatggaagtgcaggccctcccccaactggtgaagaggatacagcagaaaaagatgagttgtagacactgatctgctagtgctgtaatattgtaaatactggactcaggaacttttgttaggaaaaaattgaaagaacttaagtctcgaatgtaattggaatcttcacctcagagtggagttgaaactgctatagcctaagcggctgtttactgcttttcattagcagttgctcacatgtctttgggtgggggggagaagaagaattggccatcttaaaaagcgggtaaaaaacctgggttagggtgtgtgttcaccttcaaaatgttctatttaacaactgggtcatgtgcatctggtgtaggaagttttttctaccataagtgacaccaataaatgtttgttatttacactggtctaatgtttgtgagaagcttctaattagatcaattacttattttaggaaatttaagactagatactcgtgtgtggggtgaggggagggagtatttggtatgttgggataaggaaacacttctatttaatgcttccagggatttttttttttttttttaaccctcctgggcccaagtgatccttccacctcagtctcccagctaattgagaccacaggcttgttaccaccatgctcggcttttgcattaatctaagaaaaggggagagaagttaatccacatctttactcaggcaaggggcatttcacagtgcccaagagtggggttttcttgaacatacttggtttcctatttccccttatctttctaaaactgcctttctggtggctttttttaaaattattactaatgatgcttttatagctgcttggattctctgagaaatgatggggagtgagtgatcactggtattaactttatacacttggatttcatttgtaactttaggatgtaaaggtatattgtgaaccctagctgtgtcagaatctccatccctgaaatttctcattagtggtactggggtgggatcttggatggtgacattgaaactacactaaatcccctcactatgaatgggttgttaaaggcaatggtttgtgtcaaaactggtttaggattacttagattgtgttcctgaagaaaagagtccaggtaaatggtatgatcaataaaggacaggctggtgctaacataaaatccaatattgtaatcctagcactttgggaggccaaggcgggtggatcacaaggtcaagagatagagaccatctttgccaacatggtgaaactccatctctactgaaaatacaaaaattagctgggcgtggtagtgcaagctgaaggctgaggcaggagaatcactcgaacccgggaggcagaggttgcagtgagccgagatcacaccactgtactccagcccggcactccagcctggcgacaagagtgagactccacctcaaaaaaaaaaaaaagaatccaatactgcccaaggataggtattttatagatgggcaactggctgaaaggttaattctctagggctagtagaactggatcccaacaccaaactcttaattagacctaggcctcagctgcactgcccgaaaagcatttgggcagaccctgagcagaatactggtctcaggccaagcccaatacagccattaaagatgacctacagtgctgtgtaccctggggcaatagggttaaatggtagttagcaactagggctagtcttcccttacctcaaaggctctcactaccgtggaccacctagtctgtaactctttctgaggagctgttactgaatattaaaaagatagacttcaactatgaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3309 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS
GeneID:3309 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3309 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:3309 -> Molecular function: GO:0016887 [ATPase activity] evidence: ISS
GeneID:3309 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI
GeneID:3309 -> Molecular function: GO:0030674 [protein binding, bridging] evidence: NAS
GeneID:3309 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:3309 -> Molecular function: GO:0043022 [ribosome binding] evidence: IEA
GeneID:3309 -> Molecular function: GO:0051082 [unfolded protein binding] evidence: TAS
GeneID:3309 -> Molecular function: GO:0051087 [chaperone binding] evidence: TAS
GeneID:3309 -> Molecular function: GO:0051787 [misfolded protein binding] evidence: IDA
GeneID:3309 -> Biological process: GO:0002576 [platelet degranulation] evidence: TAS
GeneID:3309 -> Biological process: GO:0006200 [ATP catabolic process] evidence: ISS
GeneID:3309 -> Biological process: GO:0006983 [ER overload response] evidence: IEA
GeneID:3309 -> Biological process: GO:0006987 [activation of signaling protein activity involved in unfolded protein response] evidence: TAS
GeneID:3309 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:3309 -> Biological process: GO:0021589 [cerebellum structural organization] evidence: IEA
GeneID:3309 -> Biological process: GO:0021680 [cerebellar Purkinje cell layer development] evidence: IEA
GeneID:3309 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:3309 -> Biological process: GO:0030433 [ER-associated protein catabolic process] evidence: TAS
GeneID:3309 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IEA
GeneID:3309 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: TAS
GeneID:3309 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: IEA
GeneID:3309 -> Biological process: GO:0042149 [cellular response to glucose starvation] evidence: IDA
GeneID:3309 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:3309 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:3309 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
GeneID:3309 -> Biological process: GO:0060904 [regulation of protein folding in endoplasmic reticulum] evidence: TAS
GeneID:3309 -> Biological process: GO:0071353 [cellular response to interleukin-4] evidence: IEA
GeneID:3309 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
GeneID:3309 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
GeneID:3309 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IMP
GeneID:3309 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: TAS
GeneID:3309 -> Cellular component: GO:0005788 [endoplasmic reticulum lumen] evidence: TAS
GeneID:3309 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:3309 -> Cellular component: GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] evidence: IDA
GeneID:3309 -> Cellular component: GO:0008180 [COP9 signalosome] evidence: IDA
GeneID:3309 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:3309 -> Cellular component: GO:0030176 [integral to endoplasmic reticulum membrane] evidence: IDA
GeneID:3309 -> Cellular component: GO:0030496 [midbody] evidence: IDA
GeneID:3309 -> Cellular component: GO:0034663 [endoplasmic reticulum chaperone complex] evidence: IDA
GeneID:3309 -> Cellular component: GO:0042470 [melanosome] evidence: IEA
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DBCLS
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