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2025-05-09 16:49:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004969 5896 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens insulin-degrading enzyme (IDE), transcript variant 1,
mRNA.
ACCESSION NM_004969
VERSION NM_004969.3 GI:260099674
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5896)
AUTHORS Leal,M.C., Magnani,N., Villordo,S., Buslje,C.M., Evelson,P.,
Castano,E.M. and Morelli,L.
TITLE Transcriptional regulation of insulin-degrading enzyme modulates
mitochondrial amyloid beta (Abeta) peptide catabolism and
functionality
JOURNAL J. Biol. Chem. 288 (18), 12920-12931 (2013)
PUBMED 23525105
REMARK GeneRIF: IDE-Met(1) links the mitochondrial biogenesis pathway with
mitAbeta levels and organelle functionality.
REFERENCE 2 (bases 1 to 5896)
AUTHORS Wilk,J.B., Shrine,N.R., Loehr,L.R., Zhao,J.H., Manichaikul,A.,
Lopez,L.M., Smith,A.V., Heckbert,S.R., Smolonska,J., Tang,W.,
Loth,D.W., Curjuric,I., Hui,J., Cho,M.H., Latourelle,J.C.,
Henry,A.P., Aldrich,M., Bakke,P., Beaty,T.H., Bentley,A.R.,
Borecki,I.B., Brusselle,G.G., Burkart,K.M., Chen,T.H., Couper,D.,
Crapo,J.D., Davies,G., Dupuis,J., Franceschini,N., Gulsvik,A.,
Hancock,D.B., Harris,T.B., Hofman,A., Imboden,M., James,A.L.,
Khaw,K.T., Lahousse,L., Launer,L.J., Litonjua,A., Liu,Y.,
Lohman,K.K., Lomas,D.A., Lumley,T., Marciante,K.D., McArdle,W.L.,
Meibohm,B., Morrison,A.C., Musk,A.W., Myers,R.H., North,K.E.,
Postma,D.S., Psaty,B.M., Rich,S.S., Rivadeneira,F., Rochat,T.,
Rotter,J.I., Artigas,M.S., Starr,J.M., Uitterlinden,A.G.,
Wareham,N.J., Wijmenga,C., Zanen,P., Province,M.A., Silverman,E.K.,
Deary,I.J., Palmer,L.J., Cassano,P.A., Gudnason,V., Barr,R.G.,
Loos,R.J., Strachan,D.P., London,S.J., Boezen,H.M.,
Probst-Hensch,N., Gharib,S.A., Hall,I.P., O'Connor,G.T., Tobin,M.D.
and Stricker,B.H.
TITLE Genome-wide association studies identify CHRNA5/3 and HTR4 in the
development of airflow obstruction
JOURNAL Am. J. Respir. Crit. Care Med. 186 (7), 622-632 (2012)
PUBMED 22837378
REFERENCE 3 (bases 1 to 5896)
AUTHORS Cui,P.J., Cao,L., Wang,Y., Deng,Y.L., Xu,W., Wang,G., Zhang,Y.,
Zheng,L., Fei,Q.Z., Zhang,T. and Chen,S.D.
TITLE The association between two single nucleotide polymorphisms within
the insulin-degrading enzyme gene and Alzheimer's disease in a
Chinese Han population
JOURNAL J Clin Neurosci 19 (5), 745-749 (2012)
PUBMED 22502914
REMARK GeneRIF: In the context of APOEepsilon4-negative status,
insulin-degrading enzyme variants are significantly associated with
Alzheimer disease in some genetic models.
REFERENCE 4 (bases 1 to 5896)
AUTHORS Kumar,S., Singh,S., Hinze,D., Josten,M., Sahl,H.G., Siepmann,M. and
Walter,J.
TITLE Phosphorylation of amyloid-beta peptide at serine 8 attenuates its
clearance via insulin-degrading and angiotensin-converting enzymes
JOURNAL J. Biol. Chem. 287 (11), 8641-8651 (2012)
PUBMED 22267728
REMARK GeneRIF: Phosphorylation of amyloid-beta peptide at serine 8
attenuates its clearance via insulin-degrading and
angiotensin-converting enzymes.
REFERENCE 5 (bases 1 to 5896)
AUTHORS Bartl,J., Scholz,C.J., Hinterberger,M., Jungwirth,S., Wichart,I.,
Rainer,M.K., Kneitz,S., Danielczyk,W., Tragl,K.H., Fischer,P.,
Riederer,P. and Grunblatt,E.
TITLE Disorder-specific effects of polymorphisms at opposing ends of the
Insulin Degrading Enzyme gene
JOURNAL BMC Med. Genet. 12, 151 (2011)
PUBMED 22107728
REMARK GeneRIF: The upstream polymorphism IDE2 was found to influence AD
risk and to trigger the Abeta42 plasma level, whereas the
downstream polymorphism IDE7 modified the T2DM risk; no
associations were found for the intronic variant IDE9.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 5896)
AUTHORS Farris,W., Leissring,M.A., Hemming,M.L., Chang,A.Y. and Selkoe,D.J.
TITLE Alternative splicing of human insulin-degrading enzyme yields a
novel isoform with a decreased ability to degrade insulin and
amyloid beta-protein
JOURNAL Biochemistry 44 (17), 6513-6525 (2005)
PUBMED 15850385
REMARK GeneRIF: This study systematically characterizes IDE mRNAs,
identifies a novel, catalytically inefficient splice form and
compares its subcellular distribution, kinetic properties and
ability to degrade amyloid beta protein to the known isoform.
REFERENCE 7 (bases 1 to 5896)
AUTHORS Wroblewski,V.J., Masnyk,M., Khambatta,S.S. and Becker,G.W.
TITLE Mechanisms involved in degradation of human insulin by cytosolic
fractions of human, monkey, and rat liver
JOURNAL Diabetes 41 (4), 539-547 (1992)
PUBMED 1607078
REFERENCE 8 (bases 1 to 5896)
AUTHORS Ding,L., Becker,A.B., Suzuki,A. and Roth,R.A.
TITLE Comparison of the enzymatic and biochemical properties of human
insulin-degrading enzyme and Escherichia coli protease III
JOURNAL J. Biol. Chem. 267 (4), 2414-2420 (1992)
PUBMED 1733942
REFERENCE 9 (bases 1 to 5896)
AUTHORS Espinosa,R. III, Lemons,R.S., Perlman,R.K., Kuo,W.L., Rosner,M.R.
and Le Beau,M.M.
TITLE Localization of the gene encoding insulin-degrading enzyme to human
chromosome 10, bands q23----q25
JOURNAL Cytogenet. Cell Genet. 57 (4), 184-186 (1991)
PUBMED 1743072
REFERENCE 10 (bases 1 to 5896)
AUTHORS Whitsett,J.A. and Lessard,J.L.
TITLE Characteristics of the microvillus brush border of human placenta:
insulin receptor localization in brush border membranes
JOURNAL Endocrinology 103 (4), 1458-1468 (1978)
PUBMED 758022
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB219527.1, BC096337.1,
BX648462.1, CK824565.1, DA879845.1 and CF780766.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 30, 2009 this sequence version replaced gi:155969706.
Summary: This gene encodes a zinc metallopeptidase that degrades
intracellular insulin, and thereby terminates insulins activity, as
well as participating in intercellular peptide signalling by
degrading diverse peptides such as glucagon, amylin, bradykinin,
and kallidin. The preferential affinity of this enzyme for insulin
results in insulin-mediated inhibition of the degradation of other
peptides such as beta-amyloid. Deficiencies in this protein's
function are associated with Alzheimer's disease and type 2
diabetes mellitus but mutations in this gene have not been shown to
be causitive for these diseases. This protein localizes primarily
to the cytoplasm but in some cell types localizes to the
extracellular space, cell membrane, peroxisome, and mitochondrion.
Alternative splicing results in multiple transcript variants
encoding distinct isoforms. Additional transcript variants have
been described but have not been experimentally verified.[provided
by RefSeq, Sep 2009].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer protein (isoform 1). Alternative
translation initiation of this transcript variant produces an
isoform that lacks 41 aa from the N-terminus and, purportedly,
lacks an N-terminal mitochondrial targeting sequence.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M21188.1, BC096336.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-37 DB219527.1 1-37
38-3167 BC096337.1 2-3131
3168-4973 BX648462.1 3333-5138
4974-5366 CK824565.1 174-566
5367-5740 DA879845.1 122-495
5741-5896 CF780766.1 284-439
FEATURES Location/Qualifiers
source 1..5896
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q23-q25"
gene 1..5896
/gene="IDE"
/gene_synonym="INSULYSIN"
/note="insulin-degrading enzyme"
/db_xref="GeneID:3416"
/db_xref="HGNC:5381"
/db_xref="MIM:146680"
exon 1..174
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
misc_feature 53..55
/gene="IDE"
/gene_synonym="INSULYSIN"
/note="upstream in-frame stop codon"
CDS 77..3136
/gene="IDE"
/gene_synonym="INSULYSIN"
/EC_number="3.4.24.56"
/note="isoform 1 is encoded by transcript variant 1;
insulinase; insulin protease; Abeta-degrading protease"
/codon_start=1
/product="insulin-degrading enzyme isoform 1"
/protein_id="NP_004960.2"
/db_xref="GI:155969707"
/db_xref="CCDS:CCDS7421.1"
/db_xref="GeneID:3416"
/db_xref="HGNC:5381"
/db_xref="MIM:146680"
/translation="
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
"
misc_feature 200..202
/gene="IDE"
/gene_synonym="INSULYSIN"
/note="Region: alternative start codon"
misc_feature 209..2950
/gene="IDE"
/gene_synonym="INSULYSIN"
/note="Secreted/periplasmic Zn-dependent peptidases,
insulinase-like [Posttranslational modification, protein
turnover, chaperones]; Region: Ptr; COG1025"
/db_xref="CDD:31228"
misc_feature 296..712
/gene="IDE"
/gene_synonym="INSULYSIN"
/note="Insulinase (Peptidase family M16); Region:
Peptidase_M16; pfam00675"
/db_xref="CDD:201385"
misc_feature 788..1324
/gene="IDE"
/gene_synonym="INSULYSIN"
/note="Peptidase M16 inactive domain; Region:
Peptidase_M16_C; pfam05193"
/db_xref="CDD:203199"
misc_feature 1082..1102
/gene="IDE"
/gene_synonym="INSULYSIN"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P14735.4);
Region: Substrate binding exosite"
misc_feature 1151..1165
/gene="IDE"
/gene_synonym="INSULYSIN"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P14735.4);
Region: Substrate binding"
misc_feature 2192..2743
/gene="IDE"
/gene_synonym="INSULYSIN"
/note="Peptidase M16 inactive domain; Region:
Peptidase_M16_C; pfam05193"
/db_xref="CDD:203199"
misc_feature 2633..2650
/gene="IDE"
/gene_synonym="INSULYSIN"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P14735.4);
Region: SlyX motif"
exon 175..359
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 360..567
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 390
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:79711272"
variation 425
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:74593235"
variation 529
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:76929785"
exon 568..737
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 738..860
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 861..973
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 974..1136
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
STS 1019..1120
/gene="IDE"
/gene_synonym="INSULYSIN"
/standard_name="IDE"
/db_xref="UniSTS:502984"
exon 1137..1229
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 1146
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:77824934"
exon 1230..1321
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 1322..1402
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 1403..1506
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 1431
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:34708742"
exon 1507..1609
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 1610..1732
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 1693
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35426658"
variation 1723
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:79491549"
exon 1733..1815
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 1816..1960
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 1822
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:5030982"
exon 1961..2071
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 1975
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:2229709"
exon 2072..2192
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
STS 2144..3050
/gene="IDE"
/gene_synonym="INSULYSIN"
/standard_name="Ide"
/db_xref="UniSTS:506987"
exon 2193..2284
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 2240
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:76587725"
exon 2285..2396
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 2397..2564
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 2449
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:35640611"
exon 2565..2837
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
variation 2609
/gene="IDE"
/gene_synonym="INSULYSIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:1042444"
exon 2838..2899
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 2900..2972
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 2973..3040
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
exon 3041..5896
/gene="IDE"
/gene_synonym="INSULYSIN"
/inference="alignment:Splign:1.39.8"
STS 3171..3270
/gene="IDE"
/gene_synonym="INSULYSIN"
/standard_name="GDB:193867"
/db_xref="UniSTS:155775"
STS 3172..3269
/gene="IDE"
/gene_synonym="INSULYSIN"
/standard_name="D10S2141"
/db_xref="UniSTS:20873"
STS 5103..5286
/gene="IDE"
/gene_synonym="INSULYSIN"
/standard_name="STS-D29519"
/db_xref="UniSTS:28873"
STS 5163..5312
/gene="IDE"
/gene_synonym="INSULYSIN"
/standard_name="WI-17525"
/db_xref="UniSTS:60139"
polyA_signal 5314..5319
/gene="IDE"
/gene_synonym="INSULYSIN"
polyA_site 5333
/gene="IDE"
/gene_synonym="INSULYSIN"
ORIGIN
gcatgcgcagtgcgcagggccggctcgaagcgcaagcaggaagcgtttgcggtgatcccggcgactgcgctggctaatgcggtaccggctagcgtggcttctgcaccccgcactgcccagcaccttccgctcagtcctcggcgcccgcctgccgcctccggagcgcctgtgtggtttccaaaaaaagacttacagcaaaatgaataatccagccatcaagagaataggaaatcacattaccaagtctcctgaagacaagcgagaatatcgagggctagagctggccaatggtatcaaagtacttcttatcagtgatcccaccacggataagtcatcagcagcacttgatgtgcacataggttcattgtcggatcctccaaatattgctggcttaagtcatttttgtgaacatatgctttttttgggaacaaagaaataccctaaagaaaatgaatacagccagtttctcagtgagcatgcaggaagttcaaatgcctttactagtggagagcataccaattactattttgatgtttctcatgaacacctagaaggtgccctagacaggtttgcacagttttttctgtgccccttgttcgatgaaagttgcaaagacagagaggtgaatgcagttgattcagaacatgagaagaatgtgatgaatgatgcctggagactctttcaattggaaaaagctacagggaatcctaaacaccccttcagtaaatttgggacaggtaacaaatatactctggagactagaccaaaccaagaaggcattgatgtaagacaagagctactgaaattccattctgcttactattcatccaacttaatggctgtttgtgttttaggtcgagaatctttagatgacttgactaatctggtggtaaagttattttctgaagtagagaacaaaaatgttccattgccagaatttcctgaacaccctttccaagaagaacatcttaaacaactttacaaaatagtacccattaaagatattaggaatctctatgtgacatttcccatacctgaccttcagaaatactacaaatcaaatcctggtcattatcttggtcatctcattgggcatgaaggtcctggaagtctgttatcagaacttaagtcaaagggctgggttaatactcttgttggtgggcagaaggaaggagcccgaggttttatgttttttatcattaatgtggacttgaccgaggaaggattattacatgttgaagatataattttgcacatgtttcaatacattcagaagttacgtgcagaaggacctcaagaatgggttttccaagagtgcaaggacttgaatgctgttgcttttaggtttaaagacaaagagaggccacggggctatacatctaagattgcaggaatattgcattattatcccctagaagaggtgctcacagcggaatatttactggaagaatttagacctgacttaatagagatggttctcgataaactcagaccagaaaatgtccgggttgccatagtttctaaatcttttgaaggaaaaactgatcgcacagaagagtggtatggaacccagtacaaacaagaagctataccggatgaagtcatcaagaaatggcaaaatgctgacctgaatgggaaatttaaacttcctacaaagaatgaatttattcctacgaattttgagattttaccgttagaaaaagaggcgacaccataccctgctcttattaaggatacagctatgagcaaactttggttcaaacaagatgataagttttttttgccgaaggcttgtctcaactttgaatttttcagcccatttgcttatgtggaccccttgcactgtaacatggcctatttgtaccttgagctcctcaaagactcactcaacgagtatgcatatgcagcagagctagcaggcttgagctatgatctccaaaataccatctatgggatgtatctttcagtgaaaggttacaatgacaagcagccaattttactaaagaagattattgagaaaatggctacctttgagattgatgaaaaaagatttgaaattatcaaagaagcatatatgcgatctcttaacaatttccgggctgaacagcctcaccagcatgccatgtactacctccgcttgctgatgactgaagtggcctggactaaagatgagttaaaagaagctctggatgatgtaacccttcctcgccttaaggccttcatacctcagctcctgtcacggctgcacattgaagcccttctccatggaaacataacaaagcaggctgcattaggaattatgcagatggttgaagacaccctcattgaacatgctcataccaaacctctccttccaagtcagctggttcggtatagagaagttcagctccctgacagaggatggtttgtttatcagcagagaaatgaagttcacaataactgtggcatcgagatatactaccaaacagacatgcaaagcacctcagagaatatgtttctggagctcttctgtcagattatctcggaaccttgcttcaacaccctgcgcaccaaggagcagttgggctatatcgtcttcagcgggccacgtcgagctaatggcatacagggcttgagattcatcatccagtcagaaaagccacctcactacctagaaagcagagtggaagctttcttaattaccatggaaaagtccatagaggacatgacagaagaggccttccaaaaacacattcaggcattagcaattcgtcgactagacaaaccaaagaagctatctgctgagtgtgctaaatactggggagaaatcatctcccagcaatataattttgacagagataacactgaggttgcatatttaaagacacttaccaaggaagatatcatcaaattctacaaggaaatgttggcagtagatgctccaaggagacataaggtatccgtccatgttcttgccagggaaatggattcttgtcctgttgttggagagttcccatgtcaaaatgacataaatttgtcacaagcaccagccttgccacaacctgaagtgattcagaacatgaccgaattcaagcgtggtctgccactgtttccccttgtgaaaccacatattaacttcatggctgcaaaactctgaagattccccatgcatgggaaagtgcaagtggatgcattcctgagtcttccagagcctaagaaaatcatcttggccactttaatagtttctgattcactattagagaaacaaacaaaaaattgtcaaatgtcattatgtagaaatattataaatccaaagtaaattacaaaatcttatagatgtagaatattttttaaatacatgcctcttaaatattttaaaatttttcttttgattactgagagaaatttccccaatataacaatgcttaaaatgaatgatattcctatagaatcttccttccctattctgtaaaatagtcacttgtccgaagaaagttaaaagttagctcttttctaaaagcctcctagcttgacatagaaggcttcacaacatttagaaaggtaataactttttaaaaattgatcctcaaatttgctttctacttgatggtttcatgtaaatcagtggaaaacattacatttggcagatgataaagcaatgtcatcttttattagtgaaatgctggttatataaggcatggttttaatctttttataaaatttgaacatgttttttatgccaactcgtaaaatgctagaaaaccctacttatttacaatgctagaaatacagacttaccttacatcaattttgtcctaaaccgaatttctcaggattactgtggtttctttcattctgattgaattatattgacctacttcttcatagttggtttgcagtgttccatgagttttacttttcctcatcaacatattgctttaacacaacatatttatttaacacgtacaaatagggtcaacttcagatcctactgagtgtgtgacatgcttttccaacatcagctttttgtaaccacctgtataactttttattacagtgaaattgcagtcagtatgtgaaccaaaatatcttgcccctttatgaatttaaaaggcagccaatacaaagccacctttttggaaatataaaaagtaaagccttgcattcttatatagcaggtcttcataaaactctaaaatcccttgttgctaccagtctaatcttgccttaaatgttaagttattttttgaatatataaatataaacatataaacacagatgatgactggagtagacttttaaaaaaatatttttttcatgagatactattttaggtgaaattgttactgtagatttaacagctgttttgaaatatttactgttattaaaacttgcttcaagagaaattgtgaatatatttccatatacaagcactagtaacagtaagtggccctgtcatccactaactcaggcaaagtaaagaatggcatttttgaaggacattttacctccccatatgatttgattggctaggactttcttctgtaaagtcataccttttcacatcttaagtttttacatttgccattttccaaatctcaattttgggcaagaacgatatagtcacaactatggggctgctttcaaaagcggggctccatttctactgtcagatcaatgtggtgctgtaaccatctttttatccctaccttcaagaacctccttatatgaagcctgtctttatccatcagaaggtgtgtgaaatcatcacttccttctggttttatgtatttgtagactatgcagcttttcattaaactgcaagtatatacaagacagatctgaaattaggcctgagtgttccgatccaccactgtactagtaaataaaaatccacctaccttttatgtggaaaattatgtgctattgagtaacttttagctcttttttaaaaaatgggtgaaatttaagtgtcttttttatgagaatgacacatgaagagatctgagagcaatctcatgtagtcttccatgaacctgcaattgtttggtatgcgtcagcattttccaatttccaggttggatctagagctgctgttgatcactcaggcatactaatggattcatttagatgggtccaagctgcagtccatgagcaataacagactaccccagatactgcagtttacgcagtgcttagtaaatgagatttgtggaactaagttattagttacctgaggcttcttaagaaagtcttcttttttgaccagttgatgtgaaagagggagcatgtgacacagccagtatggtggagtgctagggttatcctgtttacaataaatcgcctgaatttcacctctggagtctgcatttgtattatttttccagttttagtgaaatagtacagtggccagtcctcagcctacctctcaacatcccagtttgaccagatttcttgctttcattgttcataatgcagaaagcagtgaattatattaacattttaaaagtgtttctgggtaacaatgatttttgtcaaatagaagactcaatttcacaaccttaagaatagatcacttttgtaaaacaagaatctcagtatttgatgttggactccttgctgtgagtattgtcactgactccaaacccagaaagatttgttcctgcccttacagggatgaaaataaaaaggatagaaaaaatatttctctcctctacaatgagtccttacatcttcttgccacatctccagctgcagtttaggcagatatcttgttcaatctctgtcttcttgatccctgtcaaaataatttttctactcatatagtggccagttggctcaggcaggcatttcaagaggaatctgcttgttcctcacttttccagcataggacagtggtccagcccgcacagtcagc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3416 -> Molecular function: GO:0001540 [beta-amyloid binding] evidence: IEA
GeneID:3416 -> Molecular function: GO:0001948 [glycoprotein binding] evidence: IPI
GeneID:3416 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: IDA
GeneID:3416 -> Molecular function: GO:0005102 [receptor binding] evidence: IPI
GeneID:3416 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3416 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:3416 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IDA
GeneID:3416 -> Molecular function: GO:0016887 [ATPase activity] evidence: IEA
GeneID:3416 -> Molecular function: GO:0031626 [beta-endorphin binding] evidence: IEA
GeneID:3416 -> Molecular function: GO:0042277 [peptide binding] evidence: IPI
GeneID:3416 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:3416 -> Molecular function: GO:0043130 [ubiquitin binding] evidence: IPI
GeneID:3416 -> Molecular function: GO:0043559 [insulin binding] evidence: IDA
GeneID:3416 -> Molecular function: GO:0043559 [insulin binding] evidence: IPI
GeneID:3416 -> Biological process: GO:0006508 [proteolysis] evidence: IDA
GeneID:3416 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: NAS
GeneID:3416 -> Biological process: GO:0008340 [determination of adult lifespan] evidence: IDA
GeneID:3416 -> Biological process: GO:0010815 [bradykinin catabolic process] evidence: IDA
GeneID:3416 -> Biological process: GO:0010992 [ubiquitin homeostasis] evidence: IDA
GeneID:3416 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:3416 -> Biological process: GO:0032461 [positive regulation of protein oligomerization] evidence: IDA
GeneID:3416 -> Biological process: GO:0042447 [hormone catabolic process] evidence: IEA
GeneID:3416 -> Biological process: GO:0045861 [negative regulation of proteolysis] evidence: IEA
GeneID:3416 -> Biological process: GO:0050435 [beta-amyloid metabolic process] evidence: IDA
GeneID:3416 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IDA
GeneID:3416 -> Biological process: GO:0051289 [protein homotetramerization] evidence: IEA
GeneID:3416 -> Biological process: GO:0051291 [protein heterooligomerization] evidence: IEA
GeneID:3416 -> Biological process: GO:0051603 [proteolysis involved in cellular protein catabolic process] evidence: IDA
GeneID:3416 -> Biological process: GO:1901142 [insulin metabolic process] evidence: IDA
GeneID:3416 -> Biological process: GO:1901143 [insulin catabolic process] evidence: IDA
GeneID:3416 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
GeneID:3416 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:3416 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3416 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:3416 -> Cellular component: GO:0005777 [peroxisome] evidence: IDA
GeneID:3416 -> Cellular component: GO:0005782 [peroxisomal matrix] evidence: IEA
GeneID:3416 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:3416 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:3416 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:3416 -> Cellular component: GO:0031597 [cytosolic proteasome complex] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_004960 -> EC 3.4.24.56
by
@meso_cacase at
DBCLS
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