2025-05-09 17:08:41, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004298 4755 bp mRNA linear PRI 17-JUN-2013 DEFINITION Homo sapiens nucleoporin 155kDa (NUP155), transcript variant 2, mRNA. ACCESSION NM_004298 VERSION NM_004298.3 GI:509155835 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4755) AUTHORS Tarazon,E., Rivera,M., Rosello-Lleti,E., Molina-Navarro,M.M., Sanchez-Lazaro,I.J., Espana,F., Montero,J.A., Lago,F., Gonzalez-Juanatey,J.R. and Portoles,M. TITLE Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes JOURNAL PLoS ONE 7 (11), E48957 (2012) PUBMED 23152829 REFERENCE 2 (bases 1 to 4755) AUTHORS Parvez,B. and Darbar,D. TITLE The 'missing' link in atrial fibrillation heritability JOURNAL J Electrocardiol 44 (6), 641-644 (2011) PUBMED 21924735 REFERENCE 3 (bases 1 to 4755) AUTHORS Kehat,I., Accornero,F., Aronow,B.J. and Molkentin,J.D. TITLE Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins JOURNAL J. Cell Biol. 193 (1), 21-29 (2011) PUBMED 21464227 REMARK GeneRIF: The Nup155-mediated localization was required for HDAC4's effect on gene expression. REFERENCE 4 (bases 1 to 4755) AUTHORS Mitchell,J.M., Mansfeld,J., Capitanio,J., Kutay,U. and Wozniak,R.W. TITLE Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane JOURNAL J. Cell Biol. 191 (3), 505-521 (2010) PUBMED 20974814 REMARK GeneRIF: The Nup155 depletion massively alters nuclear envelope structure, causing a dramatic decrease in Nuclear pore complexes numbers and the improper targeting of membrane proteins to the inner nuclear membrane. REFERENCE 5 (bases 1 to 4755) AUTHORS Rayala,H.J., Kendirgi,F., Barry,D.M., Majerus,P.W. and Wente,S.R. TITLE The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155 JOURNAL Mol. Cell Proteomics 3 (2), 145-155 (2004) PUBMED 14645504 REFERENCE 6 (bases 1 to 4755) AUTHORS Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E., Dargemont,C. and Benichou,S. TITLE Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1 JOURNAL J. Biol. Chem. 277 (47), 45091-45098 (2002) PUBMED 12228227 REFERENCE 7 (bases 1 to 4755) AUTHORS Zhang,X., Yang,H., Yu,J., Chen,C., Zhang,G., Bao,J., Du,Y., Kibukawa,M., Li,Z., Wang,J., Hu,S., Dong,W., Wang,J., Gregersen,N., Niebuhr,E. and Bolund,L. TITLE Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene JOURNAL Gene 288 (1-2), 9-18 (2002) PUBMED 12034489 REFERENCE 8 (bases 1 to 4755) AUTHORS Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A. TITLE Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase JOURNAL J. Biol. Chem. 274 (52), 37125-37130 (1999) PUBMED 10601273 REFERENCE 9 (bases 1 to 4755) AUTHORS Zhang,X., Yang,H., Corydon,M.J., Zhang,X., Pedersen,S., Korenberg,J.R., Chen,X.N., Laporte,J., Gregersen,N., Niebuhr,E., Liu,G. and Bolund,L. TITLE Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA JOURNAL Genomics 57 (1), 144-151 (1999) PUBMED 10191094 REFERENCE 10 (bases 1 to 4755) AUTHORS Gorlich,D. and Mattaj,I.W. TITLE Nucleocytoplasmic transport JOURNAL Science 271 (5255), 1513-1518 (1996) PUBMED 8599106 REMARK Review article COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC401967.1, DA249538.1, AB018334.1, BM478072.1, BC039257.1, AI037962.1 and BQ435836.1. On Jun 4, 2013 this sequence version replaced gi:24430147. Summary: Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]. Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB018334.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-88 DC401967.1 1-88 89-341 DA249538.1 1-253 342-504 AB018334.1 1-163 505-505 BM478072.1 254-254 506-4191 AB018334.1 165-3850 4192-4540 BC039257.1 4004-4352 4541-4726 AI037962.1 30-215 c 4727-4731 BQ435836.1 683-687 4732-4755 AI037962.1 1-24 c FEATURES Location/Qualifiers source 1..4755 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="5" /map="5p13.1" gene 1..4755 /gene="NUP155" /gene_synonym="N155" /note="nucleoporin 155kDa" /db_xref="GeneID:9631" /db_xref="HGNC:8063" /db_xref="MIM:606694" exon 1..461 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" misc_feature 404..406 /gene="NUP155" /gene_synonym="N155" /note="upstream in-frame stop codon" exon 462..599 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" CDS 482..4480 /gene="NUP155" /gene_synonym="N155" /note="isoform 2 is encoded by transcript variant 2; nuclear pore complex protein Nup155; 155 kDa nucleoporin" /codon_start=1 /product="nuclear pore complex protein Nup155 isoform 2" /protein_id="NP_004289.1" /db_xref="GI:4758844" /db_xref="CCDS:CCDS43310.1" /db_xref="GeneID:9631" /db_xref="HGNC:8063" /db_xref="MIM:606694" /translation="
MSDMDYPLQGPGLLSVPNLPEISSIRRVPLPPELVEQFGHMQCNCMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRHLLVLATPVDIVILGLSYANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFLAGKDGCLYEVAYQAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYTRSEKGVIQVYDLGQDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLLAVTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASSTVEKPSKVHRALYSKGILLMAASENEDNDILWCVNHDTFPFQKPMMETQMTAGVDGHSWALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLRHLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGEAQMRFPTTLPPPSNVGPILGSPVYSSSPVPSGSPYPNPSFLGTPSHGIQPPAMSTPVCALGNPATQATNMSCVTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAIESSVPCQLLESVLQELKGLQEFLDRNSQFAGGPLGNPNTTAKVQQRLIGFMRPENGNPQQMQQELQRKFHEAQLSEKISLQAIQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKITTFKDLVIRDKELTGALIASLINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANELLQRSRQVQNKTEKERMLRESLKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEPEEDIVGLQAFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHFEQMLKLSQRSKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYMDLLWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAECKLAIIHCAGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPRFFPLDFIVQFLEQQVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKPLHLLDCIHVLLIRYVENPSQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQAITGNFKSLQAKLERLH
" misc_feature 530..1831 /gene="NUP155" /gene_synonym="N155" /note="Nup133 N terminal like; Region: Nucleoporin_N; pfam08801" /db_xref="CDD:204070" misc_feature 2402..4069 /gene="NUP155" /gene_synonym="N155" /note="Non-repetitive/WGA-negative nucleoporin C-terminal; Region: Nucleoporin_C; pfam03177" /db_xref="CDD:190553" exon 600..696 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 697..767 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 768..860 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 861..1027 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1028..1133 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1134..1207 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1208..1299 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1300..1397 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1398..1550 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1551..1651 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1652..1822 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1823..1933 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1934..2028 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2029..2117 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2118..2180 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2181..2328 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2329..2395 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2396..2511 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2512..2609 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2610..2740 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2741..2932 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2933..3071 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3072..3207 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3208..3361 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3362..3466 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3467..3621 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3622..3751 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" STS 3678..3839 /gene="NUP155" /gene_synonym="N155" /standard_name="MARC_21512-21513:1032982746:3" /db_xref="UniSTS:268564" exon 3752..3865 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3866..3986 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3987..4097 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 4098..4234 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 4235..4341 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 4342..4747 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" polyA_signal 4519..4524 /gene="NUP155" /gene_synonym="N155" polyA_site 4542 /gene="NUP155" /gene_synonym="N155" /note="This is an internal site." polyA_signal 4724..4729 /gene="NUP155" /gene_synonym="N155" polyA_site 4747 /gene="NUP155" /gene_synonym="N155" ORIGIN
atgaagcggaagtgcgtcatgtcgaggcgccaaggcgctcgtttggcgcgcgcgccctaggcggcggatctaagctaacttcttggatcttttcttgtttctccttggtttttgactttttctggaccctggtgtctacgatttccgagatgccgtcttctttgttgggcgcggcgatgccggcctctacatctgccgcagccctgcaggaagctctggaaaatgctggacggctcatcgaccgtcagttgcaagaggaccgcatgtacccggacctttccgagctgcttatggtgtctgccccaagtgagtgatagtgaccctgctttctcaacctaaaggactctcgcctgacttcctaatttgctacttatccccagcgttggtcccggcgaggatatgctgagatttatggcactgttggctgcatttttggagaacagcaagcagcttcttttcagataatcccaccgtttctggcatgtcagatatggattatcctttgcaaggacctggtttgctgtccgtacccaaccttccagagatcagttccatccgaagagttcctctcccacctgaacttgttgagcagtttggacatatgcagtgtaattgcatgatgggtgtgttccctcctatcagcagagcttggctcacaattgacagtgatatattcatgtggaactatgaggatggaggagaccttgcctattttgatggacttagtgagactattcttgctgtggggcttgtgaagccaaaagcaggcatctttcaacctcatgtgcgacacctcctggttttggcgacccctgtagacatagtaattcttggactcagctatgctaatttgcaaacaggttctggagttcttaatgatagtttgtctggtggaatgcagttgcttccagatcctttatattctcttcctactgataatacttaccttttaacaataacttccactgataatggcagaattttcttggctggaaaggatggctgtttatatgaagtagcctaccaggctgaagcagggtggtttagccaaagatgtaggaaaataaaccactcaaagagctcactttctttccttgttccttccttgctacaattcacgttctcagaagatgatcctattcttcaaattgcaattgataattctagaaatattttatatacacgatctgagaaaggagtaatacaggtgtatgatttgggacaagatggacaaggaatgagcagagttgcctctgtgtcacagaatgccattgtctctgctgctggtaacattgctaggaccatcgatcgttctgtttttaaaccaattgtccaaatagcagtgattgaaaattctgaatcactggactgtcagttattggctgtcacacatgcaggtgttaggttatattttagcacttgtccattcagacagccattagcacggcctaatacactgacgctggttcatgtccgcttacctcctggattctcagcatcttcaaccgtggaaaagccttcaaaagtacatagagctctttatagtaaaggtattctattgatggcagcctcagaaaatgaggataatgatattttatggtgtgtcaaccatgatacttttcctttccaaaagccaatgatggaaacccagatgacagctggtgttgatggtcattcctgggctctttctgcgatagatgaattgaaagtagataaaataattacacctttaaacaaggatcatattccaataactgattcaccagttgttgtacagcagcacatgttacctccgaagaaatttgttctcctctcagcacaggggagccttatgtttcataaacttagacctgtagatcaactgaggcatctacttgtgagtaatgtgggaggagatggagaagagattgaaagattctttaaattacatcaggaagaccaggcttgtgcaacttgccttattcttgcttgctccactgctgcctgtgatagagaagtatctgcctgggctactcgggctttctttaggtatggtggtgaagcacagatgagatttccaaccactcttccgcctccaagtaatgttggtcccatcttggggtctcctgtctattctagttctcctgttcctagtggtagtccctatccaaatccatcctttttgggaacaccgtctcatggtatacagcctcctgccatgtcaactccagtgtgtgctctgggaaacccagcaactcaggccacaaatatgagttgtgtgactggaccagagattgtgtactctggaaaacacaatggtatttgcatttacttttctcggatcatgggaaacatttgggatgcaagcttagttgtggagagaatattcaagagtggcaacagagagatcactgcaattgaaagtagtgttccctgccaactgctagagtcagtgctacaagaactaaagggtttgcaggaatttctagacagaaactcccagtttgcaggaggaccattaggaaatccaaatactactgctaaagtgcagcagaggctgataggattcatgcgtcctgaaaacggaaatccccagcaaatgcaacaggaactgcagaggaagtttcatgaggctcaactaagtgaaaagatttcacttcaggcaattcagcagttggttcgaaaatcatatcaggctctggctttatggaaacttctttgtgaacatcaattcactatcattgtggcagaacttcagaaggaacttcaagagcagctgaagatcaccacctttaaagatcttgtaatcagggacaaagaactcacaggggcattaattgcttctcttatcaactgctacatcagagataatgccgctgttgatggcattagtttacatttacaggatatctgcccacttctatatagcactgatgatgcaatttgttctaaggcaaatgagcttctccagcgttcccgacaagttcaaaataagactgaaaaagaaagaatgttaagggaatcattaaaggaatatcaaaaaattagcaatcaagtggacctttccaatgtttgtgctcagtatagacaagtgagattttatgagggtgtggtggaactttctcttacggctgcagagaaaaaagatcctcaaggtcttgggcttcatttctataaacatggagaaccagaagaagacatagttggacttcaggccttccaagaaagattaaacagttacaaatgcattacagacacacttcaagaactggtaaatcaaagtaaggccgctcctcagtctcccagtgtacccaaaaaacctggtcctccagtgttgtcatctgatccaaatatgctgagtaatgaagaagcaggacatcattttgaacaaatgcttaaattgtcacagcgatccaaggatgagctctttagtattgccctttataattggctaatacaagtcgaccttgcagataagctgctacaggttgcttctccatttctggagccacatctagtccgaatggccaaagttgatcaaaacagagttcgttatatggatttactctggcggtattacgagaagaacagaagtttcagtaatgctgctcgtgtactgtccagactggctgacatgcatagcacagaaatttcacttcagcagcgactagagtacattgctcgagccattcttagtgccaaaagttccactgccatttcatcaatagctgccgatggtgaatttcttcatgaattagaagaaaaaatggaggttgctaggatccaacttcagatacaggagacactacaaaggcagtattcccatcattcttctgtacaggatgcagtttctcagctggattctgagctgatggacataactaagctttatggggaatttgctgacccatttaaacttgcagagtgcaaacttgcaataattcattgtgccggttattcagaccctatattggtgcagacactttggcaagatatcatagagaaagaattgagtgacagtgtgacattgagctcctcggatagaatgcatgctcttagtctcaagattgttctccttggcaaaatttatgctggcacaccacgcttctttcctttagattttattgtacagtttttagaacagcaggtttgtactttgaactgggatgtgggcttcgtaatacagacaatgaatgaaattggagtaccattacctagactactagaagtttatgatcagttgttcaaatcacgggatccattctggaacagaatgaagaagccactgcaccttttggattgtatacatgtattattgataagatatgttgagaatcccagccaagttttaaattgtgaaaggagaagatttacaaatctctgcctggatgctgtttgtggttaccttgttgagctccagtctatgagctcgtcagtagcagtacaagccatcactgggaattttaaatctcttcaagctaaattagaacggcttcattaattactgtgatatactttcatccgttttatgatctgtaaaataaaaactcagctgggtccagatatcaggtgttctaaatctaagaatgtaagaacaatcttaatagaaatatgtttttaataagtggctaatatctacaaatagtacctttgctaaatgaattcttttttatgactattttgttttttagtaattgggtgaaaaaacaactgaaatgagattatttattattttaacataaggattaaaaaaatttagaaactcttaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9631 -> Molecular function: GO:0005215 [transporter activity] evidence: TAS GeneID:9631 -> Molecular function: GO:0017056 [structural constituent of nuclear pore] evidence: IEA GeneID:9631 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:9631 -> Biological process: GO:0005975 [carbohydrate metabolic process] evidence: TAS GeneID:9631 -> Biological process: GO:0006406 [mRNA export from nucleus] evidence: IEA GeneID:9631 -> Biological process: GO:0006606 [protein import into nucleus] evidence: IEA GeneID:9631 -> Biological process: GO:0006998 [nuclear envelope organization] evidence: IDA GeneID:9631 -> Biological process: GO:0007077 [mitotic nuclear envelope disassembly] evidence: TAS GeneID:9631 -> Biological process: GO:0008645 [hexose transport] evidence: TAS GeneID:9631 -> Biological process: GO:0010827 [regulation of glucose transport] evidence: TAS GeneID:9631 -> Biological process: GO:0015758 [glucose transport] evidence: TAS GeneID:9631 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:9631 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS GeneID:9631 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:9631 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS GeneID:9631 -> Biological process: GO:0086014 [regulation of atrial cardiac muscle cell action potential] evidence: IEA GeneID:9631 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA GeneID:9631 -> Cellular component: GO:0005635 [nuclear envelope] evidence: TAS GeneID:9631 -> Cellular component: GO:0005643 [nuclear pore] evidence: IEA GeneID:9631 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IEA
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