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2025-11-15 16:57:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003944 1768 bp mRNA linear PRI 22-JUN-2013
DEFINITION Homo sapiens selenium binding protein 1 (SELENBP1), transcript
variant 1, mRNA.
ACCESSION NM_003944
VERSION NM_003944.3 GI:385137126
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1768)
AUTHORS Jerome-Morais,A., Wright,M.E., Liu,R., Yang,W., Jackson,M.I.,
Combs,G.F. Jr. and Diamond,A.M.
TITLE Inverse association between glutathione peroxidase activity and
both selenium-binding protein 1 levels and Gleason score in human
prostate tissue
JOURNAL Prostate 72 (9), 1006-1012 (2012)
PUBMED 22072582
REMARK GeneRIF: Glutathione peroxidase (GPx)-1 enzyme activity is
inversely correlated with selenium binding protein (SBP)-1 levels
in prostate tissue, based on the Gleason score.
REFERENCE 2 (bases 1 to 1768)
AUTHORS Xia,Y.J., Ma,Y.Y., He,X.J., Wang,H.J., Ye,Z.Y. and Tao,H.Q.
TITLE Suppression of selenium-binding protein 1 in gastric cancer is
associated with poor survival
JOURNAL Hum. Pathol. 42 (11), 1620-1628 (2011)
PUBMED 21497372
REMARK GeneRIF: The 3-year survival rate of gastric cancer patients with
high expression of selenium-binding protein 1 was significantly
higher than that of patients with low expression
REFERENCE 3 (bases 1 to 1768)
AUTHORS Raucci,R., Colonna,G., Guerriero,E., Capone,F., Accardo,M.,
Castello,G. and Costantini,S.
TITLE Structural and functional studies of the human selenium binding
protein-1 and its involvement in hepatocellular carcinoma
JOURNAL Biochim. Biophys. Acta 1814 (4), 513-522 (2011)
PUBMED 21338716
REMARK GeneRIF: A reduced SELENBP1 expression by immunohistochemistry in
liver tissues of patients with hepatocarcinoma (HCC), is reported.
REFERENCE 4 (bases 1 to 1768)
AUTHORS Johnatty,S.E., Beesley,J., Chen,X., Macgregor,S., Duffy,D.L.,
Spurdle,A.B., deFazio,A., Gava,N., Webb,P.M., Rossing,M.A.,
Doherty,J.A., Goodman,M.T., Lurie,G., Thompson,P.J., Wilkens,L.R.,
Ness,R.B., Moysich,K.B., Chang-Claude,J., Wang-Gohrke,S.,
Cramer,D.W., Terry,K.L., Hankinson,S.E., Tworoger,S.S.,
Garcia-Closas,M., Yang,H., Lissowska,J., Chanock,S.J.,
Pharoah,P.D., Song,H., Whitemore,A.S., Pearce,C.L., Stram,D.O.,
Wu,A.H., Pike,M.C., Gayther,S.A., Ramus,S.J., Menon,U.,
Gentry-Maharaj,A., Anton-Culver,H., Ziogas,A., Hogdall,E.,
Kjaer,S.K., Hogdall,C., Berchuck,A., Schildkraut,J.M.,
Iversen,E.S., Moorman,P.G., Phelan,C.M., Sellers,T.A.,
Cunningham,J.M., Vierkant,R.A., Rider,D.N., Goode,E.L., Haviv,I.
and Chenevix-Trench,G.
CONSRTM Ovarian Cancer Association Consortium; Australian Ovarian Cancer
Study Group; Australian Cancer Study (Ovarian Cancer)
TITLE Evaluation of candidate stromal epithelial cross-talk genes
identifies association between risk of serous ovarian cancer and
TERT, a cancer susceptibility 'hot-spot'
JOURNAL PLoS Genet. 6 (7), E1001016 (2010)
PUBMED 20628624
REMARK GeneRIF: Meta-analysis of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1768)
AUTHORS Zhang,P., Zhang,C., Wang,X., Liu,F., Sung,C.J., Quddus,M.R. and
Lawrence,W.D.
TITLE The expression of selenium-binding protein 1 is decreased in
uterine leiomyoma
JOURNAL Diagn Pathol 5, 80 (2010)
PUBMED 21143902
REMARK GeneRIF: Decreased expression of selenium-binding protein 1 in
uterine leiomyoma may indicate a role of the protein in
tumorigenesis.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1768)
AUTHORS Porat,A., Sagiv,Y. and Elazar,Z.
TITLE A 56-kDa selenium-binding protein participates in intra-Golgi
protein transport
JOURNAL J. Biol. Chem. 275 (19), 14457-14465 (2000)
PUBMED 10799528
REFERENCE 7 (bases 1 to 1768)
AUTHORS Chang,P.W., Tsui,S.K., Liew,C., Lee,C.C., Waye,M.M. and Fung,K.P.
TITLE Isolation, characterization, and chromosomal mapping of a novel
cDNA clone encoding human selenium binding protein
JOURNAL J. Cell. Biochem. 64 (2), 217-224 (1997)
PUBMED 9027582
REFERENCE 8 (bases 1 to 1768)
AUTHORS Czar,M.J., Owens-Grillo,J.K., Dittmar,K.D., Hutchison,K.A.,
Zacharek,A.M., Leach,K.L., Deibel,M.R. Jr. and Pratt,W.B.
TITLE Characterization of the protein-protein interactions determining
the heat shock protein (hsp90.hsp70.hsp56) heterocomplex
JOURNAL J. Biol. Chem. 269 (15), 11155-11161 (1994)
PUBMED 8157642
REFERENCE 9 (bases 1 to 1768)
AUTHORS Lanfear,J., Fleming,J., Walker,M. and Harrison,P.
TITLE Different patterns of regulation of the genes encoding the closely
related 56 kDa selenium- and acetaminophen-binding proteins in
normal tissues and during carcinogenesis
JOURNAL Carcinogenesis 14 (3), 335-340 (1993)
PUBMED 8453708
REFERENCE 10 (bases 1 to 1768)
AUTHORS Bartolone,J.B., Birge,R.B., Bulera,S.J., Bruno,M.K.,
Nishanian,E.V., Cohen,S.D. and Khairallah,E.A.
TITLE Purification, antibody production, and partial amino acid sequence
of the 58-kDa acetaminophen-binding liver proteins
JOURNAL Toxicol. Appl. Pharmacol. 113 (1), 19-29 (1992)
PUBMED 1553752
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB288439.1, BC009084.1 and
BQ045424.1.
On Apr 21, 2012 this sequence version replaced gi:16306549.
Summary: This gene encodes a member of the selenium-binding protein
family. Selenium is an essential nutrient that exhibits potent
anticarcinogenic properties, and deficiency of selenium may cause
certain neurologic diseases. The effects of selenium in preventing
cancer and neurologic diseases may be mediated by selenium-binding
proteins, and decreased expression of this gene may be associated
with several types of cancer. The encoded protein may play a
selenium-dependent role in ubiquitination/deubiquitination-mediated
protein degradation. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene.
[provided by RefSeq, Apr 2012].
Transcript Variant: This variant (1) encodes isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC009084.1, AK315643.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-46 DB288439.1 1-46
47-1751 BC009084.1 1-1705
1752-1768 BQ045424.1 1-17 c
FEATURES Location/Qualifiers
source 1..1768
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21.3"
gene 1..1768
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/note="selenium binding protein 1"
/db_xref="GeneID:8991"
/db_xref="HGNC:10719"
/db_xref="HPRD:05007"
/db_xref="MIM:604188"
exon 1..97
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
CDS 94..1512
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/note="isoform 1 is encoded by transcript variant 1; 56
kDa selenium-binding protein"
/codon_start=1
/product="selenium-binding protein 1 isoform 1"
/protein_id="NP_003935.2"
/db_xref="GI:16306550"
/db_xref="CCDS:CCDS995.1"
/db_xref="GeneID:8991"
/db_xref="HGNC:10719"
/db_xref="HPRD:05007"
/db_xref="MIM:604188"
/translation="
MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVIHRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHKVIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERPGGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPADVEAGLYGSHLYVWDWQRHEIVQTLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKNEGGTWSVEKVIQVPPKKVKGWLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGPVQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIREGSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI
"
misc_feature 115..1509
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/note="56kDa selenium binding protein (SBP56); Region:
SBP56; pfam05694"
/db_xref="CDD:147702"
exon 98..154
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
exon 155..267
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
exon 268..453
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
variation 332
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/replace="a"
/replace="g"
/db_xref="dbSNP:1043849"
variation 425
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/replace="c"
/replace="t"
/db_xref="dbSNP:11539467"
exon 454..574
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
variation 457
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/replace="a"
/replace="g"
/db_xref="dbSNP:35396382"
variation 497
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/replace="g"
/replace="t"
/db_xref="dbSNP:1043857"
exon 575..757
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
exon 758..936
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
variation 877
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/replace="a"
/replace="g"
/db_xref="dbSNP:1043860"
variation 885
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043861"
exon 937..1015
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
exon 1016..1137
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
exon 1138..1230
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
STS 1156..1431
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/standard_name="ECD09001"
/db_xref="UniSTS:290047"
exon 1231..1349
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
exon 1350..1753
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/inference="alignment:Splign:1.39.8"
variation 1362
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/replace="a"
/replace="g"
/db_xref="dbSNP:1127513"
STS 1401..1654
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/standard_name="WI-20043"
/db_xref="UniSTS:70113"
STS 1422..1684
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/standard_name="REN33842"
/db_xref="UniSTS:358642"
STS 1488..1668
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/standard_name="A002D26"
/db_xref="UniSTS:65169"
STS 1488..1668
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/standard_name="G19959"
/db_xref="UniSTS:65168"
STS 1524..1690
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
/standard_name="SHGC-2948"
/db_xref="UniSTS:16359"
polyA_signal 1727..1732
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
polyA_site 1753
/gene="SELENBP1"
/gene_synonym="hSBP; LPSB; SBP56; SP56"
ORIGIN
tataaattccctcccttcgctccttccccggaacagcggcctctgacaccagcacagcaaacccgccgggatcaaagtgtaccagtcggcagcatggctacgaaatgtgggaattgtggacccggctactccacccctctggaggccatgaaaggacccagggaagagatcgtctacctgccctgcatttaccgaaacacaggcactgaggccccagattatctggccactgtggatgttgaccccaagtctccccagtattgccaggtcatccaccggctgcccatgcccaacctgaaggacgagctgcatcactcaggatggaacacctgcagcagctgcttcggtgatagcaccaagtcgcgcaccaagctggtgctgcccagtctcatctcctctcgcatctatgtggtggacgtgggctctgagccccgggccccaaagctgcacaaggtcattgagcccaaggacatccatgccaagtgcgaactggcctttctccacaccagccactgcctggccagcggggaagtgatgatcagctccctgggagacgtcaagggcaatggcaaagggggttttgtgctgctggatggggagacgttcgaggtgaaggggacatgggagagacctgggggtgctgcaccgttgggctatgacttctggtaccagcctcgacacaatgtcatgatcagcactgagtgggcagctcccaatgtcttacgagatggcttcaaccccgctgatgtggaggctggactgtacgggagccacttatatgtatgggactggcagcgccatgagattgtgcagaccctgtctctaaaagatgggcttattcccttggagatccgcttcctgcacaacccagacgctgcccaaggctttgtgggctgcgcactcagctccaccatccagcgcttctacaagaacgagggaggtacatggtcagtggagaaggtgatccaggtgccccccaagaaagtgaagggctggctgctgcccgaaatgccaggcctgatcaccgacatcctgctctccctggacgaccgcttcctctacttcagcaactggctgcatggggacctgaggcagtatgacatctctgacccacagagaccccgcctcacaggacagctcttcctcggaggcagcattgttaagggaggccctgtgcaagtgctggaggacgaggaactaaagtcccagccagagcccctagtggtcaagggaaaacgggtggctggaggccctcagatgatccagctcagcctggatgggaagcgcctctacatcaccacgtcgctgtacagtgcctgggacaagcagttttaccctgatctcatcagggaaggctctgtgatgctgcaggttgatgtagacacagtaaaaggagggctgaagttgaaccccaacttcctggtggacttcgggaaggagccccttggcccagcccttgcccatgagctccgctaccctgggggcgattgtagctctgacatctggatttgaactccaccctcatcacccacactccctattttgggccctcacttccttggggacctggcttcattctgctctctcttggcacccgacccttggcagcatgtaccacacagccaagctgagactgtggcaatgtgttgagtcatatacatttactgaccactgttgcttgttgctcactgtgctgcttttccatgagctcttggaggcaccaagaaataaactcgtaaccctgtccttcagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8991 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8991 -> Molecular function: GO:0008430 [selenium binding] evidence: IEA
GeneID:8991 -> Biological process: GO:0015031 [protein transport] evidence: IEA
GeneID:8991 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:8991 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:8991 -> Cellular component: GO:0016020 [membrane] evidence: IEA
by
@meso_cacase at
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