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2025-05-09 17:03:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003088 2812 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens fascin homolog 1, actin-bundling protein
(Strongylocentrotus purpuratus) (FSCN1), mRNA.
ACCESSION NM_003088
VERSION NM_003088.3 GI:347360903
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2812)
AUTHORS Ma,Y., Li,A., Faller,W.J., Libertini,S., Fiorito,F.,
Gillespie,D.A., Sansom,O.J., Yamashiro,S. and Machesky,L.M.
TITLE Fascin 1 is transiently expressed in mouse melanoblasts during
development and promotes migration and proliferation
JOURNAL Development 140 (10), 2203-2211 (2013)
PUBMED 23633513
REMARK GeneRIF: fascin 1 promotes cell migration and has a role in growth
and cell cycle progression
REFERENCE 2 (bases 1 to 2812)
AUTHORS Hanker,L.C., Karn,T., Holtrich,U., Graeser,M., Becker,S.,
Reinhard,J., Ruckhaberle,E., Gevensleben,H. and Rody,A.
TITLE Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer
JOURNAL Anticancer Res. 33 (2), 371-377 (2013)
PUBMED 23393326
REMARK GeneRIF: FSCN1 is frequently expressed in primary epithelial
ovarian cancer
REFERENCE 3 (bases 1 to 2812)
AUTHORS Kim,S.J., Kim,D.C., Kim,M.C., Jung,G.J., Kim,K.H., Jang,J.S.,
Kwon,H.C., Kim,Y.M. and Jeong,J.S.
TITLE Fascin expression is related to poor survival in gastric cancer
JOURNAL Pathol. Int. 62 (12), 777-784 (2012)
PUBMED 23252866
REMARK GeneRIF: fascin expression was related to worse survival rates and
can be an independent poor prognostic factor in gastric cancer.
REFERENCE 4 (bases 1 to 2812)
AUTHORS Hashimoto,Y., Kim,D.J. and Adams,J.C.
TITLE The roles of fascins in health and disease
JOURNAL J. Pathol. 224 (3), 289-300 (2011)
PUBMED 21618240
REMARK Review article
REFERENCE 5 (bases 1 to 2812)
AUTHORS Bros,M., Ross,X.L., Pautz,A., Reske-Kunz,A.B. and Ross,R.
TITLE The human fascin gene promoter is highly active in mature dendritic
cells due to a stage-specific enhancer
JOURNAL J. Immunol. 171 (4), 1825-1834 (2003)
PUBMED 12902483
REMARK GeneRIF: Fascin regulatory sequences are found solely in the
5'-flanking promoter region; the promoter exerts robust activity in
dendritic cells (DC) and a fascin-positive neuronal cell line;
promoter activity in DC markedly increases with maturation of DC.
REFERENCE 6 (bases 1 to 2812)
AUTHORS Pinkus,G.S., Pinkus,J.L., Langhoff,E., Matsumura,F., Yamashiro,S.,
Mosialos,G. and Said,J.W.
TITLE Fascin, a sensitive new marker for Reed-Sternberg cells of
hodgkin's disease. Evidence for a dendritic or B cell derivation?
JOURNAL Am. J. Pathol. 150 (2), 543-562 (1997)
PUBMED 9033270
REFERENCE 7 (bases 1 to 2812)
AUTHORS Mosialos,G., Yamashiro,S., Baughman,R.W., Matsudaira,P., Vara,L.,
Matsumura,F., Kieff,E. and Birkenbach,M.
TITLE Epstein-Barr virus infection induces expression in B lymphocytes of
a novel gene encoding an evolutionarily conserved 55-kilodalton
actin-bundling protein
JOURNAL J. Virol. 68 (11), 7320-7328 (1994)
PUBMED 7933116
REFERENCE 8 (bases 1 to 2812)
AUTHORS Duh,F.M., Latif,F., Weng,Y., Geil,L., Modi,W., Stackhouse,T.,
Matsumura,F., Duan,D.R., Linehan,W.M., Lerman,M.I. et al.
TITLE cDNA cloning and expression of the human homolog of the sea urchin
fascin and Drosophila singed genes which encodes an actin-bundling
protein
JOURNAL DNA Cell Biol. 13 (8), 821-827 (1994)
PUBMED 8068206
REFERENCE 9 (bases 1 to 2812)
AUTHORS Yamashiro-Matsumura,S. and Matsumura,F.
TITLE Intracellular localization of the 55-kD actin-bundling protein in
cultured cells: spatial relationships with actin, alpha-actinin,
tropomyosin, and fimbrin
JOURNAL J. Cell Biol. 103 (2), 631-640 (1986)
PUBMED 3525578
REFERENCE 10 (bases 1 to 2812)
AUTHORS Yamashiro-Matsumura,S. and Matsumura,F.
TITLE Purification and characterization of an F-actin-bundling
55-kilodalton protein from HeLa cells
JOURNAL J. Biol. Chem. 260 (8), 5087-5097 (1985)
PUBMED 3886649
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI546742.1, AK095254.1,
BC000521.2 and BU629782.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 20, 2011 this sequence version replaced gi:49472815.
Summary: This gene encodes a member of the fascin family of
actin-binding proteins. Fascin proteins organize F-actin into
parallel bundles, and are required for the formation of actin-based
cellular protrusions. The encoded protein plays a critical role in
cell migration, motility, adhesion and cellular interactions.
Expression of this gene is known to be regulated by several
microRNAs, and overexpression of this gene may play a role in the
metastasis of multiple types of cancer by increasing cell motility.
Expression of this gene is also a marker for Reed-Sternberg cells
in Hodgkin's lymphoma. A pseudogene of this gene is located on the
long arm of chromosome 15. [provided by RefSeq, Sep 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC006304.2, U03057.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3 BI546742.1 1-3
4-123 AK095254.1 1-120
124-2795 BC000521.2 15-2686
2796-2812 BU629782.1 1-17 c
FEATURES Location/Qualifiers
source 1..2812
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p22"
gene 1..2812
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="fascin homolog 1, actin-bundling protein
(Strongylocentrotus purpuratus)"
/db_xref="GeneID:6624"
/db_xref="HGNC:11148"
/db_xref="HPRD:04068"
/db_xref="MIM:602689"
exon 1..964
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/inference="alignment:Splign:1.39.8"
misc_feature 12
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="transcription initiation site"
variation 18
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:374232009"
variation 80
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:11557814"
variation 100
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:11557817"
variation 115
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:113466135"
variation 124
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:369511249"
CDS 133..1614
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="55 kDa actin-bundling protein; singed-like (fascin
homolog, sea urchin)"
/codon_start=1
/product="fascin"
/protein_id="NP_003079.1"
/db_xref="GI:4507115"
/db_xref="CCDS:CCDS5342.1"
/db_xref="GeneID:6624"
/db_xref="HGNC:11148"
/db_xref="HPRD:04068"
/db_xref="MIM:602689"
/translation="
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
"
misc_feature 136..138
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylthreonine; propagated from
UniProtKB/Swiss-Prot (Q16658.3); acetylation site"
misc_feature 169..534
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="Fascin-like domain; members include
actin-bundling/crosslinking proteins facsin,
histoactophilin and singed; identified in sea urchin,
Drosophila, Xenopus, rodents, and humans; The fascin-like
domain adopts a beta-trefoil topology and contains an...;
Region: Fascin; cd00257"
/db_xref="CDD:29332"
misc_feature 244..246
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q16658.3); phosphorylation site"
misc_feature 247..249
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="PKC phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:29332"
misc_feature 247..249
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKC; propagated from
UniProtKB/Swiss-Prot (Q16658.3); phosphorylation site"
misc_feature 247..249
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01501"
misc_feature 547..900
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="Fascin-like domain; members include
actin-bundling/crosslinking proteins facsin,
histoactophilin and singed; identified in sea urchin,
Drosophila, Xenopus, rodents, and humans; The fascin-like
domain adopts a beta-trefoil topology and contains an...;
Region: Fascin; cd00257"
/db_xref="CDD:29332"
misc_feature 637..639
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="PKC phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:29332"
misc_feature 910..1266
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="Fascin-like domain; members include
actin-bundling/crosslinking proteins facsin,
histoactophilin and singed; identified in sea urchin,
Drosophila, Xenopus, rodents, and humans; The fascin-like
domain adopts a beta-trefoil topology and contains an...;
Region: Fascin; cd00257"
/db_xref="CDD:29332"
misc_feature 991..993
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="PKC phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:29332"
misc_feature 1279..1611
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="Fascin-like domain; members include
actin-bundling/crosslinking proteins facsin,
histoactophilin and singed; identified in sea urchin,
Drosophila, Xenopus, rodents, and humans; The fascin-like
domain adopts a beta-trefoil topology and contains an...;
Region: Fascin; cd00257"
/db_xref="CDD:29332"
misc_feature 1360..1362
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/note="PKC phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:29332"
variation 175
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:11557821"
variation 207
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:11557820"
variation 303
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:372943444"
variation 344
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:201797140"
variation 392
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:11557819"
variation 402
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:61732762"
variation 410
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:61732763"
variation 411
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:140188726"
variation 420
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:145834301"
variation 423
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:369117139"
variation 426
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:146600697"
variation 453
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:141452968"
variation 459
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:376016880"
variation 471
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:61731540"
variation 486
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:200701274"
variation 492
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:61731541"
variation 512
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:11557818"
variation 531
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:145145668"
variation 545
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:138722128"
variation 561
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201120266"
variation 578
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:61731557"
variation 594
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:143649632"
variation 624
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:61731558"
variation 694
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371640415"
variation 726
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:374555702"
variation 730
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:61731559"
variation 750
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:112714846"
variation 775
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:61732760"
variation 792
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:61732761"
variation 807
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:187465308"
variation 864
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199712638"
variation 921
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:145153592"
variation 948
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:17764881"
variation 963
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200989728"
exon 965..1121
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/inference="alignment:Splign:1.39.8"
variation 990
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373614334"
variation 997
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:113330783"
variation 1000
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201645418"
variation 1026
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:147410388"
variation 1027
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373803657"
variation 1056
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:73052796"
variation 1064
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:111761155"
variation 1079
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:143738037"
variation 1085
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:150576558"
variation 1092
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:11557822"
variation 1110
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:374500646"
exon 1122..1243
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/inference="alignment:Splign:1.39.8"
variation 1140
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:1640233"
variation 1154
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:377275041"
variation 1162
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:186765948"
variation 1224
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:148787065"
exon 1244..1411
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/inference="alignment:Splign:1.39.8"
variation 1250
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:11557815"
variation 1293
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:375630058"
variation 1297
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:369724252"
variation 1311
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:144434787"
variation 1334
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:139232758"
variation 1368
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:144028572"
variation 1369
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:146612530"
variation 1389
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:376197791"
variation 1390
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:369086654"
variation 1395
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:151247331"
variation 1396
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:202027851"
exon 1412..2796
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/inference="alignment:Splign:1.39.8"
variation 1450
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371109603"
variation 1451
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:17850070"
variation 1468
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:140594742"
variation 1474
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:371278589"
variation 1531
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199567587"
variation 1535
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373729143"
variation 1545
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:368024232"
variation 1548
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:201678383"
variation 1560
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:138127333"
variation 1575
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:376411605"
variation 1577
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142450075"
variation 1578
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:113601886"
variation 1594
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:369926891"
variation 1620
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:374456091"
variation 1623
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:116867877"
variation 1625
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:116036920"
variation 1634
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:373433239"
variation 1651
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:376574679"
variation 1707
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="g"
/db_xref="dbSNP:375923451"
variation 1840
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace=""
/replace="c"
/db_xref="dbSNP:146589678"
variation 1849
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="g"
/replace="t"
/db_xref="dbSNP:368725715"
variation 1888
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:137877258"
STS 1923..2784
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/standard_name="FSCN1__6758"
/db_xref="UniSTS:466191"
variation 2030
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:185458134"
variation 2054
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="t"
/db_xref="dbSNP:73334479"
variation 2126
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="t"
/db_xref="dbSNP:1054201"
variation 2191
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:3735288"
variation 2372
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="t"
/db_xref="dbSNP:77878566"
variation 2471
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace=""
/replace="g"
/db_xref="dbSNP:35340467"
variation 2581
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="c"
/db_xref="dbSNP:111913918"
STS 2664..2768
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/standard_name="G62033"
/db_xref="UniSTS:139123"
STS 2664..2751
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/standard_name="RH28419"
/db_xref="UniSTS:84106"
variation 2740
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="c"
/replace="t"
/db_xref="dbSNP:8772"
polyA_signal 2769..2774
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
polyA_site 2789
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
variation 2790
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
/replace="a"
/replace="g"
/db_xref="dbSNP:113634843"
polyA_site 2796
/gene="FSCN1"
/gene_synonym="FAN1; HSN; p55; SNL"
ORIGIN
agctgggctttgtggagcgctgcggagggtgcgtgcgggccgcggcagccgaacaaaggagcaggggcgccgccgcagggacccgccacccacctcccggggccgcgcagcggcctctcgtctactgccaccatgaccgccaacggcacagccgaggcggtgcagatccagttcggcctcatcaactgcggcaacaagtacctgacggccgaggcgttcgggttcaaggtgaacgcgtccgccagcagcctgaagaagaagcagatctggacgctggagcagccccctgacgaggcgggcagcgcggccgtgtgcctgcgcagccacctgggccgctacctggcggcggacaaggacggcaacgtgacctgcgagcgcgaggtgcccggtcccgactgccgtttcctcatcgtggcgcacgacgacggtcgctggtcgctgcagtccgaggcgcaccggcgctacttcggcggcaccgaggaccgcctgtcctgcttcgcgcagacggtgtcccccgccgagaagtggagcgtgcacatcgccatgcaccctcaggtcaacatctacagcgtcacccgtaagcgctacgcgcacctgagcgcgcggccggccgacgagatcgccgtggaccgcgacgtgccctggggcgtcgactcgctcatcaccctcgccttccaggaccagcgctacagcgtgcagaccgccgaccaccgcttcctgcgccacgacgggcgcctggtggcgcgccccgagccggccactggctacacgctggagttccgctccggcaaggtggccttccgcgactgcgagggccgttacctggcgccgtcggggcccagcggcacgctcaaggcgggcaaggccaccaaggtgggcaaggacgagctctttgctctggagcagagctgcgcccaggtcgtgctgcaggcggccaacgagaggaacgtgtccacgcgccagggtatggacctgtctgccaatcaggacgaggagaccgaccaggagaccttccagctggagatcgaccgcgacaccaaaaagtgtgccttccgtacccacacgggcaagtactggacgctgacggccaccgggggcgtgcagtccaccgcctccagcaagaatgccagctgctactttgacatcgagtggcgtgaccggcgcatcacactgagggcgtccaatggcaagtttgtgacctccaagaagaatgggcagctggccgcctcggtggagacagcaggggactcagagctcttcctcatgaagctcatcaaccgccccatcatcgtgttccgcggggagcatggcttcatcggctgccgcaaggtcacgggcaccctggacgccaaccgctccagctatgacgtcttccagctggagttcaacgatggcgcctacaacatcaaagactccacaggcaaatactggacggtgggcagtgactccgcggtcaccagcagcggcgacactcctgtggacttcttcttcgagttctgcgactataacaaggtggccatcaaggtgggcgggcgctacctgaagggcgaccacgcaggcgtcctgaaggcctcggcggaaaccgtggaccccgcctcgctctgggagtactagggccggcccgtccttccccgcccctgcccacatggcggctcctgccaaccctccctgctaaccccttctccgccaggtgggctccagggcgggaggcaagcccccttgcctttcaaactggaaaccccagagaaaacggtgcccccacctgtcgcccctatggactccccactctcccctccgcccgggttccctactcccctcgggtcagcggctgcggcctggccctgggagggatttcagatgcccctgccctcttgtctgccacggggcgagtctggcacctctttcttctgacctcagacggctctgagccttatttctctggaagcggctaagggacggttgggggctgggagccctgggcgtgtagtgtaactggaatcttttgcctctcccagccacctcctcccagccccccaggagagctgggcacatgtcccaagcctgtcagtggccctccctggtgcactgtccccgaaacccctgcttgggaagggaagctgtcgggtgggctaggactgacccttgtggtgtttttttgggtggtggctggaaacagcccctctcccacgtggcagaggctcagcctggctcccttccctggagcggcagggcgtgacggccacagggtctgcccgctgcacgttctgccaaggtggtggtggcgggcgggtaggggtgtgggggccgtcttcctcctgtctctttcctttcaccctagcctgactggaagcagaaaatgaccaaatcagtattttttttaatgaaatattattgctggaggcgtcccaggcaagcctggctgtagtagcgagtgatctggcggggggcgtctcagcaccctccccagggggtgcatctcagccccctctttccgtccttcccgtccagccccagccctgggcctgggctgccgacacctgggccagagcccctgctgtgattggtgctccctgggcctcccgggtggatgaagccaggcgtcgccccctccgggagccctggggtgagccgccggggcccccctgctgccagcctcccccgtccccaacatgcatctcactctgggtgtcttggtcttttattttttgtaagtgtcatttgtataactctaaacgcccatgatagtagcttcaaactggaaatagcgaaataaaataactcagtctgcagccccagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6624 -> Molecular function: GO:0003779 [actin binding] evidence: IDA
GeneID:6624 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6624 -> Molecular function: GO:0008144 [drug binding] evidence: IDA
GeneID:6624 -> Molecular function: GO:0030674 [protein binding, bridging] evidence: IEA
GeneID:6624 -> Molecular function: GO:0051015 [actin filament binding] evidence: IDA
GeneID:6624 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
GeneID:6624 -> Biological process: GO:0016477 [cell migration] evidence: IMP
GeneID:6624 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: IDA
GeneID:6624 -> Biological process: GO:0048870 [cell motility] evidence: IDA
GeneID:6624 -> Biological process: GO:0051017 [actin filament bundle assembly] evidence: IDA
GeneID:6624 -> Cellular component: GO:0001725 [stress fiber] evidence: IDA
GeneID:6624 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:6624 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IDA
GeneID:6624 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
GeneID:6624 -> Cellular component: GO:0030175 [filopodium] evidence: IDA
GeneID:6624 -> Cellular component: GO:0071437 [invadopodium] evidence: IDA
by
@meso_cacase at
DBCLS
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