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2025-05-09 17:09:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002747 4736 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens mitogen-activated protein kinase 4 (MAPK4), mRNA.
ACCESSION NM_002747
VERSION NM_002747.3 GI:89276768
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4736)
AUTHORS Long,W., Foulds,C.E., Qin,J., Liu,J., Ding,C., Lonard,D.M.,
Solis,L.M., Wistuba,I.I., Qin,J., Tsai,S.Y., Tsai,M.J. and
O'Malley,B.W.
TITLE ERK3 signals through SRC-3 coactivator to promote human lung cancer
cell invasion
JOURNAL J. Clin. Invest. 122 (5), 1869-1880 (2012)
PUBMED 22505454
REMARK GeneRIF: A previously unknown role for ERK3 in promoting lung
cancer cell invasiveness by phosphorylating SRC-3 and regulating
SRC-3 proinvasive activity by site-specific phosphorylation.
REFERENCE 2 (bases 1 to 4736)
AUTHORS De la Mota-Peynado,A., Chernoff,J. and Beeser,A.
TITLE Identification of the atypical MAPK Erk3 as a novel substrate for
p21-activated kinase (Pak) activity
JOURNAL J. Biol. Chem. 286 (15), 13603-13611 (2011)
PUBMED 21317288
REMARK GeneRIF: identify the Erk3 protein as a novel class I Pak substrate
and further suggest a role for Pak kinase activity in atypical MAPK
signaling.
REFERENCE 3 (bases 1 to 4736)
AUTHORS Deleris,P., Trost,M., Topisirovic,I., Tanguay,P.L., Borden,K.L.,
Thibault,P. and Meloche,S.
TITLE Activation loop phosphorylation of ERK3/ERK4 by group I
p21-activated kinases (PAKs) defines a novel
PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway
JOURNAL J. Biol. Chem. 286 (8), 6470-6478 (2011)
PUBMED 21177870
REMARK GeneRIF: Activation loop phosphorylation of ERK3/ERK4 by group I
p21-activated kinases (PAKs) defines a novel
PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
REFERENCE 4 (bases 1 to 4736)
AUTHORS Aberg,E., Torgersen,K.M., Johansen,B., Keyse,S.M., Perander,M. and
Seternes,O.M.
TITLE Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a
novel MAPK interaction motif
JOURNAL J. Biol. Chem. 284 (29), 19392-19401 (2009)
PUBMED 19473979
REMARK GeneRIF: Data defined a novel MK5 interaction motif (FRIEDE) within
both ERK4 and ERK3 that is essential for binding to the C-terminal
region of MK5.
REFERENCE 5 (bases 1 to 4736)
AUTHORS Lerner-Marmarosh,N., Miralem,T., Gibbs,P.E. and Maines,M.D.
TITLE Human biliverdin reductase is an ERK activator; hBVR is an ERK
nuclear transporter and is required for MAPK signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 105 (19), 6870-6875 (2008)
PUBMED 18463290
REMARK GeneRIF: These findings, together with observations that si-hBVR
blocked activation of ERK and Elk1 by IGF1 and prevented formation
of ternary complex between MEK/ERK/hBVR, define the critical role
of hBVR in ERK signaling and nuclear functions of the kinase.
REFERENCE 6 (bases 1 to 4736)
AUTHORS Davis,R.J.
TITLE Transcriptional regulation by MAP kinases
JOURNAL Mol. Reprod. Dev. 42 (4), 459-467 (1995)
PUBMED 8607977
REMARK Review article
REFERENCE 7 (bases 1 to 4736)
AUTHORS Seger,R. and Krebs,E.G.
TITLE The MAPK signaling cascade
JOURNAL FASEB J. 9 (9), 726-735 (1995)
PUBMED 7601337
REMARK Review article
REFERENCE 8 (bases 1 to 4736)
AUTHORS Zhu,A.X., Zhao,Y., Moller,D.E. and Flier,J.S.
TITLE Cloning and characterization of p97MAPK, a novel human homolog of
rat ERK-3
JOURNAL Mol. Cell. Biol. 14 (12), 8202-8211 (1994)
PUBMED 7969157
REFERENCE 9 (bases 1 to 4736)
AUTHORS Li,L., Wysk,M., Gonzalez,F.A. and Davis,R.J.
TITLE Genomic loci of human mitogen-activated protein kinases
JOURNAL Oncogene 9 (2), 647-649 (1994)
PUBMED 8290275
REFERENCE 10 (bases 1 to 4736)
AUTHORS Gonzalez,F.A., Raden,D.L., Rigby,M.R. and Davis,R.J.
TITLE Heterogeneous expression of four MAP kinase isoforms in human
tissues
JOURNAL FEBS Lett. 304 (2-3), 170-178 (1992)
PUBMED 1319925
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC050299.1, X59727.1,
BC040493.1 and AI088913.1.
On Mar 9, 2006 this sequence version replaced gi:6715608.
Summary: Mitogen-activated protein kinase 4 is a member of the
mitogen-activated protein kinase family. Tyrosine kinase growth
factor receptors activate mitogen-activated protein kinases which
then translocate into the nucleus where it phosphorylates nuclear
targets. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK295058.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-942 BC050299.1 1-942
943-2067 X59727.1 480-1604
2068-4518 BC040493.1 1664-4114
4519-4736 AI088913.1 1-218 c
FEATURES Location/Qualifiers
source 1..4736
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21.1"
gene 1..4736
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="mitogen-activated protein kinase 4"
/db_xref="GeneID:5596"
/db_xref="HGNC:6878"
/db_xref="MIM:176949"
exon 1..130
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/inference="alignment:Splign:1.39.8"
variation 48
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:146548264"
variation 97
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:190769648"
exon 131..1546
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/inference="alignment:Splign:1.39.8"
variation 135
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="g"
/replace="t"
/db_xref="dbSNP:142956846"
variation 150
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:181934847"
variation 325
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:377162712"
variation 462
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:370642437"
variation 543
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049710"
variation 763
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:1049711"
variation 816
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:138390517"
misc_feature 911..913
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="upstream in-frame stop codon"
variation 943
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="g"
/replace="t"
/db_xref="dbSNP:3752085"
variation 978
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:370578537"
variation 979
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:372936554"
CDS 1001..2764
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/EC_number="2.7.11.24"
/note="Erk3-related; p63-MAPK; MAP kinase 4; MAP kinase
isoform p63; extracellular signal-regulated kinase 4"
/codon_start=1
/product="mitogen-activated protein kinase 4"
/protein_id="NP_002738.2"
/db_xref="GI:89276769"
/db_xref="CCDS:CCDS42437.1"
/db_xref="GeneID:5596"
/db_xref="HGNC:6878"
/db_xref="MIM:176949"
/translation="
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
"
misc_feature 1040..2053
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="Catalytic domain of the Serine/Threonine Kinases,
Mitogen-Activated Protein Kinases 4 and 6; Region:
STKc_MAPK4_6; cd07854"
/db_xref="CDD:143359"
misc_feature 1058..1936
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="Protein kinase domain; Region: Pkinase; pfam00069"
/db_xref="CDD:200973"
misc_feature order(1076..1087,1091..1096,1100..1102,1139..1141,
1145..1147,1190..1192,1232..1234,1313..1324,1331..1333,
1337..1342,1445..1447,1451..1453,1457..1462,1466..1468,
1499..1504,1511..1513,1556..1558,1562..1573,1577..1579,
1691..1693)
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="active site"
/db_xref="CDD:143359"
misc_feature order(1076..1087,1091..1096,1100..1102,1139..1141,
1145..1147,1232..1234,1313..1324,1331..1333,1340..1342,
1451..1453,1457..1462,1466..1468,1499..1504)
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:143359"
misc_feature order(1190..1192,1337..1339,1445..1447,1451..1453,
1511..1513,1556..1558,1562..1573,1577..1579,1691..1693)
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:143359"
misc_feature order(1223..1225,1325..1330,1343..1345,1373..1375,
1382..1384,1403..1405,1469..1480,1484..1486,1943..1945,
1949..1951,1958..1960)
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="KIM docking site [polypeptide binding]; other site"
/db_xref="CDD:143359"
misc_feature 1499..1579
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/note="activation loop (A-loop); other site"
/db_xref="CDD:143359"
misc_feature 1556..1564
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P31152.2);
Region: SEG motif"
misc_feature 1556..1558
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PAK1, PAK2 and PAK3; propagated
from UniProtKB/Swiss-Prot (P31152.2); phosphorylation
site"
misc_feature 1586..1588
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[10]
/db_xref="HPRD:01497"
misc_feature 1982..1999
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P31152.2);
Region: FRIEDE motif"
variation 1001
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201113430"
variation 1024
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370265083"
variation 1049
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374524649"
variation 1050
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:34207571"
variation 1072
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:370695586"
variation 1084
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:3752086"
variation 1108
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367914884"
variation 1112
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:3752087"
variation 1122
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199879399"
variation 1139
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367684848"
variation 1155
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140972647"
variation 1162
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56259916"
variation 1163
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61747609"
variation 1169
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:369990219"
variation 1170
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373566179"
variation 1183
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:55800528"
variation 1186
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:56328353"
variation 1190
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372835108"
variation 1208
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200603915"
variation 1252
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56335862"
variation 1297
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200651462"
variation 1298
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199714690"
variation 1303
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368717366"
variation 1309
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:377215882"
variation 1330
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:55888637"
variation 1331
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200812352"
variation 1340
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:186595195"
variation 1359
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:376833028"
variation 1360
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:370581359"
variation 1382
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372903985"
variation 1403
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:375617264"
variation 1405
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370089598"
variation 1408
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="g"
/replace="t"
/db_xref="dbSNP:373807658"
variation 1423
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:45484996"
variation 1426
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373515540"
variation 1457
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201642307"
variation 1465
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:371208782"
variation 1474
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372619410"
variation 1487
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:376363938"
variation 1489
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:45471400"
variation 1500
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375005333"
variation 1522
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:191006677"
exon 1547..1691
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/inference="alignment:Splign:1.39.8"
variation 1564
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373908500"
variation 1588
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200093759"
variation 1591
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:371497095"
variation 1611
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374923849"
variation 1636
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368403152"
variation 1663
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:372337672"
variation 1671
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201585776"
exon 1692..1853
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/inference="alignment:Splign:1.39.8"
variation 1723
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372444429"
variation 1745
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:375703786"
variation 1746
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:369281315"
variation 1751
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace=""
/replace="g"
/db_xref="dbSNP:66911538"
variation 1786
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:375115857"
variation 1812
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:144944694"
variation 1837
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:16952476"
variation 1847
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200724420"
exon 1854..2067
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/inference="alignment:Splign:1.39.8"
variation 1865
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:376293194"
variation 1872
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:371938450"
variation 1877
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:374522930"
variation 1888
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368937966"
variation 1948
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:9953234"
variation 1950
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:183692158"
variation 1960
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:199726442"
variation 2003
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201688372"
variation 2005
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371446025"
variation 2020
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199859025"
variation 2023
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201644833"
variation 2046
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:368928539"
variation 2055
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:186466272"
variation 2056
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:55784156"
variation 2060
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="t"
/db_xref="dbSNP:376409655"
exon 2068..4736
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/inference="alignment:Splign:1.39.8"
variation 2112
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:3752089"
variation 2203
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373760952"
variation 2207
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="t"
/db_xref="dbSNP:199532611"
variation 2275
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201785400"
variation 2317
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:201371342"
variation 2338
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:202060655"
variation 2343
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371041289"
variation 2398
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368636904"
variation 2437
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:56329210"
variation 2578
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374164796"
variation 2645
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:368327562"
variation 2659
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372005204"
variation 2668
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="g"
/replace="t"
/db_xref="dbSNP:374912748"
variation 2671
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:150838442"
variation 2729
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:202116209"
variation 2753
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:7506742"
variation 2799
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:182939342"
variation 2803
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:369768996"
STS 2868..3047
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/standard_name="RH80094"
/db_xref="UniSTS:90223"
STS 2928..3057
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/standard_name="SHGC-30831"
/db_xref="UniSTS:60855"
variation 2938
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:371909184"
variation 3084
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:117538599"
variation 3094
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:369187150"
variation 3103
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:187274075"
variation 3112
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371792734"
variation 3151
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="g"
/replace="t"
/db_xref="dbSNP:139987399"
variation 3154
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:117876156"
variation 3201
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:190903705"
variation 3210
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:143981075"
STS 3214..3513
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/standard_name="G43235"
/db_xref="UniSTS:94901"
STS 3244..3452
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/standard_name="G59817"
/db_xref="UniSTS:136966"
variation 3255
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:183090695"
variation 3284
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:187725356"
variation 3343
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:1049712"
variation 3354
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049713"
variation 3428
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:3288"
variation 3465
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:192502665"
variation 3494
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:184360910"
variation 3620..3621
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace=""
/replace="c"
/db_xref="dbSNP:35835049"
variation 3639
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:147310972"
variation 3723
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:188104940"
variation 3747
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:192840046"
variation 3770
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="t"
/db_xref="dbSNP:1049714"
variation 3859
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="g"
/replace="t"
/db_xref="dbSNP:117572218"
variation 3865
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:140996922"
variation 3948..3949
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace=""
/replace="gc"
/db_xref="dbSNP:71796948"
variation 3950
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:73431466"
variation 3953
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:71357248"
variation 4005
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149843351"
variation 4055
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:145878730"
variation 4090
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="g"
/db_xref="dbSNP:184556363"
variation 4094
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:148600103"
variation 4146
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:142067224"
variation 4216
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:146692699"
variation 4283
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:77980688"
variation 4296
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:74860287"
STS 4304..4570
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/standard_name="STS-X59727"
/db_xref="UniSTS:30227"
variation 4336
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140313726"
STS 4405..4567
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/standard_name="STS-T28761"
/db_xref="UniSTS:37486"
variation 4482
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="c"
/db_xref="dbSNP:3813088"
variation 4519
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:8724"
variation 4523
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:188921998"
STS 4532..4721
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/standard_name="STS-R37298"
/db_xref="UniSTS:3540"
variation 4571
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371538793"
variation 4670
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="t"
/db_xref="dbSNP:181577660"
variation 4673
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:146496996"
variation 4692
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="t"
/db_xref="dbSNP:185109855"
polyA_signal 4713..4718
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
variation 4719
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="a"
/replace="g"
/db_xref="dbSNP:111349400"
variation 4728
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
/replace="g"
/replace="t"
/db_xref="dbSNP:190553333"
polyA_site 4734
/gene="MAPK4"
/gene_synonym="ERK-4; ERK3; Erk4; MAPK 4; p63MAPK; PRKM4"
ORIGIN
gctgtcggggcgaccgcgggagctcgccgtgcgccgtggctgggaccggcctggccgagcgcgccggcgccgcggccgcagacaaagggcggctcgcgcccgggccgccacgctctcgggctctgcctcgggaaggagacttggtctgaaagatgccacattcctgcagcctctcttggtgcagtggaatacagtcttgggcgaggtggcgtggatgagctggtgaaagaggatgctgcccacatccaaaggctccagaggatcctggcctggcagctgagctcccctgcatttggaacctcaggcgtaacttggtgtagagctcatgaaaggtgcttgtgtttctccagcttttttcaccagtgcttaccagactggctcaggttttggaatctaaggtgagctggtagaaacaggagaggtagaaagaagcccctggatgcctccagaattcattgatgggatccctgcatactgcttggaacacagaaagaggctgtgacacagctgagctttggagcatcttaaggagctcagctcagcaaacaactcttgcatttcagccagaaagagcctcttgtaacaaagtattcaaaggggagagtttctgcatcttttactttgcagtccactatggtagaaaacttgacattccatagataatgatactgggttttctttccaagatgccagctttaaaagaaatatgagccattctaagctttaagaagggttcaggaaacacaggaattagtagacagccctcccaatgcaggttaagacgacagcctgcgcccccaactagcacagctcagcgagcatgaccatatgccattctcgtctccagagagctggtggcagtgacctcactaggagaaaacacatccctcagccgtgggacttgacagaatgaggtgcgcgagggaggccgctagccgagacttggcctttcctgactgcccctgtgttacctgggcagctccagatcactgagcccacaatggctgagaagggtgactgcatcgccagtgtctatgggtatgacctcggtgggcgctttgttgacttccaacccctgggcttcggtgtcaatggtttggtgctgtcggccgtggacagccgggcctgccggaaggtcgctgtgaagaagattgccctgagcgatgcccgcagcatgaagcacgcgctccgagagatcaagatcattcggcgcctggaccacgacaacatcgtcaaagtgtacgaggtgctcggtcccaagggcactgacctgcagggtgagctgttcaagttcagcgtggcgtacatcgtccaggagtacatggagaccgacctggcacgcctgctggagcagggcacgctggcagaagagcatgccaagctgttcatgtaccagctgctccgcgggctcaagtacatccactccgccaacgtgctgcacagggacctgaagcccgccaacatcttcatcagcacagaggacctcgtgctcaagattggggatttcgggttggcaaggatcgttgatcagcattactcccacaagggttatctgtcagaagggttggtaacaaagtggtaccgttccccacgactgctcctttcccccaataactacaccaaagccatcgacatgtgggccgccggctgcatcctggctgagatgcttacggggagaatgctctttgctggggcccatgagctggagcagatgcaactcatcctggagaccatccctgtaatccgggaggaagacaaggacgagctgctcagggtgatgccttcctttgtcagcagcacctgggaggtgaagaggcctctgcgcaagctgctccctgaagtgaacagtgaagccatcgactttctggagaagatcctgacctttaaccccatggatcgcctaacagctgagatggggctgcaacacccctacatgagcccatactcgtgccctgaggacgagcccacctcacaacaccccttccgcattgaggatgagatcgacgacatcgtgctgatggccgctaaccagagccagctgtccaactgggacacgtgcagttccaggtaccctgtgagcctgtcgtcggacctggagtggcggcctgaccggtgccaggacgccagcgaggtacagcgcgacccgcgcgcgggttcggcgccactggctgaggacgtgcaggtggacccgcgcaaggactcgcacagcagctccgagcgcttcctagagcagtcgcactcgtccatggagcgcgccttcgaggccgactacgggcgctcctgcgactacaaggtggggtcgccgtcctacctggacaagctgctgtggcgcgacaacaagccgcaccactactcggagcccaagctcatcctggacctgtcgcactggaagcaggcggccggcgcgccccccacggccacggggctggcggacacgggggcgcgcgaggacgagccggccagcctcttcctggagatcgcgcagtgggtcaagagcacgcagggcggcccagagcacgccagcccgcccgccgacgaccccgagcgccgcttgtctgcctcgccccccggccgcccggccccggtggacggcggcgccagcccccagttcgacctggacgtgttcatctcccgcgccctgaagctctgcaccaagcccgaggacctgccggacaataaactgggcgacctcaatggtgcgtgcatccccgagcaccctggcgacctcgtgcagaccgaggccttctccaaagaaaggtggtgagggcggaggggccgctccaggccccacagagcaggagacccccagagaaagccggggctggcaggaggcggccgcccttcccgcccctctctgctgccttggggttggcagaacacgtgaaggatccgaggagcgagaggaatgtccatttcttaaactgccttaataactagcctttaacctgtgggagcgggtttgaacaggaccctggcttaggggttgatcactttcctagcaaaggggagaccacatgtggtgcacagggaagaaacggctttagacagcagtctgcgggccccacctgggtggcaggatgccgagaaatcttgcagaggtagctccgaaaccatctggcccaactagcctcaactgacagctgaggaaaggcaattaggcccagagaggcagagacactcgcttaagatcacaggcttagtgtgaggacgagcttgaaatcccagtctcctggcccccaggccagggtctgtccaccatagaatgtcttcctctactggggtcgttctggctttttgttagaaacttggtctgagatgtttcttccctgtccattaccattcgatgttcttttattcagagcaatgtttcttgtattctgaaactggaaactgaaccagtttgtttctcctagtcaccaagcatactttcctggctccccaagtacttaaatgttctcatctgtcgcacccctgtatttgcctcacccctgcatggtcggaaatcttcgtttcaggtcagaacagcctggggtctgtgggtaaaatcagcccttctcccaggcctgtgcacacaccccctcagcactccctatgcactttcctgacacgcaaagacacagccctctttccccactgggcgtcctaccccagtgaggttgaaggcaccaattccaagaatccctccaacctccctgccagcactcccccttcaccccacacccggcccccccacctaaccacagcgcctctccagacctacctcgggacctaatgttctctacatgaactgctcatttggaggacagcagtgaggtcctgccatagagcaaatgtgttaggagagaaggtttcacatgggacccaacatccttcatcaatactttcctgagtttgatcatccatttagccttgacaaacagcagaccctacagagatgtgttggagagcacgtcgtgaccttgggggcaaggaatccagaaaggtaggaagatatgaaaagagaggtgtcaacagcaagggctcttaggggtcaggcaccagcatggagacctcatgacaaaggaagggactcaaagcagcaatgcccctcatagtgtaggctaaggtgagtttggtgcatgcaaacctgtgtgctcacccacagagcatggggtaatggtgtgtagacacaggccctctgcagaagcgtggggtggggacactgacagcccctatctggtccccaggaacattctaccatttctgccactggtgttcagctccttctcttcccccaacactcccaaagatacccacaggaagtccagccagtttccaggtagaggattccaccagttggtcttgggctgcgttcaccctcacatcacagcaccttaaatctaatcagcaaactataatttgtacgttgaaacctgcaacacattagaaacttatatttaaaaacagaattaatcacactgaccaacttttaaatggaaaatatgtaaataggaagtgtttgggttttgttttttctttaagaaaaagaaatgtacaccactcctcatgtgccattttgtcctcagagggcggctttacttttttggtaaaggaacaagctgctggccttgaccaggagttcatatataactgttattacagaggaattgttataactactaatgtttttaaaaaatttattaaacattattaaacttgatcaggtcaggccaaataaagttttattggaacacaga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5596 -> Molecular function: GO:0004707 [MAP kinase activity] evidence: IEA
GeneID:5596 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5596 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5596 -> Molecular function: GO:0019901 [protein kinase binding] evidence: ISS
GeneID:5596 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: ISS
GeneID:5596 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:5596 -> Biological process: GO:0000165 [MAPK cascade] evidence: TAS
GeneID:5596 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:5596 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:5596 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:5596 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002738 -> EC 2.7.11.24
by
@meso_cacase at
DBCLS
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