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2025-05-09 16:34:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002661 4289 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens phospholipase C, gamma 2
(phosphatidylinositol-specific) (PLCG2), mRNA.
ACCESSION NM_002661
VERSION NM_002661.3 GI:345525418
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4289)
AUTHORS Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
TITLE Loci associated with N-glycosylation of human immunoglobulin G show
pleiotropy with autoimmune diseases and haematological cancers
JOURNAL PLoS Genet. 9 (1), E1003225 (2013)
PUBMED 23382691
REFERENCE 2 (bases 1 to 4289)
AUTHORS Zhou,Q., Lee,G.S., Brady,J., Datta,S., Katan,M., Sheikh,A.,
Martins,M.S., Bunney,T.D., Santich,B.H., Moir,S., Kuhns,D.B., Long
Priel,D.A., Ombrello,A., Stone,D., Ombrello,M.J., Khan,J.,
Milner,J.D., Kastner,D.L. and Aksentijevich,I.
TITLE A hypermorphic missense mutation in PLCG2, encoding phospholipase
Cgamma2, causes a dominantly inherited autoinflammatory disease
with immunodeficiency
JOURNAL Am. J. Hum. Genet. 91 (4), 713-720 (2012)
PUBMED 23000145
REMARK GeneRIF: Overexpression of the altered p.Ser707Tyr protein and ex
vivo experiments using affected individuals' leukocytes showed
clearly enhanced PLCgamma2 activity.
REFERENCE 3 (bases 1 to 4289)
AUTHORS Fu,G., Chen,Y., Schuman,J., Wang,D. and Wen,R.
TITLE Phospholipase Cgamma2 plays a role in TCR signal transduction and T
cell selection
JOURNAL J. Immunol. 189 (5), 2326-2332 (2012)
PUBMED 22837484
REMARK GeneRIF: PLCgamma2 participates in T cell receptor (TCR) signal
transduction and plays a role in T cell selection in a transgenic
mouse model.
REFERENCE 4 (bases 1 to 4289)
AUTHORS Ombrello,M.J., Remmers,E.F., Sun,G., Freeman,A.F., Datta,S.,
Torabi-Parizi,P., Subramanian,N., Bunney,T.D., Baxendale,R.W.,
Martins,M.S., Romberg,N., Komarow,H., Aksentijevich,I., Kim,H.S.,
Ho,J., Cruse,G., Jung,M.Y., Gilfillan,A.M., Metcalfe,D.D.,
Nelson,C., O'Brien,M., Wisch,L., Stone,K., Douek,D.C., Gandhi,C.,
Wanderer,A.A., Lee,H., Nelson,S.F., Shianna,K.V., Cirulli,E.T.,
Goldstein,D.B., Long,E.O., Moir,S., Meffre,E., Holland,S.M.,
Kastner,D.L., Katan,M., Hoffman,H.M. and Milner,J.D.
TITLE Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2
deletions
JOURNAL N. Engl. J. Med. 366 (4), 330-338 (2012)
PUBMED 22236196
REMARK GeneRIF: Genomic deletions in PLCG2 cause gain of PLCgamma(2)
function, leading to signaling abnormalities in multiple leukocyte
subsets and a phenotype encompassing both excessive and deficient
immune function.
REFERENCE 5 (bases 1 to 4289)
AUTHORS Leon,C.M., Barbosa,C.M., Justo,G.Z., Borelli,P., Resende,J.D. Jr.,
de Oliveira,J.S., Ferreira,A.T. and Paredes-Gamero,E.J.
TITLE Requirement for PLCgamma2 in IL-3 and GM-CSF-stimulated MEK/ERK
phosphorylation in murine and human hematopoietic stem/progenitor
cells
JOURNAL J. Cell. Physiol. 226 (7), 1780-1792 (2011)
PUBMED 21506110
REMARK GeneRIF: Data indicate a role for PLCgamma2 and Ca(2+) signaling
through the modulation of MEK/ERK in IL3/GM-csf stimulated human
hematopoietic stem/progenitor cells.
REFERENCE 6 (bases 1 to 4289)
AUTHORS Yan,W. and Ratnam,M.
TITLE Preferred sites of glycosylphosphatidylinositol modification in
folate receptors and constraints in the primary structure of the
hydrophobic portion of the signal
JOURNAL Biochemistry 34 (44), 14594-14600 (1995)
PUBMED 7578066
REFERENCE 7 (bases 1 to 4289)
AUTHORS Zauli,G., Previati,M., Caramelli,E., Bassini,A., Falcieri,E.,
Gibellini,D., Bertolaso,L., Bosco,D., Robuffo,I. and Capitani,S.
TITLE Exogenous human immunodeficiency virus type-1 Tat protein
selectively stimulates a phosphatidylinositol-specific
phospholipase C nuclear pathway in the Jurkat T cell line
JOURNAL Eur. J. Immunol. 25 (9), 2695-2700 (1995)
PUBMED 7589147
REFERENCE 8 (bases 1 to 4289)
AUTHORS Liao,F., Shin,H.S. and Rhee,S.G.
TITLE In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by
src-family protein tyrosine kinases
JOURNAL Biochem. Biophys. Res. Commun. 191 (3), 1028-1033 (1993)
PUBMED 7682059
REFERENCE 9 (bases 1 to 4289)
AUTHORS Ohta,S., Matsui,A., Nazawa,Y. and Kagawa,Y.
TITLE Complete cDNA encoding a putative phospholipase C from transformed
human lymphocytes
JOURNAL FEBS Lett. 242 (1), 31-35 (1988)
PUBMED 2849563
REFERENCE 10 (bases 1 to 4289)
AUTHORS Banno,Y., Yada,Y. and Nozawa,Y.
TITLE Purification and characterization of membrane-bound phospholipase C
specific for phosphoinositides from human platelets
JOURNAL J. Biol. Chem. 263 (23), 11459-11465 (1988)
PUBMED 2841328
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP351485.1, AB208914.1 and
BC007565.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 6, 2011 this sequence version replaced gi:117320536.
Summary: The protein encoded by this gene is a transmembrane
signaling enzyme that catalyzes the conversion of
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol
1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium
as a cofactor. IP3 and DAG are second messenger molecules important
for transmitting signals from growth factor receptors and immune
system receptors across the cell membrane. [provided by RefSeq, Sep
2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC007565.1, AB208914.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-529 BP351485.1 1-529
530-1326 AB208914.1 522-1318
1327-1365 BC007565.1 1296-1334
1366-1674 AB208914.1 1358-1666
1675-2824 BC007565.1 1644-2793
2825-3834 AB208914.1 2817-3826
3835-4289 BC007565.1 3804-4258
FEATURES Location/Qualifiers
source 1..4289
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q24.1"
gene 1..4289
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="phospholipase C, gamma 2
(phosphatidylinositol-specific)"
/db_xref="GeneID:5336"
/db_xref="HGNC:9066"
/db_xref="MIM:600220"
exon 1..131
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
exon 132..371
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
misc_feature 137..139
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="upstream in-frame stop codon"
variation 138
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:141718763"
variation 145
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375123176"
variation 171
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:150565405"
variation 174
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138699122"
CDS 179..3976
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/EC_number="3.1.4.11"
/note="PLC-IV; PLC-gamma-2; phospholipase C-IV;
phosphoinositide phospholipase C-gamma-2"
/codon_start=1
/product="1-phosphatidylinositol 4,5-bisphosphate
phosphodiesterase gamma-2"
/protein_id="NP_002652.2"
/db_xref="GI:117320537"
/db_xref="CCDS:CCDS42204.1"
/db_xref="GeneID:5336"
/db_xref="HGNC:9066"
/db_xref="MIM:600220"
/translation="
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSNSKFYS
"
misc_feature 227..565
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="Phospholipase C (PLC) pleckstrin homology (PH)
domain; Region: PH_PLC; cd01248"
/db_xref="CDD:176324"
misc_feature order(248..271,293..313,329..349,365..379,392..406,
461..481,500..517,530..565)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="core domain; other site"
/db_xref="CDD:176324"
misc_feature order(266..268,287..289,299..301,347..349)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="inositol phosphate binding site [chemical binding];
other site"
/db_xref="CDD:176324"
misc_feature <905..1105
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="Phosphoinositide-specific phospholipase C,
efhand-like; Region: efhand_like; pfam09279"
/db_xref="CDD:150071"
misc_feature 1109..>1552
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="Catalytic domain of metazoan
phosphoinositide-specific phospholipase C-gamma; Region:
PI-PLCc_gamma; cd08592"
/db_xref="CDD:176534"
misc_feature order(1157..1162,1247..1249,1253..1255,1292..1294,
1394..1396,1538..1540,1544..1546)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="putative active site [active]"
/db_xref="CDD:176534"
misc_feature order(1157..1159,1292..1294)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="catalytic site [active]"
/db_xref="CDD:176534"
misc_feature order(1160..1162,1247..1249,1253..1255,1394..1396)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="putative Ca binding site [ion binding]; other site"
/db_xref="CDD:176534"
misc_feature 1757..2059
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="N-terminal Src homology 2 (N-SH2) domain in
Phospholipase C gamma; Region: SH2_N-SH2_PLC_gamma_like;
cd10341"
/db_xref="CDD:199829"
misc_feature order(1796..1798,1868..1870,1874..1876,1898..1900,
1931..1933)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:199829"
misc_feature order(1907..1909,1934..1936,1979..1981,2048..2050)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:199829"
misc_feature 2099..2410
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="C-terminal Src homology 2 (C-SH2) domain in
Phospholipase C gamma; Region: SH2_C-SH2_PLC_gamma_like;
cd09932"
/db_xref="CDD:198186"
misc_feature order(2135..2137,2192..2194,2252..2254,2258..2260)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198186"
misc_feature order(2255..2257,2336..2338)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198186"
misc_feature 2375..2377
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2435..2437
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by BTK; propagated from
UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
misc_feature 2435..2437
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:01301"
misc_feature 2435..2437
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:00655"
misc_feature 2435..2437
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:00796"
misc_feature 2435..2437
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:01080"
misc_feature 2453..2455
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by BTK; propagated from
UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
misc_feature 2453..2455
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:01301"
misc_feature 2453..2455
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:00655"
misc_feature 2453..2455
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:00796"
misc_feature 2453..2455
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:01080"
misc_feature 2453..2455
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02248"
misc_feature 2495..2659
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="Src homology 3 domain of Phospholipase C (PLC)
gamma 2; Region: SH3_PLCgamma2; cd11969"
/db_xref="CDD:212902"
misc_feature order(2510..2512,2528..2530,2534..2539,2594..2596,
2630..2632,2642..2647)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212902"
misc_feature <2954..3271
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="Catalytic domain of phosphoinositide-specific
phospholipase C-like phosphodiesterases superfamily;
Region: PI-PLCc_GDPD_SF; cl14615"
/db_xref="CDD:213131"
misc_feature 3359..3739
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="C2 domain present in Phosphoinositide-specific
phospholipases C (PLC); Region: C2_PLC_like; cd00275"
/db_xref="CDD:175974"
misc_feature order(3422..3424,3494..3496,3590..3592,3596..3598,
3614..3616,3620..3622)
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/note="Ca2+ binding pocket [ion binding]; other site"
/db_xref="CDD:175974"
misc_feature 3767..3769
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02248"
misc_feature 3827..3829
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
misc_feature 3827..3829
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02248"
misc_feature 3911..3913
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
variation 189
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199972098"
variation 190
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376949064"
variation 195
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:202002041"
variation 200
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:9936371"
variation 235
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369542354"
variation 241
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374235189"
variation 255
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:189301790"
STS 256..673
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/standard_name="GDB:386186"
/db_xref="UniSTS:157145"
variation 260
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:61749044"
variation 266
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:372502550"
variation 288
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:147349332"
variation 305
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370352962"
variation 311
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:368137889"
variation 327
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370242901"
variation 328
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370683432"
variation 349
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374354863"
variation 352
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1143685"
exon 372..515
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 380
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:184409507"
variation 443
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199638859"
variation 475
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1143686"
variation 497
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377058251"
variation 502
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:189282309"
exon 516..609
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 517
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374930194"
variation 576
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:61755444"
variation 584
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:367885048"
variation 593
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:372085742"
exon 610..657
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
exon 658..742
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 663
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:142022471"
variation 665
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375598204"
variation 683
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200464512"
variation 711
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200981336"
variation 718
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:150276286"
exon 743..826
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 752
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:367898185"
variation 757
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:201080992"
variation 759
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:372054297"
variation 760
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:375368103"
variation 772
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:368738612"
variation 778
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142140333"
variation 805
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374983573"
variation 807
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201487295"
variation 825
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201294738"
exon 827..870
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 833
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376192123"
variation 856
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:111553163"
variation 866
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373962897"
exon 871..943
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 885
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199760975"
variation 892
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138981519"
variation 909
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11548656"
variation 920
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:373142398"
variation 929
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:190840748"
exon 944..1045
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 948
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:45443101"
variation 949
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369555285"
variation 962
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:372563994"
variation 980
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1143687"
variation 998
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:370148064"
variation 1007
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372494175"
variation 1030
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:190687540"
variation 1035
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:142098187"
exon 1046..1164
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1054
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:375222873"
variation 1057
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368107827"
variation 1058
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:112648604"
variation 1067
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370697615"
variation 1101
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199636472"
variation 1111
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368534849"
variation 1123
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372795428"
exon 1165..1250
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1165
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200506549"
variation 1192
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200149635"
variation 1227
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200824224"
variation 1228
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:185739725"
variation 1250
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377757324"
exon 1251..1371
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1264
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375876385"
variation 1270
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369150321"
variation 1285
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201652976"
variation 1294
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369732261"
variation 1303
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374233612"
variation 1318
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:112374290"
variation 1324
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138637229"
variation 1327
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1143688"
variation 1330
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:13333713"
variation 1338
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:201654184"
variation 1366
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:13333716"
exon 1372..1540
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1414
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372240617"
variation 1436
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201490178"
variation 1456
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199514190"
variation 1470
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:367678289"
variation 1487
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200137340"
variation 1507
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369281824"
variation 1520
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200919414"
exon 1541..1645
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1560
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:3935625"
variation 1561
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369098550"
variation 1597
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372678135"
variation 1622
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:187956469"
variation 1627
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201746780"
exon 1646..1735
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1656
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369542682"
variation 1675
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1143689"
variation 1682
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199761977"
variation 1711
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:151013036"
exon 1736..1911
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1737
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201391996"
variation 1743
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:72824905"
variation 1747
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:199708049"
variation 1750
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373910195"
variation 1769
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200736474"
variation 1773
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:370429726"
variation 1780
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:375195776"
variation 1799
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11548657"
variation 1807
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374641731"
variation 1849
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372347274"
variation 1873
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:375590398"
variation 1876
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:11548654"
variation 1890
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:75472618"
variation 1901
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375546602"
variation 1909
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:147406608"
exon 1912..2112
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 1923
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200325678"
variation 1990
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:191668546"
variation 2026
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200081833"
variation 2037
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:147396004"
variation 2050
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368337142"
variation 2086
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374419817"
variation 2094
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377753289"
variation 2101
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374927413"
variation 2102
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:367884906"
exon 2113..2232
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2137
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:117835631"
variation 2147..2148
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace=""
/replace="c"
/db_xref="dbSNP:67343424"
variation 2189
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:150833842"
variation 2194
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:187116990"
variation 2203
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373752237"
variation 2214
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:374768937"
exon 2233..2413
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2251
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377223625"
variation 2253
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:370718047"
variation 2261
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374334218"
variation 2272
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:143195637"
variation 2293
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372245335"
variation 2326
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367677388"
variation 2339
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:187454354"
variation 2344
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375200129"
variation 2356
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201084625"
variation 2358
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369516453"
variation 2359
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:372269946"
variation 2369
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:377095061"
variation 2372
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369760877"
variation 2379
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199516791"
variation 2380
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200025641"
variation 2389
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368933697"
variation 2410
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201591234"
exon 2414..2485
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2430
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:374154653"
variation 2434
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:376208314"
variation 2437
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370847174"
variation 2438
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:190001915"
variation 2440
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:74032923"
variation 2462
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368910187"
variation 2479
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374390386"
exon 2486..2595
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2490
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201803492"
variation 2497
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375781279"
variation 2502
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142825971"
variation 2507
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:181588253"
variation 2509
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372491825"
variation 2533
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:185307548"
variation 2553
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:202210217"
variation 2571
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:117077093"
variation 2575
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:376061730"
exon 2596..2692
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2605
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200844173"
variation 2647
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376517417"
variation 2672
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368530152"
variation 2681
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:186829827"
variation 2683
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368887042"
variation 2692
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:115583707"
exon 2693..2759
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2720
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:114618894"
variation 2722
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373866566"
variation 2749
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:377749396"
variation 2756
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370187601"
exon 2760..2917
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2775
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11548655"
variation 2802
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:375364337"
variation 2809
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:200677528"
variation 2816
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:3189935"
variation 2825
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:17856213"
variation 2830
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:371218195"
variation 2832
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199703276"
variation 2833
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:187441573"
variation 2838
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:369092713"
variation 2839
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:201601618"
variation 2857
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373344892"
variation 2884
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375379804"
variation 2899
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:3189936"
variation 2915
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369704658"
exon 2918..3020
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 2956
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371069005"
variation 2959
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374334077"
variation 2978
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:73598710"
variation 3015
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:139462941"
exon 3021..3230
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 3045
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376030995"
variation 3052
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369336417"
variation 3060
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371326699"
variation 3070
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:377084065"
variation 3076
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:61749046"
variation 3091
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377752384"
variation 3092
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369090249"
variation 3094
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1143690"
variation 3103
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:377123977"
variation 3115
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374150535"
variation 3118
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376216756"
variation 3131
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199840870"
variation 3193
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374501993"
variation 3229
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:190262183"
exon 3231..3376
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 3253
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368241065"
variation 3260
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:71400186"
variation 3271
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1071644"
variation 3275
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376667295"
variation 3287
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373561919"
variation 3290
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200813182"
variation 3303
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:114262189"
variation 3305
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201647862"
STS 3307..3416
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/standard_name="RH65041"
/db_xref="UniSTS:88565"
variation 3310
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369077109"
variation 3327
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372812991"
variation 3328
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376070393"
variation 3370
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:200366770"
variation 3372..3373
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace=""
/replace="g"
/db_xref="dbSNP:34401463"
exon 3377..3491
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 3380
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375154673"
variation 3439
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:368071289"
variation 3459
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374901017"
variation 3462
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1130733"
variation 3484
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372282607"
variation 3490
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375577536"
exon 3492..3659
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 3505
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:368897845"
variation 3514
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:193128632"
variation 3521
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372606303"
variation 3552
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374877793"
variation 3558
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:369259797"
variation 3570
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:376734359"
variation 3574
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201475640"
variation 3592
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:61755443"
variation 3607
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373377275"
variation 3636
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:146175110"
exon 3660..3748
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 3670
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:187113357"
variation 3671
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372557475"
variation 3672
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199571184"
variation 3674
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:374517633"
variation 3701
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368684142"
variation 3729
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374746148"
exon 3749..3933
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
variation 3751
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201682723"
variation 3795
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373686679"
variation 3806
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377701753"
variation 3815
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:369966847"
variation 3828
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373013824"
variation 3829
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377396134"
variation 3835
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:201318091"
variation 3848
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199530350"
variation 3849
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370547009"
variation 3860
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:202108152"
variation 3871
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:62046284"
variation 3904
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:76506409"
variation 3908
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:200800716"
variation 3930
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368482871"
exon 3934..4272
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/inference="alignment:Splign:1.39.8"
STS 3939..4271
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/standard_name="SHGC-60970"
/db_xref="UniSTS:44012"
STS 3941..4238
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/standard_name="GDB:633458"
/db_xref="UniSTS:158510"
variation 3964
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:374430619"
variation 4004
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:200846103"
variation 4010
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377755967"
variation 4011
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:45554137"
variation 4013
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201801906"
variation 4034
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:187446555"
STS 4052..4210
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/standard_name="RH68327"
/db_xref="UniSTS:8578"
variation 4086
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1130756"
variation 4115
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:192708751"
variation 4161
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:80134881"
variation 4237
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:8357"
polyA_signal 4250..4255
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
polyA_site 4272
/gene="PLCG2"
/gene_synonym="APLAID; FCAS3"
ORIGIN
agtagcgagcgccggcggcggagggcgtgagcggcgctgagtgacccgagtcgggacgcgggctgcgcgcgcgggaccccggagcccaaacccggggcaggcgggcagctgtgcccgggcggcacggccagcttcctgatttctcccgattccttccttctccctggagcggccgacaatgtccaccacggtcaatgtagattcccttgcggaatatgagaagagccagatcaagagagccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccccgagcggagaaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgccgacaagatcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaagatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctatatggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaggatgcagttaactggctctctggcttgaaaatcttacaccaggaagcgatgaatgcgtccacgcccaccattatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagcatcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgccaagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaacagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaattcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgctgtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcaggatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaactgctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagcatctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcattactggatctcctcgtcacataacacgtaccttacaggtgaccagctgcggagcgagtcgtccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgctgggacgggcccgatgggaagccggtcatctaccatggctggacgcggactaccaagatcaagtttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttcccagtgatcctgtccatcgaggagcactgcagcgtggagcaacagcgtcacatggccaaggccttcaaggaagtatttggcgacctgctgttgacgaagcccacggaggccagtgctgaccagctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccccgaggcgatgtggatgtcaacatggaggacaagaaggacgaacacaagcaacagggggagctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccattgccgatgccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggatataccccctacagaactacattttggggagaaatggttccacaagaaggtggagaagaggacgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcaccttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtcaggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactacttgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacgcacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccccacgagtccaagccgtggtactatgacagcctgagccgcggagaggcagaggacatgctgatgaggattccccgggacggggccttcctgatccggaagcgagaggggagcgactcctatgccatcaccttcagggctaggggcaaggtaaagcattgtcgcatcaaccgggacggccggcactttgtgctggggacctccgcctattttgagagtctggtggagctcgtcagttactacgagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctggagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtggatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactacaaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctccaaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttcccatccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattattgaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtcgtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagcagcagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggtttcagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgggagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaaccagcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggagacgaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaagggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttccgcctctggctgtgcggttctcagatggtggcactcaatttccagacggcagataagtacatgcagatgaatcacgcattgttttctctcaatgggcgcacgggctacgttctgcagcctgagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctgatgacgctgacagtcaaggttctcggtgctcgccatctccccaaacttggacgaagtattgcctgtccctttgtagaagtggagatctgtggagccgagtatgacaacaacaagttcaagacgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtgacatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttatgaagaagatatgttcagcgatcccaactttcttgctcatgccacttaccccattaaagcagtcaaatcaggattcaggtccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctcctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgtcgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacaccagaacttgcgcaatgccaaccgggatgccctggttaaagagttcagtgttaatgagaaccagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaacagcaagttttactcatagaagctggggtatgtgtgtaagggtattgtgtgtgtgcgcatgtgtgtttgcatgtaggagaacgtgccctattcacactctgggaagacgctaatctgtgacatcttttcttcaagcctgccatcaaggacatttcttaagacccaactggcatgagttggggtaatttcctattattttcatcttggacaactttcttaacttatattctttatagaggattccccaaaatgtgctcctcatttttggcctctcatgttccaaacctcattgaataaaagcaatgaaaaccttgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5336 -> Molecular function: GO:0004435 [phosphatidylinositol phospholipase C activity] evidence: IDA
GeneID:5336 -> Molecular function: GO:0004435 [phosphatidylinositol phospholipase C activity] evidence: TAS
GeneID:5336 -> Molecular function: GO:0004629 [phospholipase C activity] evidence: TAS
GeneID:5336 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
GeneID:5336 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5336 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:5336 -> Biological process: GO:0002316 [follicular B cell differentiation] evidence: IEA
GeneID:5336 -> Biological process: GO:0006661 [phosphatidylinositol biosynthetic process] evidence: IDA
GeneID:5336 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:5336 -> Biological process: GO:0009395 [phospholipid catabolic process] evidence: IEA
GeneID:5336 -> Biological process: GO:0010468 [regulation of gene expression] evidence: IEA
GeneID:5336 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: TAS
GeneID:5336 -> Biological process: GO:0019722 [calcium-mediated signaling] evidence: NAS
GeneID:5336 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:5336 -> Biological process: GO:0030183 [B cell differentiation] evidence: ISS
GeneID:5336 -> Biological process: GO:0032237 [activation of store-operated calcium channel activity] evidence: IEA
GeneID:5336 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
GeneID:5336 -> Biological process: GO:0032959 [inositol trisphosphate biosynthetic process] evidence: IEA
GeneID:5336 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5336 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
GeneID:5336 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: IEA
GeneID:5336 -> Biological process: GO:0043647 [inositol phosphate metabolic process] evidence: TAS
GeneID:5336 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5336 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5336 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: ISS
GeneID:5336 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: ISS
GeneID:5336 -> Biological process: GO:0051209 [release of sequestered calcium ion into cytosol] evidence: IDA
GeneID:5336 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5336 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:5336 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002652 -> EC 3.1.4.11
by
@meso_cacase at
DBCLS
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