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2025-05-09 17:00:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002639 2633 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin),
member 5 (SERPINB5), mRNA.
ACCESSION NM_002639
VERSION NM_002639.4 GI:167860125
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2633)
AUTHORS Shi,J., Liu,H., Wang,H.L., Prichard,J.W. and Lin,F.
TITLE Diagnostic utility of von Hippel-Lindau gene product, maspin, IMP3,
and S100P in adenocarcinoma of the gallbladder
JOURNAL Hum. Pathol. 44 (4), 503-511 (2013)
PUBMED 23079206
REMARK GeneRIF: This study demonstrates that the immunostaining profile of
pVHL-/IMP3+/maspin+/S100P+ is useful in the distinction of
adenocarcinoma of the gallbladder from normal/reactive conditions.
REFERENCE 2 (bases 1 to 2633)
AUTHORS Kim,M., Ju,H., Lim,B. and Kang,C.
TITLE Maspin genetically and functionally associates with gastric cancer
by regulating cell cycle progression
JOURNAL Carcinogenesis 33 (12), 2344-2350 (2012)
PUBMED 22962304
REMARK GeneRIF: Maspin genetically and functionally associates with
gastric cancer by regulating cell cycle progression.
REFERENCE 3 (bases 1 to 2633)
AUTHORS Acikalin,D., Oner,U., Can,C., Acikalin,M.F. and Colak,E.
TITLE Predictive value of maspin and Ki-67 expression in transurethral
resection specimens in patients with T1 bladder cancer
JOURNAL Tumori 98 (3), 344-350 (2012)
PUBMED 22825520
REMARK GeneRIF: Findings suggested that the evaluation of maspin
expression in stage T1 bladder tumors is a useful prognostic marker
for predicting the tumor behavior.
REFERENCE 4 (bases 1 to 2633)
AUTHORS Ma,L., Shen,Y.Y., Zhou,P., Zhou,J. and Guo,F.
TITLE [NF-kappaB subunits regulate maspin expression in prostate cancer
cells in vitro]
JOURNAL Zhonghua Zhong Liu Za Zhi 34 (3), 165-168 (2012)
PUBMED 22780967
REMARK GeneRIF: The expression of RelB negatively regulates the endogenous
expression of maspin in prostate cancer cells in vitro.
REFERENCE 5 (bases 1 to 2633)
AUTHORS Neal,C.L., Henderson,V., Smith,B.N., McKeithen,D., Graham,T.,
Vo,B.T. and Odero-Marah,V.A.
TITLE Snail transcription factor negatively regulates maspin tumor
suppressor in human prostate cancer cells
JOURNAL BMC Cancer 12, 336 (2012)
PUBMED 22857708
REMARK GeneRIF: This study is the first report showing that Snail can
negatively regulate maspin expression by directly repressing maspin
promoter activity, leading to increased cell migration and
invasion.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2633)
AUTHORS Pemberton,P.A., Tipton,A.R., Pavloff,N., Smith,J., Erickson,J.R.,
Mouchabeck,Z.M. and Kiefer,M.C.
TITLE Maspin is an intracellular serpin that partitions into secretory
vesicles and is present at the cell surface
JOURNAL J. Histochem. Cytochem. 45 (12), 1697-1706 (1997)
PUBMED 9389773
REFERENCE 7 (bases 1 to 2633)
AUTHORS Sager,R., Sheng,S., Pemberton,P. and Hendrix,M.J.
TITLE Maspin. A tumor suppressing serpin
JOURNAL Adv. Exp. Med. Biol. 425, 77-88 (1997)
PUBMED 9433491
REMARK Review article
REFERENCE 8 (bases 1 to 2633)
AUTHORS Pemberton,P.A., Wong,D.T., Gibson,H.L., Kiefer,M.C.,
Fitzpatrick,P.A., Sager,R. and Barr,P.J.
TITLE The tumor suppressor maspin does not undergo the stressed to
relaxed transition or inhibit trypsin-like serine proteases.
Evidence that maspin is not a protease inhibitory serpin
JOURNAL J. Biol. Chem. 270 (26), 15832-15837 (1995)
PUBMED 7797587
REFERENCE 9 (bases 1 to 2633)
AUTHORS Schneider,S.S., Schick,C., Fish,K.E., Miller,E., Pena,J.C.,
Treter,S.D., Hui,S.M. and Silverman,G.A.
TITLE A serine proteinase inhibitor locus at 18q21.3 contains a tandem
duplication of the human squamous cell carcinoma antigen gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (8), 3147-3151 (1995)
PUBMED 7724531
REFERENCE 10 (bases 1 to 2633)
AUTHORS Zou,Z., Anisowicz,A., Hendrix,M.J., Thor,A., Neveu,M., Sheng,S.,
Rafidi,K., Seftor,E. and Sager,R.
TITLE Maspin, a serpin with tumor-suppressing activity in human mammary
epithelial cells
JOURNAL Science 263 (5146), 526-529 (1994)
PUBMED 8290962
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL602439.1, CV575332.1, BM955647.1 and AC036176.8.
On Feb 15, 2008 this sequence version replaced gi:142377273.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U04313.1, AK312765.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084, ERS025085 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-648 AL602439.1 4-651
649-1118 CV575332.1 136-605
1119-1396 BM955647.1 347-624
1397-2633 AC036176.8 23638-24874 c
FEATURES Location/Qualifiers
source 1..2633
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21.33"
gene 1..2633
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="serpin peptidase inhibitor, clade B (ovalbumin),
member 5"
/db_xref="GeneID:5268"
/db_xref="HGNC:8949"
/db_xref="MIM:154790"
exon 1..135
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="alignment:Splign:1.39.8"
misc_feature 26..28
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="upstream in-frame stop codon"
variation 87
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:75113857"
exon 136..310
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="alignment:Splign:1.39.8"
variation 140
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:77710366"
CDS 143..1270
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="protease inhibitor 5 (maspin); serine (or cysteine)
proteinase inhibitor, clade B (ovalbumin), member 5; PI-5;
peptidase inhibitor 5"
/codon_start=1
/product="serpin B5"
/protein_id="NP_002630.2"
/db_xref="GI:167860126"
/db_xref="CCDS:CCDS32839.1"
/db_xref="GeneID:5268"
/db_xref="HGNC:8949"
/db_xref="MIM:154790"
/translation="
MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP
"
misc_feature 152..1267
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="Maspin (mammary serine proteinase inhibitor), a
member of the serpin superfamily, with a multitude of
effects on cells and tissues at an assortment of
developmental stages. Maspin has tumor suppressing
activity against breast and prostate cancer. In...;
Region: maspin_like; cd02057"
/db_xref="CDD:29132"
misc_feature 221..1267
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="serpin-like protein; Provisional; Region: PHA02660"
/db_xref="CDD:165039"
misc_feature order(629..652,1100..1123)
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="shutter residues; other site"
/db_xref="CDD:29132"
misc_feature order(662..706,719..745)
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="gate residues; other site"
/db_xref="CDD:29132"
misc_feature 1127..1132
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="hinge residues; other site"
/db_xref="CDD:29132"
misc_feature order(1130..1141,1184..1201)
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/note="reactive center loop; other site"
/db_xref="CDD:29132"
misc_feature 1160..1165
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="non-experimental evidence, no additional
details recorded"
/note="Reactive bond homolog (By similarity); propagated
from UniProtKB/Swiss-Prot (P36952.2); other site"
variation 153
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371513895"
STS 163..297
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/standard_name="GDB:435245"
/db_xref="UniSTS:157216"
variation 168
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:374163653"
variation 169
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:145802990"
variation 175
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148566348"
variation 177
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:142546858"
variation 178
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2292294"
variation 184
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:141915869"
variation 185
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:145765491"
variation 186
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147782595"
variation 229
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:377003982"
variation 261
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201251421"
variation 262
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:113058642"
variation 267
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:180726460"
variation 273
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="t"
/db_xref="dbSNP:140384163"
variation 284
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:150383460"
exon 311..448
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="alignment:Splign:1.39.8"
variation 312
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:138019543"
variation 319
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371063228"
variation 335
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149514262"
variation 338
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:61735448"
variation 342
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375704233"
variation 348
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138319338"
variation 373
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200213704"
variation 409
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:34866511"
variation 413
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:372076697"
variation 414
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146056603"
variation 422
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377697959"
variation 439
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:371320466"
exon 449..566
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="alignment:Splign:1.39.8"
variation 456
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:61761883"
variation 466
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:141561710"
variation 467
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:150909720"
variation 475
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:12454742"
variation 523
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:200364734"
variation 525
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:145559318"
variation 530
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:374983437"
exon 567..709
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="alignment:Splign:1.39.8"
variation 592
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200888395"
variation 615
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373734502"
variation 652
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:2289518"
variation 668
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2289519"
variation 689
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:140393612"
variation 701
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:2289520"
exon 710..877
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="alignment:Splign:1.39.8"
variation 713
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:145448576"
variation 733
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:148829613"
variation 858
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="t"
/db_xref="dbSNP:367852622"
variation 862
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371720610"
variation 864
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:373752630"
exon 878..2633
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/inference="alignment:Splign:1.39.8"
variation 894
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="t"
/db_xref="dbSNP:201024367"
variation 957
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:142654718"
variation 965
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201595465"
variation 971
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:374389438"
variation 972
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:151011754"
variation 993
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:140803243"
variation 998
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:144771613"
variation 1009
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:200796901"
variation 1018
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:138711296"
variation 1036
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:1455556"
variation 1048
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="t"
/db_xref="dbSNP:200606458"
variation 1097
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:1455555"
variation 1099
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:181635681"
variation 1105
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138689781"
variation 1106
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376750114"
variation 1133
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:185364126"
variation 1136
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:149353823"
variation 1147
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:372972017"
variation 1165
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:370247320"
variation 1177
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:373768833"
variation 1232
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:144814891"
variation 1240
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:8093128"
STS 1274..1432
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/standard_name="GDB:435240"
/db_xref="UniSTS:157215"
variation 1393
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:190132510"
variation 1431..1433
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace=""
/replace="t"
/db_xref="dbSNP:35377797"
variation 1433
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:112777966"
variation 1513
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:182350521"
variation 1557
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:186059840"
variation 1592
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148559989"
variation 1636
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:12150761"
STS 1664..1996
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/standard_name="SHGC-12569"
/db_xref="UniSTS:11720"
variation 1674
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:73468519"
variation 1744
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:77230459"
variation 1879
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:115195446"
variation 1900
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:73964614"
variation 1905
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1004"
variation 1912
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:894"
variation 1991
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:112795011"
variation 1994
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="t"
/db_xref="dbSNP:56132922"
variation 2039
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376940464"
STS 2177..2362
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/standard_name="RH17976"
/db_xref="UniSTS:58530"
variation 2177
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:73468520"
variation 2218
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:17071220"
variation 2241
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:142907436"
variation 2244
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="t"
/db_xref="dbSNP:80107199"
variation 2332
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:183993214"
variation 2435
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:150696400"
variation 2460
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:11664401"
variation 2467
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="c"
/db_xref="dbSNP:73964616"
variation 2479..2480
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace=""
/replace="tac"
/db_xref="dbSNP:370788886"
variation 2499
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:112120554"
variation 2507..2508
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace=""
/replace="a"
/db_xref="dbSNP:35023912"
variation 2513
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="t"
/db_xref="dbSNP:79329017"
variation 2548
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="g"
/replace="t"
/db_xref="dbSNP:11152386"
variation 2563
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="c"
/replace="g"
/db_xref="dbSNP:15964"
variation 2596
/gene="SERPINB5"
/gene_synonym="maspin; PI5"
/replace="a"
/replace="g"
/db_xref="dbSNP:11542560"
ORIGIN
agtgggcgtggcggtgctgcccaggtgagccaccgctgcttctgcccagacacggtcgcctccacatccaggtctttgtgctcctcgcttgcctgttccttttccacgcattttccaggataactgtgactccaggcccgcaatggatgccctgcaactagcaaattcggcttttgccgttgatctgttcaaacaactatgtgaaaaggagccactgggcaatgtcctcttctctccaatctgtctctccacctctctgtcacttgctcaagtgggtgctaaaggtgacactgcaaatgaaattggacaggttcttcattttgaaaatgtcaaagatgtaccctttggatttcaaacagtaacatcggatgtaaacaaacttagttccttttactcactgaaactaatcaagcggctctacgtagacaaatctctgaatctttctacagagttcatcagctctacgaagagaccgtatgcaaaggaattggaaactgttgacttcaaagataaattggaagaaacgaaaggtcagatcaacaactcaattaaggatctcacagatggccactttgagaacattttagctgacaacagtgtgaacgaccagaccaaaatccttgtggttaatgctgcctactttgttggcaagtggatgaagaaattttctgaatcagaaacaaaagaatgtcctttcagagtcaacaagacagacaccaaaccagtgcagatgatgaacatggaggccacgttctgtatgggaaacattgacagtatcaattgtaagatcatagagcttccttttcaaaataagcatctcagcatgttcatcctactacccaaggatgtggaggatgagtccacaggcttggagaagattgaaaaacaactcaactcagagtcactgtcacagtggactaatcccagcaccatggccaatgccaaggtcaaactctccattccaaaatttaaggtggaaaagatgattgatcccaaggcttgtctggaaaatctagggctgaaacatatcttcagtgaagacacatctgatttctctggaatgtcagagaccaagggagtggccctatcaaatgttatccacaaagtgtgcttagaaataactgaagatggtggggattccatagaggtgccaggagcacggatcctgcagcacaaggatgaattgaatgctgaccatccctttatttacatcatcaggcacaacaaaactcgaaacatcattttctttggcaaattctgttctccttaagtggcatagcccatgttaagtcctccctgacttttctgtggatgccgatttctgtaaactctgcatccagagattcattttctagatacaataaattgctaatgttgctggatcaggaagccgccagtacttgtcatatgtagccttcacacagatagaccttttttttttttccaattctatcttttgtttccttttttcccataagacaatgacatacgcttttaatgaaaaggaatcacgttagaggaaaaatatttattcattatttgtcaaattgtccggggtagttggcagaaatacagtcttccacaaagaaaattcctataaggaagatttggaagctcttcttcccagcactatgctttccttctttgggatagagaatgttccagacattctcgcttccctgaaagactgaagaaagtgtagtgcatgggacccacgaaactgccctggctccagtgaaacttgggcacatgctcaggctactataggtccagaagtccttatgttaagccctggcaggcaggtgtttattaaaattctgaattttggggattttcaaaagataatattttacatacactgtatgttatagaacttcatggatcagatctggggcagcaccctataaatcaacaccttaatatgctgcaacaaaatgtagaatattcagacaaaatggatacataaagactaagtagcccataaggggtcaaaatttgctgccaaatgcgtatgccaccaacttacaaaaacacttcgttcgcagagcttttcagattgtggaatgttggataaggaattatagacctctagtagctgaaatgcaagaccccaagaggaagttcagatcttaatataaattcactttcatttttgatagctgtcccatctggtcatttggttggcactagactggtggcaggggcttctagctgacttgcacagggattctcacaatagccgatatcagaatttgtgttgaaggaacttgtctcttcatctaatatgatagcgggaaaaggagaggaaactactgcctttagaaaatataagtaaagtgattaaagtgctcacgttaccttgacacatagtttttcagtctatgggtttagttactttagatggcaagcatgtaacttatattaatagtaatttgtaaagttggttggataagctatccgtgttgcaggttcatggattacttctctataaaaaatatgtatttaccaaaaattttgtgacattccttctcccatctcttccttgacctgcattgtaaataggttcttcttgttctgagattcaatattgaatttttcctatgctattgacaataaaatattattgaactaca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5268 -> Molecular function: GO:0004867 [serine-type endopeptidase inhibitor activity] evidence: IBA
GeneID:5268 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5268 -> Biological process: GO:0002009 [morphogenesis of an epithelium] evidence: IEA
GeneID:5268 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
GeneID:5268 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: IBA
GeneID:5268 -> Biological process: GO:0030162 [regulation of proteolysis] evidence: IBA
GeneID:5268 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: IEA
GeneID:5268 -> Biological process: GO:0050678 [regulation of epithelial cell proliferation] evidence: IEA
GeneID:5268 -> Biological process: GO:0060512 [prostate gland morphogenesis] evidence: IEA
GeneID:5268 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
GeneID:5268 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
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@meso_cacase at
DBCLS
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