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2025-05-09 16:52:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001277335 2794 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens RAS p21 protein activator 4B (RASA4B), mRNA.
ACCESSION NM_001277335 XM_003118598 XM_003118599 XM_003118600 XM_003119053
XM_003119054 XM_003119055 XM_003959919 XM_003960009
VERSION NM_001277335.1 GI:472824973
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2794)
AUTHORS Lockyer,P.J., Kupzig,S. and Cullen,P.J.
TITLE CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK
pathway
JOURNAL Curr. Biol. 11 (12), 981-986 (2001)
PUBMED 11448776
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC093668.4.
On or before Apr 3, 2013 this sequence version replaced
gi:410170527, gi:310120064, gi:310120066, gi:410170525,
gi:310118383, gi:310118385, gi:410170364, gi:410170366.
CCDS Note: The exon combination of this transcript is based on the
paralogous transcript alignment AK026441.1.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
inferred exon combination :: based on alignments, homology
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-132 AC093668.4 131596-131727 c
133-189 AC093668.4 125875-125931 c
190-303 AC093668.4 124129-124242 c
304-365 AC093668.4 123549-123610 c
366-495 AC093668.4 120645-120774 c
496-577 AC093668.4 117113-117194 c
578-709 AC093668.4 115046-115177 c
710-804 AC093668.4 114649-114743 c
805-922 AC093668.4 110797-110914 c
923-1073 AC093668.4 110419-110569 c
1074-1138 AC093668.4 110090-110154 c
1139-1251 AC093668.4 109228-109340 c
1252-1444 AC093668.4 108831-109023 c
1445-1582 AC093668.4 108488-108625 c
1583-1727 AC093668.4 107775-107919 c
1728-1897 AC093668.4 107066-107235 c
1898-2033 AC093668.4 102413-102548 c
2034-2154 AC093668.4 98989-99109 c
2155-2219 AC093668.4 97775-97839 c
2220-2794 AC093668.4 97089-97663 c
FEATURES Location/Qualifiers
source 1..2794
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22.1"
gene 1..2794
/gene="RASA4B"
/note="RAS p21 protein activator 4B"
/db_xref="GeneID:100271927"
/db_xref="HGNC:35202"
exon 1..132
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
CDS 68..2341
/gene="RASA4B"
/codon_start=1
/product="putative Ras GTPase-activating protein 4B"
/protein_id="NP_001264264.1"
/db_xref="GI:472824974"
/db_xref="CCDS:CCDS59506.1"
/db_xref="GeneID:100271927"
/db_xref="HGNC:35202"
/translation="
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
"
misc_feature 83..445
/gene="RASA4B"
/note="C2 domain first repeat present in RasA1 and RasA4;
Region: C2A_Rasal1_RasA4; cd04054"
/db_xref="CDD:176018"
misc_feature order(128..130,146..148,287..289,293..295,311..313)
/gene="RASA4B"
/note="Ca2+ binding pocket [ion binding]; other site"
/db_xref="CDD:176018"
misc_feature 467..838
/gene="RASA4B"
/note="C2 domain second repeat present in RasA1 and RasA4;
Region: C2B_RasA1_RasA4; cd04025"
/db_xref="CDD:175991"
misc_feature order(512..514,530..532,671..673,677..679,695..697)
/gene="RASA4B"
/note="Ca2+ binding pocket [ion binding]; other site"
/db_xref="CDD:175991"
misc_feature 860..1717
/gene="RASA4B"
/note="Ras-GTPase Activating Domain of RASA4; Region:
RasGAP_RASA4; cd05395"
/db_xref="CDD:213343"
misc_feature order(974..976,1082..1084,1088..1090,1094..1099,
1103..1105,1112..1114,1124..1126,1457..1459,1481..1486,
1493..1498,1505..1507,1568..1570,1577..1582,1589..1591,
1601..1603,1607..1609,1628..1633)
/gene="RASA4B"
/note="putative RAS interface [polypeptide binding]; other
site"
/db_xref="CDD:213343"
misc_feature 1691..1972
/gene="RASA4B"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl17171"
/db_xref="CDD:247725"
misc_feature <1904..2059
/gene="RASA4B"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl17171"
/db_xref="CDD:247725"
exon 133..189
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 190..303
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 304..365
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 366..495
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 496..577
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 578..709
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 710..804
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 805..922
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 923..1073
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 1074..1138
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
variation 1121
/gene="RASA4B"
/replace="a"
/replace="g"
/db_xref="dbSNP:746316"
exon 1139..1251
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 1252..1444
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 1445..1582
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 1583..1727
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 1728..1897
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 1898..2033
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 2034..2154
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 2155..2219
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
exon 2220..2794
/gene="RASA4B"
/inference="alignment:Splign:1.39.8"
ORIGIN
agtccagcgcccgccgcccgccaccccggaccccggtgtctggcttcccccgagccggcaccccgcgatggccaagcgcagctcgctgtacatccgcatcgtggaggggaagaaccttcccgccaaggacatcactggcagcagcgacccctactgcatcgtgaaggtggacaatgagcccatcatcaggacagccacagtgtggaagaccctgtgccccttctggggtgaggagtaccaagtgcacctgccgcccaccttccacgctgtggctttctatgtcatggatgaggatgccctcagccgggacgacgttatcggaaaggtctgccttacaagggacaccatagcctctcaccctaagggtttcagcgggtgggcccacctgacagaggtcgaccccgacgaggaggtgcagggcgagatccacctgcggctggaagtgtggccaggggcccgggcctgccggctacgctgctctgtgctggaggccagggatctggccccaaaggaccgcaatggcacatctgaccccttcgtccgagtgcgctacaagggccggacacgggagacctcgatcgtgaagaagtcatgctacccacgctggaatgagacgtttgaatttgagctgcaggagggggccatggaggcgctgtgcgtggaggcctgggactgggaccttgtcagccgaaacgacttcctgggcaaagtggtgattgatgtccagagactgcgggtggtgcagcaggaggagggctggttccggctgcagcccgaccagtccaagagccggcggcatgacgagggcaacctgggctccttgcagctggaggtgcggctgcgggacgagacggtgctgccctccagctactaccagccactggtgcacctgctgtgccacgaggtcaagctgggcatgcagggcccagggcagctgatcccactcatcgaggagacaaccagcaccgagtgtcgccaggacgtggccacgaacctgctcaagctcttcctggggcaggggctggccaaggacttcctggacctgctcttccagctggagctgagtcgcaccagtgagaccaacaccctgttccggagcaactctctggcctcaaagtccgtggagtcttttctgaaggtggccgggatgcagtacctgcacggcgtcctgggccccatcatcaacaaggtgtttgaggagaagaagtacgtggagctggaccccagcaaagtggaagttaaggatgtagggtgctccgggctgcaccgcccgcagaccgaggccgaggtgctggagcagagcgcgcagacgctgcgcgcccacctgggggccctgctgagcgcgctcagccgctcggttcgcgcgtgccccgccgtggtgcgcgccaccttccgccagctcttccggcgcgtgcgcgagcgcttccccggcgcccagcacgagaatgtaccgttcatcgccgtcaccagcttcctgtgcctgcgcttcttctctcccgccatcatgtcgcccaagctcttccacctgcgggagcgccacgcggacgcccgcaccagccgcaccctgctcctgttggccaaggcagtccagaacgtgggcaacatggacacgccggcttccagggccaaggaggcttggatggagccgctgcagcccaccgtgcaccagggcgtggcgcagctgaaggacttcatcaccaagctcgtggacatcgaggagaaggacgagctggacctgcagcggacgctgagtttgcaggcgccacctgtgaaggaggggccactcttcatccacaggaccaagggcaagggccccctcatgtcctcctccttcaagaagctctacttctccctcactaccgaggccctcagcttcgcgaagacgcccagctccaagtgtgtgaatgagcttaaccagtggctgtctgcgctgcggaaggtgagcatcaacaacaccggactgctgggctcctaccaccctggcgtcttccgtggggacaagtggagctgctgccaccaaaaagagaagacaggtcagggctgcgataagacccggtcacgggtgaccctgcaggagtggaatgaccctcttgaccatgaccttgaggcccagctcatctaccggcacctgctgggcgtggaggccatgctgtgggagaggcaccgggagctgagcgggggcgcagaggcaggcacggtgcccacgagccctggcaaagtccccgaggactcattggcccggctgctccgggtgctgcaggacctccgcgaggcccatagctccagcccggccggctccccaccctcagagcccaactgcctcctggagctgcagacgtgaggcccgccctacgctccccttgctgagtcccctgccaagcgctcggagcccccccaggacactctgcaccccctcaccccggtcctcctcattagggtgcagggcctaggtctcttccaggtgggggaggggggagagtcaggaataaggggatccccagaagtgcagagctgagcaggcttgggcctgtcatggctggccggaagtgtccccagctccctacagacgctgtagccatcactgcctctccagggaccctcctctcctgcccaggacagacccagccagaaccactgctaggatgggccgcacccaggggtctggcctccagggacctagagaatgggagggagaacggggccccaggagacccggccgccaccccacccgctacccttgggtgccacagggctgtgctgttgccaacagtaaacctgctcttactgtccaggc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:100271927 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IEA
GeneID:100271927 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:100271927 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:100271927 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IEA
GeneID:100271927 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: IEA
GeneID:100271927 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:100271927 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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